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334篇 您的检索式：作者名="LUCAS P A"

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	题名	作者	年代	出处	被引量
1	Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis.	Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider	2012	World Journal of Gastroenterology2012，18，32：	9
2	Implications of Multiple Phenotypes Observed in Prolactin Receptor Knockout Mice显示文摘	KELLY P A BINART N LUCAS B	2001	Front Neuroendocrinol2001，22，：	1
3	Implications of multiple pbenotypes observed in prolactin receptor knockout mice显示文摘	KELLY P A B1NART N LUCAS B	2001	Front Neuroendocrin2001，22，2：	1
4	A prediction of performance of commercial coal gasifiers显示文摘	Watkinson A P Lucas J P Lim C J	1991	Fuel1991，70，4：	1
5	Vinyl sulfonate co-polymers for high-temperature filtration control of wa- ter-base muds显示文摘	Perricone A C Enright D P Lucas J M	1986	SPE Drilling Engineering1986，1，5：	1
6	On surfaces in the 3-dimensional Lorentz-Minkowski space显示文摘	FerrAndez A Lucas P	1992	Pacific J Math1992，153，1：	1
7	A prediction of performance of commercial coal gasifers显示文摘	Watkinson A P Lucas J P Lim C J	1991	Fuel1991，70，4：	1
8	Class A helix-loop-helix proteins are positive regulators of several cyclin-dependent kinase inhibitors' promoter activity and negatively affect cell growth 显示文摘	Pagliuca A Gallo P De Luca P	2000	Cancer Res2000，60，5：	1
9	Synthesis and diagnostic electrochemistry of nanocrystalline Li1+xMn2-xO4 powders of controlled Li content显示文摘	Lucas P Angell C A	2000	J Electrochem Soc2000，147，12：	1
10	Synthesis,chemical polymerization and electrochemical properties of low band gap conducting polymers for use in suercapacitors 显示文摘	Soudan P Lucas P Ho H A	2001	J Mater Chem2001，11，3：	1
11	Characterization of a new kerati nolytic bacterium that completely degrades native feather ker- atin 显示文摘	Riffel A Lucas F Heeb P	2003	Archives of Microbiology2003，179，4：	1
12	Feature depth observation 显示文摘	A D Luca G Oriolo P R Giordano	2008	International Journal of Robotic Research2008，27，10：	1
13	SWASHES: A compilation of Shallow-Water analytic solutions for hydraulic and environmental studies 显示文摘	DELESTRE O LUCAS C KSINANT P A	2013	International Journal for Numerical Methods in Fluids2013，72，：	1
14	Classifying hypersurfaces in the Lorentz- Minkowski space with a charact- eristic eigenvector显示文摘	FerrAndez A Lucas P	1992	Tokyo J Math1992，15，2：	1
15	Characterization of a new keratinolytic bacterium that completely degrades native feather keratin 显示文摘	Riffel A Lucas F Heeb P	2003	Arch Microbiol2003，179，：	1
16	Randomised controlled trial of a synthetic triglyceride milk formula for preterm infants显示文摘	Lucas A Quinlan P Abrams S	1997	Archives of Disease in Childhood1997，77，3：	1
17	A prediction of performance of commercial coal gasificrs显示文摘	WATKINSON A P LUCAS J P LIM C J	1991	Fuel1991，70，4：	1
18	Direct ampholyte-free liquid-phase isoelectric peptide focusing: application to the human serum proteome显示文摘	XIAO Z CONRADS T P LUCAS D A	2004	Electrophoresis2004，25，1：	1
19	Outlier Detection in Cointegration Analysis 显示文摘	FRANSES P H LUCAS A	1998	Journal of Business & Economic Statistics1998，，16：	1
20	The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘	Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y	2013	Nature genetics2013，45，1：	1

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