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| 1 | Interaction Between Charge Characteristics and Cu^(2+) Adsorption-Desorption of Soils with Variable or Permanent Charge显示文摘Charge characteristics and Cu2+ adsorption-desorption of soils with variable charge (latosol) and per-manent charge (brown soil) and the relationship between them were studied by means of back-titration andadsorption equilibrium respectively. The amount of variable negative charge was much less in variable-chargesoil than in permanent-charge soil and increased with the pH in the system, but the opposite trend occurredin the points of zero charge (PZCs). The amount of Cu2+ ions sorbed by permanent-charge soil was morethan that by variable-charge soil and increased with the increase of Cu2+ concentration within a certainrange in the equilibrium solution. The amount of Cu2+ ions desorbed with KCl from permanent-chargesoil was more than that from variable-charge soil, but the amount of Cu2+ ions desorbed with de-ionizedwater from permanent-charge soil was extremely low whereas there was still a certain amount of desorptionfrom variable-charge soil. The increase of PZC of soils with variable or permanent charge varied with theincrement of Cu2+ ions added. When the same amount of Cu2+ ions was added, the increments of PZC andvariable negative surface charge of permanent-charge soil were different from those of variable-charge soil. | LI XUEYUAN, LING WANTING and HE JIZHENGKey Laboratory of Subtropical Soil Resources and Environment, Chinese Ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070 (China) | 2002 | Pedosphere2002，12，4： | 12 |
| 2 | Alpha-2-macroglobulin as a radioprotective agent: a review显示文摘Radiation is an important modality in cancer treatment, and eighty percent of cancer patients need radiotherapy at some point during their clinical management. However, radiation-induced damage to normal tissues restricts the therapeutic doses of radiation that can be delivered to tumours and thereby limits the effectiveness of the treatment. The use of radioprotectors represents an obvious strategy to obtain better tumour control using a higher dose in radiotherapy. However, most of the synthetic radioprotective compounds studied have shown inadequate clinical efficacy owing to their inherent toxicity and high cost. Hence, the development of radioprotective agents with lower toxicity and an extended window of protection has attracted a great deal of attention, and the identification of alternative agents that are less toxic and highly effective is an absolute necessity. Recent studies have shown that alpha-2-macroglobulin(α2M) possesses radioprotective effects. α2M is a tetrameric, disulfide-rich plasma glycoprotein that functions as a nonselective inhibitor of different types of non-specific proteases and as a carrier of cytokines, growth factors, and hormones. α2M induces protein factors whose interplay underlies radioprotection, which supports the idea that α2M is the central effector of natural radioprotection in the rat. Pretreatment with α2M has also induced a significant reduction of irradiation-induced DNA damage and the complete restoration of liver and body weight. Mihailovi? et al. concluded that the radioprotection provided by α2M was in part mediated through cytoprotection of new blood cells produced in the bone marrow; these authors also indicated that an important aspect of the radioprotective effect of amifostine was the result of the induction of the endogenous cytoprotective capability of α2M. The radioprotective effects of α2M are possibly due to antioxidant, antifibrosis, and anti-inflammatory functions, as well as the maintenance of homeostasis, and enhancement of the DNA repair and cell recovery processes. This review is the first to summarise the observations and elucidate the possible mechanisms responsible for the beneficial effects of α2M. The lacunae in the existing knowledge and directions for future research are also addressed. | Xueying Chen Xiangbo Kong Zhaoqiang Zhang Wei Chen Jieyu Chen Huanyang Li Wanting Cao Yaping Ge Silian Fang | 2014 | Chinese Journal of Cancer Research2014，26，5： | 7 |
