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| 1 | Wilson’s disease显示文摘 | Aftab Ala Ann P Walker Keyoumars Ashkan James S Dooley Michael L Schilsky | 2007 | The Lancet . 2007 (9559)2007，，9559： | 3 |
| 2 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | Biology of Trichogramma ostriniae (Hymenoptera: Trichogrammatidae) reared on Ostriniae nubilalis (Lepidoptera: Pyralidae) and survey for additional hosts显示文摘 | HOFFMANN M P WALKER D L SHELTON A M | 1998 | Entomophaga1998，40，： | 2 |
| 4 | The role of periodic agitation and water addition in managing moisture limitations during high-solids aerobic decomposition显示文摘 | Walker L P Nock T D Gossett J M VanderGheynst J S | 1999 | Process Biochemistry1999，34，： | 2 |
| 5 | Biological invasion by Myricafaya in Hawai'i: plant demography, nitrogen fixation, ecosystem effects显示文摘 | VITOUSEK P M WALKER L R | 1989 | Ecological Monographs1989，59，： | 1 |
| 6 | Activity studies of eight purified cellulases:specificity,synergism and binding domain effects显示文摘 | IRWIN D SPEZIO M WALKER L P | 1993 | Biotechnol Bioeng1993，42，： | 1 |
| 7 | Cardiac T2* Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Major显示文摘 | P Kirk M Roughton J B. Porter J M. Walker M A. Tanner J Patel D Wu J Taylor M A. Westwood L J. Anderson D J. Pennell | 2009 | Circulation2009，，20： | 1 |
| 8 | Splenic T lympho- cytes die preferentially during heat-induced apoptosis: NuMA reorganization as a marker显示文摘 | Sodja C Brown D L Walker P R | 1998 | Journal of cell science1998，111，16： | 1 |
| 9 | Structure,and origin by injection of lava under surface crust,of tumuli,“lava rises”,“lava-rise pits”,and“lava-inflation clefts”in Hawaii显示文摘 | Walker G P L | 1991 | Bulletin of Volcanology1991，53，： | 1 |
| 10 | Biological invasion by myrica-faya in hawaii - plant demography, nitrogenfixation, ecosystem effects显示文摘 | Vitousek P M Walker L R | 1989 | Ecological Monographs1989，59，3： | 1 |
| 11 | Measurement of interlayer spacings and crystal sizes in turbostratic carbons显示文摘 | SHORT M A WALKER P L | 1963 | Carbon1963，1，： | 1 |
| 12 | The synthesis and antiviral properties of E-5- (2-bromovinyl) -4'-thio-deoxyurichine 显示文摘 | Dyson M R Coe P L Walker R T | 1991 | J Chem Soc Chem Commun1991，，： | 1 |
| 13 | Implications for timing of andean uplift from thermal resetting of radiation-damaged zircon in the Cordillera Huayhuash, Northem Peru 显示文摘 | Garver J I Reiners P W Walker L J | 2005 | The Journal of Geology2005，113，2： | 1 |
| 14 | Production of activatied carbons :use of CO2 versus H2O as activating agent显示文摘 | Walker P L | 1996 | Carbon1996，34，10： | 1 |
| 15 | Aberrant global methylation patterns affect the molecularpathogenesis and prognosis of multiple myeloma显示文摘 | WALKER B A WARDELLL C P CHIECCHIO L | 2011 | Blood2011，117，2： | 1 |
| 16 | Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish显示文摘 | BROWNING L M WALKER C G MANDER A P | 2012 | Am J Clin Nutr2012，96，4： | 1 |
| 17 | Genetic variation in cyclooxygenase 1:effects on response to aspirin显示文摘 | Halushka M K Walker L P Halushka P V | 2003 | Clin Pharmacol Ther2003，73，1： | 1 |
| 18 | Role of nitric oxide in lipopolysaccharide-induced oxidant stress in the rat kidney显示文摘 | Zhang C Walker L M Mayeux P R | 2000 | Biochemical Pharmacology2000，59，2： | 1 |
| 19 | An invader alters germination and growth of native dominant Uee in Hawaii 显示文摘 | WALKER L R VITOUSEK P M | 1991 | Ecolo- gy1991，，： | 1 |
| 20 | Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA显示文摘 | Leslie A Kavanagh D Honeyborne I Pfafferott K Edwards C Pillay T Hilton L Thobakgale C Ramduth D Draenert R Le Gall S Luzzi G Edwards A Brander C Sewell A K Moore S Mullins J Moore C Mallal S Bhardwaj N Yusim K Phillips R Klenerman P Korber B Kiepiela P Walker B Goulder P | 2005 | J Exp Med2005，201，6： | 1 |
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