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| 1 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 2 | Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry. | Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni | 2015 | World Journal of Psychiatry2015，5，1： | 6 |
| 3 | Comparison between hepaticojejunostomy and hepaticoduodenostomy after excision of choledochal cyst in children:a cohort study显示文摘Objective Hepaticojejunostomy(HJ)and hepaticoduodenostomy(HD)are commonly used biliary reconstruction techniques after choledochal cyst excision.HD has been suggested to be a more physiologic alternative during reconstruction.The objective of this study is to compare operative time,hospital stay,morbidity(leak,cholangitis,ileus,and obstruction),and mortality between HJ and HD after cyst excision.Methods This is a 14-year retrospective cohort study of pediatric patients(≤18 years old)who underwent choledochal cyst excision and subsequent biliary reconstruction at the Philippine Children’s Medical Center.Data were taken from inpatient charts,operative technique,OPD logbook,readmission,and OPD charts.results There were 122 patients:56%HD and 44%HJ.Majority were female(72%),with 1:2.6 male to female ratio.The average age was 36.1 months,with a mean follow-up of 32.8 months(range 6 months-14 years).The most common cyst was type I(87%).Operative time was longer for HJ compared with HD(321.3 vs 203.6 min;p=0.000).Hospital stay was longer with HJ compared with HD(7.7 vs 6.8 days;p=0.002).Mortality rate was low at 1.6%while morbidity was at 13.9%in both groups.Although morbidity was higher among those who underwent HD,there was no significant difference between the two procedures.Anastomotic leak(4%)and cholangitis(7.4%)were observed in HD,and ileus(7.4%)was observed in the HJ group.Conclusions In our series,HD provided less operative time and hospital stay than with HJ.We did not observe bile gastritis after HD as compared with others.It is suggested that longer follow-up is needed to confirm such findings. | Johann Paulo Suico Guzman Leandro L Resurreccion III Marcus Lester R Suntay Renato G Bernaldez | 2019 | World Journal of Pediatric Surgery2019，2，2： | 2 |
| 4 | Thermal analysis of biomass and corresponding pyrolysis products 显示文摘 | PAOLO G LEANDRO R LUCIANA A | 1996 | Fuel1996，75，5： | 1 |
| 5 | Coffee oil as a potential feedstock for biodiesel production显示文摘 | Leandro S O Adriana S F Rodrigo R S C | 2008 | Bioresource Technology2008，，99： | 1 |
| 6 | Land-use and land- cover change in Alantic Forest landscapes显示文摘 | Paula K L Leandro R T Robert M E | 2012 | Forest Ecology and Management2012，278，： | 1 |
| 7 | Partial oxidation of methane over Ni-Co perovskite catalysts显示文摘 | Camila R B S Leandro D C Nielson F P R | 2011 | Catalysis Communi- cations2011，12，7： | 1 |
| 8 | Retinal vessel segmentation using the 2-D Gabor wavelet and supervised classification显示文摘 | Soares J V B Leandro J J G Cesar R M | 2006 | IEEE Transactions on Medical Imaging2006，25，9： | 1 |
| 9 | Meta-analysis of somatostatin,octreotide and gabexate mesilate in the therapy of acute pancreatitis显示文摘 | Andriullic A Leandro G Vlemente R | 1998 | Alim Pharmacol Therap1998，12，： | 1 |
| 10 | Comparison between anaerobic threshold determined by ventilatory variables and blood lactate response in cyclists 显示文摘 | ALEXANDRE H O LEANDRO R A HERBERT G S | 2006 | Rev Bras Med Esporte2006，12，1： | 1 |
| 11 | Determination of priority pesticides in baby foods by gas chromatography tandem quadrupole mass spectrometry显示文摘 | LEANDRO C C FUSSELL R J KEELY B J | 2005 | Journal of chromatography A2005，1085，2： | 1 |
| 12 | Metaanalysis of somatostatin,octreotide and gabexatemesilate in the therapy ofacute pancreatitis显示文摘 | Andriulli A Leandro G Clemente R | 1998 | Aliment Pharmacol Ther1998，12，3： | 1 |
| 13 | Ultra-performance liquid chromatography for the determination of pesticide residues in foods by tandem quadrupole mass spectrometry with polarity switching显示文摘 | LEANDRO C C HANCOCK P FUSSELL R J | 2007 | J Chromatogr: A2007，1144，2： | 1 |
| 14 | Retinal vessel segmentation using the 2-D gabor wavelet and supervised classification显示文摘 | SOARES J V B LEANDRO J J G CESAR R M | 2006 | IEEE Transactions on Medical Imaging2006，25，9： | 1 |
| 15 | UNB neutral at- mosphere models: development and performance 显示文摘 | LEANDRO R F SANTOS M C LANGLEY R B | 2006 | Proceedings of ION NTM2006，1，： | 1 |
| 16 | 显示文摘 | LEANDRO C C HANCOCK P FUSSELL R J | 2006 | J Chromatogr: A2006，1103，1： | 1 |
| 17 | Ultra-performanceliquid chromatography for the determination of pesticide residuesin foods by tandem quadrupole mass spectrometry with polarityswitching显示文摘 | Leandro C C Hancock P Fussell R J | 2007 | J Chromatogr A2007，1144，16： | 1 |
| 18 | Ultra-performance liquid chromatography for the determination of pesticide residues in foods by tandem quadrupole mass spectrometry with polarity switchin 显示文摘 | Leandro C C Hancock P Fussell R J | 2007 | J Chromatogr A2007，1144，2： | 1 |
| 19 | Reti-nal vessel segmentation using the 2-D gabor wavelet and su-pervised classification显示文摘 | SOARES J B V LEANDRO J J G CESAR R M | 2006 | Ieee Transactions on Medical Ima-ging2006，25，9： | 1 |
| 20 | Meta-analysis of somatostatin,octreotide and gabexate mesilate in the therapy of acute pancreatitis显示文摘 | Andriulli A Leandro G Clemente R | 1998 | Aliment Pharmacol Ther1998，12，3： | 1 |
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