|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MicroRNA-185通过靶向调节DN-MT1/PTEN/Akt通路抑制肝细胞癌的生长显示文摘近来研究表明miRNAs与肝癌的发生密切相关,然而单个miRNAs的具体作用机制仍未完全阐明。作者对microR-NA-185(miR-185)在肝细胞癌生物学功能和分子机制方面做了一些研究。实验发现,与非肿瘤性的肝脏实质相比, miR-185在人肝细胞癌组织中的表达减少;qRT-PCR检测显示,与原代肝细胞相比, miR-185在人肝细胞癌细胞中的表达下降;在体外人肝细胞癌细胞中miR-185的过表达会抑制细胞的增殖和侵袭,并且阻止SCID小鼠体内肿瘤的生长。miR-185的过表达能够抑制肝细胞癌细胞中DNMT13′端非翻译区域荧光素酶的活性,当 miR-185结合位点发生突变时,就不存在该效应;miR-185的复制或过表达会减少肝细胞癌细胞中DNMT1蛋白的表达。这些结果表明DNMT1是miR-185在肝细胞癌细胞中的靶向作用蛋白。 DNMT1在miR-185诱导抑制肝细胞癌的增殖中所起的作用,可进一步通过DNMT1的过表达阻止miR-185诱导抑制肝细胞癌细胞的增殖和侵袭这一事实所证实。 miR-185的复制或过表达能够减少PTEN启动子DNA甲基化并且提高PTEN的表达,从而抑制Akt磷酸化;如果DNMT1过表达,这些效应刚好相反。以上结果表明:miR-185靶向作用于DNMT1,通过诱导PTEN和抑制Akt,从而抑制肝细胞癌细胞的增殖,活化或激活miR-185可能成为肝细胞癌新的治疗策略之一。 | Qadir X V Han C Lu D 魏建国 许春伟 | 2014 | 临床与实验病理学杂志2014，30，12： | 12 |
| 2 | Variations in Wool Growth with Nutrient Supply in Northern China显示文摘Field studies on essessment of nutritional status of the grazing sheep were carried out in each of the three major grassland regions, the eastern Inner Mongolia and beyond grassland, the Inner Mongolia - Ningxia - Gansu grassland and the Xinjiang grassland, in northern China. The results obtained showed that the wool production of fine wool sheep in these regions varied between regions and seasons, with similar seasonal patterns in all regions and that reducing the seasonal variations in nutrient supply would enhance wool production substantially. Nutritional limitations to wool growth of the grazing sheep in these regions were suggested, those were: the shortage of protein supply in winter and early spring; the poor quality of much of the pasture and the hay used as supplements, the low energy intake during winter which probably necessitated the use of body stores to maintain body temperature. | D X Lu,Iner(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)Z C Feng,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)H R Wang,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)R Z Yang,(Xinjiang Institute of Animal Science.Xinjiang Academy of Animal Science.Yiu Hou Road.Urumqi.Xinjiang Uygur Autonomous Region PRC)C T Ma,(Chinese Academy of Agricultural Sciences.Lanzhou.Gansu.PRC)D B Purser,(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)J R Lindsay(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)D W Peter(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014) | 1997 | 畜牧与饲料科学1997，22，S1： | 3 |
| 3 | In vivo chondrogenesis of adult bone-marrow-derived autologous mesenchymal stem cells显示文摘 | Chen J Wang C Lu S Wu J Guo X Duan C Dong L Song Y Zhang J Jing D Wu L Ding J Li D | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 4 | Genetic characterization of novel reassortant H1N2 influenza A viruses isolated from pigs in southeastern China显示文摘 | QI X LU C P | 2006 | Arch Virol2006，151，11： | 1 |
| 5 | Discovery of a nanomolar inhibitor of the human murinc double minute 2 (MDM2)-p53 interaction through an integrated,virtual database screening strategy显示文摘 | LU Y ZANETA N C FANG X | 2006 | J Med Chem2006，49，13： | 1 |
| 6 | A non-equilibrium diffuse discharge in atmospheric pressure air 显示文摘 | Laroussi M Lu X P Malott C M | 2003 | Plasma Sources Science and Technology2003，12，1： | 1 |
| 7 | Hole-Mediated Ferromagnetism in Polycrystalline Si1-xMnx : B Films 显示文摘 | Liu X C Lu Z H Lu Z L etal | 2006 | J Appl Phys2006，100，73： | 1 |
| 8 | Effects of σ phase in stainless steels on corrosive wear behavior in sulfuric acid 显示文摘 | Lu X C Li S Jiang X | 2001 | Wear2001，251，： | 1 |
| 9 | Surfactant-free core-shell hybrid latexes from soybean oil-based waterborne polyurethanes and poly (styrene-butyl acrylate) 显示文摘 | LU Y S YING X RICHARD C L | 2011 | Progress in Organic Coatings2011，71，5： | 1 |
| 10 | Downregulation of MUC1 and MUC1/Y expression in breast cancer cell line by a traditional Chinese medicine KangLaiTe显示文摘 | Zhang L X Li C H Lu YF | 2003 | J Tumor Marker Oncol2003，18，1： | 1 |
| 11 | Metabolites of Colletotrichum gloeosporioides,an eddophytic fungus in Artemisia mongolica显示文摘 | Zou W X Meng J C Lu H | 2000 | J Nat Prod2000，63，： | 1 |
| 12 | A novel drought-inducible gene,A TAF1,encodes a NAC family protein that negatively regulates the expression of stress-responsive genes in Arabidopsis显示文摘 | LU P L CH EN N Z AN R SU Z QI B S REN F CHEN J WANG X C | 2007 | Plant Molecular Biology2007，63，2： | 1 |
| 13 | Mean square exponential stability and periodic solutions of stochastic delay cellular neural networks显示文摘 | Lu J X Ma Y C | 2008 | Chaos Soliton&Fractals2008，38，5： | 1 |
| 14 | Anal Chim Acta显示文摘 | Cao D S Hu Q N Xu Q S Yang Y N Zhao J C Lu H M Zhang L X Liang Y Z | 2011 | 692(1-2):502011，692，12： | 1 |
| 15 | Discrete fourier transformation for seasonal-factor pattern classification and assignment显示文摘 | SHEN L O LU C X ZHAO | 2013 | IEEE Transactions on Intelligent Transportation Systems2013，14，2： | 1 |
| 16 | Synthesis and characterization of hyper- branched liquid crystalline polymer 显示文摘 | Zhang C X Lu S R Ban J F | 2010 | Key Engineering Materials2010，，： | 1 |
| 17 | Selection of image features for steganalysis based on the Fisher criterion 显示文摘 | Lu J C Liu F L Luo X Y | 2014 | Digital In- vestigation2014，11，1： | 1 |
| 18 | Systematic study on heat transfer and surface hydrodynamics of a vertical heat tube in a fluidized bed of FCC particles显示文摘 | Yao X Zhang Y Lu C | 2015 | AIChEJournal2015，61，1： | 1 |
| 19 | Electrical and mechanical properties of expanded graphite-reinforced high-density polyethylene 显示文摘 | Zheng W G Lu X H Wong S C | 2004 | Appl Polym Sci2004，91，5： | 1 |
| 20 | Silver phosphate crystal growth by screw dislocation driven of dynamic-template 显示文摘 | Wang J D Liu J K Luo C X Lu Y Yang X H | 2013 | Crystal Growth & Design2013，13，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员