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| 1 | Uric acid stimulates endothelin-1 gene expression associated with NADPH oxidase in human aortic smooth muscle cells显示文摘瞄准:最近的试验性、人的研究证明了 hyperuricemia 与高血压和心血管的疾病被联系。endothelin-1 (ET-1 ) 的提高的层次被认为是心血管的疾病的最强大的独立预言者之一。为调查尿导致酸的脉管的疾病是否与 ET-1 有关,在人的大动脉的光滑的肌肉房间(HASMC ) 的尿导致酸的 ET-1 表示被检验。方法:与尿酸,房间增长和 ET-1 表示对待的有教养的 HASMC 被检验。尿导致酸的细胞外的调整信号的家族 ases (英皇家空军之阶级最低之兵) 上的抗氧化剂预告的处理 phosphorylation 被执行阐明在增长和 ET-1 基因表示的氧化还原作用敏感的小径。结果:尿酸被发现增加 HASMC 增长, ET-1 表示和反应的氧种类生产。N-acetylcysteine 和 apo-cynin 的能力(l-[4-hydroxy-3-methoxyphenyl ] ethanone,一个 NADPH oxidase 禁止者) 建议了细胞内部的氧化还原作用小径的参与禁止尿导致酸的 ET-1 分泌物和房间增长。而且, apocynin,和 p47 phox 击倒的禁止的 ET-1 分泌物和房间增长由尿酸导致了的小介入 RNA。由 U0126 的英皇家空军之阶级最低之兵的抑制(1,4-diamino-2,3-dicyano-1,4-bis [2-aminophenylthio ] 丁二烯) 显著地压制的尿导致酸的 ET-1 表示,含有在对尿酸的反应的这条小径。另外,尿酸增加了抄写因素使活跃之物 protein-1 (AP-1 ) 调停的记者活动,以及 ERK phosphorylation。ET-1 基因倡导者的 Mutational 分析证明 AP-1 有约束力的地点是在尿导致酸的 ET-1 基因表示的重要 cis 元素。结论:这是由在 HASMC 的尿酸的 ET-1 规定的第一观察,它含有在脉管的变化的尿酸的重要角色与高血压和脉管的疾病联系了。 | Hung-hsing CHAO Ju-chi LIU Jia-wei LIN Cheng-hsien CHEN Cheng-hsi WU Tzu-hurng CHENG | 2008 | Acta Pharmacologica Sinica2008，29，11： | 31 |
| 2 | Characterization of drug responses of mini patient-derived xenografts in mice for predicting cancer patient clinical therapeutic response显示文摘Background:Patient-derived organoids and xenografts(PDXs)have emerged as powerful models in functional diag-nostics with high predictive power for anticancer drug response.However,limitations such as engraftment failure and time-consuming for establishing and expanding PDX models followed by testing drug efficacy,and inability to subject to systemic drug administration for ex vivo organoid culture hinder realistic and fast decision-making in selecting the right therapeutics in the clinic.The present study aimed to develop an advanced PDX model,namely MiniPDX,for rapidly testing drug efficacy to strengthen its value in personalized cancer treatment.Methods:We developed a rapid in vivo drug sensitivity assay,OncoVee®MiniPDX,for screening clinically relevant regimens for cancer.In this model,patient-derived tumor cells were arrayed within hollow fiber capsules,implanted subcutaneously into mice and cultured for 7 days.The cellular activity morphology and pharmacokinetics were systematically evaluated.MiniPDX performance(sensitivity,specificity,positive and negative predictive values)was examined using PDX as the reference.Drug responses were examined by tumor cell growth inhibition rate and tumor growth inhibition rate in PDX models and MiniPDX assays respectively.The results from MiniPDX were also used to evaluate its predictive power for clinical outcomes.Results:Morphological and histopathological features of tumor cells within the MiniPDX capsules matched those both in PDX models and in original tumors.Drug responses in the PDX tumor graft assays correlated well with those in the corresponding MiniPDX assays using 26 PDX models generated from patients,including 14 gastric cancer,10 lung cancer and 2 pancreatic cancer.The positive predictive value of MiniPDX was 92%,and the negative predictive value was 81%with a sensitivity of 80%and a specificity of 93%.Through expanding to clinical tumor samples,Min-iPDX assay showed potential of wide clinical application.Conclusions:Fast in vivo MiniPDX assay based on capsule implantation was developed-to assess drug responses of both PDX tumor grafts and clinical cancer specimens.The high correlation between drug responses of paired MiniPDX and PDX tumor graft assay,as well as translational data suggest that MiniPDX assay is an advanced tool for personalized cancer treatment. | Feifei Zhang Wenjie Wang Yuan Long Hui Liu Jijun Cheng Lin Guo Rongyu Li Chao Meng Shan Yu Qingchuan Zhao Shun Lu Lili Wang Haitao Wang Danyi Wen | 2018 | Cancer Communications2018，38，1： | 20 |
