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| 1 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 2 | Local immunotherapy with interleuk in-2 delivered from biodegradable p olymer microspheres combined with interstitial chemotherapy:a novel treatme nt for experimental malignant glioma显示文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradable polymers prolon gs survival against experimental brain tumors.Moreover,paracrine administration of inte rleukin-2(IL-2)has been shown to elicit a potent antitumor immune response and to improve survival in animal brain tumor models.We r eport the use of a novel polymeric mic rosphere delivery vehicle to release IL-2.We demonstr ate both in vitro release of cytokine from the microspheres and histological evidence of the inflammatory response elicited by I L-2released from the microspheres i n the rat brain.These microspheres a re used to deliver IL-2,and biodegradable polymer wafers are used to deliver BCNU,directly at the site of an intracranially implanted glioma in the rat.The two agents administered locally show a s ynergistic effect.METHODS:Fischer 344rats challenged intracranially with 9L gliosarcoma received an intracranial implant of either empty microspheres or microspheres containing IL-2(IL-2MS ).Five days later,animals in each group were randomized to receiv e polymer implants loaded with 0,3.8,or 10%BCNU at the tumor site.RESULTS:Animals that received the combination of IL-2MS a nd 3.8%BCNU polymer(median survival,28.5d )or IL-2MS and 10%BCNU polymer(median survival,45.5d )showed significantly improved surv ival compared with animals that rece ived monotherapy with IL-2microsph eres(median survival,24d ),3.8%BCNU polymer(median survival,24d ),or 10%BCNU polymer(median survival,32.5d ).Control animals had a median survival of 18days.The combination of either 3.8or 10%BCNU polymer with IL-2MS resulted in 7and 25%long-term survivors,respectively.CONCLUSION:By showing synergy of IL-2and BCNU in an animal glioma model and using a reproducible synthetic delivery sy stem for each agent (i.e.,one that did not rely on genetic ally engineered cells or viruses),we hope that the combination of local immunotherapy and chemotherapy can take an important step closer to clinical applic ation in patients with malignant brain | Rhines LD DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H | 2003 | 癌症2003，22，7： | 2 |
| 3 | A comparison of residents’ attitudes towards tourism in 10 New Zealand destinations显示文摘 | RW Lawson J Williams T Young J Cossens | 1998 | Tourism Management1998，，3： | 2 |
| 4 | The natural history and clinical consequences of aspiration in acute stroke显示文摘 | Kidd D Lawson J Nesbitt R | 1995 | QJM1995，88，6： | 1 |
| 5 | Thallium and cadmium in recent snow and firn layers in the Canadian Arctic by atomic fluorescence and adsorption spectrometries显示文摘 | Lawson G Lechner J | 1996 | Fresenius Journal o f Analytical Chemistry1996，355，： | 1 |
| 6 | Community Issues and Resident Opinions of Tourism显示文摘 | WILLIAMS J LAWSON R | 2001 | Annals of Tourism Research2001，28，2： | 1 |
| 7 | The relationship between carotid plaque composition, plaque morphology, and neurologic symptoms显示文摘 | Seeger J M Barratt E Lawson G A | 1995 | J Surg Res1995，58，3： | 1 |
| 8 | Measuring the spatial frequency transfer function of phase-measuring interferometers for laser optics显示文摘 | Wolfe C R Downie J D Lawson J K | 1996 | SPIE1996，2870，： | 1 |
| 9 | Application of optical measurement techniques to supersonic and hypersonic aer- ospace flows显示文摘 | Estruch D Lawson N J Garry K P | 2009 | Journal of Aerospace Engineering2009，22，4： | 1 |
| 10 | The responses of guard and mesophyll ceil photosynthesis to CO2 , light, and water stress in a range of specqes are similar显示文摘 | Lawson T Oxborough K Morison J L | 2003 | Journal of Experimental Botany2003，54，388： | 1 |
| 11 | An electron-microscope study of the mode of cell death induced by cancer-chemotherapeutic agents in populations of proliferating normal and neoplastic cells显示文摘 | Searle J Lawson TA Abbott PJ | 1975 | J Pathol1975，116，3： | 1 |
| 12 | Proliferative enteropathy 显示文摘 | Lawson G H K Gebhart C J | 2000 | J Comp Path2000，122，： | 1 |
| 13 | Kinoform phase plates for local plane irradiance profile control显示文摘 | Dixit S N Lawson J K Manes K R | 1994 | Opt Lett1994，19，6： | 1 |
| 14 | Scrap tyres pyrollized in molten salts显示文摘 | Lawson J W Cheng B | 1976 | Chemical Engineering News1976，54，21： | 1 |
| 15 | Paroxetine for the prevention of depression induced by high-dose interferon显示文摘 | Musselman D Lawson D Gumnick J | 2001 | N Engl J Med2001，344，13： | 1 |
| 16 | The isoprostanes in biology and medicine 显示文摘 | Pratico D Lawson JA Rokach J | 2001 | Trends Endocrinol Metab2001，12，6： | 1 |
| 17 | Experimental and computational investigation of an open transonic cavity flow显示文摘 | Atvars K Knowles K Lawson N J | 2009 | Journal of Aerospace Engineering2009，223，4： | 1 |
| 18 | An in vivo study of peripheral nerves in continuity: biomechanieal and physiolog- ical responses to elongation 显示文摘 | Peter J Driseoll Michael A Glaaby Graham M Lawson | 2002 | Journal of Orthopaedic Research2002，20，： | 1 |
| 19 | Turnover of res- ident microglia in the normal adult mouse brain 显示文摘 | Lawson L J Perry VH Gordon S | 1992 | Neuroscience1992，48，2： | 1 |
| 20 | Magnetron injection gun(MIG) design for gyrotron application显示文摘 | Baird J M Lawson W | 1986 | Int J Electronics1986，61，6： | 1 |
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