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| 1 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 2 | The Chromosome-Level Reference Genome of Tea Tree Unveils Recent Bursts of Nonautonomous LTR Retrotransposons in Driving Genome Size Evolution显示文摘Dear Editor,The tea tree Camellia sinensis,a member of the genus Camellia in the Theaceae family,includes two major cultivated varieties,C.sinensis var.assamica(CSA\Assam type)and C.sinensis var.sinensis(CSS;Chinese type)(Ming and Bartholomew,2007).Due to the high economic importance of the tea tree,considerable efforts have been made to explore genetic basis of the biosynthesis of natural metabolites that determine health benefits and diverse tea flavors(Shi et al.,2011;Li et al.,2011;Li et al.,2015;Xia et aL,2017;Liu et al.,2019). | Qun-Jie Zhang Wei L i Kui Li Hong Nan Cong Shi Yun Zhang Zhang-Yan Dai Yang-Lei Lin Xiao-Lan Yang Yan Tong Dan Zhang Cui Lu Li-Ying Feng Chen-Feng Wang Xiao-Xin Liu Jian-An Huang Wen-Kai Jiang Xing-Hua Wang Xing-Cai Zhang Evan E.Eichler Zhong-Hua Liu and Li-Zhi Gao | 2020 | Molecular Plant2020，13，7： | 27 |
| 3 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know显示文摘Granulocyte 巨噬细胞刺激殖民地的因素(GM-CSF ) 是一个重要造血的生长因素和有免疫力的调节的人。GM-CSF 也在各种各样的传播白血球的功能的活动有深刻效果。它被许多房间类型在收到有免疫力的刺激之上包括 T 房间,巨噬细胞, endothelial 房间和成纤维细胞生产。尽管 GM-CSF 局部地被生产,它能以一种 paracrine 方式行动到在主人防卫提高他们的功能的成员传播 neutrophils,单核白血球和淋巴细胞。最近的集中的调查为它增加树枝状的房间(DC ) 成熟和功能以及巨噬细胞活动的能力作为一个有免疫力的助手在 GM-CSF 的应用程序上被集中。在经历化疗的癌症病人对待嗜中性白血球减少症临床上被使用,在在治疗期间的爱滋病病人,并且在在骨髓移植以后的病人。有趣地, GM-CSF-deficient 老鼠的造血的系统看起来正常;最重要的变化在一些特定的 T 房间回答。尽管 GM-CSF 的分子的克隆用 T 房间的 cDNA 图书馆被执行, T 房间在激活以后生产 GM-CSF,是众所周知的,在 T 房间功能上有在由 T 房间和它的效果的生产的这 cytokine 的系统的调查的缺乏。在这篇文章,我们将在 T 房间主要集中于 GM-CSF 的免疫生物学。 | Yufang Shi Catherine H Liu Arthur I Roberts Jyoti Das Guangwu Xu Guangwen Ren Yingyu Zhang Liying Zhang Zeng Rong Yuan Hung Sheng William Tan Gobardhan Das Satish Devadas | 2006 | Cell Research2006，16，2： | 22 |
| 4 | International consensus statement on robotic hepatectomy surgery in 2018显示文摘The robotic surgical system has been applied in liver surgery. However,controversies concerns exist regarding a variety of factors including the safety,feasibility, efficacy, and cost-effectiveness of robotic surgery. To promote the development of robotic hepatectomy, this study aimed to evaluate the current status of robotic hepatectomy and provide sixty experts' consensus and recommendations to promote its development. Based on the World Health Organization Handbook for Guideline Development, a Consensus Steering Group and a Consensus Development Group were established to determine the topics, prepare evidence-based documents, and generate recommendations. The GRADE Grid method and Delphi vote were used to formulate the recommendations. A total of 22 topics were prepared analyzed and widely discussed during the 4 meetings. Based on the published articles and expert panel opinion, 7 recommendations were generated by the GRADE method using an evidence-based method, which focused on the safety, feasibility, indication,techniques and cost-effectiveness of hepatectomy. Given that the current evidences were low to very low as evaluated by the GRADE method, further randomized-controlled trials are needed in the future to validate these recommendations. | Rong Liu Go Wakabayashi Hong-Jin Kim Gi-Hong Choi Anusak Yiengpruksawan Yuman Fong Jin He Ugo Boggi Roberto I Troisi Mikhail Efanov Daniel Azoulay Fabrizio Panaro Patrick Pessaux Xiao-Ying Wang Ji-Ye Zhu Shao-Geng Zhang Chuan-Dong Sun Zheng Wu Kai-Shan Tao Ke-Hu Yang Jia Fan Xiao-Ping Chen | 2019 | World Journal of Gastroenterology2019，25，12： | 23 |
