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| 1 | Particle flow code simulation of intact and fissured granitic rock samples显示文摘This study presents a calibration process of three-dimensional particle flow code(PFC3D)simulation of intact and fissured granite samples.First,laboratory stressestrain response from triaxial testing of intact and fissured granite samples is recalled.Then,PFC3D is introduced,with focus on the bonded particle models(BPM).After that,we present previous studies where intact rock is simulated by means of flatjoint approaches,and how improved accuracy was gained with the help of parametric studies.Then,models of the pre-fissured rock specimens were generated,including modeled fissures in the form of“smooth joint”type contacts.Finally,triaxial testing simulations of 1 t 2 and 2 t 3 jointed rock specimens were performed.Results show that both elastic behavior and the peak strength levels are closely matched,without any additional fine tuning of micro-mechanical parameters.Concerning the postfailure behavior,models reproduce the trends of decreasing dilation with increasing confinement and plasticity.However,the dilation values simulated are larger than those observed in practice.This is attributed to the difficulty in modeling some phenomena of fissured rock behaviors,such as rock piece corner crushing with dust production and interactions between newly formed shear bands or axial splitting cracks with pre-existing joints. | Uxía Castro-Filgueira Leandro R.Alejano Diego Mas Ivars | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，5： | 10 |
| 2 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 3 | Plastic radii and longitudinal deformation profiles of tunnels excavated in strain-softening rock masses显示文摘 | Leandro R. Alejano Alfonso Rodríguez-Dono María Veiga | 2012 | Tunnelling and Underground Space Technology incorporating Trenchless Technology Research2012，，： | 2 |
| 4 | Impulsive noise measurement and characterization in a UHF digital TV channel显示文摘 | Manuel García Sánchez Leandro de Haro Miguel Calvo Ramón | 1999 | IEEE Transactions on Electromagnetic Compatibility1999，41，2： | 1 |
| 5 | Comparison of 1D/1D and 1D/2D coupled(sewer/surface)hydraulic models for urban flood simulation 显示文摘 | Leandro J Chen A Djordjevic S | 2009 | J Hydraul Eng2009，135，6： | 1 |
| 6 | The effect of colchicine on liver function tests and hepatic fibrosis in patients with chronic active hepatitis:a study of 3 cases(author's transl)显示文摘 | Leandro P Ade O e Silva A BrandSo J F Saldanha L B Pontes J F | 2013 | Arquivos de Gastroenterologia2013，15，3： | 1 |
| 7 | BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy显示文摘 | Cerchietti Leandro C Hatzi Katerina Caldas-Lopes Eloisi Yang Shao Ning Figueroa Maria E Morin Ryan D Hirst Martin Mendez Lourdes Shaknovich Rita Cole Philip A Bhalla Kapil Gascoyne Randy D Marra Marco Chiosis Gabriela Melnick Ari | 2010 | Journal of Clinical Investigation2010，，12： | 1 |
| 8 | Adsorption studies of methylene blue and gentian violet on sugarcane bagasse modified with EDTA dianhydride ( EDTAD ) in aqueous solutions : Kinetic and equilibrium aspects 显示文摘 | Km'la A G G Leandro V A G Tania M S M | 2013 | Journal of Environmental Management2013，118，： | 1 |
| 9 | Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression显示文摘 | Leandro Z. Agudelo Teresa Femenía Funda Orhan Margareta Porsmyr-Palmertz Michel Goiny Vicente Martinez-Redondo Jorge C. Correia Manizheh Izadi Maria Bhat Ina Schuppe-Koistinen Amanda T. Pettersson Duarte M.S. Ferreira Anna Krook Romain Barres Juleen R. Zi | 2014 | Cell2014，，1： | 1 |
| 10 | Thermal analysis of biomass and corresponding pyrolysis products 显示文摘 | PAOLO G LEANDRO R LUCIANA A | 1996 | Fuel1996，75，5： | 1 |
| 11 | Effect of helicobacter pylori eradication on the outcome of reflux esophagitis and chronic gastritis in the elderly, a randomized, multicenter, eight-month study 显示文摘 | Pilotto A Peril F Leandro G | 2006 | Gerontology2006，52，2： | 1 |
| 12 | Particle swarm approaches using Lozi map chaotic sequences to fuzzy modeling of an experimental thermal-vacuum system显示文摘 | Emesto A Leandro S | 2008 | Applied Soft Computing2008，8，4： | 1 |
| 13 | Reliability worth applied to transmission expansion planning based on ant colony system 显示文摘 | ARMANDO M LEANDRO S LUIZ A | 2010 | Electrical Power and Energy Sys- tems2010，32，10： | 1 |
| 14 | Clinical features of refluxesophagitis in older people:a study of 840 consecutive patients显示文摘 | Pilotto A Franceschi M Leandro G | 2006 | JAm Geriatr Soc2006，54，3： | 1 |
| 15 | External validation of biochemical indices for noninvasive evaluation of liver fibrosis in HCV chronic hepatitis显示文摘 | Iacobellis A Mangia A Leandro G | 2005 | Am J Gastroenterol2005，100，4： | 1 |
| 16 | Meta-analysis of somatostatin,octreotide and gabexate mesilate in the therapy of acute pancreatitis显示文摘 | Andriullic A Leandro G Vlemente R | 1998 | Alim Pharmacol Therap1998，12，： | 1 |
| 17 | Comparison between anaerobic threshold determined by ventilatory variables and blood lactate response in cyclists 显示文摘 | ALEXANDRE H O LEANDRO R A HERBERT G S | 2006 | Rev Bras Med Esporte2006，12，1： | 1 |
| 18 | Expression of heat shock protein in broiler embryo tissues after acute cold or heat stress显示文摘 | Leandro N S Gonzales E Ferro J A | 2004 | Mol Reprod Dev2004，67，2： | 1 |
| 19 | Pharmacological treatment can prevent pancreatic injury after ERCP:a meta-analysis显示文摘 | Andruilli A Leandro G Niro G | 2000 | Gastrointest Endosc2000，51，： | 1 |
| 20 | Metaanalysis of somatostatin,octreotide and gabexatemesilate in the therapy ofacute pancreatitis显示文摘 | Andriulli A Leandro G Clemente R | 1998 | Aliment Pharmacol Ther1998，12，3： | 1 |
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