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| 1 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 2 | Adaptive fuzzy logic control of discrete-time dynamical systems 显示文摘 | Jagannathan A Vandegrift M W Lewis F L | 2000 | Automatica2000，36，2： | 2 |
| 3 | Surgical approach to occult gastrointestinal bleeding显示文摘 | Szold A Katz L Lewis B | 1992 | Am J Surg1992，163，90： | 1 |
| 4 | Feedback linearization using neural networks显示文摘 | Yesildirec A Lewis F L | 1995 | Automatica1995，31，11： | 1 |
| 5 | Knee joint motion and ligament forces before and after ACL reconstruction 显示文摘 | Lewis J L Lew W D Hill J A | 1989 | Journal of Biomechanical Engineering1989，111，： | 1 |
| 6 | Discrete-time non- linear HJB solution using approximate dynamic programming: Convergence proof显示文摘 | Al-Tamimi A Lewis F L Abu-Khalaf M | 2008 | IEEE Transactions on Systems Man and Cybernetics Part B: Cybernetics2008，38，4： | 1 |
| 7 | Two cases of acute dexmedetomi- dine withdrawal syndrome following prolonged infusion in the inten- sive care unit: Report of cases and review of the literature 显示文摘 | Kukoyi A Coker S Lewis L | 2013 | Human and Experimental Toxicology2013，32，1： | 1 |
| 8 | Structure-function relations of heparin-mimetic sulphated xylan-oligosaccharides inhibition of Human Immunodeficiency Virus-1 infectivity in vitro显示文摘 | Stone A L Melton D J Lewis M S | 1998 | GlycoconjugateJournal1998，15，： | 1 |
| 9 | Chained aggregation of singular system显示文摘 | Christodoulou M A Mertzios B G | 1989 | IEEE Trans on Automatic and Control1989，34，9： | 1 |
| 10 | Fault tolerant operation of kinematically redundant manipulators for locked joint failures显示文摘 | Lewis L Maciejewski A | 1997 | IEEE Transaction on Robotics and Automation1997，13，4： | 1 |
| 11 | Storage of sediment-associated nutrients and contaminants in river channel and floodplain systems显示文摘 | Walling D E Owens P N Carter J Leeks G J L Lewis S Meharg A A and Wright J | 2003 | Applied Geochemistry2003，18，： | 1 |
| 12 | Effects of alkaline hydrogen peroxide treatment on in vitro degradation of cellulosic substrates by mixed ruminal microorganisms and bacteroides succinogenes S85显示文摘 | Lewis S M Montgomery L Garleb K A | 1988 | Appl Envion Microbiol1988，54，5： | 1 |
| 13 | Thalassiosira species (Bacillariophyceae) from a Scottish sea-loch 显示文摘 | Harris A S D Medlim L K Lewis J | 1995 | European Journal ofPhycology1995，30，2： | 1 |
| 14 | Eigenvalue optimization显示文摘 | Lewis A S Overton M L | 1996 | ActaNumerica1996，，5： | 1 |
| 15 | Suspended solids removal to improve shrimp (Litopenaeus vannamei) production and an evaluation of a plantbased feed in minimalexchange,superintensive culture systems显示文摘 | Ray A J Lewis B L Browdy C L | 2010 | Aquaculture2010，299，1： | 1 |
| 16 | Induction of tumorigen-esis and metastasis by the murine orthologue of tumor protein D52 显示文摘 | Lewis J D Payton L A Whitford J G | 2007 | Mol Cancer Res2007，5，2： | 1 |
| 17 | Visualization of intravenously administered contrast material in the CSF on fluid - attenuated inversion - recovery MR images: an in vitro and animal - model investigation显示文摘 | Mamourain A Hoops P Lewis L | 2000 | AJNR2000，21，1： | 1 |
| 18 | Effect of electron beam irradiation on poultry meat safety and quality显示文摘 | LEWIS S J VELASQUEZ A CUPPETT S L | 2002 | J of Poultry Science2002，81，6： | 1 |
| 19 | Mycobacterium tuberculosis induces interleukin-32 production through a caspase-1/IL-18/interferon-γ-dependent mechanism显示文摘 | Netea M G Azam T Lewis E C Joosten L A Wang M Langenberg D Meng X Chan E D Yoon D Y Ottenhoff T Kim S H and Dinarello C A | | 0，，08： | 1 |
| 20 | Thalassiosira species (Bacillariophyceae) from a Scottish sea-loch 显示文摘 | Harris A S D Medlin L K Lewis J | 1995 | Bri J Phy1995，30，： | 1 |
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