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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Spontaneous bacterial peritonitis: The clinical challenge of a leaky gut and a cirrhotic liver显示文摘Spontaneous bacterial peritonitis(SBP) is a frequent, life-threatening bacterial infection in patients with liver cirrhosis and ascites. Portal hypertension leads to increased bacterial translocation from the intestine. Failure to eliminate invading pathogens due to immune defects associated with advanced liver disease on the background of genetic predisposition may result in SBP. The efficacy of antibiotic treatment and prophylaxis has declined due to the spread of multi-resistant bacteria. Patients with nosocomial SBP and with prior antibiotictreatment are at a particularly high risk for infection with resistant bacteria. Therefore, it is important to adapt empirical treatment to these risk factors and to the local resistance profile. Rifaximin, an oral, nonabsorbable antibiotic, has been proposed to prevent SBP, but may be useful only in a subset of patients. Since novel antibiotic classes are lacking, we have to develop prophylactic strategies which do not induce bacterial resistance. Farnesoid X receptor agonists may be a candidate, but so far, clinical studies are not available. New diagnostic tests which can be carried out quickly at the patient's site and provide additional prognostic information would be helpful. Furthermore, we need tools to predict antibiotic resistance in order to tailor first-line antibiotic treatment of spontaneous bacterial peritonitis to the individual patient and to reduce mortality. | Philipp Lutz Hans Dieter Nischalke Christian P Strassburg Ulrich Spengler | 2015 | World Journal of Hepatology2015，7，3： | 12 |
| 3 | Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas显示文摘AIM:To investigate the metabolic enzymatic capacity of the colon mucosa to detoxify noxious carcinogenic compounds.METHODS:We investigated the activity of 2 conjugating enzymes-the microsomal uridine glucuronosyltransferase(UGT)and the cytosomal glutathione S-transferase(GST)in the uninvolved mucosa of the colon transversum and sigmoideum in patients with adenomatous polyps and colorectal cancer.Biopsies were taken from the mucosa during colonoscopies which were done for clinical(diagnostic)reasons.After storage,the biopsy material was homogenized and after differential centrifugation the enzyme assays were performed with 4-nitrophenol(UGT)and 1-chloro 2,4-dinitrobenzene(GST)as substrates.RESULTS:About 48 patients were included of which28 had adenomas and 20 had colorectal carcinomas confirmed by histopathology.Enzyme activities were expressed as nmol/mg per minute protein for the GST and as pmol/mg per minute protein for the UGT.Analysis of variance(F-test)indicated that both enzymes were more widely distributed in adenoma than in cancer patients.The means±SD were smaller for cancer patients:GST for adenomas 268±152 vs 241±69 for carcinomas and UGT for adenomas 197±200 vs 150±86 for carcinomas.CONCLUSION:Compared to patients with adenomatous colon polyps those with colorectal carcinoma exhibited a lower capacity of detoxifying enzyme metabolism and their activities clustered over a smaller range. | Harald P Hoensch Hennie MJ Roelofs Lutz Edler Wilhelm Kirch Wilbert HM Peters | 2013 | World Journal of Gastroenterology2013，19，36： | 3 |
| 4 | Effects of stress pretreatment on the dynamics of blood cholinesterase activity after exposure to an organophosphorus pesticide in the rat显示文摘 | Gralewicz S Swiercz R Lutz P | 2010 | Ann Agric Environ Med2010，17，1： | 1 |
| 5 | Closing of dentinal tubules by Gluma desensitizer显示文摘 | Schiipbach P Lutz F Finger WJ | 1997 | Eur J Oral Sci1997，105，51： | 1 |
| 6 | Optimal LPTV -aware bit loading in broadband PLC 显示文摘 | Muharrem A T Erik P Lutz L | 2013 | IEEE Transactions on Communications2013，61，12： | 1 |
| 7 | Isothermal Polymerase Amplification in a Centrifugal Microfluidic Foil Cartridge显示文摘 | Lutz S Weber P Focke M | 2009 | Prucedia Chemistry2009，，1： | 1 |
| 8 | Basic principles of CAOS显示文摘 | Lutz P Nolte | 2004 | Injury2004，35，： | 1 |
| 9 | Transcytosis of lipoprotein lipase across cultured endothelial ceils requires both heparan sulfate proteoglycans and the very low density lipoprotein receptor显示文摘 | OBUNIKE J C LUTZ E P LI Z | 2001 | Journal of Biology Chemistry2001，276，12： | 1 |
| 10 | Conservation of RNA editing between rice and maize plastids:are most editing events dispensable显示文摘 | Corneille S Lutz K Maliga P | | 0，，： | 1 |
| 11 | S3-Leitlinie ?Exokrines Pankreaskarzinom” 2007显示文摘 | G Adler T Seufferlein S Bischoff H.-J Brambs S Feuerbach G Grabenbauer S Hahn V Heinemann W Hohenberger J Langrehr M Lutz O Micke H Neuhaus P Neuhaus H Oettle P Schlag R Schmid W Schmiegel K Schlottmann J Werner B Wiedenmann I Kopp | 2007 | Z Gastroenterol2007，，06： | 1 |
| 12 | Simultaneous induction of CD4 T cell tolerance and CD8 T cell immunity by semimature dendritic cells 显示文摘 | Kleindienst P Wiethe C Lutz MB | 2005 | J Immunol2005，174，7： | 1 |
| 13 | Closing of dentinal tubules by Glumadesensitizer显示文摘 | Schupbach P Lutz F Finger WJ | 1997 | EurJOralSci1997，105，51： | 1 |
| 14 | Instability of magnetic fluid in a narrow gap between plates显示文摘 | VIKTOR P LUTZ T | 2005 | Journal of Magnetism and Magnetic Materials2005，，289： | 1 |
| 15 | Gene transcription of neuroglobin is upregulated by hypoxia and anoxia in the brain of the anoxia - tolerant turtle trachemys scripta 显示文摘 | Milton S L Nayak G Lutz P L | 2006 | Bomediacal Sci2006，13，4： | 1 |
| 16 | Rationally designed peptoids modulate aggregation of amyloid-beta 40显示文摘 | Turner J P Lutz R T Moore K A | 2014 | ACS chemical neuroscience2014，，： | 1 |
| 17 | 显示文摘 | SIJBESMA R B KENTGENS A P M LUTZ E T G | 1993 | J Am Chem Soc1993，115，20： | 1 |
| 18 | Setup error and motion during deep inspiration breath-hold breast ra- diotherapy measured with continuous portal imaging 显示文摘 | Lutz C M Poulsen P R Fledelius W | 2016 | Acta Oneol2016，55，2： | 1 |
| 19 | Quantum corrals显示文摘 | Crommie M F Lutz C P Eigier D M | 1995 | Physica D1995，83，： | 1 |
| 20 | Effects of low oxygen concentrations on the hatching and viability of eggs of marine calanoid copepods显示文摘 | Lutz R Marcus N H Chapman J P | 1992 | Marine Biology1992，144，： | 1 |
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