| 3 | Activation of extrasynaptic GABA_A receptors inhibits cyclothiazideinduced epileptiform activity in hippocampal CA1 neurons显示文摘Extrasynaptic GABA_A receptors(GABA_ARs)-mediated tonic inhibition is reported to involve in the pathogenesis of epilepsy.In this study,we used cyclothiazide(CTZ)-induced in vitro brain slice seizure model to explore the effect of selective activation of extrasynaptic GABA_ARs by 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-3-ol(THIP)on the CTZ-induced epileptiform activity in hippocampal neurons.Perfusion with CTZ dose-dependently induced multiple epileptiform peaks of evoked population spikes(PSs)in CA1 pyramidal neurons,and treatment with THIP(5 umol/L)significantly reduced the multiple PS peaks induced by CTZ stimulation.Western blot showed that the 5-subunit of the GABA_AR,an extrasynaptic specific GABA_AR subunit,was also significantly down-regulated in the cell membrane 2h after CTZ treatment.Our results suggest that the CTZ-induced epileptiform activity in hippocampal CA1neurons is suppressed by the activation of extrasynaptic GABA_ARs,and further support the hypothesis that tonic inhibition mediated by extrasynaptic GABA_ARs plays a prominent role in seizure generation. | Li Wan Xu Liu Zheng Wu Wanting Ren Shuzhen Kong Raya Abou Dargham Longzhen Cheng Yun Wang | 2014 | Neuroscience Bulletin2014，30，5： | 3 |
| 4 | Recent advances of vanadium-based cathode materials for zinc-ion batteries显示文摘Zn-ion batteries(ZIBs) have gained great attention as promising next-generation power sources, because of their low cost, enviable safety and high theoretical capacity. Recently, massive researches have been devoted to vanadium-based materials as cathodes in ZIBs, owing to their multiple valence states, competitive gravimetric energy density, but the capacity degradation, sluggish kinetics, low operating voltage hinder further optimization of their performance in ZIBs. This review summarizes recent progress to increase the interlayer spacing, structural stability, and the diffusion ability of the guest Zn ions, including the insertion of different ions, introduction of defects, design of diverse morphologies, the combination of other materials. We also focus on approaches to promoting the valuable performance of vanadiumbased cathodes, along with the related ongoing scientific challenges and limitations. Finally, the future perspectives and research directions of vanadium-based aqueous ZIBs are provided. | Xuerong Li Haoyan Cheng Hao Hu Kunming Pan Tongtong Yuan Wanting Xia | 2021 | Chinese Chemical Letters2021，32，12： | 2 |
| 5 | Development and Evaluation of a Wearable Lower Limb Rehabilitation Robot显示文摘This paper introduces a rigid-flexible coupling wearable exoskeleton robot for lower limb,which is designed in light of gait biomechanics and beneficial for low limb movement disorders by implementing gait training.The rationality of the proposed mechanism is shown with the implementation of the dynamic simulation through MSC ADAMS.For the purposes of lightweight,the exoskeleton mechanism is optimized through finite element analysis.It can be concluded from performance evaluation experiment,the mechanism has certain advantages over existing exoskeleton robots,namely,comfortable,lightweight,low cost,which can be utilized for rehabilitation training in medical institutions or as a daily-walking ancillary equipment for patients. | Wanting Li Keping Liu Chunxu Li Zhongbo Sun Shui Liu Jian Gu | 2022 | Journal of Bionic Engineering2022，19，3： | 2 |
| 6 | Comparison of the differentiation of dental pulp stem cells and periodontal ligament stem cells into neuron-like cells and their effects on focal cerebral ischemia显示文摘Recent studies have reported an in creasing in cidence of ischemic stroke,particularly in younger age groups.Dental pulp stem cells(DPSCs)and periodontal ligament stem cells(PDLSCs)are the most comm on stem cells acquired from the teeth of adults,even elderly people.However,there are no detailed reports on whether DPSCs or PDLSCs are suitable for the treatment of ischemic stroke.In this study,the in vitro differentiation of DPSCs and PDLSCs into neuron-like cells was evaluated.Then,we established a rat model of cerebral ischemia.DPSCs or PDLSCs were administered to animals,and the therapeutic effects of these two types of cells were investigated.The results showed that