| 5 | Risk factors of intrahepatic cholangiocarcinoma in patients with hepatolithiasis:a case-control study显示文摘BACKGROUND:Why 3.3% to 10% of all patients with hepatolithiasis develop intrahepatic cholangiocarcinoma (ICC) remains unknown.We carried out a hospital-based case-control study to identify risk factors for the development of ICC in patients with hepatolithiasis in China.METHODS:Eighty-seven patients with pathologically diagnosed hepatolithiasis associated with ICC and 228 with hepatolithiasis alone matched by sex,age (±2 years),hospital admittance and place of residence were interviewed during the period of 2000-2008.Odds ratios (OR) and 95% confidence intervals (CI) were calculated for each risk factor.RESULTS:Among the patients with hepatolithiasis associated with ICC,the mean age was 57.7 years and 61.0% were female Univariate analysis showed that the significant risk factors for ICC development in hepatolithiasis were smoking,family history of cancer,appendectomy during childhood (under age 20),and duration of symptoms >10 years.In multivariate stepwise logistic regression analysis,smoking (OR=1.931,95% CI:1.000-3.731),family history of cancer (OR=5.175,95% CI:1.216-22.022),and duration of symptoms >10 years (OR=2.348 95% CI:1.394-3.952) were independent factors.CONCLUSION:Smoking,family history of cancer and duration of symptoms >10 years may be risk factors for ICC in patients with hepatolithiasis. | Zhen-Yu Liu,Yan-Ming Zhou,Le-Hua Shi and Zheng-Feng YinAuthor Affiliations:Molecular Oncology Laboratory and Department of Comprehensive Treatment I,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China Department of Hepato-Biliary-Pancreato-Vascular Surgery,First Affiliated Hospital,Xiamen University,Xiamen 361003,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，6： | 21 |
| 6 | Prognostic evaluation of postoperative adjuvant therapy for operable cervical cancer:10 years'experience of National Cancer Center in China显示文摘Objective: The aim of this study was to investigate the prognostic factors and to evaluate the impact of adjuvant therapy on clinical outcome for early-stage cervical cancer.Methods: The clinical-pathological data of all 1,335 patients with the International Federation of Gynecology and Obstetrics(FIGO) Ib–IIa cervical cancer treated with primary radical surgery at the Chinese National Cancer Center between May 2007 and Dec 2013 were retrospectively reviewed.The median follow-up was 70 months.Results: Of all the patients,61.6% of the cases received adjuvant therapy,with 5-year disease-free survival(DFS)of 92.1% and 5-year overall survival(OS) of 95.0%.In multivariate analysis,differentiation of G3(P<0.05),lymph node metastasis(LNM,P<0.05) and lymphovascular space invasion(LVSI,P<0.05) were independent predictors for OS,while LNM(P<0.05),deep stroma invasion(DSI,P<0.05) and LVSI(P<0.05) were independent factors for DFS.The samples were stratified by histologic type,and cervical squamous cell carcinoma(SCC) was found to share the same independent factors except for differentiation of OS.As to patients with cervical adenocarcinoma/adenosquamous carcinoma(AC/ASC),differentiation was the independent predictor of OS(P<0.05); and LVSI of DFS(P<0.05).Of 236 patients with high-risk factors,there was no significant difference in survival between concurrent chemoradiotherapy(CCRT,n=195),radiotherapy(RT,n=24),and chemotherapy(CT,n=17).Among the 190 patients with LNM who underwent CCRT,124 cases showed improved DFS after sequential CT(P=0.118),with a recurrence rate decrease of 