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| 1 | Acupuncture's Role in Solving the Opioid Epidemic: Evidence, Cost-Effectiveness, and Care Availability for Acupuncture as a Primary, Non-Pharmacologic Method for Pain Relief and Management-White Paper 2017显示文摘The United States(U.S.) is facing a national opioid epidemic, and medical systems are in need of nonpharmacologic strategies that can be employed to decrease the public's opioid dependence. Acupuncture has emerged as a powerful, evidence-based, safe, cost-effective, and available treatment modality suitable to meeting this need. Acupuncture has been shown to be effective for the management of numerous types of pain conditions, and mechanisms of action for acupuncture have been described and are understandable from biomedical, physiologic perspectives. Further, acupuncture's cost-effectiveness can dramatically decrease health care expenditures, both from the standpoint of treating acute pain and through avoiding addiction to opioids that requires costly care, destroys quality of life, and can lead to fatal overdose. Numerous federal regulatory agencies have advised or mandated that healthcare systems and providers offer non-pharmacologic treatment options for pain. Acupuncture stands out as the most evidence-based, immediately available choice to fulfil these calls. Acupuncture can safely, easily, and cost-effectively be incorporated into hospital settings as diverse as the emergency department, labor and delivery suites, andneonatal intensive care units to treat a variety of commonly seen pain conditions. Acupuncture is already being successful y and meaningfully utilized by the Veterans Administration and various branches of the U.S. Military, in some studies demonstrably decreasing the volume of opioids prescribed when included in care. | arthur yin fan david w.miller bonnie bolash matthew bauer john mcdonald sarah faggert hongjian he yong ming li amy matecki lindy camardella mel hopper koppelman jennifer a.m.stone lindsay meade john pang | 2017 | Journal of Integrative Medicine2017，15，6： | 29 |
| 2 | Inhibition of hypoxia-inducible factor 1 with acriflavine sensitizes hypoxic tumor cells to photodynamic therapy with zinc phthalocyanine-encapsulating cationic liposomes显示文摘光力学的治疗(太平洋夏季时间) 是 tumorlocalized photosensitizer 与光是激动的一种肿瘤治疗在形式,它导致反应的氧种类,肿瘤 vasculature 的破坏,肿瘤组织缺氧,肿瘤房间死亡,和反肿瘤免疫者回答的正式就职的本地生产。然而,先存在肿瘤组织缺氧可以减少肿瘤到由激活组织缺氧可诱导的因素的太平洋夏季时间 1 (HIF-1 ) 幸存小径。因此,我们与吖啶黄(ACF ) 假设了 HIF-1 的那抑制将在人的表皮状的癌(A431 ) 加重房间死亡房间。A431 肿瘤房间的太平洋夏季时间用包含 photosensitizer 锌酞毒(ZnPC ) 的最新发达并且优化的 PEGylated cationic liposomes 被执行。分子的停靠表明 ACF 绑在 HIF-1 的 dimerization 领域,并且共焦的显微镜学在组织缺氧下面从 cytosol 证实了 ACF 的 translocation 到原子核。HIF-1 在 hypoxic,然而并非 normoxic 被稳定, A431 房间列在后面太平洋夏季时间。有 ACF 的 HIF-1 的抑制在 hypoxic 条件下面增加了导致太平洋夏季时间的房间死亡的程度并且减少了 HIF-1 目标基因 VEGF, PTGS2,和 EDN1 的表示。而且,在包含 ZnPC liposomes 的水的核心的 ACF 的合作封装在比得上非包含的 ACF 的太平洋夏季时间功效上产出辅助效果。在结论, HIF-1 与 liposomal ZnPC 贡献 A431 肿瘤房间幸存追随者太平洋夏季时间。HIF-1 与的抑制免费或 liposomal ACF 改进太平洋夏季时间功效。 | Mans Broekgaarden Ruud Weijer Massis Krekorian Bas van den IJssel Milan Kos Lindy K. Alles Albert C. van Wijk1 Zsolt Bikadi Eszter Hazai Thomas M. van Gulik Michal Heger | 2016 | Nano Research2016，9，6： | 4 |
| 3 | Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients显示文摘AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome. | Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour Ian Spendlove Ian O Ellis Poulam M Patel | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 4 | Development of the indirect-drive ap- proach to inertial confinemenl fusion and the tar- get physics basis for ignition and gain显示文摘 | LINDI J | 1995 | Phys ics of Plasmas1995，2，11： | 1 |
