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| 1 | Vitamin D deficiency and hepatitis viruses-associated liver diseases:a literature review显示文摘The secosteroid hormone vitamin D has, in addition to its effects in bone metabolism also functions in the modulation of immune responses against infectious agents and in inhibiting tumorigenesis. Thus, deficiency of vitamin D is associated with several malignancies, but also with a plethora of infectious diseases. Among other communicable diseases, vitamin D deficiency is involved in the pathogenesis of chronic liver diseases caused by hepatitis B and C viruses(HBV, HCV) and high prevalence of vitamin D deficiency with serum levels below 20 mg/mL in patients with HBV and HCV infection are found worldwide. Several studies have assessed the effects of vitamin D supplementation on the sustained virological response(SVR) to interferon(IFN) plus ribavirin(RBV) therapy in HBV and HCV infection. In these studies, inconsistent results were reported. This review addresses general aspects of vitamin D deficiency and, in particular, the significance of vitamin D hypovitaminosis in the outcome of HBVand HCV-related chronic liver diseases. Furthermore,current literature was reviewed in order to understand the effects of vitamin D supplementation in combination with IFN-based therapy on the virological response in HBV and HCV infected patients. | Nghiem Xuan Hoan Hoang Van Tong Le Huu Song Christian G Meyer Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，4： | 9 |
| 2 | Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection显示文摘AIM To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibilityto hepatitis B virus(HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.METHODS Four IFR5 SNPs(rs13242262 A/T, rs77416878 C/T, rs10488630 A/G, and rs2280714 T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B(CHB). n = 99; liver cirrhosis(LC), n = 131; hepatocellular carcinoma(HCC), n = 149] and in 242 healthy controls by direct sequencing and Taq Man realtime PCR assays. RESULTS Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262 T and rs10488630 G contributed to an increased risk of liver cirrhosis(LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients(OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups(LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. CONCLUSION Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. | Bui Tien Sy Nghiem Xuan Hoan Hoang Van Tong Christian G Meyer Nguyen Linh Toan Le Huu Song Claus-Thomas Bock Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，2： | 9 |
| 3 | Comparison between UV spectroscopy and nirs to assess humification process during sewage sludge and green wastes co-composting显示文摘 | Remy Albrecht Jean Le Petit Gérard Terrom Claude Périssol | 2010 | Bioresource Technology2010，，6： | 2 |
| 4 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 5 | The blueschists along the Indus Suture Zone in Ladakh, NW Himalaya 显示文摘 | Honegger K le Fort P Mascle G | 1989 | Journal of Metamorphic Geology1989，7，： | 1 |
| 6 | Propagating Extrusion Tectonies in Asia: New Insights from Simple Experiments with Plastieine显示文摘 | Tapponnier P Peltzer G le Dain A Y | 1982 | Geology1982，10，： | 1 |
| 7 | Macroporous chiral ruthenium porphyrin polymers:a new solid-phase material used as a device for catalytic asymmetric carbene transfer显示文摘 | FERRAND Y LE MAUX P SIMONNEAUX G | | 0，，： | 1 |
| 8 | A perspective on single molecule SERS: Current status and future challenges 显示文摘 | ETCHEGOIN P G LE Ru E C | 2008 | Physical Chemistry Chemical Physics2008，10，40： | 1 |
| 9 | Second trimester termination of pregnancy for fetal anomaly or death: comparing mifepristone/misoprostol to gemeprost 显示文摘 | LE ROUX P A PAHAL G S HOFFMAN L | 2001 | Eur J Obstet Gyneeol Reprod Biol2001，95，1： | 1 |
| 10 | Antinociceptive effect of bupivicaine encapsulated in poly (D, L) -lactide - Co - glycolide microspheres in the acute inflammatory pain model of carrageenin - injected rats 显示文摘 | FLETCHER D LE CORRE P GUILBAUD G | 1997 | Anesth Analg1997，84，1： | 1 |
| 11 | Inducible nitric oxide synthase,nitrotyrosine,and apoptosis in Helicobacter pylori gastritis:effect of antibiotics and antioxidants 显示文摘 | Mannick EE Bravo LE Zarama G Realpe JL Zhang XJ Ruiz B Eonthan ETH Mera R Miller MJL Correa P | 1996 | Cancer Res1996，56，： | 1 |
| 12 | Pro- pagating Extrusion Tectonics in Asia= New Insights from Simple Experiments with Plasticine显示文摘 | Tapponnier P G Peltzer A Y Le Dain | 1982 | Geology1982，10，： | 1 |
| 13 | Influence of milling condition on the FeAI intermetallic formation by mechanical alloying显示文摘 | Wolski K Le C G Delcroix P | 1996 | Materials Science and Engineering1996，207，1： | 1 |
| 14 | Rapid growth in CO2 emissions after the 2008-2009 global financial crisis 显示文摘 | Peters G P Marland G Le Quere C | 2012 | Nature Climate Change2012，2，： | 1 |
| 15 | Environmental factors affecting immune responses in Crustacea 显示文摘 | Le Moullac G Haffner P | 2000 | Aquaculture2000，191，13： | 1 |
| 16 | Harvesting singlet and triplet energy in polymer leds显示文摘 | CLEAVE V YAHIOGLU G LE BARNY P | 1999 | Advanced Materials1999，11，4： | 1 |
| 17 | Renal tubular epithelial expression of the costimulatory molecule B7RP-1(inducible costimulator ligand)显示文摘 | Schoop R Bilic G Neuweiler J Le Hir M Yoshinaga SK | 2002 | J Am Soc Nephro2002，13，6： | 1 |
| 18 | Intrathecal bupivacaine in humans:influence of volume and baricity of solutions显示文摘 | Renaud G Le Corre P | 1999 | Anesthesiology1999，91，5： | 1 |
| 19 | New insecticides with ecdysteroidal and juvenile hormone activity显示文摘 | Dhadiaiiats T S Carlson G R Le D P | 1998 | Annu Rev Entomol1998，43，： | 1 |
| 20 | Propagating extrusion tectonics in Asia: New in sights from simple experiments with plasticine显示文摘 | Tapponnier P Peltzer G Le Dain A Y | 1982 | Geology1982，10，： | 1 |
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