|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Isolated intestinal neurofibromatous proliferations in the absence of associated systemic syndromes显示文摘Gastrointestinal tract involvement by neurofi bromatous lesions is rare and occurs most frequently as one of the systemic manifestations of generalized neurofibromatosis type 1 (NF1). In this setting, the lesions may manifest as focal scattered neurofi bromas or as an extensive diffuse neural hyperplasia designated ganglioneuromatosis. Occasionally, such lesions may be the initial sign of NF1 in patients without any other clinical manifestations of the disease. Rarely, cases of isolated neurofi bromatosis of the large bowel with no prior or subsequent evidence of generalized neurofi bromatosis have been documented. We present the case of a 52 year-old female with abdominal pain and alternating bowel habits. Colonoscopic evaluation revealed multiple small polyps in the cecum and the presence of nodular mucosa in the colon and rectum. Pathologic evaluation of the biopsies from the cecum, descending colon, sigmoid colon, and rectum revealed tangled fascicles of spindle cells expanding the lamina propia leading to separation of the intestinal crypts. Immunohistochemical stains helped confirm the diagnosis of diffuse intestinal neurofibromatosis. A thorough clinical evaluation failed to reveal any stigmata of generalized neurofibromatosis. This case represents a rare presentation of isolated intestinal neurofi bromatosis in a patient without classic systemic manifestations of generalized neurofibromatosis and highlights the need in such cases for close clinical follow-up to exclude neurofibromatosis type Ⅰ or multiple endocrine neoplasia type Ⅱ. | J Elliot Carter Javier A Laurini | 2008 | World Journal of Gastroenterology2008，14，42： | 9 |
| 2 | Robust estimation of efficient mean-variance frontiers 显示文摘 | Grossi L Laurini F | 2011 | Advances in Data Analysis and Classification2011，5，： | 1 |
| 3 | Abnormal motor behavior in anencephalic fetuses显示文摘 | Visser G H A Laurini R N Devries JIP | 1998 | Early Hum Dev1998，12，3： | 1 |
| 4 | A system for mototway management based on risk rate estimation显示文摘 | Tanzi T J Guiol R Laurini R | 1998 | Safety Science1998，30，： | 1 |
| 5 | Blood veloc in the fetalvein of Galen and the outcome of highrisk pregnancyl显示文摘 | DUBIEL M BREBOROWICZ G H LAURINI R | 2001 | Eur J Obstet Gynecol Reprod Biol2001，99，1： | 1 |
| 6 | Leg extension test, sEMG and vibratory stimuli to assess functional recovery following knee joint surgery 显示文摘 | Calogero Foti Alessandro Laurini Simone Tiberti | 2012 | Muscles Ligaments and Tendons2012，2，2： | 1 |
| 7 | Spatial Multi-database Topological Continuity and Indexing: a Step Towards Seamless GIS Data Interoperability显示文摘 | Laurini R | 1998 | Geographical Information Science1998，，12： | 1 |
| 8 | Sputum cytology by the Saccomanno method in diagnosing lung malignancy 显示文摘 | Risse EK van't Hof MA Laurini RN | 1985 | Diagn Cytopathoh1985，1，4： | 1 |
| 9 | Hepatic veno-occlusive disease in newborn infant of a woman drinking herbal tea显示文摘 | Roulet M Laurini R Rivier L | 1988 | The Journal of pediatrics1988，112，3： | 1 |
| 10 | Imaging of cervico-thoracic lymphangiomas in children显示文摘 | Borecky N Gudinchet F Laurini R | 1995 | Pediatr Radiol1995，25，2： | 1 |
| 11 | Arterial branches to the Palmaris Longus muscle显示文摘 | Wafae N Itezerote AM Laurini NH | 1997 | Morphologie1997，81，253： | 1 |
| 12 | MYC and BCL2 protein expression predicts survival in patients with diffuse large B-cell lymphoma treated with rituximab 显示文摘 | Perry AM Alvarado- Bernal Y Laurini JA | 2014 | Br J Haematol2014，165，3： | 1 |
| 13 | MYC and BCL2protein expression predicts survival in patients with diffuse largeB-cell lymphoma treated with rituximab显示文摘 | Perry AM Alvarado-Bernal Y Laurini JA* | 2014 | Br J Haematol2014，165，3： | 1 |
| 14 | Interstitial cellsof Cajal are normally distributed in both ganglionated andaganglionic bowel in Hirschsprung's disease显示文摘 | Newman CJ Laurini RN Lesbros Y | 2003 | Pediatr SurgInt2003，19，910： | 1 |
| 15 | Gastrointestinal stromal tumor: A review of the literature显示文摘 | Laurini JA Carter JE | 2010 | Arch Pathol Lab Med2010，134，1： | 1 |
| 16 | Early gastric carcinoma with focal advanced cancer:a particular subtype of gastric carcinoma显示文摘 | Osterheld M C Laurini R Saraga E | 1998 | Hum Pathol1998，29，8： | 1 |
| 17 | Geographic Ontologies, Gazetteers and Multilingualism显示文摘 | Robert Laurini | 2015 | Future Internet 20152015，123，： | 1 |
| 18 | Topological reorganization of Inconsistent geographic databases: a step toward their certification显示文摘 | Laurini R and Milleret-Raffort F | 1994 | Computer and Graphics1994，18，： | 1 |
| 19 | Constrained smoothing-splines for the term structure of interest rates显示文摘 | Laurini M P Moura M | 2010 | Insurance: Mathematics and Economics2010，46，2： | 1 |
| 20 | An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile显示文摘Gene therapy using small interfering RNA(siRNA)is emerging as a novel therapeutic approach to treat various diseases.However,safe and efficient siRNA delivery still constitutes the major obstacle for clinical implementation of siRNA therapeutics.Here we report an ionizable supramolecular dendrimer vector,formed via self-assembly of a small amphiphilic dendrimer,as an effective siRNA delivery system with a favorable safety profile.By virtue of the ionizable tertiary amine terminals,the supramolecular dendrimer has a low positively charged surface potential and no notable cytotoxicity at physiological pH.Nonetheless,this ionizable feature imparted sufficient surface charge to the supramolecular dendrimer to enable formation of a stable complex with siRNA via electrostatic interactions.The resulting siRNA/dendrimer delivery system had a surface charge that was neither neutral,thus avoiding aggregation,nor too high,thus avoiding cytotoxicity,but was sufficient for favorable cellular uptake and endosomal release of the siRNA.When tested in different cancer cell lines and patient-derived cancer organoids,this dendrimer-mediated siRNA delivery system effectively silenced the oncogenes Myc and Akt2 with a potent antiproliferative effect,outperforming the gold standard vector,Lipofectamine 2000.Therefore,this ionizable supramolecular dendrimer represents a promising vector for siRNA delivery.The concept of supramolecular dendrimer nanovectors via self-assembly is new,yet easy to implement in practice,offering a new perspective for supramolecular chemistry in biomedical applications. | Dinesh Dhumal Wenjun Lan Ling Ding Yifan Jiang Zhenbin Lyu Erik Laurini Domenico Marson Aura Tintaru Nelson Dusetti Suzanne Giorgio Juan Lucio Iovanna Sabrina Pricl Ling Peng | 2021 | Nano Research2021，14，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员