| 5 | Differential expression of proteins and mRNAs from border cells and root tips of pea 显示文摘 | Lindy A Brigham | 1995 | Plant Physiol1995，109，： | 1 |
| 6 | S- ynergistic effectb of polymorphism in uncou pling protein 1 and beta3- adrenergic recep tor genes on long- term body weight change in Finnish type2 diabetic and non- diabetic control subjects显示文摘 | VALVE R LINDI V | 2000 | Int J Obesity2000，24，： | 1 |
| 7 | Association of the leu 72 met polymorphism of the ghrelin gene with the risk of type 2 dia- betes in sujects with in paired glucose tole - rance in the Finnish diabetes prevention study 显示文摘 | Magerociation U Lindi V Lindstrom J | 2006 | Diabet Med2006，23，6： | 1 |
| 8 | Chronic post traumatic stress disorder and diagnostic CO morbidity in a disaster sample显示文摘 | Green BL Lindy JD Grace MC | 1992 | J Nerv Ment Dis1992，180，6： | 1 |
| 9 | Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the finnish diabetes prevention study显示文摘 | Lindi VI Uusitupa MI Lindstr m J | 2002 | Diabetes2002，51，8： | 1 |
| 10 | A Hospital-Based Palliative Care Service for Patients With Advanced Organ Failure in Sub-Saharan Africa Reduces Admissions and Increases Home Death Rates显示文摘 | Taylor DesRosiers Clint Cupido Elizabeth Pitout Lindi van Niekerk Motasim Badri Liz Gwyther Richard Harding | 2013 | Journal of Pain and Symptom Management2013，，： | 1 |
| 11 | Adult mammalian forebrain ependymal and subependymal was demonstrate proliferative potential, but only subependymal cells have neural stem cell charateristics显示文摘 | Viment T Lindi M | 1999 | J Neurosci1999，19，11： | 1 |
| 12 | Effect of the Pro12Ala polymorphism of the PPAR-gamma2 gene on long-term weight change in Finnish non-diabetic subjects 显示文摘 | Sivenius K Niskanen L | 2001 | Diabetologia2001，44，： | 1 |
| 13 | Ideologies of Motherhood and Experiences of Work:Pregnant Women in Man- age -ment and Professional Careers 显示文摘 | Lindy Fursman | 2002 | Working Paper2002，，34： | 1 |
| 14 | Cellulose nanocrystals grafted with polystyrene chains through surface-initiated atom transfer radical polymerization (SI-ATRP) 显示文摘 | Gaelle M Lindy H Wim T | 2009 | Langmuir2009，25，14： | 1 |
| 15 | The Swift Ultra-Violet/Optical Telescope显示文摘 | Peter W. A. Roming Thomas E. Kennedy Keith O. Mason John A. Nousek Lindy Ahr Richard E. Bingham Patrick S. Broos Mary J. Carter Barry K. Hancock Howard E. Huckle S D. Hunsberger Hajime Kawakami Ronnie Killough T Scott Koch Michael K. Mclelland Kelly Smith | 2005 | Space Science Reviews (-)2005，，3： | 1 |
| 16 | Chronic post traumatic str- ess disorder and diagnostic CO morbidity in a disaster sample 显示文摘 | Green BL Lindy JD Grace MC | 1992 | J Nerv Ment Dis1992，180，6： | 1 |
| 17 | Risk factors for PTSD and other diagnoses in a general sample of veterans显示文摘 | Green BL Grace MC Lindy JD | 1990 | Am J Psychiatry1990，147，6： | 1 |
| 18 | Vitamin D status is associated with sun exposure, vitamin D and calcium intake, acculturation and attitudes in immigrant East Asian women living in Sydney显示文摘 | Kaye E. Brock Liang Ke Marilyn Tseng Lindy Clemson Fung K. Koo Haeyoung Jang Markus J. Seibel Elias Mpofu David R. Fraser Rebecca S. Mason | 2013 | Journal of Steroid Biochemistry and Molecular Biology2013，，： | 1 |
| 19 | The effects of the Pro12Ala polymorphism of the PPARgamma-2 gene on lipid metabolism interact with body size at birth显示文摘 | Eriksson J Lindi V Uusitupa M | 2003 | Clin Genet2003，64，4： | 1 |
| 20 | Development of the indirect-drive approach to inertial confinement fusion and the target physics basis for ignition and gain显示文摘 | LindI J D | 1995 | Phys Plasmas1995，2，11： | 1 |
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