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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design显示文摘Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).We hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)is non-inferior to rt-PA in achieving excellent functional outcome at 90 days,when administered within 4.5 hours of ischaemic stroke onset.Methods and design Tenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events(TRACE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority study.Patients eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 mg.Medications considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day follow-up.Study outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 days.Secondary efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke Scale.Safety outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any cause.Discussion There is no completed registration study of TNK in AIS worldwide.TRACE Ⅱ strives to provide evidence for a new drug application for rhTNK-tPA in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in China. | Shuya Li Bruce C V Campbell Lee H Schwamm Marc Fisher Mark Parsons Hao Li Yuesong Pan Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，1： | 2 |
| 3 | Characterization of intrapelvic pressure during ureteropyeloscopy with ureteral access sheaths显示文摘 | Jamil Rehman Manoj Monga Jaime Landman David I Lee Tamer Felfela Marius C Conradie Rajamahanty Srinivas Chandru P Sundaram Ralph V Clayman | 2003 | Urology2003，，4： | 2 |
| 4 | A simple method for cryopreservation of Ginkgo biloba callus显示文摘 | Elena V P Lee E J Wu C H | 2009 | Plant Cell Tissue and Organ Culture2009，97，3： | 1 |
| 5 | Consumer acceptance of roasted peanuts affected by storage temperature and humidity conditions显示文摘 | Lee C M Resurrection A V A | 2006 | LWT-Food scitechnol2006，39，： | 1 |
| 6 | An extensive class of small RNAs in Caenorhabditis elegans 显示文摘 | LEE R C AMBROS V | 2001 | Science2001，294，5543： | 1 |
| 7 | Spreading of Turbulent Round Jet in Coflow显示文摘 | Chu P C K Lee J H Chu V H | 1999 | Journal of Hydraulic Engineering1999，125，2： | 1 |
| 8 | The value of information sharing in a two-level supply chain显示文摘 | Lee H So V K Tang C | 2000 | Management Science2000，46，5： | 1 |
| 9 | Minority report in fraud detection: classification of skewed data显示文摘 | Phua C Alahakoon D Lee V | 2004 | ACM SIGKDD Explorations News- letter2004，6，1： | 1 |
| 10 | 查看详情显示文摘 | D W Yoon D E Gross V M Lynch J M Sessler B P Hay C H Lee | | 0，，： | 1 |
| 11 | Nested Containment List (NCList): A New Algorithm for Accelerating Interval Query of Genome Alignment and Interval databases 显示文摘 | Alekseyenko A V Lee C J | 2007 | Bioinfor- maties2007，23，11： | 1 |
| 12 | Incidence and risk fac- tors of oral mucositis in paediatric and adolescent pa- tients undergoing chemotherapy显示文摘 | Cheng K K F Lee V Li C H | 2011 | Oral Oncol2011，47，3： | 1 |
| 13 | Metal nanoerystal memories-part I: device design and fabrication 显示文摘 | LIU Z LEE C NARAYANAN V | 2002 | IEEE Electron Device Letters2002，49，9： | 1 |
| 14 | Full color emission from Ⅱ -Ⅵ semiconductor quantum dot-polymer composites显示文摘 | Lee J Sundar V C Heine J R | 2000 | Advanced Materials2000，12，15： | 1 |
| 15 | Factor space theory in fuzzy information processingcomposition of states of factors and multifactorial decision making显示文摘 | Li Hongxing Yen V C Lee E S | 2000 | Computers and Mathematics with Applications2000，39，： | 1 |
| 16 | Prevalence of hospital infection and antibiotic use at a university medical center in Hong Kong显示文摘 | Lee M K Chiu C S Chow V C | 2007 | J Hosp Infect2007，65，4： | 1 |
| 17 | Antioxidant activity of fresh apples 显示文摘 | EBERHARDT M V LEE C Y LIU R H | 2000 | Nature2000，405，： | 1 |
| 18 | Transverse response of underground cavities and pipes to incident SV waves显示文摘 | Davis C A Lee V W Bardet J P | 2001 | Earthquake Engineering and Structural Dynamics2001，30，： | 1 |
| 19 | Curcumin- induced HDAC inhibition and attenuation of medulloblas- toma growth in vitro and in vivo 显示文摘 | Lee SJ Krauthauser C Maduskuie V | 2011 | BMC Cancer2011，11，： | 1 |
| 20 | Swine influenza H1N1 virus induces acute inflammato- ry immune responses in pig lungs: a potential animal model for human H1N1 influenza virus显示文摘 | Khatri M Dwivedi V Krakowka S Manickam C Ali A Wang L Qin Z Renukaradhya G J Lee C W | 2010 | J Virol2010，84，11： | 1 |
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