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| 1 | Factor analysis identifies subgroups of constipation显示文摘AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction.METHODS:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport questionnaire.One hundred of these patients had colonic transit measured scintigraphically.Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology.Cluster analysis was used to determine whether indi-vidual patients naturally group into distinct subtypes.RESULTS:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors.Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool frequency.The majority of patients with these characteristics also reported regular laxative use.CONCLUSION:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated population.However,clear stratification into clinically identifiable groups remains imprecise. | Philip G Dinning Mike Jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski Nicholas J Talley Ian J Cook | 2011 | World Journal of Gastroenterology2011，17，11： | 3 |
| 2 | Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study显示文摘BACKGROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney failure.Challenges exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is paramount.AIM To identify risk factors associated with delayed graft function(DGF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 patients.The primary outcome was the occurrence of DGF.RESULTS The incidence of DGF was 27%.Under logistic regression,eight independent risk factors for DGF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressure<110 mmHg,intraoperative phenylephrine administration,cold storage time≥16 h,donation after cardiac death,donor history of coronary artery disease,donor terminal creatinine≥1.9 mg/dL,and a hypothermic machine perfusion(HMP)pump resistance≥0.23 mmHg/mL/min.CONCLUSION We delineate the association between DGF and recipient characteristics of preinduction mean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine. | Nicholas V Mendez Yehuda Raveh Joshua J Livingstone Gaetano Ciancio Giselle Guerra George W Burke III Vadim B Shatz Fouad G Souki Linda J Chen Mahmoud Morsi Jose M Figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu | 2021 | World Journal of Transplantation2021，11，4： | 2 |
| 3 | Stem cells for cardiac repair: an introduction显示文摘Cardiovascular disease is a major cause of morbidity and mortality throughout the world. Most cardiovascular diseases, such as ischemic heart disease and cardiomyopathy, are associated with loss of functional cardiomyocytes. Unfortunately, the heart has a limited regenerative capacity and is not able to replace these cardiomyocytes once lost. In recent years, stem cells have been put forward as a potential source for cardiac regeneration. Pre-clinical studies that use stem cell-derived cardiac cells show promising results. The mechanisms,though, are not well understood, results have been variable, sometimes transient in the long term, and often without a mechanistic explanation.There are still severalmajor hurdles to be taken. Stem cell-derived cardiac cells should resemble original cardiac cell types and be able to integrate in the damaged heart. Integration requires administration of stem cell-derived cardiac cells at the right time using the right mode of delivery. Once delivered, transplanted cells need vascularization, electrophysiological coupling with the injured heart, and prevention of immunological rejection. Finally, stem cell therapy needs to be safe, reproducible, and affordable. In this review, we will give an introduction to the principles of stem cell based cardiac repair. | Bastiaan C du Pr(e) Pieter A Doevendans Linda W van Laake | 2013 | Journal of Geriatric Cardiology2013，10，2： | 2 |
| 4 | Grading system modification and management of blunt aortic injury显示文摘 | Kaavya N Reddy Tim Matatov Linda D Doucet Maureen Heldmann Cynthia X Zhao Wayne W Zhang | 2013 | Chinese Medical Journal2013，，3： | 2 |
| 5 | Kinetics and mechanism of pentaehlorophenol degradation by sonication, ozonation, and sonolytic ozonation显示文摘 | LINDA K W NOAH M HOFFMANN M R | 2000 | Environ Sci Technol2000，34，： | 1 |
| 6 | How undergraduates are affected by service participation显示文摘 | Alexander W Astin Linda JS | 1998 | Journal of College Student Development1998，39，3： | 1 |
| 7 | Probiotics stimulate liver and plasma protein synthesis in piglets with dextran sulfate induced colitis and macronutrient restriction显示文摘 | Scott V H Keely G F Linda J W | 2008 | Journal of Nutrition2008，138，： | 1 |
| 8 | Zf 9,a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis显示文摘 | Vlad R Avraham L Linda W | 1998 | Proc Natl Acad Sci1998，95，： | 1 |
| 9 | Differences in replication of a DNA template containing an ethyl phosphotriester by T4 DNA polymerase and Escherichia coli DNA polymerase I显示文摘 | Laura T Michael W Linda J | | 0，，17： | 1 |
| 10 | Liquefaction of Autographa californica Nucleopolyhedrovirus-Infected Insects Is Dependent on the Integrity of Virus-Encoded Chitinase and Cathepsin Genes显示文摘 | Rachael E Hawtin Tamara Zarkowska Kevin Arnold Carole J Thomas Graham W Gooday Linda A King John A Kuzio Robert D Possee | 1997 | Virology1997，，： | 1 |
| 11 | Adsorption dissorption characteristics of lead in various types of soil 显示文摘 | ROBBET W PETERS LINDA S | 1992 | environmental progress1992，11，3： | 1 |
| 12 | Site Qual:an Integrated Mea-sure of Web site quality显示文摘 | Harold W Webb Linda A Webb | | 0，，06： | 1 |
| 13 | Disability Behavior: Income Change and Motivation to Work 显示文摘 | SAAD Z N LINDA W H | 1972 | Industrial and Labor Relations Review1972，25，2： | 1 |
| 14 | The relevance of cell size on ultrasoundinduced hemolysis in mouse and human blood in vitro显示文摘 | Miller M W Battaglia Linda F | 2003 | Ultrasound in Med & Biol2003，29，： | 1 |
| 15 | Effects of substrata on the polarization of bovine endometrial epithelial cells in vitro 显示文摘 | Linda M J Erby W Donald H S | 1990 | Cell and Tissue Research1990，261，1： | 1 |
| 16 | Size as a parameter for solvent effects on Candida antarctica lipase B enantioselectivity显示文摘 | Linda Fransson Jerry W King | 2002 | Biochimical et Biophysica Acta (BBA)-Protein Structure and Molecular Enzymology2002，1594，2： | 1 |
| 17 | Disease transmission models with density-dependent demo- graphics显示文摘 | Hethcote Herbert W Gao Linda Q | 1992 | Mathematical Biosciences1992，128，2： | 1 |
| 18 | Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial显示文摘 | Edward J Gane Stuart K Roberts Catherine AM Stedman Peter W Angus Brett Ritchie Rob Elston David Ipe Peter N Morcos Linda Baher Isabel Najera Tom Chu Uri Lopatin M Michelle Berrey William Bradford Mark Laughlin Nancy S Shulman Patrick F Smith | 2010 | The Lancet2010，，9751： | 1 |
| 19 | Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy显示文摘 | Kevin J Martin Klaus Olgaard Jack W Coburn Giorgio M Coen Masafumi Fukagawa Craig Langman Hartmut H Malluche James T McCarthy Shaul G Massry Otto Mehls Isidro B Salusky Justin M Silver Miroslaw T Smogorzewski Eduardo M Slatopolsky Linda McCann | 2004 | American Journal of Kidney Diseases2004，，3： | 1 |
| 20 | Why is your state nurse practice actimportant to school nursing practice显示文摘 | Nancy C Pam M Linda W | 2008 | NASN Newsletter2008，23，2： | 1 |
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