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| 1 | Outcome of 1355 consecutive transabdominal chorionic villus samplings in 1351 patients显示文摘Background The true risk of choronic villus sampling (C VS) is poorly defined. The objective of this study was to review the clinical o utcome of transabdominal CVS performed in a university teaching unit, with an em phasis on the complication rate. Methods A comprehensive audit database was maintained for 1351 pregnant women, including 17 sets of twin pregnancies, who had a CVS. Details a nd outcome of all CVSs made in the unit between May 1996 and May 2004 were revie wed. All CVSs were performed by one of 5 operators using the identical techniqu es. Results All procedures were performed transabdominally. A tota l of 1355 CVSs were performed because there were 4 dichorionic twin pregnancies which required 2 punctures. The mean gestation at CVS was (11.8±0.7) weeks, and 97.3% of the procedures were performed between 11 and 13 completed weeks. The majority (96.2%) required only 1 puncture to achieve correct needle placeme nt. The procedure failed to obtain an adequate sample in 4 subjects (0.30%). A total of 1351 chromosomal studies were requested and there was 1 case (0.07%) of culture failure. The results of chromosomal studies were available within 1 4 days in 36.7% of the cases and within 21 days in 94.0%. Overall, 77 chromos omal abnormalities (5.7%) and 5 cases of thalassemia major were detected. Preg nancy outcome was unknown in only 13 singleton subjects (0.96%). In the remain ing 1355 fetuses, there were 76 pregnancy terminations (5.56%), 10 fetal losses with obvious obstetric causes (0.73%), and 21 potentially procedure-relat ed fetal losses (1.54%). In the last group, the majority had one or more co-e xisting obstetric complications. The background fetal loss rate for pregnancies at similar gestational age in the unit was about 0.8%. Therefore, the procedu re-related fetal loss rate was estimated to be at the maximum of 0.74%. Conclusions In experienced hands, first trimester transabdomina l CVS is an accurate and safe invasive prenatal diagnostic procedure. It should be one of the treatment options available to pregnant women who require prenata l genetic diagnosis. | LAU Tze Kin LEUNG Tak Yeung FUNG Tak Yuen Daljit S SAHOTA LEUNG Tse Ngong | 2005 | Chinese Medical Journal2005，，20： | 8 |
| 2 | Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries显示文摘one-bead-one-compound (OBOC ) 组合的肽图书馆是一个强大的工具识别 ligand 和受体相互作用。这里,我们使用了 OBOC 图书馆技术识别对主要贝壳变应原 tropomyosin 的免疫球蛋白 E (IgE ) epitopes 特定的 mimotopes。有 8-12 氨基酸残余的 OBOC 肽图书馆为 tropomyosin 的 IgE mimotopes 与贝壳过敏症从病人与浆液样品被屏蔽。25 mimotopes 从屏蔽被识别,他们到 tropomyosin 特定的 IgE 的有约束力的反应被肽 ELISA 证实。这些 mimotopes 能基于顺序相同被划分成七簇,并且由聚类的 mimotopes 的 EpiSearch 印射的 epitope 被执行描绘并且证实 mimotopes 的有效性。五从六预言的 epitopes 被发现与 tropomyosin 的以前识别的 epitopes 重叠。为了推进,证实 mimotopes 的模仿潜力, BALB/c 老鼠被使免疫, mimotopes 结合了到锁眼恋栈者 hemocyanin 和 assayed 让他们的能力导致 tropomyosin 特定的抗体。那收到的 mimotope 免疫被发现有 tropomyosin 特定的免疫球蛋白 G 的提高的水平的 BALB/c 老鼠,然而并非收到了无关的 mimotope 的老鼠。这研究用整个 sera 开创 OBOC 图书馆的成功的申请屏蔽并且识别多重虾变应原 mimotopes 并且验证他们在 vitro 使用的模仿潜力,在 vivo,并且在 silico 方法。 | Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 3 | Afterloading radiotherapy for local persistence of nasopharyngeal carcinoma显示文摘 | Teo P Leung S F Choi P | 1994 | Br J Radiol1994，67，794： | 2 |
| 4 | Neural network based short-term load forecasting using weather compensation显示文摘 | Chow T W S Leung C T | 1996 | IEEE Trans on Power Systems1996，11，4： | 2 |
| 5 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 6 | Structure of the 2 promoters of the human LCK gene differential accumulation of 2 classes of LCK transcripts in T-cells 显示文摘 | Takadera T Leung S Gernone A | 1989 | Mol Cell Biol1989，9，： | 1 |
| 7 | Clarithromycin resistance and efficacy of clarithromycin-containing triple eradication therapy for Helicobacter pylori infection in type 2 diabetes mellitus patients显示文摘 | Hung IF Chan P Leung S | 2009 | Helicobacter2009，14，6： | 1 |
| 8 | Modification of Hough Transform for circles and ellipses detection using a 2-dimensional array 显示文摘 | Raymond K K Yip Peter K S Tam Dennis N K Leung | 1992 | Pattern Recognition1992，25，9： | 1 |
| 9 | Tuning of the structure and parameters of a neural network using an improved genetic algorithms显示文摘 | Frank H F Leung H K Lams S H Ling | 2003 | EEE Trans Neural Networks2003，14，1： | 1 |
| 10 | Credit Default Swap Valuation with Counterparty Risk显示文摘 | Leung S Y Kwok Y K | 2005 | Kyoto Economic Reuiew2005，74，1： | 1 |
| 11 | Prognostic factors in nasopharyngeal carcinoma investigated by computer tomographyan analysis of 659 patients显示文摘 | TEO P SHIU W LEUNG S F | 1992 | Radio Oncol1992，23，2： | 1 |
| 12 | Two-level finite element method for plane cracks显示文摘 | Leung A Y T Wong S C | 1989 | Communications in Applied Numerical Methods1989，5，： | 1 |
| 13 | Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort 显示文摘 | Li D Fareh S Leung TK | 1999 | Circulation1999，100，1： | 1 |
| 14 | Molecular identification of the lobster muscle protein tropomyosin as a seafood allergen 显示文摘 | Leung P S Chen Y C Mykles D L | 1998 | Mol Mar Biol Biotechnol1998，7，1： | 1 |
| 15 | Prevalence andrisk factors of Human Papillomavirus (HPV) infection insouthern Chinese women-a population-based study 显示文摘 | Liu S S Chan K Y Leung R C | 2011 | PLoSOne2011，6，5： | 1 |
| 16 | Nueleolar pro- teome dynamics显示文摘 | Andersen J S Lam Y W Leung A K | 2005 | Nature2005，433，： | 1 |
| 17 | Interlocking intramedul-lary nailing for supracondylar and intereondylar fracture of the distalpart of the femur显示文摘 | LEUNG K S SHEN WY SOWS | 1991 | J Bone Joint Am1991，73，3： | 1 |
| 18 | Learning Nonlinear Multi- regression Networks Based on Evolutionary Computation 显示文摘 | Leung K S Wong M L Lam W | 2002 | IEEE Transaction on Systems Man and Cybernetics Part B2002，32，： | 1 |
| 19 | The Google file system显示文摘 | GHEMAWAT S GOBIOFF H LEUNG S T | 2003 | ACM SIGOPS Operating Systems Review2003，37，5： | 1 |
| 20 | Intracranial hemorrhage: mechanisms of secondary brain injury 显示文摘 | Lok J Leung W Murphy S | 2011 | Acta Neurochir Suppl2011，111，： | 1 |
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