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| 1 | Effects of dietary Bacillus amyloliquefaciens supplementation on growth performance,intestinal morphology, inflammatory response, and microbiota of intra-uterine growth retarded weanling piglets显示文摘Background: The focus of recent research has been directed toward the probiotic potential of Bacillus amyloliquefaciens(BA) on the gut health of animals. However, little is known about BA's effects on piglets with intra-uterine growth retardation(IUGR). Therefore, this study investigated the effects of BA supplementation on the growth performance,intestinal morphology, inflammatory response, and microbiota of IUGR piglets.Methods: Eighteen litters of newborn piglets were selected at birth, with one normal birth weight(NBW) and two IUGR piglets in each litter(i.e., 18 NBW and 36 IUGR piglets in total). At weaning, the NBW piglet and one of the IUGR piglets were assigned to groups fed a control diet(i.e., the NBW-CON and IUGR-CON groups). The other IUGR piglet was assigned to a group fed the control diet supplemented with 2.0 g BA per kg of diet(i.e., IUGR-BA group). The piglets were thus distributed across three groups for a four-week period.Results: IUGR reduced the growth performance of the IUGR-CON piglets compared with the NBW-CON piglets. It was also associated with decreased vil us sizes, increased apoptosis rates, reduced goblet cel numbers, and an imbalance between pro-and anti-inflammatory cytokines in the smal intestine. Supplementation with BA improved the average daily weight gain and the feed efficiency of the IUGR-BA group compared with the IUGR-CON group(P < 0.05). The IUGR-BA group exhibited increases in the ratio of jejunal vil us height to crypt depth, in ileal vil us height, and in ileal goblet cel density. They also exhibited decreases in the numbers of jejunal and ileal apoptotic cel s and ileal proliferative cel s(P < 0.05). Supplementation with BA increased interleukin 10 content, but it decreased tumor necrosis factor alpha level in the smal intestines of the IUGR-BA piglets(P < 0.05). Furthermore, compared with the IUGR-CON piglets, the IUGR-BA piglets had less Escherichia coli in their jejunal digesta, but more Lactobacil us and Bifidobacterium in their ileal digesta(P < 0.05).Conclusions: Dietary supplementation with BA improves morphology, decreases inflammatory response, and regulates microbiota in the smal intestines of IUGR piglets, which may contribute to improved growth performance during early life. | Yue Li Hao Zhang Weipeng Su Zhixiong Ying Yueping Chen Lili Zhang Zhaoxin Lu Tian Wang | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 16 |
| 2 | Neomycin biosynthesis is regulated positively by AfsA-g and NeoR in Streptomyces fradiae CGMCC 4.7387显示文摘Neomycins are a group of aminoglycoside antibiotics with both clinical and agricultural applications.To elucidate the regulatory mechanism of neomycin biosynthesis,we completed draft genome sequencing of a neomycin producer Streptomyces fradiae CGMCC 4.7387 from marine sediments,and the neomycin biosynthesis gene cluster was identified.Inactivation of the afsA-g gene encoding a γ-butyrolactone(GBL) synthase in S.fradiae CGMCC 4.7387 resulted in a significant decrease of neomycin production.Quantitative RT-PCR analysis revealed that the transcriptional level of neoR and the aphA-neoGH operon were reduced in the afsA-g::aac(3)Ⅳ mutant.Interestingly,a conserved binding site of AdpA,a key activator in the GBL regulatory cascade,was discovered upstream of neoR,a putative regulatory gene encoding a protein with an ATPase domain and a tetratricopeptide repeat domain.When neoR was inactivated,the neomycin production was reduced about 40%in comparison with the WT strain.Quantitative RT-PCR analysis revealed that the transcriptional levels of genes in the aphA-neoGH operon were reduced clearly in the neoR::aac(3)Ⅳ mutant.Finally,the titers of neomycin were improved considerably by overexpression of qfsA-gand neoR in S.fradiae CGMCC 4.7387. | Xiangxi Meng Wenzhao Wang Zhoujie Xie Pengwei Li Yue Li Zhengyan Guo Yingjian Lu Jie Yang Kaile Guan Zhaoxin Lu Huarong Tan Yihua Chen | 2017 | Science China(Life Sciences)2017，60，9： | 7 |
