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| 1 | Role of retinoids in the prevention and treatment of colorectal cancer显示文摘Vitamin A and its derivatives, retinoids, have been widely studied for their use as cancer chemotherapeutic agents. With respect to colorectal cancer(CRC), several critical mutations dysregulate pathways implicated in progression and metastasis, resulting in aberrant Wnt/β-catenin signaling, gain-of-function mutations in K-ras and phosphatidylinositol-3-kinase/Akt, cyclooxygenase-2 over-expression, reduction of peroxisome proliferatoractivated receptor γ activation, and loss of p53 function. Dysregulation leads to increased cellular proliferation and invasion and decreased cell-cell interaction and differentiation. Retinoids affect these pathways by various mechanisms, many involving retinoic acid receptors(RAR). RAR bind to all-trans-retinoic acid(ATRA) to induce the transcription of genes responsible for cellular differentiation. Although most research concerning the chemotherapeutic efficacy of retinoids focuses on the ability of ATRA to decrease cancer cell proliferation, increase differentiation, or promote apoptosis; as CRC progresses, RAR expression is often lost, rendering treatment of CRCs with ATRA ineffective. Our laboratory focuses on the ability of dietary vitamin A to decrease CRC cell proliferation and invasion via RAR-independent pathways. This review discusses our research and others concerning the ability of retinoids to ameliorate the defective signaling pathways listed above and decrease tumor cell proliferation and invasion through both RAR-dependent and RAR-independent mechanisms. | Catherine C Applegate Michelle A Lane | 2015 | World Journal of Gastrointestinal Oncology2015，7，10： | 2 |
| 2 | Promotion of Pt/γ-Al2O3 by Ce for preferential oxidation of CO in H2显示文摘 | Son I H Lane A M | 2001 | Catalysis Letters2001，176，34： | 2 |
| 3 | Atrial fibrillation显示文摘 | Gregory YH Lip Hung Fat Tse Deirdre A Lane | 2012 | The Lancet . 2012 (9816)2012，，： | 2 |
| 4 | Slope stability analysis by finite element显示文摘 | Griffiths D V Lane P A | 1999 | Geotechnique1999，49，3： | 1 |
| 5 | Rhododendron albiflorum Hook (Ericaceae):one taxon or two 显示文摘 | WANG I R | 1993 | Rhodora1993，95，： | 1 |
| 6 | Slope stability analysis by finite elements 显示文摘 | Grif~ths D V Lane P A | 1999 | Geotechniq ue1999，49，3： | 1 |
| 7 | Flight control design using nonlinear inverse dynamics显示文摘 | Lane S A Enns D F Garrard W L | 1988 | Automatica1988，24，4： | 1 |
| 8 | Plasticity contributions to interface adhesion in thin - film interconnect structures 显示文摘 | LANE M DUSKARDT A VAINCHTEIN R H | 2000 | Journal of Materials Research2000，，15： | 1 |
| 9 | Transcriptional regulation of gene expression during adipocyte differentiation显示文摘 | MACDAUGALD O A LANE M D | 1995 | Annu Rev Biochem1995，64，： | 1 |
| 10 | IL-1beta and TNF-alpha induce Increased Expression of CCL28 by Airway Epithelial Cells Via an NFkappaB-dependent Pathway 显示文摘 | O'Goman M T Jatoi N A Lane S J | 2005 | Cell Immunol2005，238，2： | 1 |
| 11 | Echinoderm faunas of the Hon-gguleleng Formation,Late Devonian(Famennian),Xinjiang-uygur Autonomous Region,People's Republic of China显示文摘 | Lane N G Waters J A Maples C G | 1997 | The Paleonto-logical Society Memoir1997，47，： | 1 |
| 12 | Perinatal Nutrition,Epigenetics,and Disease显示文摘 | Joss-Moore L A Lane R H | 2011 | NeoReviews2011，12，9： | 1 |
| 13 | Engineering calculations of suspended sediment显示文摘 | Lane E W Kalinske A A | 1941 | AGU1941，22，： | 1 |
| 14 | Slope stability analysis by finite elements显示文摘 | Griffiths D V Lane P A | 1999 | Geotechnique1999，49，3： | 1 |
| 15 | The heme oxygenase sys- tem abates hyperglycemia in Zueker diabetic fatty rats by potentiating insulin- sensitizing pathways 显示文摘 | Ndisang JF Lane N Jadhav A | 2009 | Endo- crinology2009，150，5： | 1 |
| 16 | A processbased soil erosion model for USDA-water erosion prediction project technology 显示文摘 | Nearing M A Foster G R Lane L J | 1989 | Trans of the ASAE1989，32，： | 1 |
| 17 | The analysis of natural microbial populations by ribosomal RNA sequence显示文摘 | Pace N R Stahl D A Lane D J | 1986 | Advance in Microbial Ecology1986，9，： | 1 |
| 18 | Serum amyloid A, properdin, complement 3, and toll-like receptors are expressed locally in human sinonasal tissue 显示文摘 | Lane AP Truong-Tran QA Myers A | 2006 | Am J Rhinol2006，20，1： | 1 |
| 19 | Development of Normative Date for the Profile of Mood States for Use with Athletic Samples 显示文摘 | TERRY P C LANE A M | 2000 | JAppl Sport Psycho12000，12，： | 1 |
| 20 | Modeling and visualization of leaf venation patterns显示文摘 | Runiins A Fuhrer M Lane B | 2005 | ACM Transactions on Graphics2005，24，3： | 1 |
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