| 3 | Mycoplasma infections and different human carcinomas显示文摘AIM To explore relationships between human carcinomas and mycoplasma infection.METHODS Monoclonal antibody PD4, which specifically recognizes a distinct protein from mycoplasma hyorhinis, was used to detect mycoplasma infection in different paraffinembedded carcinoma tissues with immunohistochemistry. PCR was applied to amplify the mycoplasma DNA from the positive samples for confirming immunohistochemistry.RESULTS Fifty of 90 cases (56%) of gastric carcinoma were positive for mycoplasma hyorhinis. In other gastric diseases, the mycoplasma infection ratio was 28% (18/49) in chronic superficial gastritis, 30% (14/ 46) in gastric ulcer and 37% (18/ 49) in intestinal metaplasia. The difference is significant with gastric cancer (X2=12.06, P<0.05). In colon carcinoma, the mycoplasma infection ratio was 55.1% (32/58), but it was 20.9% (10/49) in adenomarous polyp (X2=13.46, P<0.005).Gastric and colon cancers with high differentiation had a higher mycoplasma infection ratio than those with low differentiation (P< 0.05). Mycoplasma infection in esophageal cancer, lung cancer, breast cancer and glioma was 50.9% (27/53), 52.6% (31/ 59), 39.7%(25/63) and 41% (38/91), respectively. The mycoplasma DNA was successfully amplified with the DNA extracted from the cancer tissues that were positive for mycoplasma infection (detected with antibody PD4).CONCLUSION There was high correlation between mycoplasma infection and different cancers, which suggests the possibility of an association between the two. The mechanism involved in oncogenesis by mycoplasma remains unknown. | Su Huang Ji You Li Jan Wu Lin Meng Cheng Chao Shou Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100034. ChinaSu Huang, received B. A from Jiangxi Medical College of China in 1994. Now she is a graduate student pursuing a Ph. D degree at the Peking University School of Oncology. | 2001 | World Journal of Gastroenterology2001，7，2： | 18 |
| 4 | Expression of VEGF_(121)in gastric carcinoma MGC803 cell line显示文摘INTRODUCTIONVascular endothelial growth factor(VEGF)whichis also known as vascular permeability factor(VPF)is a heparin-binding,dimeric polypeptide growthfactor and a potent mitogen for endothelial cells.VEGF can stimulate the endothelial cell growth andenhance the motility through its two knownreceptors flt-1 and KDR.Acting through thesereceptors,VEGF may stimulate angiogenesis | Xue Jun Tian Jian Wu Lin Meng Zhi Wei Dang Cheng Chao Shou Beijing Institute for Cancer Research,Oncology School of Beijing Medical University,Beijing 100034,China Institute of Cancer Research,Chinese Academy of Medical Sciences,Beijing 100021,China | 2000 | World Journal of Gastroenterology2000，6，2： | 17 |
| 5 | A new technology for coal and gas control based on the in situ stress distribution and the roadway layout显示文摘An auxiliary gas control technology is described that can reduce coal and gas outburst accidents when there is no existing protective coal seam and gas pre-draining is not effective.Numerical simulation methods were used to study the stress distribution ahead of the roadway face for different in situ stresses.The results from the simulation can then provide a new gas control technology.The results show that a high stress concentration,high stresses,and high displacement gradients appear ahead of the roadway face when the maximum in situ stress is aligned perpendicular to the roadway axis.The risk of gas outburst is higher when the stresses decrease rapidly over distance and when the release of more energy occurs immediately after driving the roadway.The gas outburst risk is much smaller when the in situ stress is aligned parallel to the roadway axis.During design of the coal mine most of the coal roadways should be arranged to parallel the maximum in situ stress.This will decrease the outburst risk in general and may be considered a new gas outburst prevention method. | Yang Wei Lin Baiquan Zhai Cheng Li Xianzhong Sun Xin Zhang Chao | 2012 | International Journal of Mining Science and Technology2012，22，2： | 11 |
