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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Decomposition of surface EMG signals 显示文摘 | DE LUCA C J ADAM A WOTIZ R | 2006 | Journal of Neurophysiology2006，96，3： | 1 |
| 3 | The role of EGF - related peptides in tumor growth 显示文摘 | Normanno N Bianco C De Luca A | 2001 | Front Biosci2001，6，5： | 1 |
| 4 | The role of EGF-related peptldes in tumor growth 显示文摘 | NORMANNO N BIANCO C DE LUCA A | 2001 | Front Biosci2001，6，1： | 1 |
| 5 | Candidemia: species involved, virulence factors and antimycotic susceptibility显示文摘 | De Luca C Guglilminetti M Ferrario A | 2012 | New Microbiol2012，35，4： | 1 |
| 6 | A prediction of performance of commercial coal gasifiers显示文摘 | Watkinson A P Lucas J P Lim C J | 1991 | Fuel1991，70，4： | 1 |
| 7 | Vinyl sulfonate co-polymers for high-temperature filtration control of wa- ter-base muds显示文摘 | Perricone A C Enright D P Lucas J M | 1986 | SPE Drilling Engineering1986，1，5： | 1 |
| 8 | A Novel Numerical Optimization Algorithm Inspired From Weed Colonization显示文摘 | Mehrabian A R Lucas C | 2006 | Ecological Informatics2006，1，3： | 1 |
| 9 | A prediction of performance of commercial coal gasifers显示文摘 | Watkinson A P Lucas J P Lim C J | 1991 | Fuel1991，70，4： | 1 |
| 10 | Experi-mentally Validated CO2 Ejector Operation Characteristic Used in a Numerical Investigation of Ejector Cycle 显示文摘 | Lucas C Koehler J Schroder A | 2013 | International Journal of Refrigeration2013，36，： | 1 |
| 11 | Spreadsheet Analysis and Design显示文摘 | Ronen B Palley M A Lucas H C J R | 1989 | Communications of the ACM1989，32，1： | 1 |
| 12 | Synthesis and diagnostic electrochemistry of nanocrystalline Li1+xMn2-xO4 powders of controlled Li content显示文摘 | Lucas P Angell C A | 2000 | J Electrochem Soc2000，147，12： | 1 |
| 13 | Recruitment Order of Motor Units in Human Vastus Lateralis Muscle Is Maintained during Fatiguing Contractions 显示文摘 | ADAM A D E LUCA C | 2003 | Neurophysiol2003，90，： | 1 |
| 14 | Implementation of emotional controller for Interior permanent-magnet synchronous motor drive 显示文摘 | RAHMAN M A MILASI R M LUCAS C | 2008 | IEEE Transactions on Industry Applications2008，44，5： | 1 |
| 15 | A Novel Numerical Optimization Algorithm Inspired from Weed Colonization显示文摘 | Mehrabian A R Lucas C | | 0，，04： | 1 |
| 16 | SWASHES: A compilation of Shallow-Water analytic solutions for hydraulic and environmental studies 显示文摘 | DELESTRE O LUCAS C KSINANT P A | 2013 | International Journal for Numerical Methods in Fluids2013，72，： | 1 |
| 17 | Diagnostic accuracy of the MMSE in detecting probable and possible Alzheimer's disease in ethnically diverse highly educated indi- viduals: an analysis of the NACC database 显示文摘 | SPERING C C HOBSON V LUCAS J A | 2012 | J Gerontol A Biol Sci Med Sci2012，67，8： | 1 |
| 18 | A novel numerical optimization algorithm inspired from weed colonization显示文摘 | LUCAS C | 2006 | Ecological Informatics2006，1，4： | 1 |
| 19 | Workshop summary:Nutrition of the extremely low birth weight infant 显示文摘 | Hay W Jr Lucas A Herid W C | 1999 | Pediatrics1999，10，4960： | 1 |
| 20 | Redesign of ultrasonic block horns for improved vibration performance 显示文摘 | Lucas M Smith A C | 1997 | Journal of Vibration and Acoustics1997，119，： | 1 |
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