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| 1 | 外耦合布拉格光栅 5μm量子级联激光器(英文)显示文摘窄带宽的 Al Ga As/ Ga As布拉格光栅耦合到 In P的半导体量子级联激光器从而产生稳定的激光频谱 ,其激光谱线宽度在 1纳米左右。如果不加光栅 ,非稳定的自由激射的激光器的谱线宽度有 3 0 nm左右。 | 彭川 LE H Q Sarangan A M Ishaug B Thompson L | 2003 | 重庆邮电学院学报(自然科学版)2003，15，3： | 4 |
| 2 | Relationship between the severity of hepatitis C virus-related liver disease and the presence of Helicobacter species in the liver: A prospective study显示文摘AIM: To determine the presence of Helicobacter species DNA in the liver of chronic hepatitis C (CHC) patients with and without cirrhosis as compared to controls, and to identify the bacterial species involved. METHODS: Seventy-nine consecutive patients (HBV and HIV negative) with a liver sample obtained after liver biopsy or hepatic resection were studied: 41 with CHC without cirrhosis, 12 with CHC and cirrhosis, and 26 controls (HCV negative). Polymerase chain reactions (PCRs) targeting Helicobacter 16S rDNA and species- specific were performed on DNA extracted from the liver. A gastric infection with H pylori was determined by serology and confirmed by 13C-urea breath test. RESULTS: Overall, Helicobacter 16S rDNA was found in 16 patients (20.2%). Although positive cases tended to be higher in CHC patients with cirrhosis (41.6%) than in those without cirrhosis (17.0%) or in controls (15.4%), the difference was not statistically significant (P =0.08). H pylori-like DNA was identified in 12 cases and H. pullorum DNA in 2, while 2 cases remained unidenti- fied. Gastric infection with H pylori was found in only 2 of these patients. CONCLUSION: Our results do not confirm the associ- ation of Helicobacter species DNA in the liver of CHC patients with advanced liver disease. The lack of correlation between positive H pylori serology and the presence of H pylori-like DNA in the liver may indicate the presence of a variant of this species. | Laurent Castéra Anne Pedeboscq Marcia Rocha Brigitte Le Bail Corinne Asencio Victor de Lédinghen Pierre-Henri Bernard Christophe Laurent Marie-Edith Lafon Maylis Capdepont Patrice Couzigou Paulette Bioulac-Sage Charles Balabaud FrancisMégraud Armelle Ménard | 2006 | World Journal of Gastroenterology2006，12，45： | 3 |
| 3 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 4 | Germanene: a novel two-dimensional germanium allotrope akin to graphene and silicene显示文摘 | M E Dávila L Xian S Cahangirov A Rubio G Le Lay | 2014 | New Journal of Physics2014，，： | 3 |
| 5 | Induction of a high incidence of lung tumors in C57BL/6 mice with multiple ethyl carbamate injections显示文摘 | York E Miller Lori D Dwyer-Nield Robert L Keith Mysan Le Wilbur A Franklin Alvin M Malkinson | 2003 | Cancer Letters2003，，2： | 2 |
| 6 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 7 | Fibrodysplasia ossificans progressiva 显示文摘 | Kaplan F S Le Merrer M Glaser D L | 2008 | Best Pract Res Clin Rheumatol2008，22，1： | 1 |
| 8 | A central role for inflammation in the pathogenesis of diabetic retinopathy显示文摘 | Joussen A M Poulaki V Le M L | 2004 | FASEB J2004，18，12： | 1 |
| 9 | Exploring the neutral invertase-oxidative stress defence connection in Ara-bidopsis thaliana显示文摘 | XIANG L LE ROY K BOLOURI-MOGHADDAM M K etal | 2011 | Journal of Experimental Botany2011，6211，： | 1 |
| 10 | 显示文摘 | Colas B Le Meste M | 1992 | J Food Sci1992，57，3： | 1 |
| 11 | Structure-property relationship in intumescent polymeric formulations containing wastezeolite-based material as a synergistic agent显示文摘 | R M Estevao L Le Bras M Delobel R | 2004 | European Polymer Journal2004，40，7： | 1 |
| 12 | Alien species alert: Crassostrea gigas (Pacific oyster) 显示文摘 | Miossec L Le Deuff R M Goulletquer P | 2009 | ICES Cooperative Research Report2009，299，： | 1 |
| 13 | Inflammation, complement, ischemia and amoebic survival in acute experimental amoebic liver abscesses in hamsters显示文摘 | A Olivos-Garc??a M Nequiz-Avenda?o E Tello R.D Mart??nez A González-Canto R López-Vancell M.C Garc??a de León I Montfort R Pérez-Tamayo | 2004 | Experimental and Molecular Pathology2004，，1： | 1 |
| 14 | Uterine pathologies in pa- tients undergoing tamoxifen therapy for breast cancer:ultrasonograph- ie, hysteroscopic and histological findings 显示文摘 | Le Donne M Lentini M De Meo L | 2005 | Eur J Gynaecol On- col2005，26，： | 1 |
| 15 | Role of MAPKs in development and differentiation:lessons from knockout miee显示文摘 | Aouadi M Binetnly B Caron L Le Marchand-Brustel Y Bost F | 2006 | Biochimie2006，88，9： | 1 |
| 16 | A group Ⅱ intron has invaded the genus Azotobacter and is inserted within the termination codon of the essential groEL gene显示文摘 | Ferat J L Le Gouar M Michel F | 2003 | Mol Microbiol2003，49，5： | 1 |
| 17 | BMP-2 sig-naling in ovarian cancer and its association with poor prognosis显示文摘 | Le Page C Puiffe M L Meunier L | 2009 | J Ovarian Res2009，2，： | 1 |
| 18 | Transcranial magnetic stimulation at 1 Hertz improves clinical symptoms in children with To- urette syndrome for at least 6 months显示文摘 | Le K Liu L Sun M | 2013 | J Clin Neurosci2013，20，2： | 1 |
| 19 | Are plants useful as accumulation indicators of metal bioavailability? 显示文摘 | REMON E BOUCHARDON J L LE GU DARD M | 2013 | Environmental Pollution2013，175，： | 1 |
| 20 | Osteoblastic cell behaviour on different titanium implant surfaces显示文摘 | Le Guehennec L Lopez-Heredia M A Enkel B | 2008 | Acta Biomaterialia2008，4，3： | 1 |
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