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| 1 | Acute kidney injury and hepatorenal syndrome in cirrhosis显示文摘Acute kidney injury(AKI)in cirrhosis,including hepatorenal syndrome(HRS),is a common and serious complication in cirrhotic patients,leading to significant morbidity and mortality.AKI is separated into two categories,non-HRS AKI and HRS-AKI.The most recent definition and diagnostic criteria of AKI in cirrhosis and HRS have helped diagnose and prognosticate the disease.The pathophysiology behind non-HRS-AKI and HRS is more complicated than once theorized and involves more processes than just splanchnic vasodilation.The common biomarkers clinicians use to assess kidney injury have significant limitations in cirrhosis patients;novel biomarkers being studied have shown promise but require further studies in clinical settings and animal models.The overall management of non-HRS AKI and HRS-AKI requires a systematic approach.Although pharmacological treatments have shown mortality benefit,the ideal HRS treatment option is liver transplantation with or without simultaneous kidney transplantation.Further research is required to optimize pharmacologic and nonpharmacologic approaches to treatment.This article reviews the current guidelines and recommendations of AKI in cirrhosis. | Kapil Gupta Abhishek Bhurwal Cindy Law Scott Ventre Carlos D Minacapelli Savan Kabaria You Li Christopher Tait Carolyn Catalano Vinod K Rustgi | 2021 | World Journal of Gastroenterology2021，27，26： | 5 |
| 2 | Skeletal myoblast based delivery of angiogenic growth factors:a comparison between angiopoietin-1 and VEGF gene delivery for therapeutic angiogenesis in the heart显示文摘Objectives This study investigated the efficacy of human skeletal myoblasts (SkM) mediated either human vascular endothelial growth factor-165 (hVEGF165) or angiopoietin-1 (Ang-1) on vascular development and myocardial regional perfusion. Methods A porcine heart model of chronic infarction was created in 28 female swine by coronary artery ligation. The animals were randomized into: (1) group-1, DMEM injected (n=6), (2) group-2, Ad-null transduced SkM transplanted (n=6), (3) group-3, Ad-hVEGF165 transduced SkM transplanted (n=8), and (4) group-4, Ad-Ang-1 transduced SkM (n=8). Three weeks later, 5 ml DMEM containing 3×108 SkM carrying exogenous genes were intramyocardially injected into 20 sites in left ventricle in groups-2, -3 and -4. Animals in group-1 were injected 5 ml DMEM without cells. Animals were kept on 5 mg/kg cyclosporine per day for 6 weeks. Regional blood flow was measured using fluorescent microspheres. The heart was explanted at 2, 6 and 12 weeks after transplantation for histological studies. Results Histological examination showed survival of lac-z expressing myoblasts in host tissue. Capillary density based on Von Willebrand factor-VIII (vWF-VIII) at low power field (×100) was 57.13±11.85 in group-3 at 6 weeks and declined to 32.1±5.21 at 12 weeks, while it was 39.9±10.26 at 6 weeks and increased to 45.14±6.54 at 12 weeks in group-4. The mature blood vessel index was highest in group- 4 at 6 and 12 weeks after transplantation. The regional blood flow in the center and peri-infarct area was significantly increased in animals of groups-3 and -4. Conclusions SkM carrying either hVEGF165 or Ang-1 induced neovascularization with increased blood flow. Ang-1 overexpression resulted in mature and stable blood vessel formation and may be a more potent arteriogenic inducer for neovascularization. | Husnain Kh Haider In-Chin Song Peter K Law Eugene KW Sim | 2006 | Journal of Geriatric Cardiology2006，3，3： | 3 |
| 3 | 湍流预混火焰点火与传播特性研究显示文摘可燃预混气的点火与传播过程是发动机燃烧领域最重要的课题之一,尤其是湍流与化学反应的相互作用对预混气点火和火焰传播的影响机理有待进一步研究。本文利用定压球形火焰研究了氢气/氧气/氩气(Le<1)在可燃极限条件(当量比0.3)下湍流对点火与火焰传播过程的影响,研究表明,在该工况下,湍流有助于可燃气点火过程,火焰传播过程中,由于湍流的影响,局部拉伸率大于0的区域火焰传播增快,局部拉伸率小于0的区域火焰传播受到抑制,甚至出现局部熄火。 | 霍佳龙 杨声 任祝寅 C K Law | 2018 | 工程热物理学报2018，39，2： | 3 |