| 6 | Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury显示文摘High mobility group box 1(HMGB1)is a ubiquitous nuclear protein that is present in almost all cells and regulates the activity of innate immune responses in both intracellular and extracellular settings.Current evidence suggests that HMGB1 plays a pivotal role in human pathological and pathophysiological processes such as the inflammatory response,immune reactions,cell migration,aging,and cell death.Sepsis is a systemic inflammatory response syndrome(SIRS)that occurs in hosts in response to microbial infections with a proven or suspected infectious etiology and is the leading cause of death in intensive care units worldwide,particularly in the aging population.Dysregulated systemic inflammation is a classic characteristic of sepsis,and suppression of HMGB1 may ameliorate inflammation and improve patient outcomes.Here,we focus on the latest breakthroughs regarding the roles of HMGB1 in sepsis and sepsis-related organ injury,the ways by which HMGB1 are released,and the signaling pathways and therapeutics associated with HMGB1.This review highlights recent advances related to HMGB1:the regulation of HMBG1 might be helpful for both basic research and drug development for the treatment of sepsis and sepsis-related organ injury. | Chao Deng Lin Zhao Zhi Yang Jia-jia Shang Chang-yu Wang Ming-zhi Shen Shuai Jiang Tian Li Wen-cheng Di Ying Chen He Li Ye-dong Cheng Yang Yang | 2022 | Acta Pharmacologica Sinica2022，43，3： | 11 |
| 7 | Numerical simulation of influence of Langmuir adsorption constant on gas drainage radius of drilling in coal seam显示文摘To determine reasonable distance of gas pre-drainage drillings in coal seams, a solid–gas coupling model that takes gas adsorption effect into account was constructed. In view of different adsorption constants,the paper conducted the numerical simulation of pre-drainage gas in drillings along coal seam, studied the relationship of adsorption constants and permeability, gas pressure, and effective drainage radius of coal seams, and applied the approach to the layout of pre-drainage gas drillings in coal seams. The results show that the permeability of coal seams is on the gradual increase with time, which is divided into three sections according to the increase rate: the drainage time 0–30 d is the sharp increase section;30–220 d is the gradual increase section; and the time above 200 d is the stable section. The permeability of coal seams is in negative linear and positive exponent relation with volume adsorption constant VLand pressure adsorption constant PL, respectively. The effective drainage radius is in negative linear relation with VLand in positive exponent relation with PL. Compared with the former design scheme, the engineering quantity of drilling could be reduced by 25%. | Lin Haifei Huang Meng Li Shugang Zhang Chao Cheng Lianhua | 2016 | International Journal of Mining Science and Technology2016，26，3： | 10 |
| 8 | Study on 'fracturing-sealing' integration technology based on high-energy gas fracturing in single seam with high gas and low air permeability显示文摘To improve the gas extraction efficiency of single seam with high gas and low air permeability,we developed the'fracturing-sealing'integration technology,and carried out the engineering experiment in the3305 Tunliu mine.In the experiment,coal seams can achieve the aim of antireflection effect through the following process:First,project main cracks with the high energy pulse jet.Second,break the coal body by delaying the propellant blasting.Next,destroy the dense structure of the hard coal body,and form loose slit rings around the holes.Finally,seal the boreholes with the'strong-weak-strong'pressurized sealing technology.The results are as follows:The average concentration of gas extraction increases from8.3%to 39.5%.The average discharge of gas extraction increases from 0.02 to 0.10 m^3/min.The tunneling speeds up from 49.5 to 130 m/month.And the permeability of coal seams improves nearly tenfold.Under the same conditions,the technology is much more efficient in depressurization and antireflection than common methods.In other words,it will provide a more effective way for the gas extraction of single seam with high gas and low air permeability. | Zhang Chao Lin Baiquan Zhou Yan Zhai Cheng Zhu Chuanjie | 2013 | International Journal of Mining Science and Technology2013，23，6： | 10 |