| 3 | Isolation and characterization of a co-producer of fengycins and surfactins, endophytic Bacillus amyloliquefaciens ES-2, from Scutellaria baicalensis Georgi显示文摘 | Lijun Sun Zhaoxin Lu Xiaomei Bie Fengxia Lu Shengyuan Yang | 2006 | World Journal of Microbiology and Biotechnology2006，，12： | 2 |
| 4 | 2008 Stability Analysis of the Immersed Boundary Method for a Two-Dimensional Membrane with Bending Rigidity显示文摘In this paper,we analyze the stability of the Immersed Boundary Methodapplied to a membrane-fluid system with a plasma membrane immersed in an incompressibleviscous fluid.We show that for small deformations,the planar rest state isstable for a membrane with bending rigidity.The smoothed version,using a standardregularization technique for the singular force,is also shown to be stable.Furthermore,we show that the coupled fluid-membrane system is stiff and smoothing helpsto reduce the stiffness.Compared to the system of elastic fibers immersed in an incompressiblefluid,membrane with bending rigidity consist of a wider range of decayrates.Therefore numerical instability could occur more easily for an explicit methodwhen the time step size is not sufficiently small,even though the continuous problemis stable. | Zhaoxin Gong Huaxiong Huang Chuanjing Lu | 2008 | Communications in Computational Physics2008，3，3： | 2 |
| 5 | Identification of archaeon producing hyperthermophilic α-amylase and characterization of the α-Amylase显示文摘 | WANG Shujun LU Zhaoxin LU Mingsheng | 2008 | Applied Microbiology and Biotechnology2008，80，4： | 1 |
| 6 | Preservation of fresh-cut celery by treatment of ozonated water显示文摘 | Likui Zhang Zhaoxin Lu Zhifang Yu | 2004 | Food Control2004，16，： | 1 |
| 7 | Detection of Salmonella enterica serovar Dublin by polymerase chain reaction in multiplex format显示文摘 | Ligong Zhai Xiaohan Kong Zhaoxin Lu Fengxia Lv Chong Zhang Xiaomei Bie | 2014 | Journal of Microbiological Methods2014，，： | 1 |
| 8 | Isolation and Identification of an Endophytic Strain EJS-3 Producing显示文摘 | Fengxia Lu Lijun Sun Zhaoxin Lu | | 0，，： | 1 |
| 9 | Effect of radiation pretreat- ment on enzymatic hydrolysis of rice straw with low con- centrations of alkali solution显示文摘 | LU Zhaoxin Kumakura M | 1993 | Bioresource Technology1993，43，1： | 1 |
| 10 | Preservation of fresh-cut celery by treatment of ozonated water显示文摘 | Zhang Likui Lu Zhaoxin Yu Zhinfang | 2005 | Food control2005，16，： | 1 |
| 11 | Lipase-catalysed acidolysis of lard with caprylic acid to produce structured lipid显示文摘 | ZHAO Haizhen LU Zhaoxin LU Fengxia | 2006 | Inter- national Journal of Food Science and Technology2006，41，9： | 1 |
| 12 | Separation and extraction of antimicrobial lipopeptides produced by Bacillus amyloliquefaciens ES-2 with macroporous resin显示文摘 | Yu Wang Zhaoxin Lu Xiaomei Bie Fengxia Lv | 2010 | European Food Research and Technology2010，，2： | 1 |
| 13 | Study on microencapsulation of curcumin pigments by spray drying显示文摘 | WANG Yu LU Zhaoxin LU Fengxia | 2009 | European Food Research and Technology2009，229，3： | 1 |
| 14 | Lipase-catalysed acidolysis of lard with caprylic acid to produce structured lipid显示文摘 | ZHAO Haizhen LU Zhaoxin LU Fengxia | | 0，，： | 1 |
| 15 | Preservation effects of gamma irradiation on fresh-cut celery显示文摘 | Lu Zhaoxin Yu Zhifang Gao Xiang | 2005 | Journal of Food Engineering2005，67，： | 1 |
| 16 | A Newly Isolated Organic Solvent Tolerant Staphylococcus saprophyficus M36 Produced Organic Solvent-Stable Lipase显示文摘 | Fang Yaowei Lu Zhaoxin Lv Fengxia | 2006 | Current Microbiology2006，53，： | 1 |
| 17 | In vitro and in vivo antioxidant activity of exopolysaccharides from endophytic bacterium Paenibacillus polymyxa EJS-3显示文摘 | Jun Liu Jianguang Luo Hong Ye Yi Sun Zhaoxin Lu Xiaoxiong Zeng | 2010 | Carbohydrate Polymers2010，，4： | 1 |
| 18 | Effects of blanching on the aetivitiea of PPO, POD and PAL from Artemisia Selengensis显示文摘 | YU Zhifang KANG Ruoyi LU Zhaoxin | 2005 | Food Research International2005，38，3： | 1 |
| 19 | Hypoglycaemic effect of comatin, an antidiabetic substance separated from Coprinus comatus broth, on alloxan-induced-diabetic rats显示文摘 | Zhongyang Ding Yingjian Lu Zhaoxin Lu Fengxia Lv Yuhong Wang Xiaomei Bie Feng Wang Kechang Zhang | 2009 | Food Chemistry2009，，1： | 1 |
| 20 | Effect of gamma irradiation on quality-maintaining of fresh-cut lettuce显示文摘 | ZHANG Likui LU Zhaoxin LU Fengxia | 2006 | Food Control2006，17，3： | 1 |
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