| 4 | Percutaneous transluminal angioplasty balloons for endoscopic ultrasound-guided pancreatic duct interventions显示文摘BACKGROUND Endoscopic ultrasound(EUS)-guided main pancreatic duct(PD)access may be used when conventional endoscopic retrograde cholangiopancreatography(ERCP)techniques fail.The use of a percutaneous transluminal angioplasty balloon(PTAB),originally developed for vascular interventions,can be used to facilitate transmural(e.g.,transgastric)PD access and to dilate high-grade pancreatic strictures.AIM To describe the technique,efficacy,and safety of PTABs for EUS-guided PD interventions.METHODS Patients who underwent EUS with use of a PTAB from March 2011 to August 2021 were retrospectively identified from a tertiary care medical center supply database.PTABs included 3-4 French angioplasty catheters with 3-4 mm balloons designed to use over a 0.018-inch guidewire.The primary outcome was technical success.Secondary outcomes included incidence of adverse events(AEs)and need for early reintervention.RESULTS A total of 23 patients were identified(48%female,mean age 55.8 years).Chronic pancreatitis was the underlying etiology in 13(56.5%)patients,surgically altered anatomy(SAA)with stricture in 7(30.4%),and SAA with post-operative leak in 3(13.0%).Technical success was achieved in 20(87%)cases.Overall AE rate was 26%(n=6).All AEs were mild and included 1 pancreatic duct leak,2 cases of post-procedure pancreatitis,and 3 admissions for post-procedural pain.No patients required early re-intervention.CONCLUSION EUS-guided use of PTABs for PD access and/or stricture management is feasible with an acceptable safety profile and can be considered in patients when conventional ERCP cannulation fails. | Jad P AbiMansour Barham K Abu Dayyeh Michael J Levy Andrew C Storm John A Martin Bret T Petersen Ryan J Law Mark D Topazian Vinay Chandrasekhara | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，8： | 2 |
| 5 | Effects of hydrocarbon substitution on atmospheric hydrogen-air flame propagation显示文摘 | Law C K Kwon O C | 2004 | International Journal of Hydrogen Energy2004，29，8： | 1 |
| 6 | Change management for collaborative engineering显示文摘 | Law K H | 1995 | Computing in Civil Engineering1995，2，： | 1 |
| 7 | The Effects of Leader and Follower Emotional Intelligence on Performance and Attitude:A Exploratory Study显示文摘 | LAW K S | 2002 | Leadership Quarterly2002，13，2： | 1 |
| 8 | Marked-based control of linear structural systems 显示文摘 | Lynch J P Law K H | 2002 | Earthquake Engineering and Structural Dynamics2002，31，10： | 1 |
| 9 | Constructive Conflict in China:Cooperative Conflict as a Bridge between East and West 显示文摘 | Tjosvold D Hui C Law K S | 2001 | Journal of World Business2001，36，2： | 1 |
| 10 | Self-expanding metallic stent as a bridge to surgery versus emergency resection for obstructing left-sided colorectal cancer:a case-matched study 显示文摘 | Ng K C Law W L Lee Y M et aI | 2006 | J Gas- trointest Surg2006，10，： | 1 |
| 11 | Pulsating and Hydrodynamic Instabilities at Large Lewis Numbers 显示文摘 | Yuan J Ju Y Law C K | 2006 | Combustion and Flame2006，4，： | 1 |
| 12 | Expressionof LM02 is associated with t(14;18)/IGH-BCL2 fusion but notBCL6 translocations in diffuse large B-cell lymphoma 显示文摘 | DURNICK D K LAW M E MAURER M J | 2010 | Am J Clin Pathol2010，134，2： | 1 |
| 13 | Studies on kinetics and reuse of spent liquor in the TEMPO-mediated selective oxidation of mechanical pulp 显示文摘 | Mao Lianshan Ma Pu Law K | 2010 | Ind Eng Chem Res2010，49，： | 1 |
| 14 | A simpfified model for the com- bustion of uncoated boron particles 显示文摘 | Makino A Law C K | 1988 | Combustion Sci- ence and Technology1988，61，： | 1 |
| 15 | Large-eddy simulation of starting buoyant jets显示文摘 | Wang R Q Law A W K Adams E E | 2011 | Environmental Fluid Mechanics2011，11，6： | 1 |
| 16 | Nonalcoholic fatty liver disease显示文摘 | Law K Brunt E M | | 0，，04： | 1 |
| 17 | Majorana Fermion induced resonant andreev reflection显示文摘 | Law K T Lee P A Ng T K | | 0，，23： | 1 |
| 18 | Leader-member Exchange As A Mediator of the Relationship be- tween Transformational Leadership and Followers' Performance and Organizational Citizenship Behavior显示文摘 | WANG H LAW K S HACKETT R D WANG D CHEN Z X | 2005 | The Academy of Man- agement Journal2005，48，3： | 1 |
| 19 | Coupled hydrodynamicand diffusional-thermal instabilities in flame propaga-tion at subunity Lewis numbers显示文摘 | YUAN J JU Y LAW C K | 2005 | Physics of Fluids2005，17，07： | 1 |
| 20 | The construct and criterion validity of emotional intelligence and its potential utility for management studies显示文摘 | Law K S Wong C S Song L J | 2004 | J Appl Psychol2004，89，3： | 1 |
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