| 9 | Soybean AP1 homologs control flowering time and plant height显示文摘Flowering time and plant height are key agronomic traits that directly affect soybean(Glycine max)yield.APETALA1(AP1)functions as a class A gene in the ABCE model for floral organ development,helping to specify carpel,stamen,petal,and sepal identities.There are four AP1 homologs in soybean,all of which are mainly expressed in the shoot apex.Here,we used clustered regularly interspaced short palindromic repeats(CRISPR)–CRISPR-associated protein 9 technology to generate a homozygous quadruple mutant,gmap1,with loss-of-function mutations in all four GmAP1 genes.Under short-day(SD)conditions,the gmap1 quadruple mutant exhibited delayed flowering,changes in flower morphology,and increased node number and internode length,resulting in plants that were taller than the wild type.Conversely,overexpression of GmAP1a resulted in early flowering and reduced plant height compared to the wild type under SD conditions.The gmap1 mutant and the overexpression lines also exhibited altered expression of several genes related to flowering and gibberellic acid metabolism,thereby providing insight into the role of GmAP1 in the regulatory networks controlling flowering time and plant height in soybean.Increased node number is the trait with the most promise for enhancing soybean pod number and grain yield.Therefore,the mutant alleles of the four AP1 homologs described here will be invaluable for molecular breeding of improved soybean yield. | Liyu Chen Haiyang Nan Lingping Kong Lin Yue Hui Yang Qingsong Zhao Chao Fang Haiyang Li Qun Cheng Sijia Lu Fanjiang Kong Baohui Liu Lidong Dong | 2020 | Journal of Integrative Plant Biology2020，62，12： | 9 |
| 10 | An overview of laser-based multiple metallic material additive manufacturing: from macro- to micro-scales显示文摘Additive manufacturing(AM)is an emerging customized three-dimensional(3D)functional product fabrication technology.It provides a higher degree of design freedom,reduces manufacturing steps,cost and production cycles.However,existing metallic component 3D printing techniques are mainly for the manufacture of single material components.With the increasing commercial applications of AM technologies,the need for 3D printing of more than one type of dissimilar materials in a single component increases.Therefore,investigations on multi-material AM(MMAM)emerge over the past decade.Lasers are currently widely used for the AM of metallic components where high temperatures are involved.Here we report the progress and trend in laser-based macro-and micro-scale AM of multiple metallic components.The methods covered in this paper include laser powder bed fusion,laser powder directed energy deposition,and laser-induced forward transfer for MMAM applications.The principles and process/material characteristics are described.Potential applications and challenges are discussed.Finally,future research directions and prospects are proposed. | Chao Wei Zhizhou Zhang Dongxu Cheng Zhe Sun Menghui Zhu Lin Li | 2021 | International Journal of Extreme Manufacturing2021，3，1： | 7 |
| 11 | Large-scale blow spinning of heat-resistant nanofibrous air filters显示文摘Particulate matter(PM)pollution has become a serious problem worldwide and various kinds of nanofibrous filters aiming to solve the problem have been developed.It is urgent to remove PM from high-temperature pollution sources,such as industrial emissions,coal furnaces,and automobile exhaust gases.However,filtration at pollution sources remains challenging because most existing air filters are not resistant to high temperature.Herein,heat-resistant polyimide(PI)nanofibrous air filters are fabricated via a simple and scalable solution blow-spinning method.These air filters show excellent thermal