PDLSCs had a higher differentiation rate than DPSCs.Immunofluorescence studies showed that the expression of the neuronal differentiation markerThy-1 was higher in PDLSCs than in DPSCs,and other gene markers of neuronal differentiation showed corresponding trends,which were confirmed by western blot analysis.In this process,the Notch and Wnt signaling pathways were inhibited and activated,respectively.Fin ally,rats with transient occlusion of the right middle cerebral artery were used as a model to assess the therapeutic effect of PDLSCs and DPSCs on ischemia.The results showed that rats in the PDLSC-treated group emitted significantly greater red fluorescence signal than the DPSC-treated group.PDLSC transplantation promoted the recovery of neurological function more effectively than DPSC transplantation.Hence,PDLSCs represent an autogenous source of adult mesenchymal stem cells with desirable biological properties and may be an ideal candidate for clinical applications. | Tingting Wu Wanting Xu Hanlin Chen Shasha Li Rengang Dou Hongtao Shen Xue Liu Xiaoyu Liu Yongfeng Hong Jiacai He | 2020 | Acta Biochimica et Biophysica Sinica2020，52，9： | 2 |
| 7 | Molecular Mechanism of Induction on Apoptosis of Human Esophageal Cancer HCE-4 Cells by Active Components from Astragalus membranaceus显示文摘[Objectives] To investigate the pharmacologic effects of active components from A. membranaceus on human esophageal cancer HCE-4 cells and its apoptosis mechanism. [Methods] The viabilities of HCE-4 cells were measured by MTT assay. The induction of active components from A. membranaceus on apoptosis of HCE-4 cells was detected by Annexin V-FITC/PI double staining. The apoptotic-related protein expression levels were determined by Western blotting. [Results] Formononetin and astragaloside IV suppressed the proliferation of HCE-4 cells in a dose-dependent manner. The Annexin V-FITC/PI double staining results showed that formononetin and astragaloside IV could induce HCE-4 cells apoptosis in a time-dependent manner. The Western blotting results showed that formononetin and astragaloside IV could significantly down-regulate p-AKT,pro-caspase-3,and increase cle-caspase-3 protein expression in HCE-4 cells. [Conclusions]Active components from A. membranaceus such as formononetin and astragaloside IV significantly inhibited the proliferation of human esophageal cancer HCE-4 cells by inducing mitochondrial dependent apoptosis via AKT signaling pathway. | Jiaru WANG Yinghua LUO Xianji PIAO Chang LIU Yi ZHANG Hao WANG Jinqian LI Wanting XU Yang LIU Yiqin WU Chenghao JIN | 2018 | Medicinal Plant2018，9，1： | 2 |
| 8 | Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebuasl ischemis in rats显示文摘 | Chen J Li Y Want L | 2001 | Stroke2001，32，4： | 1 |
| 9 | Effects of dietary vitamin K_(3) levels on growth,coagulation,calcium content,and antioxidant capacity in largemouth bass,Micropterus salmoides显示文摘An 8-week feeding trial investigated the optimum dietary vitamin K3 requirements of largemouth bass.A total of 600 healthy fish(12.96±0.07 g)were fed diets containing varying levels of vitamin K3 at 0.78(K0),5.80(K5),10.82(K10),15.84(K15),and 20.85(K20)mg/kg with four replicates per level.Results showed that dietary vitamin K3 enhanced growth,with weight gain rate and specific growth rate in K15 trials significantly higher than K0 trials(P<0.05).No significant difference was observed in the content of crude protein,crude lipid,moisture,ash,and phosphorus in muscle tissue(P>0.05).However,the supplementation of vitamin K3 significantly contributed to calcium accumulation in muscle tissues and vertebrae(P<0.05)and increased red blood cell counts(P<0.05).The blood coagulation time decreased significantly with increasing dietary vitamin K3 from 0.78 to 10.82 mg/kg(P<0.05)before stabilizing(P>0.05).The antioxidant capacity was improved with the addition of vitamin K3,which was inconsistent with the changes in malondialdehyde and MK-4(a form of menaquinone)within liver and serum,suggesting that the toxicity of excessive artificial vitamin K3 may account for this difference.Using regression analysis,the appropriate dietary vitamin K3 levels within a largemouth bass diet was determined to be in the range of 9.93-15.22 mg/kg,which will provide a reference for the preparation of vitamin premix and artificial diet for largemouth bass. | Xiang Wei Ying Hang Xiang Li Xueming Hua Xiangming Cong Wanting Yi Xu Guo | 2023 | Aquaculture and Fisheries2023，8，2： | 1 |
