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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | The influence of film crystallinity on the coupling efficiency of ZnO optical modulator waveguides显示文摘 | Koch M H Timbrell P Y Lamb R N | 1995 | Semicond Sci Technol1995，10，： | 2 |
| 3 | The early Medieval Warm Epoch and its sequel显示文摘 | Lamb H H | 1965 | Palaeogeography Palaeoclimato1ogy Palaeoecology1965，1，： | 1 |
| 4 | Oviposition and larval establishment of Sitodiplosis mosellana (Diptera:Cecidomyiidae) on wheat (Gramineae) At different growth stages显示文摘 | Ding H Lamb R J | 1999 | The Canadian Entomologist1999，，131： | 1 |
| 5 | Synthesis of Nanostruc- tured Titania Powders via Hydrolysis of Titanium Isoprop- oxide in Supercritical Carbon Dioxide 显示文摘 | STALLLINGS W E LAMB H H | 2003 | Langmuir2003，19，7： | 1 |
| 6 | Use of the Dumon Y- stent in the management of malignant disease involving the carina:a retrospective review of 86 patients 显示文摘 | Dutau H Toutblanc B Lamb C | 2004 | Chest2004，126，3： | 1 |
| 7 | A novel Pd/MgAlOx catalyst for NOX storage-reduction显示文摘 | SILLETTI B A ADAMS R T SIGMON S M NIKOLOPOULOS A SPIVEY J J LAMB H H | 2006 | Catal Today2006，114，1： | 1 |
| 8 | Left ventricular remodeling early after aortic valve replacement:differential effects on diastolic function in aortic valve stenosis and aortic regurgitation显示文摘 | LAMB H J BEYERBACHT H P ROOS A D | 2002 | J Am Coll Cardiol2002，40，： | 1 |
| 9 | Poly ( 1-1actide ) Crystalliza- tion Induced by Multiwall Carbon Nanotubes at Very Low Loading 显示文摘 | Xu H Dai X Lamb P | 2009 | J Polym Sci Part B: Polym Phys2009，47，： | 1 |
| 10 | Making control decisions for Sitodiplosis mosellana in wheat (Gramineae) using sticky traps 显示文摘 | McKenzie R I H Wise I L | 2002 | Canada Entomology2002，，134： | 1 |
| 11 | The oxidative burst in plant disease resist- ance显示文摘 | Lamb C Dixon H A | 1997 | Ann Rev Plant Mol Biol1997，，48： | 1 |
| 12 | Pexiganan acetate显示文摘 | Lamb H M Wiseman L R | 1998 | Drugs1998，56，： | 1 |
| 13 | Impaired calcium release during fatigue显示文摘 | Allen D G Lamb G D and Westerblad H | 2008 | J Appl Physiol2008，104，1： | 1 |
| 14 | On the propagation of tremors over the surface of an elastic solid显示文摘 | Lamb H | 1904 | Philos Trans R Soc London Ser A1904，，1： | 1 |
| 15 | Types and spells of weather around the year in the Britishlsles显示文摘 | Lamb H H | 1950 | Quarterly Journal Royal Meteorological Society1950，76，： | 1 |
| 16 | Comparative analysis of the QUTR transcription repressor protein and the three Cterminal domains of the pentafunctional AROM enzyme显示文摘 | LAMB H K MOORE J D LAKEY J H | 1996 | Biochemical Journal1996，313，： | 1 |
| 17 | Skeletal musclefatigue:cellular mechnisms显示文摘 | ALLEN D G LAMB G D WESTERBLAD H | 2008 | Physiol Rev2008，88，1： | 1 |
| 18 | Effect of posterolateral scar tissue on clinical and echocardiographic improvement after cardiac resynchronization therapy显示文摘 | Bleeker GB Kaandorp TA Lamb H J | 2006 | Circulation2006，113，7： | 1 |
| 19 | Assessment of diastolic function by cardiovascular magnetic resonance 显示文摘 | PAELINCK B P LAMB H J BAX J J | 2002 | Am Heart J2002，144，2： | 1 |
| 20 | A plant homolog of the neutrophil NADPH oxidase gp^91phox subunit gene encodes a plasma membrane protein with Ca^2- binding motifs显示文摘 | KELLER T DAMUDE H G WERNER D DOERNER P DIXON R A LAMB C | 1998 | Plant Cell1998，10，2： | 1 |
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