stability at high temperature up to 420℃.They exhibit a filtration efficiency as high as 99.73%at ambient temperature and over 97%at 300℃.In addition,a field test shows that the filters remove>97%of PM from the car exhaust fumes.Hence,the blow-spun PI nanofibrous membranes combined with the facile preparation strategy have great potential in high temperature air filtration fields and other similar applications such as water purification and protein separation. | Ziwei Li Jianan Song Yuanzheng Long Chao Jia Zhenglian Liu Lei Li Cheng Yang Junchen Liu Sen Lin Haiyang Wang Yibo Liu Minghao Fang Hui Wu | 2020 | Nano Research2020，13，3： | 6 |
| 12 | Parallel selection of distinct Tof5 alleles drove the adaptation of cultivated and wild soybean to high latitudes显示文摘Photoperiod responsiveness is a key factor limiting the geographic distribution of cultivated soybean and its wild ancestor.In particular,the genetic basis of the adaptation in wild soybean remains poorly understood.In this study,by combining whole-genome resequencing and genome-wide association studies we identified a novel locus,Time of Flowering 5(Tof5),which promotes flowering and enhances adaptation to high latitudes in both wild and cultivated soybean.By genomic,genetic and transgenic analyses we showed that Tof5 en-codes a homolog of Arabidopsis thaliana FRUITFULL(FUL).Importantly,further analyses suggested that different alleles of Tof5 have undergone parallel selection.The Tof5H1 allele was strongly selected by humans after the early domestication of cultivated soybean,while Tof5H2 allele was naturally selected in wild soybean,and in each case facilitating adaptation to high latitudes.Moreover,we found that the key flowering repressor E1 suppresses the transcription of Tof5 by binding to its promoter.In turn,Tof5 physically associates with the promoters of two important FLOWERING LOCUS T(FT),FT2a and FT5a,to upregulate their transcription and promote flowering under long photoperiods.Collectively,ourfindings provide insights into how wild soybean adapted to high latitudes through natural selection and indicate that cultivated soybean underwent changes in the same gene but evolved a distinct allele that was artificially selected after domestication. | Lidong Dong Qun Cheng Chao Fang Lingping Kong Hui Yang Zhihong Hou Yongli Li Haiyang Nan Yuhang Zhang Qingshan Chen Chunbao Zhang Kun Kou Tong Su Lingshuang Wang Shichen Li Haiyang Li Xiaoya Lin Yang Tang Xiaohui Zhao Sijia Lu Baohui Liu Fanjiang Kong | 2022 | Molecular Plant2022，15，2： | 5 |
| 13 | Reductive amination of 1,6-hexanediol with Ru/Al2O3 catalyst in supercritical ammonia显示文摘Hexamethylenediamine(HMDA) is an important reagent for the synthesis of Nylon-6,6, and it is usually produced by the hydrogenation of adiponitrile using a toxic reagent of hydrocyanic acid. Herein, we developed an environmental friendly route to produce HMDA via catalytic reductive amination of 1,6-hexanediol(HDO) in the presence of hydrogen. The activities of several heterogeneous metal catalysts such as supported Ni, Co, Ru, Pt, Pd catalysts were screened for the present reaction in supercritical ammonia without any additives. Among the catalysts examined, Ru/Al_2O_3 presented a high catalytic activity and highest selectivity for the desired product of HMDA. The high performance of Ru/Al_2O_3 was discussed based on the Ru dispersion and the surface properties like the acid-basicity. In addition, the reaction parameters such as reaction temperature,time, H_2 and NH_3 pressure were examined, and the reaction processes were discussed in detail. | Yan Li Haiyang Cheng Chao Zhang Bin Zhang Tong Liu Qifan Wu Xinluona Su Weiwei Lin Fengyu Zhao | 2017 | Science China Chemistry2017，60，7： | 5 |