| 10 | Determinants of Lens Vault and Association With Narrow Angles in Patients From Singapore显示文摘 | Gavin S. Tan Mingguang He Wanting Zhao Lisandro M. Sakata Jialiang Li Monisha E. Nongpiur Raghavan Lavanya David S. Friedman Tin Aung | 2012 | American Journal of Ophthalmology2012，，1： | 1 |
| 11 | Poly(ether ether ketone ketone) based imidazolium as anion exchange membranes for alkaline fuel cells显示文摘An imidazolium functionalized poly(ether ether ketone ketone)(PEEKK-DIm OH)anion exchange membrane(AEM)readily soluble in certain low-boiling-point solvents(isopropanol)is prepared.The solubility results are consistent with the results of molecular dynamics simulations.By varying the chloromethylation reaction temperature or concentrated sulfuric acid concentration of PEEKK,the degrees of chloromethylation of PEEKK are changed from 54% to 92%,the corresponding PEEKK-DIm OH AEMs with the ion exchange capacities(IECs)of 1.14–1.65 mmol·g^(-1).The PEEKK-DIm OH 92% AEM shows high hydroxide conductivity(31 m S·cm^(-1)),suitable water uptake(94%)and acceptable swelling ratio(39%)at 60°C.In addition,the PEEKK-DIm OH AEMs possess good thermal and alkaline stability.The maximum power density(46.16 mW·cm^(-2))of fuel cell prepared with PEEKK-DIm OH 92%AEM as exchange membrane and ionomer is much higher than that with commercial AHA membranes.All the above results indicate that the PEEKK used in this study is a promising AEM matrix material for alkaline fuel cells. | Tiantian Li Xuemei Wu Wanting Chen Xiaoming Yan Dongxing Zhen Xue Gong Jiafei Liu Shaofeng Zhang Gaohong He | 2018 | Chinese Journal of Chemical Engineering2018，26，10： | 1 |
| 12 | Identification of two glycerophosphodiester phosphodiesterase genes in maize leaf phosphorus remobilization显示文摘Phosphate deficiency is one of the leading causes of crop productivity loss.Phospholipid degradation liberates phosphate to cope with phosphate deficiency.Glycerophosphodiester phosphodiesterases(GPX-PDEs)hydrolyse the intermediate products of phospholipid catabolism glycerophosphodiesters into glycerol-3-phosphate,a precursor of phosphate.However,the function of GPX-PDEs in phosphate remobilization in maize remains unclear.In the present study,we characterized two phosphate deficiency-inducible GPX-PDE genes,ZmGPX-PDE1 and ZmGPX-PDE5,in maize leaves.ZmGPX-PDE1 and ZmGPX-PDE5 were transcriptionally regulated by ZmPHR1,a well-described phosphate starvation-responsive transcription factor of the MYB family.Complementation of the yeast GPX-PDE mutant gde1Δindicated that ZmGPX-PDE1 and ZmGPX-PDE5 functioned as GPX-PDEs,suggesting their roles in phosphate recycling from glycerophosphodiesters.In vitro enzyme assays showed that ZmGPX-PDE1 and ZmGPX-PDE5 catalysed glycerophosphodiester degradation with different substrate preferences for glycerophosphoinositol and glycerophosphocholine,respectively.ZmGPX-PDE1 was upregulated during leaf senescence,and more remarkably,loss of ZmGPXPDE1 inmaize compromised the remobilization of phosphorus fromsenescing leaves to young leaves,resulting in a stay-green phenotype under phosphate starvation.These results suggest that ZmGPX-PDE1 catalyses the degradation of glycerophosphodiesters in maize,promoting phosphate recycling from senescing leaves to new leaves.This mechanism is crucial for improving phosphorus utilization efficiency in crops. | Jingxin Wang Wenbo Pan Alexiy Nikiforov William King Wanting Hong Weiwei Li Yang Han Jana Patton-Vogt Jianbo Shen Lingyun Cheng | 2021 | The Crop Journal2021，9，1： | 1 |
| 13 | Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats显示文摘 | Chen J Li Y Want L | 2001 | Stroke2001，32，4： | 1 |
| 14 | Proton induced single event upset cross section prediction for 0.15 μm six-transistor (6T) silicon-on-insulator static random access memories显示文摘 | Lei Li Wanting Zhou Huihua Liu | 2012 | Journal of Nuclear Science and Technology2012，，： | 1 |
| 15 | Prediction of low-LET ion induced single event upset cross sections for advanced SRAM显示文摘 | Wanting Zhou Jianhao Hu Lei Li | 2013 | Journal of Nuclear Science and Technology2013，，： | 1 |
