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	题名	作者	年代	出处	被引量
1	Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF.	Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz	2012	Hepatobiliary & Pancreatic Diseases International2012，11，4：	3
2	CD133 as a biomarker for putative cancer stem cells in solid tumours: limitations, problems and challenges显示文摘	Philipp Grosse‐Gehling Christine A Fargeas Claudia Dittfeld Yvette Garbe Malcolm R Alison Denis Corbeil Leoni A Kunz‐Schughart	2012	J. Pathol2012，，3：	2
3	Transforming growth factorbeta1 and activin A generate antiproliferative signaling in thyroid cancer cells显示文摘	Matsuo SE Leoni SG Colquhoun A	2006	J Endocrinol2006，190，1：	1
4	Inhibition of cytomegalovirus infection by lactoferrin in vitro and in vivo显示文摘	Leonie Beljaars Barry W A van der Strate Hester I Bakker	2004	Antiviral Research2004，63，：	1
5	The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines显示文摘	Leoni F Zaliani A Bertolini G Porro G Pagani P Pozzi P	2002	Proc Natl Acad Sci USA2002，99，：	1
6	The antitumor histone deacety-lase inhibitor suberoylanilide hydroxamic acid exhibits anti-in-flammatory properties via suppression of cytokines显示文摘	Leoni F Zaliani A Bertolini G Porro G Pagani P Pozzi P Dona G Fossati G Sozzani S* Azam T Bufler P Fantuzzi G Goncharov I Kim SH Pomerantz BJ Reznikov LL SiegmundB Dinarello CA Mascagni P	2002	ProcNatl Acad Sci USA2002，99，：	1
7	Co-consumption of sugars or ethanol and glucose in a Saccharomyces cerevisiae strain deleted in the HXK2 gene显示文摘	Leonie M Ramsdonk Jasper A Diderich Arthur Kuiper etal	2001	Yeast2001，18，：	1
8	Engraftment capacity of mesenchymal cells following hematopoietie stem cell transplantation in patients receiving reduced-intensity conditioning regimen 显示文摘	Poloni A Leoni P Buscemi L	2006	Leukemia2006，20，2：	1
9	Oxysterols and neurodegenerative diseases 显示文摘	Bj6rkhem I Cedazo-Minguez A Leoni V	2009	Molec Aspects Med2009，30，3：	1
10	The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits anti-inflammatory properties via suppression of cytokines显示文摘	Leoni F Zaliani A Bertolini G	2002	Proc Natl Acad Sci USA2002，99，5：	1
11	Anisotropic creep model for soft soils显示文摘	LEONI M KAESTUNEN M VERMEER P A	2008	Geotechnique2008，58，3：	1
12	Ron receptor tyrosine kinase-dependent hepatic neutrophil recruitment and survival bene?t in a murine model of bacterial peritonitis显示文摘	Caldwell CC Martignoni A Leonis MA	2008	Crit Care Med2008，36，：	1
13	Nanoporous biocapsules for the encapsulation of insulinoma cells:Biotransport and biocompatibility considerations显示文摘	Desai T A	2001	IEEE Transactions on Biomedical Engineering2001，48，11：	1
14	Prospective, randomized comparison of deep or supperfcial cervieal plexus block for carotid eudarterectomy surrgery显示文摘	Leoni A Margrin S Mascotto G	1998	Anesthesiology1998，89，4：	1
15	Epidemiology and risk factors for urinary tract infection in patients with spinal cord injury显示文摘	Esclarin de Ruz A Garcia Leoni ME Herruzo Cabrera R	2000	J Urol2000，164，：	1
16	Epidemi- ology and risk factors for urinary tract infection in patients with spinal cord ir~iury显示文摘	Esclarin De Ruz A Garcia Leoni E Herruzo Cabrera R	2000	J Urol2000，164，4：	1
17	Micromachined biocapsules for cell-based sensing and delivery显示文摘	Desal Tejal A	2004	Advanced Drug Delivery Reviews2004，56，2：	1
18	Anisotropic Creep Model for Soft Soils 显示文摘	LEONI M KARSTUNEN M VERMEER P A	2008	Geotechnique2008，58，3：	1
19	Ultrasound-guided liver resections for hepatocellular carcinoma显示文摘	Torzilli G Leoni P Gendarini A	2002	Hepatogastroenterology2002，49，43：	1
20	The antitumor historic deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines显示文摘	Leoni F Zaliani A Bertolini G	2002	Proceedings of the National Academy of Sciences2002，99，5：	1

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