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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | The Use of Simvastatin for the Prevention of Gallstones in the Lithogenic Prairie Dog Model显示文摘 | Kurt G Davis MD Thomas M Wertin MD John P Schriver MD FACS | 2003 | Obesity Surgery2003，，6： | 2 |
| 3 | Combined depth and ID-based shadow buffers显示文摘 | KURT P PIRANHA B | 2004 | Game Programming Gens2004，4，： | 1 |
| 4 | Phragmitesaustralis expansion in Dela- ware Bay salt marshes 显示文摘 | Kurt R P Richard T F | 2005 | Ecological Engineering2005，25，3： | 1 |
| 5 | Effects of supple-mentation with foliages of selected multipurpose trees,their mixtures or wheat bran on feed intake, plasma enzyme activities, live weight and scrotal circumference gains in Menz sheep显示文摘 | Solomon M Kurt J P Azage T | 2004 | Livestock Production Science2004，89，： | 1 |
| 6 | Histopathology of submandibular glands removed for sialolithiasis 显示文摘 | Kurt AM Dulguerov P | 2001 | Ann Otol Rhinol Laryngol2001，110，2： | 1 |
| 7 | Gas analysis by infra- red spectroscopy as a tool for electrical fault diagnostics in SF~ insulated equipment显示文摘 | Heise H M Kurte R Fischer P | 1997 | Fresenius Journal of Analytical Chem istry1997，358，5： | 1 |
| 8 | Gas analysis by infrared spectroscopy as a tool for electrical fault diagnostics in SF6 insulated equipment显示文摘 | HEISE H M KURTE R FISCHER P | 1997 | Fresenius'' Journal of Analytical Chemistry1997，，9358： | 1 |
| 9 | Aortic valve replacement in octogenarians:outcome and predictors of complications显示文摘 | Litmathe J Feindt P Kurt M | 2011 | Hellenic J Cardiol2011，52，3： | 1 |
| 10 | Feed intake, live weight gain and reproductive performance of Menz ewes supplemented with Lablab purpureus,graded levels of Leucaena pallida 14203 and Sesbania sesban 1198显示文摘 | Kurt J P Solomon M Azage T | 2004 | Livestock Production Science2004，87，： | 1 |
| 11 | Investigation into the importance of the stomatal pathway in the exchange of PCBs between air and plants 显示文摘 | Barber J L Kurt P B Thomas G 0 | 2002 | Environmental Science and Technology2002，36，： | 1 |
| 12 | Self-organized criticality:an explanation of 1/f noise显示文摘 | BAK P CHAO TANG KURT WIESENFELD | 1987 | Physical Renew Letters1987，59，4： | 1 |
| 13 | Measurement of intracompartmental pressure: A comparison of the slit catheter,side-ported needle, and simple needle显示文摘 | Mode BR Kurt Thorderson P | 1993 | J Bone Joint Surg1993，75，： | 1 |
| 14 | An examination of the influence of CPA firm type,size,and MAS provision on loan officer decisions and perceptions显示文摘 | Mckinley S Kurt K Reckers P | 1985 | Journal of Accounting Research1985，，： | 1 |
| 15 | Semi-solid casting of aluminium al- loys: a status report显示文摘 | STEPHEN P M KURT B | 1997 | Modern Casting1997，，2： | 1 |
| 16 | Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding显示文摘 | Joseph L Kim Kurt A Morgenstern James P Griffith Maureen D Dwyer John A Thomson Mark A Murcko Chao Lin Paul R Caron | 1998 | Structure1998，，1： | 1 |
| 17 | Self-orgainzed criticality显示文摘 | BAK P CHAO TANG KURT WIESENFDD | 1988 | Physical Review1988，38，36： | 1 |
| 18 | [11C] Methionine and [18F] Fluorodeoxyglucose PET in the follow-up of glioblastoma multiforme显示文摘 | Christian P?tzi Alexander Becherer Christine Marosi Georgios Karanikas Monika Szabo Robert Dudczak Kurt Kletter Susanne Asenbaum | 2007 | Journal of Neuro - Oncology2007，，3： | 1 |
| 19 | Luminescence from minerals excited by subnanosecond pulses of runaway electrons generated in an atmospheric-pressure high-voltage discharge in air显示文摘 | Babich L P Becker Kurt H Loiko T V | 2009 | IEEE Transactions on Plasma Science2009，37，11： | 1 |
| 20 | Critical role of Toll - like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury显示文摘 | Velayudham A Hritz I Dolganiuc A Mandrekar P Kurt - Jones E Sza- bo G | 2006 | Journal of Hep- atology2006，45，： | 1 |
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