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| 1 | Stroke mechanisms and outcomes of isolated symptomatic basilar artery stenosis显示文摘background While diffuse atherosclerotic disease affecting the posterior circulation has been described extensively,the prevalence,natural history and angiographic characteristics of isolated symptomatic basilar artery stenosis(ISBAS)remain unknown.Methods We reviewed our prospective institutional database to identify patients with≥50% symptomatic basilar artery(BA)stenosis without significant atherosclerotic burden in the vertebral or posterior cerebral arteries.Stroke mechanism,collateral circulation,and degree and length of stenosis were analysed.The primary outcome was time from index event to new transient ischaemic attack(TIA),acute ischaemic stroke(AIS)or death.Other outcome variables included modified Rankin Scale(mRS)score on discharge and last follow-up.results Of 6369 patients with AIS/TIA,91(1.43%)had ISBAS.Seventy-three(80.2%)patients presented with AIS and 18(19.8%)with TIA.Twenty-nine(31.9%)were women and the median age was 66.8±13.6 years.The mean follow-up time was 2.7 years.The most common stroke mechanism was artery-to artery thromboembolism(45.2%),followed by perforator occlusion(28.7%)and flow-dependent/hypoperfusion(15.1%).The percentage of stenosis was lower in patients who had favourable outcome compared with those with mRS 3-6 on discharge(78.3±14.3 vs 86.9±14.5,p=0.007).Kaplan-Meier curves showed higher recurrence/death rates in patients with≥80% stenosis,mid-basilar location and poor collateral circulation.Approximately 13% of patients with ISBAS presented with complete BA occlusion.Conclusion ISBAS is an uncommon(1.43%)cause of TIA and AIS.Men in their 60s are mostly affected,and artery-to artery embolism is the most common stroke mechanism.Mid-basilar location,≥80% stenosis and poor collateral circulation are important factors associated with worse prognosis. | Edgar A Samaniego Amir Shaban Santiago Ortega-Gutierrez Jorge A Roa David M Hasan Colin Derdeyn Biyue Dai Harold Adams Enrique Leira | 2019 | Stroke & Vascular Neurology2019，4，4： | 10 |
| 2 | Reliability-based analysis of a stretch-bending process for aluminium extrusions 显示文摘 | HOPPERSTAD O S LEIRA B J REMSETH S | 1999 | Computers and Structures1999，71，： | 2 |
| 3 | Blood Pressure Decrease During the Acute Phase of Ischemic Stroke Is Associated With Brain Injury and Poor Stroke Outcome显示文摘 | José Castillo Rogelio Leira María M. García Joaquín Serena Miguel Blanco Antoni Dávalos | 2004 | Stroke: Journal of the American Heart Association2004，，2： | 2 |
| 4 | 血管损伤的分子标记与脑内出血的早期蔓延有关 | Silva Y. Leira R. Tejada J. A. D' avalos 沈才飞 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，6： | 2 |
| 5 | Plasma Metalloproteinase-9 Concentration Predicts Hemorrhagic Transformation in Acute Ischemic Stroke显示文摘 | Mar Castellanos Rogelio Leira Joaquín Serena José M. Pumar Ignacio Lizasoain José Castillo Antoni Dávalos | 2003 | Stroke: Journal of the American Heart Association2003，，1： | 2 |
| 6 | Brainstem involvement in hypertensive encephalopathy:clinical and radiological findings 显示文摘 | Cruz-Flores S de Assis Aquino Gondim F Leira EC | 2004 | Neurology2004，62，8： | 1 |
| 7 | Plasma metallopro teinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke显示文摘 | Castellanous M Leira R Serena S | 2003 | Stroke2003，34，： | 1 |
| 8 | Dynamic Response and Fluid/structure Interaction of Submerged Floating Tunnels显示文摘 | SVEIN Remseth BERNT J leira KNUT M Okstad | 1999 | Computers & Structures1999，72，4： | 1 |
| 9 | Treating patients with 'wake-up' stroke: the experience of the AbESTF- I1 trial 显示文摘 | Adams HP Jr Leira EC Tomer JC | 2008 | Stroke2008，39，12： | 1 |
| 10 | Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke显示文摘 | Castellanos M Leira R Serena J | 2003 | Stroke2003，34，1： | 1 |
| 11 | Influence of combined acid treatment on physico-chemical characteristics of ultrastable zeolite Y and on its catalytic properties in the disproportionation of ethylbenzene 显示文摘 | Leiras Gomes A C | 1997 | Applied Catalysis A: General1997，148，： | 1 |
| 12 | Early neurologic deterioration in intracerebral hemorrhage: predictors and associated factors 显示文摘 | Leira R Davalos A Silva Y | 2004 | Neurology2004，63，3： | 1 |
| 13 | Neurological deterioration in acute lacunar infarctions:The role of excitatory and inhibyory neurotransmitters显示文摘 | Serend J Leira R Castillo J | 2001 | Stroke2001，32，： | 1 |
| 14 | Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke显示文摘 | Castellanos M Leira R Serena J | 2003 | Stroke2003，34，1： | 1 |
| 15 | Blood pressure decrease during the acute phase of ischemic stroke is associated with braininjury and poor stroke outcome 显示文摘 | Castitlo J Leira R Garcia MM | 2004 | Stroke2004，35，2： | 1 |
| 16 | Neuroprotective effect of aspirin in patients with acute cerebral infarction显示文摘 | Castillo J Leira R Moro MA | | 0，，03： | 1 |
| 17 | Baseline NIH Stroke Scale score strongly predicts outcome after stroke: A report of the Trial of Org 10172 in Acute Stroke Treatment(TOAST)显示文摘 | ADAMS H P J R DAVIS P H LEIRA E C | 1999 | Neurology1999，53，1： | 1 |
| 18 | Blood pressure decrease during the acute phase of ischemic stroke is associated with brain injury and poor stroke outcome显示文摘 | Castillo J Leira R Garcia MM | 2004 | Stroke2004，35，2： | 1 |
| 19 | Early neurologic deterioration in intracerebral hemorrhage: predictors and associaled factors显示文摘 | Leira R Davalos A Silva Y | 2004 | Neurology2004，63，3： | 1 |
| 20 | Blood pressure decreaseduring the acute phase of ischemic stroke is associated with braininjury and poor stroke outcome 显示文摘 | Castillo J Leira R Gareia MM | 2004 | Stroke2004，35，2： | 1 |
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