14%,though the difference was not statistically significant.Patients with single intermediate-risk factors like DSI or LVSI were found to partially benefit from adjuvant therapy,but the difference was not statistically significant.Conclusions: LNM,LVSI,DSI and differentiation were found to be independent prognostic factors for operable cervical cancer.Aggressive postoperative adjuvant therapy based on single risk factors in Chinese National Cancer Center could benefit survival.CCRT+CT outperformed CCRT in high-risk patients.For patients with single non-high-risk factor,the role of adjuvant therapy needs to be further discussed. | Tong Shu Dan Zhao Bin Li Yating Wang Shuanghuan Liu Pingping Li Jing Zuo Ping Ba i RongZhang Lingying Wu | 2017 | Chinese Journal of Cancer Research2017，29，6： | 12 |
| 7 | Metal-organic framework-derived porous shuttle-like vanadium oxides for sodium-ion battery application显示文摘有分层的结构的钒氧化物为锂离子电池和钠离子电池(亲族) 正在答应候选人。自我模板途径,从金属器官的框架(MOF ) 包含转变进多孔的金属氧化物,是完成理想的电气化学的性能的一个新奇、有效的方法。在这研究,多孔的像梭的钒氧化物(即, V 2 O 5, V 2 O 3/C) 被与一个特定的锻烧过程把 MIL-88B (V) 用作先锋成功地准备。作为 proof-of-concept 应用, asprepared 多孔的像梭的 V 2 O 3/C 为亲族被用作阳极材料。多孔的像梭的 V 2 与金属性的行为有固有的分层的结构的 O 3/C, ,展出优秀电气化学的性质。417, 247, 202, 176, 164,和 149 mAhants 的显著的率能力,仅仅 CC 一?? | Yangsheng Cai Guozhao Fang Jiang Zhou Sainan Liu Zhigao Luo Anqiang Pan Guozhong Cao I Shuquan Liang | 2018 | Nano Research2018，11，1： | 12 |
| 8 | 青海共和盆地达连海湖泊流域表土花粉-气候响应面分析显示文摘孢粉分析是研究过去全球变化的一种重要方法,而研究花粉与现代气候之间的相互关系是古气候定量重建研究中的前沿课题。要预测未来气候的中长期变化,必须从花粉记录中定量提取古气候信息,建立的多种孢粉-气候数学模型必须经过不同边界条件下的古气候数据检验校正才能应用到实际当中。花粉-气候响应面方法是考虑了花粉与气候间的非线形关系上,提出的将现代花粉丰度在地理空间的分布转换为气候空间的分布,并以提供定量的古气候数据,已被广泛应用于COHMAP等各种重要古气候研究项目。本文就是利用该方法,以青藏高原东北部共和盆地达连海湖泊流域54个表土样品中的花粉丰度及采样点的气候参数为基础数据,通过主成分分析选择了特征值高且指示意义明显的4种花粉类型,对其丰度与7月平均温度及年平均降水量两个气候参数进行多项式回归分析,其结果显示模型对数据拟合较好,为定量重建该区古气候变化提出了较为准确的数量指标。 | 陈英玉 QING Hai-ruo VELEZ M I LIU Meng 魏豆豆 蔡遥 | 2014 | 地球学报2014，35，1： | 10 |
| 9 | Immune checkpoint inhibitor-related hepatotoxicity:A review显示文摘The application of immune checkpoint inhibitors(ICI)in advanced cancer has been a major development in the last decade.The indications for ICIs are constantly expanding into new territory across different cancers,disease stages and lines of therapy.With this increased use,adverse events including immune checkpoint inhibitor-related hepatotoxicity(ICH)have emerged as an important clinical problem.This along with the introduction of ICI as first-and second-line treatments for advanced hepatocellular carcinoma makes ICH very relevant to gastroenterologists and hepatologists.The incidence of ICH varies between 1%-20%depending on the number,type and dose of ICI received.Investigation and management generally involve excluding differential diagnoses and following a stepwise escalation of withholding or ceasing ICI,corticosteroid treatment and adding other immunosuppressive agents depending on the severity of toxicity.The majority of patients with ICH recover and some may even safely recommence ICI therapy.Guideline recommendations are largely based on evidence derived from retrospective case series which highlights a priority for future research. | Devika Remash David S Prince Catriona McKenzie Simone I Strasser Steven Kao Ken Liu | 2021 | World Journal of Gastroenterology2021，27，32： | 9 |
| 10 | Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction显示文摘 | Xiao-E Jia Ke Ma Tao Xu Lei Gao Shuang Wu Cong Fu Wenjuan Zhang Zhizhang Wang Kaiyu Liu Mei Dong Changbin Jing Chunguang Ren Zhiwei Dong Yi Chen Yi Jin Qiuhua Huang Xing Chang Min Deng Li Li Lingfei Luo Jun Zhu Yongjun Dang Hung-Chun Chang Leonard I Zon Yi Zhou Saijuan Chen Weijun Pan | 2015 | Cell Research2015，25，8： | 8 |
