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| 1 | 9 二磷酸盐导致颌骨坏死:7例报告及文献复习显示文摘二磷酸盐、焦磷酸盐衍生物是破骨细胞抑制剂,临床主要用于预防骨质疏松症及肿瘤的骨转移。但应用二磷酸盐(bisphosphonates)、帕米磷酸盐(Pamindronate)、唑来膦酸(Zolendronic acid)治疗疾病所导致颌骨坏死的报道逐渐增多,这些患者一般首诊口腔外科医师并由其治疗.上颌骨骨坏死若不处理可导致鼻窦炎,耳鼻咽喉科医师也参与其中。该文对2003~2004年间2所医院的7例患者进行回顾,对患者病史进行分析。结果:患者均有顽固性骨髓炎病史及二磷酸盐服用史.4例发病期间正应用二磷酸盐,3例先前应用过二磷酸盐。3例行手术切除死骨,1例行鼻窦镜手术。结论:二磷酸盐导致颌骨坏死的报道逐渐增多,且治疗困难。因此,对易感人群及此药的安全剂量需要进一步研究。 | Mortensen M Lawson W Montazem A | 2007 | 中国口腔颌面外科杂志2007，5，2： | 4 |
| 2 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 3 | Local immunotherapy with interleuk in-2 delivered from biodegradable p olymer microspheres combined with interstitial chemotherapy:a novel treatme nt for experimental malignant glioma显示文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradable polymers prolon gs survival against experimental brain tumors.Moreover,paracrine administration of inte rleukin-2(IL-2)has been shown to elicit a potent antitumor immune response and to improve survival in animal brain tumor models.We r eport the use of a novel polymeric mic rosphere delivery vehicle to release IL-2.We demonstr ate both in vitro release of cytokine from the microspheres and histological evidence of the inflammatory response elicited by I L-2released from the microspheres i n the rat brain.These microspheres a re used to deliver IL-2,and biodegradable polymer wafers are used to deliver BCNU,directly at the site of an intracranially implanted glioma in the rat.The two agents administered locally show a s ynergistic effect.METHODS:Fischer 344rats challenged intracranially with 9L gliosarcoma received an intracranial implant of either empty microspheres or microspheres containing IL-2(IL-2MS ).Five days later,animals in each group were randomized to receiv e polymer implants loaded with 0,3.8,or 10%BCNU at the tumor site.RESULTS:Animals that received the combination of IL-2MS a nd 3.8%BCNU polymer(median survival,28.5d )or IL-2MS and 10%BCNU polymer(median survival,45.5d )showed significantly improved surv ival compared with animals that rece ived monotherapy with IL-2microsph eres(median survival,24d ),3.8%BCNU polymer(median survival,24d ),or 10%BCNU polymer(median survival,32.5d ).Control animals had a median survival of 18days.The combination of either 3.8or 10%BCNU polymer with IL-2MS resulted in 7and 25%long-term survivors,respectively.CONCLUSION:By showing synergy of IL-2and BCNU in an animal glioma model and using a reproducible synthetic delivery sy stem for each agent (i.e.,one that did not rely on genetic ally engineered cells or viruses),we hope that the combination of local immunotherapy and chemotherapy can take an important step closer to clinical applic ation in patients with malignant brain | Rhines LD DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H | 2003 | 癌症2003，22，7： | 2 |
| 4 | CMOS micromachined low power microlamp vacuum sensor显示文摘 | MA Y ROBINSON A M LAWSON R P W | 2002 | IEEE2002，，： | 2 |
| 5 | Bmp4 is required for the generation of primordial germ cells in the mouse embryo 显示文摘 | Lawson K A Duma N R Roelen B A | 1999 | Genetics Development1999，13，： | 1 |
| 6 | Bank predication:an investigation of cash flow based models 显示文摘 | Aziz Emanuel A D Lawson G | 1998 | Journal of Management Studies1998，，25： | 1 |
| 7 | Predicted structure and electronic properties of individual carbon nanocones and nanostructures assembled from nanocones显示文摘 | Shenderova O A Lawson B L Areshkin D | 2001 | Nanotechnology2001，12，： | 1 |
| 8 | The relationship between carotid plaque composition, plaque morphology, and neurologic symptoms显示文摘 | Seeger J M Barratt E Lawson G A | 1995 | J Surg Res1995，58，3： | 1 |
| 9 | Spontaneous abortion,sex ratio,and paternal occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin显示文摘 | Schnorr T M Lawson C C Whelan E A | 2001 | Environ Health Perspect2001，109，11： | 1 |
| 10 | Intestinal adenomatosis in the pig:Immunofluorescent and electron microscopic studies显示文摘 | Rowland A C Lawson G H K | 1974 | Res Vet Sci1974，17，： | 1 |
| 11 | Review of emerging issues in sediment treatment显示文摘 | Murphy T P Lawson A Kumagai M | 1999 | Aquatic Ecosystem Health and Management1999，2，： | 1 |
| 12 | Design manufacturingintegration and flight testing of a health monitoring system fora prototype unmanned airborne vehicle显示文摘 | LAWSON C P MONTERZINO G A | 2014 | Proceedings of theInstitution of Mechanical Engineers Part G:Journal ofAerospace Engineering2014，228，7： | 1 |
| 13 | Knockdownmortality,repellency,and residual effects of insecticides for controlof adult Bactericera cockerelli (Hemiptera:Psyllidae)显示文摘 | Gharalari A H Nansen C Lawson D S | 2009 | Journalof Economic Entomology2009，102，3： | 1 |
| 14 | Isolated sphenoid sinus disease:An analysis of 132 cases 显示文摘 | 4,Lawson A Reino AJ | 1997 | Laryngoscope1997，107，： | 1 |
| 15 | Bank prediction:an investigation of cash flow based models显示文摘 | EMANUEL D LAWSON G | 1988 | Journal of Management Studies1988，，25： | 1 |
| 16 | Effect of ICAM-1 polymorphism on endothelial cells in vitro 显示文摘 | Lawson C Holder A Rose M | 2004 | Cardiovasc Pathol2004，13，3： | 1 |
| 17 | The validity of Kolb learning styles and Neo-Piagetian developmental levels in CollegeBiology显示文摘 | Lawson A E Johnson M | 2002 | Studies in Higher Education2002，27，1： | 1 |
| 18 | An in vivo study of peripheral nerves in continuity: biomechanieal and physiolog- ical responses to elongation 显示文摘 | Peter J Driseoll Michael A Glaaby Graham M Lawson | 2002 | Journal of Orthopaedic Research2002，20，： | 1 |
| 19 | The phylogeny of the genus Clostridium: proposal of five new genera and eleven new species eombinations显示文摘 | COLLINS M D LAWSON P A WILLEMS A | 1994 | Int J Syst Baeteriol1994，44，4： | 1 |
| 20 | Quasicontinuous posets显示文摘 | Gierz G Lawson J D Stralka A | 1983 | Houston Journal of Mathematics1983，9，： | 1 |
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