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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Experimental Evaluation of Intelligent Assistance for Navigation 显示文摘 | Amant R S Long T Duiberg M S | 1998 | Knowledge-based Systems1998，11，1： | 2 |
| 3 | Superior Fe-ZSM-5 Catalyst for Selective Catalytic Reduction of Nitric Oxide by Ammonia显示文摘 | Long R Q Yang R T | 1999 | J Am Chem Soc1999，121，23： | 1 |
| 4 | Carbon nanotubes as a superior sorbent for nitrogen oxides显示文摘 | Long R Q Yang R T | 2001 | Ind Eng Chem Res2001，40，： | 1 |
| 5 | Selective catalytic reduction of nitrogen oxides by ammonia over Fe3+-pillared clay catalysts显示文摘 | Long R Q Yang R T | 1999 | J Catal1999，186，： | 1 |
| 6 | Fe - ZSM - 5 for Selective Catalytic Reductionof NO with NH3 : A Comparative Study of Different PreparationTechniques显示文摘 | Long R Q Yang R T | 2001 | Catalysis Letters2001，74，34： | 1 |
| 7 | Selective catalytic reduction of NO with ammonia over V2 05 doped TiO2 pillared clay catalysts显示文摘 | Long R Q Yang R T | 2000 | Appl Catal B: Envir2000，，24： | 1 |
| 8 | Carbon nanotubes as superior sorbent for dioxin removal 显示文摘 | Long R Q Yang R T | 2001 | J Am Chem Soc2001，123，9： | 1 |
| 9 | Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): Implications for nanoparticle neuro- toxicity 显示文摘 | Long T C Saleh N Tilton R D | 2006 | Environmental Science & Technology2006，40，14： | 1 |
| 10 | Rural Resident's Attitudes Toward Recreation and Tourism Development显示文摘 | ALLEN L R H R HAFER P T LONG | 1993 | Ournal of Travel Research1993，21，4： | 1 |
| 11 | Frequency-stabilized cavity ring-down spectroscopy 显示文摘 | Long D A Cygan A Van Zee R D Okumura M Miller C E Lisak D Hodges J T | 2012 | Chemical Physics Letters2012，536，： | 1 |
| 12 | Developments in high density cherries in the USA显示文摘 | Long L Facteau T Nuňezelisea R | 2005 | Acta Horticulturae2005，667，： | 1 |
| 13 | Selective catalytic redution of nitrogen oxides by ammonia over Fe3+-exchanged TiO2-pillared clay catalysts显示文摘 | Yang R T | 1999 | J Catal1999，186，2： | 1 |
| 14 | Resident Attitudes Toward Legal Gambling显示文摘 | Kang Y P T Long R R Perdue | 1996 | Annals of Tourism Research1996，23，1： | 1 |
| 15 | Structure of 1-ethyl-3-methyl imidazoliu hexafluorophosphate: model for room temperature molten salts显示文摘 | Carlin R T De Long H C | 1994 | J Chem Soc Chem Commun1994，，3： | 1 |
| 16 | The promoting role of rare earth oxides on Fe-exchanged TiO2-pillared clay for selective catalytic reduction of nitric oxide by ammonia显示文摘 | Yang R T | 2000 | Appl Catal B2000，27，2： | 1 |
| 17 | The promoting role of rare earth oxideson Fe-exchanged TiO2-pillared clay for selective catalyticreduction of nitric oxide by ammonia显示文摘 | LONG R Q YANG R T | 2000 | Applied Catalysis B:Environmental2000，27，2： | 1 |
| 18 | Carbo nanotubes as superior sor- bent for dioxin removal显示文摘 | Long R Q Yang R T | 2001 | Journal of the American Chemical Society2001，23，9： | 1 |
| 19 | Bail Bearing Ddynamic Analysis Using Computer Methods - Part I : Analysis 显示文摘 | Meeks C R Long T | 1996 | Jour- nal of Tribology1996，118，1： | 1 |
| 20 | Carbon nanotubes as superior sorbent for dioxin removal显示文摘 | LONG R Q YANG R T | 2001 | Journal of the American Chemi-cal Society2001，123，： | 1 |
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