|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Endocrine impact of Helicobacter pylori:Focus on ghrelin and ghrelin o-acyltransferase显示文摘Ghrelin is predominantly produced by the gastric enteroendocrine cell compartment and is octanoylated by the recently discovered ghrelin o-acyltransferase (GOAT) before secretion into the bloodstream. This octanoylation is essential for many of the biological properties of ghrelin including appetite stimulation and anti-inflammatory properties as only the acylated form of ghrelin binds to the ghrelin receptor, the growth hormone secretagogue receptor (GHS-R). Given the gastric location of ghrelin production, it is perhaps not surprising that insult to the gastric mucosa affects circulating ghrelin levels in humans. Helicobacter pylori (H. pylori) infects more than f ifty percent of the world's population and once established within the gastric mucosa, can persist for life. Infection is associated with chronic gastritis, gastric atrophy and ulceration, reduced appetite and a lower body mass index (BMI). The large majority of studies investigating levels of circulating ghrelin and ghrelin expression in the stomach in patients with H. pylori infection indicate that the bacterium has a negative impact on ghrelin production and/or secretion. Eradication of infection restores ghrelin, improves appetite and increases BMI in some studies, however, a causative relationship between H. pylori-associated serum ghrelin decline and food intake and obesity has not been established. Most studies measure total ghrelin in the circulation although the measurement of the ratio of acyl/total ghrelin gives a clearer indication that the ghrelin acylation process is altered during infection and atrophy. GOAT is essential for the production of biologically-active, acyl ghrelin and the impact of H. pylori on GOAT expression and activity will be highly informative in the future. | Penny L Jeffery Michael A McGuckin Sara K Linden | 2011 | World Journal of Gastroenterology2011，17，10： | 12 |
| 2 | Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication显示文摘 | Hilde M van der Schaar Lonneke van der Linden Kjerstin H W Lanke Jeroen R P M Strating Gerhard Purstinger Erik de Vries Cornelis A M de Haan Johan Neyts Frank J M van Kuppeveld | 2012 | Cell Research2012，22，11： | 3 |
| 3 | Single-port laparoscopic cholecystectomy vs standard laparoscopic cholecystectomy:A non-randomized,agematched single center trial显示文摘AIM: To compare the safety of single-port laparoscopic cholecystectomies with standard four-port cholecystectomies.METHODS: Between January 2011 and December 2012 datas were gathered from 100 consecutive patients who received a single-port cholecystectomy. Patient baseline characteristics of all 100 single-port cholecystectomies were collected(body mass index, age, etc.) in a database. This group was compared with 100 age-matched patients who underwent a conventional laparoscopic cholecystectomy in the same period. Retrospectively, per- and postoperative data were added. The two groups were compared to each other using independent t-tests and χ2-tests, P values below 0.05 were considered significantly different.RESULTS: No differences were found between both groups regarding baseline characteristics. Operating time was significantly shorter in the total single-port group(42 min vs 62 min, P < 0.05); in procedures performed by surgeons the same trend was seen(45 min vs 59 min, P < 0.05). Peroperative complications between both groups were equal(3 in the single-port group vs 5 in the multiport group; P = 0.42). Although not significant less postoperative complications were seen in the single-port group compared with the multiport group(3 vs 9; P = 0.07). No statistically significant differences were found between both groupswith regard to length of hospital stay, readmissions and mortality. CONCLUSION: Single-port laparoscopic cholecystectomy has the potential to be a safe technique with a low complication rate, short in-hospital stay and comparable operating time. Single-port cholecystectomy provides the patient an almost non-visible scar while preserving optimal quality of surgery. Further prospective studies are needed to prove the safety of the single-port technique. | Yoen TK van der Linden Koop Bosscha Hubert A Prins Daniel J Lips | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 2 |
| 4 | Evaluation of diagnnstic criteria for ankylosing spondylitis: A proposal for modification of the New York criteria显示文摘 | Van der Linden S Valkenburg HA Cats A | 1984 | Arthritis Rheum1984，27，4： | 1 |
| 5 | Mimicking rubella virus particles by using recombinant envelope glyeoproteins and liposomes显示文摘 | Orellana A Mottershead D Vander linden I | 1999 | J Biotechnol1999，75，23： | 1 |
| 6 | Biodiversity assessment using markers for ecologically important traits显示文摘 | Van TIENDEREN P H De HAAN A A Van der LINDEN C G | 2002 | Trends Ecol Evol2002，17，： | 1 |
| 7 | Quantitative fluoroestradiol positron emission tomography imaging predicts response to endocrine treatment in breast cancer显示文摘 | Hannah M Linden Svetlana A Stekhova Jeanne M Link | 2006 | J Clin Oncol2006，24，18： | 1 |
| 8 | Programmed cell death apoptosis and alternative death styles显示文摘 | Guimaraes C A Linden R | 2004 | Eur J Biochem2004，271，： | 1 |
| 9 | Shutter image converter tubes显示文摘 | Linden B R Snell P A | 1957 | Proc IRE1957，45，3： | 1 |
| 10 | Measuring diagnostic and predictive accuracy in disease management: an introduction to receiver operating characteristic(ROC) analysis显示文摘 | Linden A | 2006 | J Eval Clin Pract2006，12，2： | 1 |
| 11 | Neutrophils, interleukin-17A and lung disease 显示文摘 | Linden A Laan M Anderson GP | 2005 | Eur Respir J2005，25，1： | 1 |
| 12 | Importance of PPAR alpha for the effects of growth hormone on hepatic lipid and lipoprotein metabolism显示文摘 | Ljungberg A Linden D Ameen C | 2007 | Growth Horm IGF Res2007，17，2： | 1 |
| 13 | Act ivat ion of complewent component S and reduced regtdatui'ezpres S in a ecohol induced liver injury in the not显示文摘 | Jarvelainen Vakeva A Lindens KO | 2010 | clinical Immunology2010，1，2： | 1 |
| 14 | Interleukin-17 family embers and in- flarnemation 显示文摘 | Kolls JK Linden A | 2004 | J Immunity2004，21，4： | 1 |
| 15 | The role of osteophytic growth in hip osteoarthritis显示文摘 | Neuman P Hulth A Linden B | 2003 | Int Orthop2003，27，5： | 1 |
| 16 | HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques 显示文摘 | HSIEH M M LINDEN S WYNTER A | 2007 | Blood2007，110，6： | 1 |
| 17 | A comparison of physostigmine and benzodiazepines for the treatment of antieholinergic poisoning 显示文摘 | Burns MJ Linden CH Graudins A | 2000 | Ann Emerg Med2000，35，4： | 1 |
| 18 | How to avoid glucose degradation products in peritoneal dialysis fluids 显示文摘 | Erixon M Wieslander A Linden T | 2006 | Petit Dial Int2006，26，4： | 1 |
| 19 | Evaluation of diagnostic criteria for ankylosing spondylitis:a proposal for modification of the New York criteria 显示文摘 | Van der linden S VHA Cats A | 1984 | Arthritis Rheum1984，27，4： | 1 |
| 20 | Interleukin-17 family members and inflammation显示文摘 | Kolls JK Linden A | 2004 | Immunity2004，21，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员