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| 1 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 2 | Nerolidol derivatives from Asteriscus sericeus 显示文摘 | Jakupovic J Lehmann L Bohlmann F | 1987 | Phytochemistry1987，26，10： | 2 |
| 3 | Some concepts of dependence显示文摘 | LEHMANN E L | 1996 | Ann Math Statist1996，43，： | 1 |
| 4 | Genetic analysis of tolerance in blueberry(Vaccinium section Cyanococcus)显示文摘 | Arora R Rowland L J Lehmann J S | 2000 | 690-6962000，，： | 1 |
| 5 | Fast prism: branch and bound hough transform for object class detection显示文摘 | Lehmann A Leibe B and Gool L | 2011 | International Journal of Computer Vision2011，94，2： | 1 |
| 6 | Biochemical analysis of the synovial fluid of the shoulder joint in patients with and with and without rotator cuff tears 显示文摘 | LEHMANN L J SCHOLLMEYER A STOEVE J | 2011 | Z Orthop Unfall2011，148，1： | 1 |
| 7 | Some concepts of dependence显示文摘 | Lehmann E L | 1966 | AnnMath Stat1966，43，： | 1 |
| 8 | An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ(PPARγ) 显示文摘 | Lehmann J M Moore L B Smith-Oliver T A et ol | 1995 | J Biol Chem1995，270，12： | 1 |
| 9 | The consensus concept for thermostability engineering of proteins 显示文摘 | Lehmann M Pasamontes L Lassen SF Wyss M | 2000 | Biochimica et Biophysica Acta (BBA) -Protein Structure and Molecular Enzy- mology2000，1543，2： | 1 |
| 10 | Estrogenic and genotoxic potential of equol and two hydroxylated metabolites of daidzein in cultured human Ishikawa cells显示文摘 | Lehmann L Esch HL Wagner J | 2005 | Toxicol Lett2005，158，1： | 1 |
| 11 | Exercise sustains the hallmarks of health显示文摘Exercise has long been known for its active role in improving physical fitness and sustaining health.Regular moderate-intensity exercise improves all aspects of human health and is widely accepted as a preventative and therapeutic strategy for various diseases.It is well-documented that exercise maintains and restores homeostasis at the organismal,tissue,cellular,and molecular levels to stimulate positive physiological adaptations that consequently protect against various pathological conditions.Here we mainly summarize how moderate-intensity exercise affects the major hallmarks of health,including the integrity of barriers,containment of local perturbations,recycling and turnover,integration of circuitries,rhythmic oscillations,homeostatic resilience,hormetic regulation,as well as repair and regeneration.Furthermore,we summarize the current understanding of the mechanisms responsible for beneficial adaptations in response to exercise.This review aimed at providing a comprehensive summary of the vital biological mechanisms through which moderate-intensity exercise maintains health and opens a window for its application in other health interventions.We hope that continuing investigation in this field will further increase our understanding of the processes involved in the positive role of moderate-intensity exercise and thus get us closer to the identification of new therapeutics that improve quality of life. | Yan Qiu Benjamin Fernández-García H.Immo Lehmann Guoping Li Guido Kroemer Carlos López-Otín Junjie Xiao | 2023 | Journal of Sport and Health Science2023，12，1： | 1 |
| 12 | The ethics of medical education显示文摘 | Jagsi R Lehmann L | 2004 | British Medical Journal2004，329，7461： | 1 |
| 13 | Activation of thenuclear receptor LXR by oxysterols defines a new hormoneresponse pathway显示文摘 | Lehmann J M Kliewer S A Moore L B | 1997 | J Biol Chem1997，272，： | 1 |
| 14 | The effects of maintenance doses of FK506 versus cyclosporine A on glucose and lipid metabolism after orthotopic liver transplantation显示文摘 | Fernandez LA Lehmann R Luzi L | 1999 | Transplantation1999，68，10： | 1 |
| 15 | An antidia2betic thiazolidinedione is a high affinity ligand for peroxisome proliferator activated receptor gamma 显示文摘 | Lehmann J N Moore L B Smith Oliver T A | 1995 | J Biol Chem1995，270，12： | 1 |
| 16 | Design aspects of calcite-dissolution reactors applied for post treatment of desalinated water显示文摘 | O Lehmann L Bimhack O l_ahav | 2013 | Desalination2013，314，： | 1 |
| 17 | Black carbon affects the cycling of non-blackcarbon in soil显示文摘 | Liang BQ Lehmann J Sohi SP Thies JE Neill BO Trujillo L Gaunt J Solomon D Groossman J Neves EG Luizao FJ | 2010 | Organic Geochemistry2010，41，2： | 1 |
| 18 | Biclique communities 显示文摘 | LEHMANN S SCHWARTZ M HANSEN L K | 2008 | Physical Review E2008，78，01： | 1 |
| 19 | A different approach for brackish water desalination, comprising acidification of the feed-water and CO2(aq) reuse for alkalinity, Ca^2+ and Mg^2+ supply in the post treatment stage 显示文摘 | Oren S Birnhaek L Lehmann O | 2012 | Separation and Purification Technology2012，89，： | 1 |
| 20 | Soy isoflavones decrease the catechol-O-methyltransferase-mediated inactivation of 4-hydroxyestradiol in cultured MCF-7 cells显示文摘 | Lehmann L Jiang L Wagner J | 2008 | Carcinogenesis2008，29，2： | 1 |
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