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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Geochemical characteristics of oils from Qaidam,Shanganning and Jianghan basins,China显示文摘 | PHILP R P FAN P LEWIS C A | 1991 | Journal of Southeast Asian Earth Sciences1991，5，3： | 1 |
| 3 | Resonant production of solitons in the RLW equation显示文摘 | LEWIS J C TJON J A | 1979 | Phys Lett A1979，73，： | 1 |
| 4 | Estimation of rela- tive bioavailability of nutrients using SAS procedures显示文摘 | Littell R C Henry P R Lewis A J | 1997 | Jour- nal of Animal Science1997，75，10： | 1 |
| 5 | Dilution of mainstreamtobacco smoke and its effects upon the evaporation anddiffusion of nicotine显示文摘 | Lewis D A Colbeck I Mariner D C | 1995 | Journal of Aerosol Science1995，26，5： | 1 |
| 6 | Valproate-induced hyperammonemic encephalopathy: a brief review显示文摘 | Lewis C Deshpande A Tesar GE | 2012 | Curt Med Res Opin2012，28，6： | 1 |
| 7 | Liquid fermentation technology for experimental production of biocontrol fungi显示文摘 | Papavizas G C Dunn M T Lewis J A | 1984 | Phytopathology1984，74，： | 1 |
| 8 | The effect of microbial phytase in a pearl millet-soybean meal diet on apparent digestibility and retention of nutrients,serum mineral concentration,and bone mineral density of nurscry pigs显示文摘 | MURRY A C LEWIS R D AMOS H E | 1997 | J Anim Sci1997，75，： | 1 |
| 9 | Suspended solids removal to improve shrimp (Litopenaeus vannamei) production and an evaluation of a plantbased feed in minimalexchange,superintensive culture systems显示文摘 | Ray A J Lewis B L Browdy C L | 2010 | Aquaculture2010，299，1： | 1 |
| 10 | Hydrolytic degradation of nonoriented poly(β-propiolactone)显示文摘 | Mathisen T Lewis M Albertsson A C | | 0，，： | 1 |
| 11 | Rheological, structural, and stress evolution of aqueous Al2O3: latex tape-cast layers 显示文摘 | MARTINEZ C J LEWIS J A | 2002 | J Am Ceram Soc2002，85，10： | 1 |
| 12 | Relationships among defoliation, red oak phenolics, and gypsy moth growth and reproduction 显示文摘 | KIDD N A C LEWIS G B BALDWIN I T | 1985 | Ecology1985，10，： | 1 |
| 13 | Chemotherapy for advanced esthesioneuroblastoma: the Mayo Clinic experience显示文摘 | McElroy E A Jr Buckner J C Lewis J E | 1998 | Neurosurgery1998，52，5： | 1 |
| 14 | Scales to measure perccivcd control developed specifically for people with tablettreated diaberes 显示文摘 | Bradley C Lewis K S Jennings A M | 1990 | Diabet Med1990，7，8： | 1 |
| 15 | Planar cell polarity acts through septins to control collective cell movement and ciliogenesis显示文摘 | Kim S K Shindo A Park T J Oh E C Ghosh S Gray R S Lewis R A Johnson C A | | 0，，5997： | 1 |
| 16 | Mycobacterium tuberculosis induces interleukin-32 production through a caspase-1/IL-18/interferon-γ-dependent mechanism显示文摘 | Netea M G Azam T Lewis E C Joosten L A Wang M Langenberg D Meng X Chan E D Yoon D Y Ottenhoff T Kim S H and Dinarello C A | | 0，，08： | 1 |
| 17 | Stable transfer of intact high molecular weight DNA into plant chromosomes显示文摘 | Hamilton C M Frary A Lewis C | 1996 | Proceedings of the National Academy of Sciences of the USA1996，93，18： | 1 |
| 18 | Hypersonic Three dimensional vis- cous shock-layer flows over blunt bodies显示文摘 | Murray A I Lewis C H | 1978 | AIAA Journal1978，16，12： | 1 |
| 19 | Vascular endothelialgrowth factor and the nervous system显示文摘 | Brockington A Lewis C Wharton S | 2004 | Neuropathol ApplNeurobiol2004，30，： | 1 |
| 20 | Conjugated linoleic acid (CLA) inhibits expression of the Spot 14(THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells显示文摘 | DONNELLY C OLSEN A M LEWIS L D | 2008 | Nutrition Cancer2008，61，1： | 1 |
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