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| 1 | 中国大陆上地幔各向异性和壳幔变形模式显示文摘近10年来,中国布设的宽频带地震台站大幅度增加.宽频带地震记录中含有大量的剪切波分裂信息,它在揭示中国大陆上地幔的各向异性特征起重要作用.本文对这些台站的远震SKS和(或)SKKS记录,采用最小切向能量的分析方法,确定各台站剪切波分裂的快波偏振方向和延迟时间.此外,还收集了前人在中国大陆及其周边地区的剪切波分裂研究的部分结果,形成拥有1020个剪切波分裂参数对的数据集.这些分裂参数展示了复杂的上地幔各向异性图像.统计分析表明,中国大陆存在较强的上地幔各向异性,平均的剪切波时间延迟为0.95 s,其中西部地区为1.01 s,东部地区为0.92 s.西部地区的各向异性强度略大于东部地区.在大尺度意义下,青藏高原及天山地区,其SKS波分裂和地表变形数据共同支持岩石圈变形模式,即地壳与岩石圈地幔是连贯变形的;东部地区的平均快波偏振方向近似平行于绝对板块运动方向,上地幔各向异性归因于软流圈流动.中部的鄂尔多斯至四川盆地一带为东、西部两种变形模式的过渡带,各向异性结构较为复杂,表现为'化石'各向异性和(或)双层各向异性.印度板块和欧亚板块的碰撞是中国大陆西部上地幔各向异性的主要影响因素,东部地区则与太平洋板块和菲律宾板块向欧亚板块俯冲有关. | 王椿镛 常利军 丁志峰 刘琼林 廖武林 Lucy M FLESCH | 2014 | 中国科学:地球科学2014，44，1： | 31 |
| 2 | Upper mantle anisotropy and crust-mantle deformation pattern beneath the Chinese mainland显示文摘Over the past 10 years,the number of broadband seismic stations in China has increased significantly.The broadband seismic records contain information about shear-wave splitting which plays an important role in revealing the upper mantle anisotropy in the Chinese mainland.Based on teleseismic SKS and SKKS phases recorded in the seismic stations,we used the analytical method of minimum transverse energy to determine the fast wave polarization direction and delay time of shear-wave splitting.We also collected results of shear-wave splitting in China and the surrounding regions from previously published papers.From the combined dataset we formed a shear-wave splitting dataset containing 1020 parameter pairs.These splitting parameters reveal the complexity of the upper mantle anisotropy image.Our statistical analysis indicates stronger upper mantle anisotropy in the Chinese mainland,with an average shear-wave time delay of 0.95 s;the anisotropy in the western region is slightly larger(1.01 s)than in the eastern region(0.92 s).On a larger scale,the SKS splitting and surface deformation data in the Tibetan Plateau and the Tianshan region jointly support the lithospheric deformation mode,i.e.the crust-lithospheric mantle coherent deformation.In eastern China,the average fast-wave direction is approximately parallel to the direction of the absolute plate motion;thus,the upper mantle anisotropy can be attributed to the asthenospheric flow.The area from the Ordos block to the Sichuan Basin in central China is the transition zone of deformation modes between the east and the west regions,where the anisotropy images are more complicated,exhibiting'fossil'anisotropy and/or two-layer anisotropy.The collision between the Indian Plate and the Eurasian Plate is the main factor of upper mantle anisotropy in the western region of the Chinese mainland,while the upper mantle anisotropy in the eastern region is related to the subduction of the Pacific Plate and the Philippine Sea Plate beneath the Eurasian Plate. | WANG ChunYong CHANG LiJun DING ZhiFeng LIU QiongLin LIAO WuLin Lucy M FLESCH | 2014 | Science China Earth Sciences2014，57，1： | 18 |
| 3 | Increased liver stiffness in alcoholic liver disease:Differentiating fibrosis from steatohepatitis显示文摘AIM:To test if inflammation also interferes with liver stiffness (LS) assessment in alcoholic liver disease (ALD) and to provide a clinical algorithm for reliable fibrosis assessment in ALD by FibroScan (FS).METHODS:We first performed sequential LS analysis before and after normalization of serum transaminases in a learning cohort of 50 patients with ALD admitted for alcohol detoxification. LS decreased in almost all patients within a mean observation interval of 5.3 d. Six patients (12%) would have been misdiagnosed with F3and F4 fibrosis but LS decreased below critical cut-off values of 8 and 12.5 kPa after normalization of trans-aminases. RESULTS:Of the serum transaminases,the decrease in LS correlated best with the decrease in glutamic oxaloacetic transaminase (GOT). No significant chang-es in LS were observed below GOT levels of 100 U/L. After establishing the association between LS and GOT levels,we applied the rule of GOT < 100 U/L for reliable LS assessment in a second validation cohort of 101 patients with histologically confi rmed ALD. By ex-cluding those patients with GOT > 100 U/L at the time of LS assessment from this cohort,the area under the receiver operating characteristic (AUROC) for cirrhosis detection by FS improved from 0.921 to 0.945 while specificity increased from 80% to 90% at a sensitivity of 96%. A similar AUROC could be obtained for lower F3 fibrosis stage if LS measurements were restricted to patients with GOT < 50 U/L. Histological grading of inflammation did not further improve the diagnostic accuracy of LS.CONCLUSION:Coexisting steatohepatitis markedly increases LS in patients with ALD independent of fibrosis stage. Postponing cirrhosis assessment by FS during alcohol withdrawal until GOT decreases to < 100 U/mL signif icantly improves the diagnostic accuracy. | Sebastian Mueller Gunda Millonig Lucie Sarovska Stefanie Friedrich Frank M Reimann Maria Pritsch Silke Eisele Felix Stickel Thomas Longerich Peter Schirmacher Helmut Karl Seitz | 2010 | World Journal of Gastroenterology2010，16，8： | 10 |