| 11 | 无放疗史的成人ETV6-NTRK3易位甲状腺乳头状癌的临床和形态学特征显示文摘据报道,ETV6-NTRK3易位甲状腺乳头状癌(PTCs)通常与放疗相关且多发生在小儿。作者描述了12例无放疗史的成人ETV6-NTRK3易位PTCs的临床病理学特征,均为经二代测序技术证实的病例。患者平均年龄为37岁,以女性多见(女:男=10:2)。6例患者行术前细针穿刺,其中4例诊断为恶性,2例诊断为“性质未定的滤泡性病变”。术后病理证实1/3(4/12)的患者有甲状腺外浸润,1/2(5/10)有淋巴结转移,1例出现了脑转移。 | Seethala R R Chiosea S I Liu C Z 黄爱清 余英豪 | 2017 | 临床与实验病理学杂志2017，33，10： | 8 |
| 12 | A broad deglacial δ^(13)C minimum event in planktonic foraminiferal records in the Okinawa Trough显示文摘The equatorial Pacific upwelling zone has been suspected of playing an important role in the global atmospheric CO2 changes associated with glacial-interglacial cycles. In order to assess the influencing scope of the surface water deglacial δ13C minimum in the tropical low-latitude Pacific, the core DGKS9603, collected from the middle Okinawa Trough, was examined for δ13C records of planktonic fo-raminifera N. dutertrei and G. ruber. The planktonic fo-raminiferal δ13C records show a clear decreasing event from 20 to 6 cal. kaBP., which is characterized by long duration of about 14 ka and amplitude shift of 0.4×10-3. Its minimum value occurred at 15.7 cal kaBP. The event shows fairly synchrony with the surface water deglacial δ13C minimum identified in the tropical Pacific and its marginal seas. Because there is no evidence in planktonic foraminiferal fauna and δ18O records for upwelling and river runoff enhancement, the broad deglacial δ13C minimum event in planktonic foraminiferal records | LI Tiegang, LIU Zhenxia, M. A. Hall, Y. Saito, S. Berne, GANG Shuxi & CHENG ZhenboInstitute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China The First Institute of Oceanography, State Oceanic Administration, Qingdao 266003, China Godwin I | 2002 | Chinese Science Bulletin2002，47，7： | 7 |
| 13 | 稀土元素分析显示文摘本文对1992~1993年间稀土元素分析化学方面的进展进行了评述,内容包括分离方法,重量法,容量法,吸光光度法,荧光光度法,原子吸收光谱法,原子发射光谱法,原子荧光光谱法,X-射线荧光光谱法,发光分析法,中子活化分析法,电化学分析法,质谱法(MS)及其他分析方法的综述,引用文献305篇。 | Liu Wenhua Wang Changqing and Cao Xiangjiu (Beijing GeneralResearch institute for Non-Ferrous Metals, Beijingl 00088 ) , Fenxi Shiyanshi , 1 994 , 1 3 ( 5 1 , 77~ 87This is the fourth biennial periodic review on rareearth elements analysis. The review i | 1994 | 分析试验室1994，13，5： | 6 |
| 14 | Integrative taxonomy of the Russet Bush Warbler Locustella mandelli complex reveals a new species from central China显示文摘Background: The Russet Bush Warbler Locustella(previously Bradypterus) mandelli complex occurs in mountains in the eastern Himalayas, southern China, Vietnam, the Philippines, and Indonesia. The taxonomy has been debated,with one(L. seebohmi) to four(L. seebohmi, L. mandelli, L. montis and L. timorensis) species having been recognised.Methods: We used an integrative approach, incorporating analyses of morphology, vocalizations and a molecular marker, to re-evaluate species limits in the L. mandelli complex.Results: We found that central Chinese L. mandelli differed from those from India through northern Southeast Asia to southeast China in plumage, morphometrics and song. All were easily classified by song, and(wing + culmen)/tail ratio overlapped only marginally. Both groups were reciprocally monophyletic in a mitochondrial cytochrome b(cytb) gene tree, with a mean divergence of 1.0 ± 0.2%. They were sympatric and mostly altitudinally segregated in the breeding season in southern Sichuan province. We found that the Mt Victoria(western Myanmar) population differed vocally from other L. mandelli, but no specimens are available. Taiwan Bush Warbler L. alishanensis was sister to the L. mandelli