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    题名 作者 年代 出处 被引量
1Lamivudine resistance mutations in patients infected with hepatitis B virus genotype D显示文摘AIM: To determine the distribution of viral genotypes for primary or acquired lamivudine resistance. METHODS: A total of 283 patients with chronic hepatitis B virus (HBV) infection (245 patients with chronic hepatitis B and 38 inactive hepatitis B surface antigen carriers) were included in the study. The HBV geno-type was determined by using quantitative real-time polymerase chain reaction and sequence analysis, and tyrosine-methionine-aspartate-aspartate (YMDD) motif mutations were determined using the reverse transcriptase hybridization method. RESULTS: Lamivudine resistance was determined in a total of 25 (10.7%) chronic hepatitis B patients. Eight subjects (4%) had primary resistance to lamivudine, and 17 (53.1%) had secondary resistance to lamivudine. Genotype D, which was isolated from 267 of the patients with chronic HBV infection, was the dominant genotype in Turkey. CONCLUSION: Identification of YMDD motif mutations should have a positive impact on the selection of proper antiviral medication for patients, even for those who are nucleoside nave.Orhan Yιldιz Bilgehan Aygen Nese Demirtürk Tuna Demirdal Dilara Inan Taner Yιldιrmak Arzu Kantürk Ediz Tütüncü Hepatitis B Study Group 2011World Journal of Gastroenterology2011,17,45:3
2Stem/progenitor cell-media- ted de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model 显示文摘Huang GT Yamaza T Shea LD 2010Tis Engin2010,16,2:1
3Comparison of POSSUM and the Portsmouth predictor equation for predicting death following vascular surgery显示文摘Wijesinghe LD Mahmood T Scott DJA 1998Brit J Surg1998,85,2:1
4The consensus coding sequences of human breast and colorectal cancers 显示文摘Sjoblom T Jones S Wood LD 2006Science2006,314,5797:1
5The consensus coding sequences of human breast and colorectal cancers显示文摘Sj(o)blom T Jones S Wood LD 0,,5797:1
6A retrospective review of 1349 cases of sebaceous carcinoma显示文摘Dasgupta T Wilson LD Yu JB 2009Cancer2009,115,:1
7Combinatorial effects of lapatinib and rapamycin in triple-negative breast can- cer cells显示文摘Liu T Yacoub R Taliaferro-Smith LD 2011Mol Cancer Ther2011,10,8:1
8Radiographic imaging techniques for the diagnosisy of abnormal uterine Bleeding显示文摘Bradley LD Falcone T Magen AB 2000Obstet Gynecol Clin North Am2000,27,2:1
9Rapid quantitative detection Of Listeria monocytogenes in meat products by real-time PCR显示文摘Rodriguez LD Jofre A Aymefich T 2004Appl Environ Microbid2004,,70:1
10Develop-mental outcome after epilepsy surgery in infancy显示文摘Loddenkemper T Holland KD Stanford LD 2007Pedia-trics2007,119,:1
11Interface automata显示文摘Alfaro Ld Henzinger T A 0,,05:1
12St em/progen itor cellmediated De Novo regenerat ion of dent al pulp with newly deposited comtinuous layer of dentin in an in vivo model显示文摘Hu a ng GT Ya ma za T Shea LD 2010Tissue Eng Part A2010,16,2:1
13The consensus coding sequences of human breast and colorectal cancers显示文摘Sj6blom T Jones S Wood LD 2006Sci- ence2006,314,5797:1
14Applied anatomy of the latissimus dorsi free flap for refinement in one-stage facial reanimation显示文摘Ferguson LD Paterson T Ramsay F 2011J Plast Reconstr Aesthet Surg2011,64,11:1
15Comparison of POSSUM and the Portsmouth predictor equation for predicting death following vascular surgery显示文摘Wijesinghe LD Mahmood T Scott DJ 1998Br J Surg1998,85,2:1
16Assessment of sleepiness andunintended sleep in Parkinson's disease patients taking dopamineagonists显示文摘Roth T Rye DB Borchert LD 2003Sleep Med2003,4,4:1
17Efficacy of low tidal volume ventilation in patients with different dinical risk factors for acute lung injury and the acute respiratory distress syndrome 显示文摘Eisner MD Thompson T Hudson LD 2001Am J Respir Grit Care Med2001,164,2:1
18Heavy ion induced DNA transfer in biological ceils Phys显示文摘Vilaithonga T Yu LD Apavatjrutb P 2004Chem2004,,71:1
19CD8alpha: plasmacytoid precursor DCs induce antigen-specific regulatory T cells that enhance HSC engraftment in vlvo显示文摘Huang Y Bozulic LD Miller T 2011Blood2011,117,8:1
20Toxoplasma gondii : secretion of a potent nucleoside triphosphate hydrolase into parasitophorous vacuole显示文摘Sibley LD Niesman IR Asai T 1994Exp Parasitol1994,79,3:1
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