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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Immunotargeted nanoshells for Integrated cancer imaging and therapy 显示文摘 | Loo C Lowery A Halas N J | 2005 | Nano Lett2005，5，： | 1 |
| 3 | Experi- mental Demonstrations of Electronic Dispersion Com- pensation for Long-Haul Transmission Using Direct- Detection Optical OFDM 显示文摘 | Schmidt B J C Lowery A J Armstrong J | 2008 | Journal of Lightwave Technology2008，26，1： | 1 |
| 4 | Dysregulated miRNA- 183 inhibits migration in breast cancer cells显示文摘 | Lowery A J Miller N Dwyer RM | 2010 | BMC Cancer2010，10，： | 1 |
| 5 | The use of titanium surgical mesh-bone graft composite in the anterior thoracic or lumbar spine after complete or partial corpectomy显示文摘 | Bhat AL Lowery GL Sei A | 1999 | Eur Spine J1999，8，4： | 1 |
| 6 | circulating microRNAs as novel minimal y invasive biomarkers for breast cancer显示文摘 | Heneghan H M Mil er N Lowery A J | | 0，，03： | 1 |
| 7 | Protein measurement with the folin phenol reagent显示文摘 | Lowery O H Rosebrough N J Farr A L | 1951 | J Biol Chem1951，193，1： | 1 |
| 8 | Power Efficient Optical OFDM 显示文摘 | Armstrong J Lowery A J | 2006 | Electronics Letters2006，42，6： | 1 |
| 9 | Revisiting AI-2 quorum sensing inhibitors: direct comparison of alkyl-DPD analogues and a natural product fimbrolide显示文摘 | Lowery C A Abe T Park J | 2009 | J Am Chem Soc2009，131，15： | 1 |
| 10 | Power efficient optical OFDM 显示文摘 | Armstrong J Lowery A J | 2006 | Electronics Letters2006，42，6： | 1 |
| 11 | lOGbit/s multimode fiber link u- sing power-efficient orthogonal-frequeney-division multi- plexing 显示文摘 | Lowery A J Armstrong J | 2005 | Optics Express2005，13，10： | 1 |
| 12 | Physical properties of triglyceride estolides from lesquerella and castor oils 显示文摘 | Isbella T A Lowery B A DeKeyser S S | 2006 | Industrial Crops and Products2006，23，3： | 1 |
| 13 | Use of autologous growth fac- tors in lumbar spinal fusion显示文摘 | Lowery GL Kulkarni S Pennisi A E | 1999 | Bone1999，25，2： | 1 |
| 14 | Orthogonal-frequency-divi- sion multiplexing for dispersion compensation of long- haul optical systems显示文摘 | Lowery A J Armstrong J | 2006 | Opt Expr2006，14，： | 1 |
| 15 | Physical properties of estolides and their ester derivatives 显示文摘 | Isbella T A Edgcomb M R Lowery B A | 2001 | Industrial Crops and Products2001，13，1： | 1 |
| 16 | Experimental demon-strations of electronic dispersion compensation for long-haul transmis-sion using direct-detection optical OFDM显示文摘 | SCHMIDT B J C LOWERY A J ARMSTRONG J | 2008 | Lightwave Technology2008，26，1： | 1 |
| 17 | Molecular and therapeutic advances in the diagnosis and management of malignant pheochromocytomas and paragangliomas显示文摘 | LOWERY A J WALSH S MCDERMOTT E W | 2013 | Oncologist2013，18，4： | 1 |
| 18 | Protein measurements with the Folin phenol reagent显示文摘 | Lowery O H Rosebrough N J Farr A L Randall R J | 1951 | J Biol Chem1951，193，： | 1 |
| 19 | The use of titanium surgical mesh -bone graft composite in the anterior thoracic or lumbar spine after complete or partial corpectomy显示文摘 | Bhat AL Lowery GL Sei A | 1999 | Eur Spine J1999，8，： | 1 |
| 20 | MicroRNA signa- tures predict oestrogen receptor,progesterone receptor and HER2/neu receptor status in breast cancer 显示文摘 | Lowery AJ Miller N Devaney A | 2009 | Breast Cancer Res2009，11，3： | 1 |
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