complex, with the most divergent song. Plumage, vocal and cytb evidence supported the distinctness of the south Vietnamese L. mandelli idonea. The Timor Bush Warbler L. timorensis, Javan Bush Warbler L.montis and Benguet Bush Warbler L. seebohmi differed distinctly in plumage, but among-population song variation in L. montis exceeded the differences between some populations of these taxa, and mean pairwise cytb divergences were only 0.5–0.9%. We also found that some L. montis populations differed morphologically.Conclusions: We conclude that the central Chinese population of Russet Bush Warbler represents a new species,which we describe herein, breeding at mid elevations in Sichuan, Shaanxi, Hubei, Hunan and Guizhou provinces.The taxonomic status of the other allopatric populations is less clear. However, as they differ to a degree comparable with that of the sympatric L. mandelli and the new species, we elevate L. idonea to species status, and retain L. seebohmi and L. montis as separate species, the latter with timorensis as a subspecies. Further research should focus on different populations of L. montis and the Mt Victoria population of L. mandelli. | Per Alstrom Canwei Xia Pamela C Rasmussen Urban Olsson Bo Dai Jian Zhao Paul J Leader Geoff J Carey Lu Dong Tianlong Cai Paul I Holt Hung Le Manh Gang Song Yang Liu Yanyun Zhang Fumin Lei | 2015 | Chinese Birds2015，，2： | 4 |
| 15 | Genesis of continental seismogenic zone and a new fault zone model显示文摘Experiments were conducted repeatedly on Mannari granite under different temperature and confining pressure conditions. Systematic micro- and submicro-structural and mechanical analyses of granite samples deformed under 1.5 GPa (confining pressure), at 25 ℃-650 ℃ temperatures and at 2×10-6s-1 strain rate show the brittle-ductile deformation microstructures and microstructural associations similar to those observed in naturally deformed crustal rocks and minerals. Brittle fracturing and crystalline plasticity co-exist and react with each other in the brittle-ductile transition domain of the continental lithosphere. The interaction between the different mechanisms in the transitional domain results in the variation of anomalous strength values, which may best explain the genesis of the continental seismogenic zone. A new fault zone model is proposed on the basis of detailed micromechanical and microstructural analyses. | LIU Junlai & M. Shimada1. Department of Earth Sciences, Changchun University of Science and Technology, Changchun 130026, China 2. RCEP, Disaster Prevention Research Institute, Kyoto University, Uji, Kyoto, 611-0011, Japan Correspondence should be addressed to Liu Junlai i | 2000 | Chinese Science Bulletin2000，45，20： | 4 |
| 16 | Structural insights into SUN-KASH complexes across the nuclear envelope显示文摘nucleoskeleton 和细胞骨架(LINC ) 的连接器建筑群由阳光和 KASH 包含域的蛋白质组成并且衔接原子信封的内部、外部的膜。LINC 建筑群在原子放,房间极化和细胞的僵硬起关键作用。以前,我们报导了人的 SUN2 的 homotrimeric 结构。我们现在决定了人的 SUN2-KASH 建筑群的水晶结构。在复杂结构, SUN 领域 homotrimer 绑在三独立 “ hook”相似 KASH 肽。在建筑群的 SUN 领域的全面符合构造非常处于它的 apo 状态类似于 SUN 领域。一个主要 conformational 变化包含 KASH 固定的阳光领域的 AA'-loop,它重排形成微型 β与 KASH 肽交往的表。KASH 领域的磅主题在 SUN 领域的 homotrimeric 接口上紧适合进一个恐水病的衣袋,我们它称为双性人衣袋。而且, SUN 领域 homotrimer 三明治的二邻近的 protomers 由结合的恐水病的相互作用和氢的 KASH 领域。这些有约束力的地点的变化在 vitro 破坏或减少在 SUN 和 KASH 域之间的协会。另外, transfection 野类型,然而并非变异, SUN2 在 Ovcar-3 房间支持房间移植。这些结果提供 LINC 建筑群的一个结构的模型,它为另外的学习是必要的物理、功能在细胞质和核质之间联合。 | Wenjia Wang Zhubing Shi Shi Jiao Cuicui Chen Huizhen Wang Guoguang Liu Qiang Wang Yun Zhao Mark I Greene Zhaocai Zhou | 2012 | Cell Research2012，22，10： | 3 |
