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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | α1-antitrypsin increases interleukin-1 receptor antagonist production during pancreatic islet graft transplantation显示文摘尽管为有类型 1 糖尿病的个人的小岛移植被显示了产出优异的血葡萄糖控制,它为长期的控制仍然保持不适当。这是部分,由于小岛损害和压力,那能导致贝它房间损失。过量 IL-1β 的抑制;活动可能最小化小岛损害,因此保存工作。IL-1 受体对手(IL-1Ra ) , IL-1β 的一个内长的禁止者;,保护小岛免受导致 cytokine 的坏死和 apoptosis 的伤害。因此,在 IL-1β 之间的不平衡;并且 IL-1Ra 可能影响到小岛的 allogeneic 和自体免疫的回答的功课。我们的组以前证明传播丝氨酸朊酶禁止者人 alpha-1-antitrypsin (hAAT ) ,以及 immunomodulatory 活动。在现在的学习,我们寻求了决定是否胰腺的小岛 hAAT 的 allograft 保护的活动被 IL-1Ra 调停感应。我们的结果证明 hAAT 在刺激巨噬细胞在 IL-1Ra 表示导致了 2.04 褶层增加并且 hAAT-pre-treated 小岛接枝在 IL-1Ra 抄本层次展出了 4.851 褶层增加,它与中等煽动性的侧面被联系。出人意料地,从 IL-1Ra-knockout 鼠标被孤立并且在 grafting 前与 hAAT 预先对待进野类型的鼠标的小岛在大概从渗入主机房间被导出的 intragraft IL-1Ra 表示产出增加,当主机的 hAAT 处理不在时的虽然。确实, hAAT-pre-treated 小岛产生了能在有教养的巨噬细胞导致 IL-1Ra 生产的 hAAT 免费的调节媒介。最后,我们证明 hAAT 为 p65 支持了不同 phosphorylation 和原子 translocation 模式,为 IL-1Ra 要求的一个关键抄写因素表示。 | Avishag Abecassis Ronen Schuster Galit Shahaf Eyal Ozeri Ross Green David E Ochayon Peleg Rider Eli C Lewis | 2014 | Cellular & Molecular Immunology2014，11，4： | 2 |
| 3 | Combining principal component analysis with an artificial neural network to perform online quality assessment of food as it cooks in a large-scale industrial oven 显示文摘 | Farrell M O Lewis E Flanagan C | 2005 | Sensors and Actuators2005，107，： | 1 |
| 4 | The effect of microbial phytase in a pearl millet-soybean meal diet on apparent digestibility and retention of nutrients,serum mineral concentration,and bone mineral density of nurscry pigs显示文摘 | MURRY A C LEWIS R D AMOS H E | 1997 | J Anim Sci1997，75，： | 1 |
| 5 | Acomparison of baseline and induced DNA damage in human spermatozoa from fertile and infertile men, using a modified comet assay显示文摘 | Hughes C M Lewis S E McKelvey-Martin V J | 1996 | Mol Hum Reprod1996，2，： | 1 |
| 6 | The coordination chemistry of 4'-phenyl-2,2':6',2″-terpyridine;the synthesis,crystal and molecular structures of 4'-phenyl-2,2':6',2″-terpyridine and bis(4'-phenyl-2,2':6',2″-terpyridine)nickel(11)chloride decahydrate显示文摘 | Constable E C Lewis J Liptrot M C | 1990 | Inorganic Chimica Acta1990，178，1： | 1 |
| 7 | Intraeardlae trans- plantation of skeletal myoblasts yields two populations of striat- ed cells in situ显示文摘 | Atkins B Z Lewis C W Kraus W E | 1999 | Ann Thorac Surg1999，67，1： | 1 |
| 8 | Chemotherapy for advanced esthesioneuroblastoma: the Mayo Clinic experience显示文摘 | McElroy E A Jr Buckner J C Lewis J E | 1998 | Neurosurgery1998，52，5： | 1 |
| 9 | Planar cell polarity acts through septins to control collective cell movement and ciliogenesis显示文摘 | Kim S K Shindo A Park T J Oh E C Ghosh S Gray R S Lewis R A Johnson C A | | 0，，5997： | 1 |
| 10 | Mycobacterium tuberculosis induces interleukin-32 production through a caspase-1/IL-18/interferon-γ-dependent mechanism显示文摘 | Netea M G Azam T Lewis E C Joosten L A Wang M Langenberg D Meng X Chan E D Yoon D Y Ottenhoff T Kim S H and Dinarello C A | | 0，，08： | 1 |
| 11 | Distinct role of macrophages in dif-ferent tumor microenvironments显示文摘 | Lewis C E Pollard J W | 2006 | Cancer Res2006，66，2： | 1 |
| 12 | Co-extrusion of Al2O3/ZrO2 bi-phase high temperature ceramics with fine scale aligned microstructures 显示文摘 | Kaya C Butler E G Lewis M H | 2003 | Journal of the European Ceramic Society2003，23，： | 1 |
| 13 | The Arabidopsis histidine phosphotransfer proteins are redundant positive regulators of cytokinin signaling显示文摘 | Hutchison C.E Li J Argueso C Gonzalez M Lee E Lewis M.W Maxwell B.B Perdue T.D SchalLer G.E Alonso J.M Ecker J.R Kieber J.J | | 0，，： | 1 |
| 14 | Differential activation of transcription factors induced by Ca^2+ response am-plitude anddurati显示文摘 | Dolmetsch R E Lewis R S Goodnow C C | | 0，，： | 1 |
| 15 | The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic in- flammation in vivo 显示文摘 | LEONI F FOSSATI G LEWIS E C | 2005 | Molecular Medicine2005，11，123456789101112： | 1 |
| 16 | Differential activation of transcription factors induced by Ca^2+ response amplitude and duration 显示文摘 | Dolmetsch R E Lewis R S Goodnow C C | 1997 | Nature1997，386，6627： | 1 |
| 17 | Alpha 1-Antitrypsin mono- therapy induces immune tolerance during islet allograft transplantation in mice显示文摘 | Lewis E C Mizrahi M Toledano M | 2008 | Proc Natl Acad Sci USA2008，105，16： | 1 |
| 18 | Low Concentration Monitoring of Exhaust Gases Using a UV-based Optical Sensor 显示文摘 | DOOLY G LEWIS E FITZPATRICK C | 2007 | IEEE Sensors Journal2007，7，5： | 1 |
| 19 | Optimal vehicle routing with real-time traffic information 显示文摘 | Kim S Lewis M E White C C | 2005 | IEEE Transactions on Intelligent Transportation Systems2005，6，2： | 1 |
| 20 | The role of phosphoinositide 3 - kinase lipid products in cell function显示文摘 | Lucia E R Lewis C C | 1999 | J Biol Chem1999，274，13： | 1 |
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