| 16 | “1+1>2”:Highly efficient removal of organic pollutants by composite nanofibrous membrane based on the synergistic effect of adsorption and photocatalysis显示文摘Adsorption and photocatalysis are regarded as two desirable technologies for wastewater remediation,but are still unsatisfactory in removal effect,eco-friendly regeneration and facile reusability.In this study,we developed a composite nanofibrous membrane material with excellent removal performance for organic pollutants based on synergistic adsorption and photocatalysis.A novel boron-doped,nitrogen-deficient graphitic carbon nitride(B-C3N4)photocatalyst as well as an amphiphilic copolymer of methyl methacrylate and acrylic acid(p(MMA-AA))were synthesized respectively,and then used to modify polyethersulfone for the fabrication of composite nanofibrous membrane with improved hydrophilicity,negativelycharge property and enhanced visible light response simultaneously.Subsequently,the synergistic effect of adsorption and photocatalytic degradation for organic pollutants were identified especially and resulted in an excellent removal efficiency even superior to the combination of adsorption and photocatalytic degradation,which could be called a“1+1>2”effect.In addition,the regeneration and reusability,the purification ability for multicomponent wastewater,and the photocatalytic mechanism,were investigated and discussed systematically.In this work,we not only prepared the nanofibrous membrane with synergistic effect of adsorption and photocatalysis,but also provided a versatile approach to design dualfunctional support material to ensure the practical applications of powdery photocatalyst in wastewater treatment. | Yuanting Xu Wanting Lin Dandan Yuan Shifan Chen Fang Li Yanping Long Chao He Weifeng Zhao Changsheng Zhao | 2022 | Journal of Materials Science & Technology2022，，29： | 1 |
| 17 | An improved architec- ture for designing modulo (2^n-- 2-p + 1 ) multipliers 显示文摘 | Li Lei Zhou Lu Zhou Wanting | 2012 | IEICE Electronics Express2012，9，14： | 1 |
| 18 | Impact of exotic and inherent dissolved organic matter on sorption of phenanthrene by soils显示文摘 | Yanzheng Gao Wei Xiong Wanting Ling Xiaorong Wang Qiuling Li | 2006 | Journal of Hazardous Materials2006，，1： | 1 |
| 19 | miRNA -regulated expression of oncogenes and tumor suppressor genes in the cisplatin -inhibited growth of K562 cells显示文摘 | Xie SY Li Y J Want PY | 2010 | Oncol Rep2010，23，6： | 1 |
| 20 | Development and validation of prognostic implications of chromosome abnormalities algorithm for newly diagnosed multiple myeloma显示文摘Fluorescence in situ hybridization(FISH)evaluation is essential for initial risk stratification in multiple myeloma(MM).The presence of specific cytogenetic abnormalities(CA)confers a heterogeneity impact on prognosis.However,the cutoff values among different centers are not uniform.Therefore,we conduct this study to better predict the prognosis of newly diagnosed MM patients based on FISH results.The Kaps method was used to calculate the chromosomal abnormal cutoff values.A total of 533 participants were included in the study.The best cutoff value of overall survival were as follows:17p20.1%,13q85%,1q21+39%,t(11;14)55.5%,t(14;16)87%,and t(4;14)53.5%.The survival analysis showed that 17pand 1q21+were the independent factors affecting both OS and progress free survival(PFS)among CA.The analysis based on the cutoff value obtained by Kaps suggested that 13q,t(14;16),17p,and 1q21+were independent factors affecting OS among CA;t(14;16),17p,and 1q21+were independent factors affecting PFS among CA.The prognostic model was constructed by the Kaps method with the Harrell concordance index(c-index)at 0.719(95%CI,0.683–0.756;corrected 0.707),which was higher than that calculated by the European Myeloma Network criteria(0.714;95%CI,0.678–0.751;corrected 0.696).In conclusion,chromosomal abnormalities in different proportions and combinations can affect the prognosis ofMMpatients.Therefore,effective criteria should be formulated to evaluate the prognosis ofMMpatients better. | Tiancheng Luo Wanting Qiang Jing Lu Haiyan He Jin Liu Lu Li Hua Jiang Weijun Fu Juan Du | 2021 | Blood Science2021，3，3： | 0 |
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