| 17 | miRNA let-7al抑制前列腺癌PC-3细胞中IGF1R的表达显示文摘miRNAlet-7al表达减少和IGF1R信号通路激活都与前列腺癌的发生发展密切相关,两者之间在肿瘤中的表达关系尚未明确。我们最近研究发现,在前列腺癌PC-3细胞中,let-7al可直接靶向调控IGFIR的表达,抑制细胞增殖。首先通过TargetScan分析,发现IGF1R是let-7al的靶基因之一,在它的3’非翻译区存在3个let-7al的靶点(T1、T2、T3)。采用实时定量PCR、免疫印迹和荧光素酶报告基因检测技术检测Pc.3细胞中let-7al对IGF1R基因表达的影响。结果显示,let-7al可直接作用于IGF1R mRNA的3’非翻译区中的T1和T2靶点,靶向抑fNIGFIR基因的表达。进一步采用RT-PCR、荧光素酶报告基因检测、MTT、流式细胞术和Hoechst 33342染色技术,检测let-7al导致的IGF1R表达下调对IGF1R信号通路的影响。结果表明,let-7al下调IGF1R表达可使E1k1活化减少、其靶基因c-los表达降低、细胞增殖抑制、凋亡增强和细胞周期阻滞;反之,抑制let-7al可使IGF1R表达上调,伴有E1k1活性增强、c-fos表达增加、细胞增殖加快。以上结果提示,miRNA let-7a有可能成为前列腺癌治疗的新靶点。 | Li-Na Wang Wei-Wen Chen Ju Zhang Chao-Yang Li Chun-Yan Liu Iing Xue Peng-Ju Zhang An-Li Jiang | 2013 | Asian Journal of Andrology2013，15，6： | 3 |
| 18 | Monitoring Greenhouses Gases over China Using Space-Based Observations Monitoring Greenhouses Gases over China Using Space-Based Observations显示文摘The atmospheric carbon dioxide(CO 2)concentration has increased to more than 405 parts per million(ppm.1 ppm=10-6 m/s 2)in 2017 due to human activities such as deforestation,land-use change and burning of fossil fuels.Although there is broad scientific consensus on the damaging consequences of the change in climate associated with increasing concentrations of greenhouse gases,fossil CO 2 emissions have continued to increase in recent years mainly from rapidly developing economies and China is now the largest emitter of CO 2 generating about 30%of all emissions globally.To allow more reliable forecast of the future state of the carbon cycle and to support the efforts for mitigation greenhouse gas emissions,a better understanding of the global and regional carbon budget is needed.Space-based measurements of CO 2 can provide the necessary observations with dense coverage and sampling to provide improved constrains on of carbon fluxes and emissions.The Chinese Global Carbon Dioxide Monitoring Scientific Experimental Satellite(TanSat)was established by the National High Technology Research and Development Program of China with the main objective of monitoring atmospheric CO 2 and CO 2 fluxes at the regional and global scale.TanSat has been successfully launched in December 2016 and as part of the Dragon programme of ESA and the Ministry of Science and Technology(MOST),a team of researchers from Europe(UK and Finland)and China has evaluated early TanSat data and contrast it against data from the GOSAT mission and models.In this manuscript,we report on retrieval intercomparisons of TanSat data using two different retrieval algorithms,on validation efforts for the Eastern Asia region using GOSAT CO 2 data and first assessments of TanSat and GOSAT CO 2 data against model calculations using the GEOS-Chem model. | Hartmut BOESCH Yi LIU Paul I PALMER Johanna TAMMINEN Jasdeep S ANAND Zhaonan CAI Ke CHE Huilin CHEN Xi CHEN Liang FENG Janne HAKKARAINEN Pauli HEIKKINEN Nikoleta KALAITZI Rigel KIVI Robert PARKER Peter SOMKUTI Jing WANG Alex WEBB Dongxu YANG Lu YAO You YI | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 2 |
| 19 | Efficacy of transient elastography in screening for large esophageal varices in patients with suspicious or proven liver cirrhosis显示文摘 | Huay‐Min WANG Gin‐Ho LO Wen‐Chi CHEN Ping‐I HSU Hsien‐Chung YU Chiun‐Ku LIN Hoi‐Hung CHAN Wei‐Lun TSAI Feng‐Woei TSAY Tsan‐Ping LIU E‐Ming WANG Kwok‐Hung LAI | 2012 | Journal of Digestive Diseases2012，，8： | 2 |
| 20 | Satellite observations of modulation of surface winds by typhoon-induced upper ocean cooling显示文摘 | LIN I I LIU W T WU C C | 2003 | Geophysical Research Letters2003，30，3： | 1 |
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