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| 1 | 胶质瘤的基因治疗(英文)显示文摘Glioblastoma multiforme(GBM) is a highly invasive brain tumour that is unvaryingly fatal in humans despite even aggressive therapeutic approaches such as surgical resection followed by chemotherapy and radiotherapy.Unconventional treatment options such as gene therapy provide an intriguing option for curbing glioma related deaths.To date,gene therapy has yielded encouraging results in preclinical animal models as well as promising safety profiles in phase I clinical trials,but has failed to demonstrate significant therapeutic efficacy in phase III clinical trials.The most widely studied antiglioma gene therapy strategies are suicide gene therapy,genetic immunotherapy and oncolytic virotherapy,and we have attributed the challenging transition of these modalities into the clinic to four major roadblocks:(1) anatomical features of the central nervous system,(2) the host immune system,(3) heterogeneity and invasiveness of GBM and(4) limitations in current GBM animal models.In this review,we discuss possible ways to jump these hurdles and develop new gene therapies that may be used alone or in synergy with other modalities to provide a powerful treatment option for patients with GBM. | Tobias A Ahmed A Moon KS Lesniak MS. | 2013 | 中华神经外科疾病研究杂志2013，12，4： | 16 |
| 2 | The cochromatic number of a graph显示文摘 | Lesniak L Straight H J | 1977 | Ars eombin1977，3，： | 1 |
| 3 | Upstream stimulatory factor is involved in the regulation of the human calcyclin(S100A6)gene显示文摘 | Lesniak W Jezierska A Kuznicki J | 2000 | Biochem Biophys Acta2000，1517，1： | 1 |
| 4 | Boron nitride (BN) and composites for high-temperature applications显示文摘 | Jens Eichler Christoph Lesniak | 2008 | J Eur Ceram Soc2008，28，： | 1 |
| 5 | CD4^+CD25^+Foxp3^+T-cell infiltration and home oxygenase-1 expression correlate with tumor grade in human gliomas显示文摘 | Andaloussi A Lesniak M S | 2007 | J Neurooncol2007，83，2： | 1 |
| 6 | The cochromatic number of a graph显示文摘 | Lesniak L Straight H | 1977 | Ars Combin1977，3，： | 1 |
| 7 | CD4^+ CD25^+ Foxp3^+ T-cell infiltration and heme oxygenase-1 expression correlate with tumor grade in human gliomas显示文摘 | E1 Andaloussi A Lesniak MS | 2007 | J Neurooncol2007，83，2： | 1 |
| 8 | Design and evaluation of the Poleidoscope: a novel digital Polariscope 显示文摘 | Lesniak J Zhang S J and Patterson E A | 2004 | Experimental Mechanics2004，44，2： | 1 |
| 9 | One-step synthesis of thermoplastic phenylsilsesquioxane polymer and its copolymers with diphenylsiloxanes显示文摘 | Lesniak E Michalska Z M Chojnowski J | 1998 | Journal of Inorganic and Organometallic Polymers1998，8，1： | 1 |
| 10 | Anatomic single-and double-bundle anterior cruciate ligament reconstruction flowchart 显示文摘 | Van Eck CF Lesniak BP Schreiber VM | 2010 | Arthroscopy2010，26，2： | 1 |
| 11 | New polythiourethane hardeners for epoxy resins 显示文摘 | Strzelee K Lesniak E Janowska G | 2005 | Polymer International2005，54，9： | 1 |
| 12 | Silver/dendrimer nanocom-posites as biomarkers:fabrication,characterization,in vitro toxicity,andintracellular detection显示文摘 | LESNIAK W BIELINSKA A U SUN K | 2005 | Nano Lett2005，5，11： | 1 |
| 13 | Targeted Therapies for Malignant Glioma显示文摘 | Ronald Mercer Matthew Tyler Ilya Ulasov Maciej Lesniak | 2009 | BioDrugs2009，，1： | 1 |
| 14 | Silver/dendrimer nanocomposites as biomarkers:fabrication,characterization,in vitro toxicity,and intracellular detection显示文摘 | LESNIAK W BIELINSKA A U SUN K | 2005 | Nano Lett2005，5，： | 1 |
| 15 | Cancer cell death by design: apoptosis, autophagy and glioma virotherapy显示文摘 | Tyler M A Ulasov I V Lesniak M S | 2009 | Autoph agy2009，5，： | 1 |
| 16 | Exercise arid hyperten- sion显示文摘 | Karen T Lesniak PHD Patricia M | 2001 | Czar Opin Cadlot2001，16，： | 1 |
| 17 | Frequency and prognostic value of cognitive disorders in stroke patients显示文摘 | Lesniak M Bak T Czepiel W | 2008 | Dement Geriatr Cogn Disord2008，26，4： | 1 |
| 18 | Silver/ dendrimer nanocomposites as biomarkers: Fabrication, characterization, in vitro toxicity, and intracellular detection 显示文摘 | Lesniak W Bielinska A U Sun K | 2005 | Nano Lett2005，5，11： | 1 |
| 19 | Silver/dendrimer nanocomposites as biomarkers : fabrication, characterization, in vitro toxicity, and tntracellular detection 显示文摘 | Lesniak W Bielinska A U Sun K | 2005 | Nano Letters2005，5，11： | 1 |
| 20 | Biochemical parameters of endothelial dysfunction in cardiological syndrome X 显示文摘 | Kolasinska-Kloth W Lesniak W Kiec-Wilk B | 2002 | Scand J clin Lab Invest2002，62，1： | 1 |
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