| 4 | Atrial tachyarrhythmia in adult congenital heart disease显示文摘The adult congenital heart disease(ACHD) population continues to grow and most cardiologists, emergency room physicians and family doctors will intermittently come into contact with these patients. Oftentimes this may be in the setting of a presentation with atrial tachyarrhythmia; one of the commonest late complications of ACHD and problem with potentially serious implications. Providing appropriate initial care and ongoing management of atrial tachyarrhythmia in ACHD patients requires a degree of specialist knowledge and an awareness of certain key issues. In ACHD, atrial tachyarrhythmia is usual y related to the abnormal anatomy of the underlying heart defect and often occurs as a result of surgical scar or a consequence of residual hemodynamic or electrical disturbances. Arrhythmias significantly increase mortality and morbidity in ACHD and are the most frequent reason for ACHD hospitalization. Intra-atrial reentrant tachycardia and atrial fibrillation are the most prevalent type of arrhythmia in this patient group. In hemodynamically unstable patients, urgent cardioversion is required. Acute management of the stable patient includes anticoagulation, rate control, and electrical or pharmacological cardioversion. In ACHD, rhythm control is the preferred management strategy and can often be achieved. However, in the long-term, medication side-effects can prove problematic. Electrophysiology studies and catheter ablation are important treatments modalities and in certain cases, surgical or percutaneous treatment of the underlying cardiac defect has a role. ACHD patients, especially those with complex CHD, are at increased risk of thromboembolic events and anticoagulation is usually required. Female ACHD patients of child bearing age may wish to pursue pregnancies. The risk of atrial arrhythmias is increased during pregnancy and management of atrial tachyarrhythmia during pregnancy needs specific consideration. | Arsha Karbassi Krishnakumar Nair Louise Harris Rachel M Wald S Lucy Roche | 2017 | World Journal of Cardiology2017，9，6： | 3 |
| 5 | Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial显示文摘 | Usha Chakravarthy Simon P Harding Chris A Rogers Susan M Downes Andrew J Lotery Lucy A Culliford Barnaby C Reeves | 2013 | The Lancet2013，，： | 2 |
| 6 | Th1 and Th2 eytokine dysregulation in human infectious,neoplastic,and inflammatory diseases显示文摘 | Lucy DR Clerici M Shearer GM | 1996 | Clin Microbiol Rev1996，9，4： | 1 |
| 7 | Role of PI3K signaling in survival and progression of prostate cancer cells to androgen refractory state显示文摘 | Horacio M Huang H J Lucy J | 2001 | Endocrinology2001，142，11： | 1 |
| 8 | Mass spectrometry-based proteomic analysis of urine in acute kidney injury following cardiopulmonary bypass:a nested case-control study显示文摘 | Ho J Lucy M Krokhin O | 2009 | Am J Kidney Dis2009，53，4： | 1 |
| 9 | Osbornk coughvariantasthma;A review of the clinic allltera ture显示文摘 | Lucy M | 1991 | Asthma1991，28，： | 1 |
| 10 | Applications of free living plant growth-promoting rhizobacteria显示文摘 | Lucy M Reed E Glick B R | 2004 | Antonie Van Leeuwenhoek2004，86，1： | 1 |
| 11 | Messenger ribonucleic acid for insulin-like growth factors-I and -II, insulin-like growth factor-binding protein-2, gonadotropin receptors, and steroidogenic enzymes in porcines follicles显示文摘 | Yuan W Lucy M C Smith M F | 1996 | Biology of Reproduction1996，，55： | 1 |
| 12 | ADSA Foundation scholar award reproductive loss in high-producing dairy cattle:where will it end显示文摘 | LUCY M C | 2001 | J Dairy Sci2001，84，： | 1 |
| 13 | Cough variant asthma:a review ofthe clinical literature显示文摘 | David J Lucy M Osbom K | 1991 | J Asthma1991，28，1： | 1 |
| 14 | Characterization of a novel endopolygalacturonase from Aspergillus niger with unique kinetic properties显示文摘 | Lucie Parenicova Harry C M Kester Jacques A E Benen | 2000 | FEBS Letters2000，467，： | 1 |
| 15 | Cough variant asthma- a review of the clinical literature显示文摘 | David J Lucy M Osbom K | 1991 | J Athma1991，28，2： | 1 |
| 16 | Oxidative desulphurisation of oils via hydrogen peroxide and heteropolyanion catalysis 显示文摘 | COLLINS E M LUCY A H SHARP C | 1997 | J Mol Catal A1997，117，13： | 1 |
| 17 | A Functional YNKI Motif in the Short Cytoplasmic Tail of Varicella-Zoster Virus Glycoprotein gH Mediates Clathrin-Dependent and Antibody-Independent Endocytosis显示文摘 | Jo P T Lucie M Charles G | 2003 | J Virol2003，77，7： | 1 |
| 18 | Characterization of the rheological, textural and sensory properties of samples of commercial us cream cheese with different fat contents显示文摘 | Brighenti M Lucy S G Lucey J A | 2008 | Journal of Dairy Science2008，91，12： | 1 |
| 19 | Apolipoprotein Eknockout as the basis for mouse models of dyslipi-demia-induced neuropathy 显示文摘 | Lucy M Hinder Andrea M | 2013 | Experimental Neurolo-gy2013，239，： | 1 |
| 20 | Non-covalent capillary coatings for protein separations in capillary electrophoresis显示文摘 | Lucy C A MacDonald A M Gulcev M D | 2008 | J Chromatogr A2008，，1184： | 1 |
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