| 14 | Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese:a Case-control Study显示文摘Objective To investigate the association between low-density lipoprotein receptor-related protein 5(LRP5) variants(rs12363572 and rs4930588) and type 2 diabetes mellitus(T2DM) in Han Chinese. Methods A total of 1842 T2 DM cases(507 newly diagnosed cases and 1335 previously diagnosed cases) and 7777 controls were included in this case-control study. PCR-RFLP was conducted to detect the genotype of the two single nucleotide polymorphisms(SNPs). Odds ratios(ORs) and 95% confidence intervals(95% CIs) were calculated to describe the strength of the association by logistic regression. Results In the study subjects, neither rs12363572 nor rs4930588 was significantly associated with T2 DM, even after adjusting for relevant covariates. When stratified by body mass index(BMI), the two SNPs were also not associated with T2 DM. Among the 3 common haplotypes, only haplotype TT was associated with reduced risk of T2DM(OR 0.820, 95% CI 0.732-0.919). In addition, rs12363572 was associated with BMI(P<0.001) and rs4930588 was associated with triglyceride levels(P=0.043) in 507 newly diagnosed T2 DM cases but not in healthy controls. Conclusion No LRP5 variant was found to be associated with T2 DM in Han Chinese, but haplotype TT was found to be associated with T2 DM. | YOU Hai Fei ZHAO Jing Zhi ZHAI Yu Jia YIN Lei PANG Chao LUO Xin Ping ZHANG Ming WANG Jin Jin LI Lin Lin WANG Yan WANG Qian WANG Bing Yuan REN Yong Cheng HU Dong Sheng | 2015 | Biomedical and Environmental Sciences2015，28，7： | 4 |
| 15 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 16 | Progress of the injection laser system of SG-Ⅱ显示文摘A high power laser system was used to drive the ignition of inertial confinement fusion(ICF), of which the high energy,the uniform focal spot, the accurate laser waveform, and the synchronization between the laser beams are key parameters.To accomplish this, global laser characteristics control should be assured, which was the main purpose of the injection laser system. In this paper, the key technological progress involved in the improvement of the performance of the injection laser of SG-II is reported, including frequency domain control, time domain control, near-field spatial shaping, preamplifier technology, and the optical parametric chirped pulse amplification pump source. | Wei Fan Youen Jiang Jiangfeng Wang Xiaochao Wang Dajie Huang Xinghua Lu Hui Wei Guoyang Li Xue Pan Zhi Qiao Chao Wang He Cheng Peng Zhang Wenfa Huang Zhuli Xiao Shengjia Zhang Xuechun Li Jianqiang Zhu Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，2： | 3 |
| 17 | Black phosphorus-based van der Waals heterostructures for mid-infrared light-emission applications显示文摘Mid-infrared(MIR)light-emitting devices play a key role in optical communications,thermal imaging,and material analysis applications.Two-dimensional(2D)materials offer a promising direction for next-generation MIR devices owing to their exotic optical properties,as well as the ultimate thickness limit.More importantly,van der Waals heterostructures-combining the best of various 2D materials at an artificial atomic level-provide many new possibilities for constructing MIR light-emitting devices of large tuneability and high integration.Here,we introduce a simple but novel van der Waals heterostructure for MIR light-emission applications built from thin-film BP and transition metal dichalcogenides(TMDCs),in which BP acts as an MIR light-emission layer.For BP–WSe_(2) heterostructures,an enhancement of~200% in the photoluminescence intensities in the MIR region is observed,demonstrating highly efficient energy transfer in this heterostructure with type-Ⅰ band alignment.For BP-MoS_(2) heterostructures,a room temperature MIR light-emitting diode(LED)is enabled through the formation of a vertical PN heterojunction at the interface.Our work reveals that the BP-TMDC heterostructure with efficient light emission in the MIR range,either optically or electrically activated,provides a promising platform for infrared light property studies and applications. | Xinrong Zong Huamin Hu Gang Ouyang Jingwei Wang Run Shi Le Zhang Qingsheng Zeng Chao Zhu Shouheng Chen Chun Cheng Bing Wang Han Zhang Zheng Liu Wei Huang Taihong Wang Lin Wang Xiaolong Chen | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 18 | Human umbilical cord mesenchymal stem cells for psoriasis:a phase 1/2a,single-arm study显示文摘Psoriasis is a common,chronic immune-mediated systemic disease that had no effective and durable treatment.Mesenchymal stem cells(MSCs)have immunomodulatory properties.Therefore,we performed a phase 1/2a,single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs(UMSCs)in the treatment of psoriasis and to preliminarily explore the possible mechanisms.Seventeen patients with psoriasis were enrolled and received UMsC infusions.Adverse events,laboratory parameters,PASl,and PGA were analyzed.We did not observe obvious side effects during the treatment and 6-month follow-up.A total of 47.1%(8/17)of the psoriasis patients had at least 40%improvement in the PASl score,and 17.6%(3/17)had no sign of disease or minimal disease based on the PGA score.And the efficiency was 25%(2/8)for males and 66.7%(6/9)for females.After UMSC transplantation(UMSCT),the frequencies of Tregs and CD4^(+)memory T cells were significantly increased,and the frequencies of T helper(Th)17 and CD4^(+)naive T cells were significantly decreased in peripheral blood(PB)of psoriasis patients.And all responders showed significant increases in Tregs and CD4^(+)memory T cells,and significant decreases in Th17 cells and serum IL-17 level after UMsCT.And baseline level of Tregs in responders were significantly lower than those in nonresponders.In conclusion,allogeneic UMSCT is safe and partially effective in psoriasis patients,and level of Tregs may be used as a potent biomarker to predict the clinical efficacy of UMSCT.Trial registration Clinical Trials NCT03765957. | Lamei Cheng Siqi Wang Cong Peng Xiao Zou Chao Yang Hua Mei Chuang Li Xian Su Na Xiao Qi Ouyang Mi Zhang Qiaolin Wang Yan Luo Minxue Shen Qun Qin Honglin Wang Wu Zhu Guangxiu Lu Ge Lin Yehong Kuang Xiang Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 19 | Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3显示文摘Adipose tissue remodelling is considered a critical pathophysiological hallmark of obesity and related metabolic diseases.Berberine(BBR),a natural isoquinoline alkaloid,has potent anti-hyperlipidaemic and anti-hyperglycaemic effects.This study aimed to explore the role of BBR in modulating adipose tissue remodelling and the underlying mechanisms.BBR protected high fat diet(HFD)-fed mice against adiposity,insulin resistance and hyperlipidemia.BBR alleviated adipose tissue inflammation and fibrosis by inhibiting macrophage infiltration,pro-inflammatory macrophage polarization and the abnormal deposition of extracellular matrix,and the effect was mediated by BBR directly binding and activating the deacetylase Sirtuin 3(SIRT3)and suppressing the activation of the mitogen-activated protein kinases and nuclear factor-κB signalling pathways.Furthermore,BBR decreased microRNA-155-5p secretion by macrophages,which in turn ameliorated liver injury.Moreover,BBR mitigated inflammatory responses in both LPS-stimulated macrophages and TNF-α-treated adipocytes and suppressed macrophage migration towards adipocytes by activating SIRT3.Collectively,this study revealed that BBR improved adipose tissue remodelling,and subsequently inhibited the secretion of microRNA-155-5p by macrophages,which alleviated adiposity,insulin resistance and liver injury in obese mice.The modulation of adipose tissue remodelling by activating SIRT3 could contribute to the anti-hyperlipidemic and anti-hyperglycemic effects of BBR. | Dan Li Chao Yang Jian-zhong Zhu Eduardo Lopez Tian Zhang Qiang Tong Cheng Peng Li-gen Lin | 2022 | Acta Pharmacologica Sinica2022，43，5： | 2 |
| 20 | Low levels of high-density lipoprotein cholesterol in patients with atherosclerotic stroke: A prospective cohort study显示文摘 | Poh-Shiow Yeh Chun-Ming Yang Sheng-Hsiang Lin Wei-Ming Wang Po-Sheng Chen Ting-Hsing Chao Huey-Juan Lin Kao-Chang Lin Chia-Yu Chang Tain-Junn Cheng Yi-Heng Li | 2013 | Atherosclerosis2013，，2： | 1 |
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