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| 1 | The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke:a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessment approaches显示文摘Neural tissue engineering,nanotechnology and neuroregeneration are diverse biomedical disciplines that have been working together in recent decades to solve the complex problems linked to central nervous system(CNS)repair.It is known that the CNS demonstrates a very limited regenerative capacity because of a microenvironment that impedes effective regenerative processes,making development of CNS therapeutics challenging.Given the high prevalence of CNS conditions such as stroke that damage the brain and place a severe burden on afflicted individuals and on society,it is of utmost significance to explore the optimum methodologies for finding treatments that could be applied to humans for restoration of function to pre-injury levels.Extracellular vesicles(EVs),also known as exosomes,when derived from mesenchymal stem cells,are one of the most promising approaches that have been attempted thus far,as EVs deliver factors that stimulate recovery by acting at the nanoscale level on intercellular communication while avoiding the risks linked to stem cell transplantation.At the same time,advances in tissue engineering and regenerative medicine have offered the potential of using hydrogels as bio-scaffolds in order to provide the stroma required for neural repair to occur,as well as the release of biomolecules facilitating or inducing the reparative processes.This review introduces a novel experimental hypothesis regarding the benefits that could be offered if EVs were to be combined with biocompatible injectable hydrogels.The rationale behind this hypothesis is presented,analyzing how a hydrogel might prolong the retention of EVs and maximize the localized benefit to the brain.This sustained delivery of EVs would be coupled with essential guidance cues and structural support from the hydrogel until neural tissue remodeling and regeneration occur.Finally,the importance of including nonhuman primate models in the clinical translation pipeline,as well as the added benefit of multi-modal neuroimaging analysis to establish non-invasive,in vivo,quantifiable imagingbased biomarkers for CNS repair are discussed,aiming for more effective and safe clinical translation of such regenerative therapies to humans. | Magdalini Tsintou Kyriakos Dalamagkas Tara LMoore Yogesh Rathi Marek Kubicki Douglas LRosene Nikos Makris | 2021 | Neural Regeneration Research2021，16，4： | 2 |
| 2 | Molecular orbital calculations on aluminosilicate tricluster molecules:implications for the structure of aluminosilicate glasses显示文摘 | KUBICKI J D Toplis M J | 2002 | Am Miner2002，87，56： | 1 |
| 3 | The application of DTI to investigate white matter abnormalities in schizophrenia显示文摘 | Kubicki M Westin CF McCarley RW Shenton ME | 2005 | Ann N Y Acad Sci2005，1064，： | 1 |
| 4 | Sorption of the antibiotic ofloxacin to mesoporous and monporous alumina and silica显示文摘 | Goyne KW Chorover J Kubicki JD | 2005 | Journal of Colloid and Interface Science2005，283，1： | 1 |
| 5 | White matter microstructure in individuals at clinical high risk of psychosis:a wholebrain diffusion tensor imaging study显示文摘 | Hohenberg CC Pasternak O Kubicki M | 2014 | Schizophr Bull2014，40，4： | 1 |
| 6 | Comparison of single-shot echo-planar and line scan protocols for diffusion tensor imaging显示文摘 | Kubicki M Maier SE Westin CF | 2004 | Acad Radiol2004，11，： | 1 |
| 7 | Uncinate fasciculus findings in schizophrenia:a magnetic resonance diffusion tensor imaging study显示文摘 | Kubicki M Westin CF Maier SE | 2002 | Am J Psychiatry2002，159，5： | 1 |
| 8 | Inverse planning simulated annealing for magnetic resonance imaging-based intracavitary high dose-rate brachytherapy for cervical cancer显示文摘 | Kubicky CD Yeh BM Lessard E | 2008 | Brachytherapy2008，7，3： | 1 |
| 9 | Extensive white matter abnor- malities in patients with first-episode schizophrenia:a diffuse tensor imaging study显示文摘 | Lee Sh Kubicki M Asami T | 2013 | Schizorphr Res2013，143，23： | 1 |
| 10 | Uncinate fasciculus findings in schizophrenia: a magnetic res- onance diffusion tensor imaging显示文摘 | Kubicki M Westin CF Maier SE | 2002 | Am J Psychia try2002，159，5： | 1 |
| 11 | Quantum chemical study of arsenic ( Ⅲ , V ) adsorption on Mn-oxides: Implications for arsenic (Ⅲ ) oxidation 显示文摘 | Zhu M Q Paul K W Kubicki J D | 2009 | Environmental Science & Technology2009，43，17： | 1 |
| 12 | A review of diffusion tensor imaging studies in schizophrenia显示文摘 | Kubicki M McCarley R Westin C | 2007 | Psychiatr Res2007，41，12： | 1 |
| 13 | Diffusion tensor imaging and its application to neuropsychiatric disorders 显示文摘 | Kubicki M Westin CF Maier SE | 2002 | Harv Rev Psychiatry2002，10，6： | 1 |
| 14 | Extensive white matter ab-normalities in patients with first-episode schizophrenia:a Diffu- sion Tensor Imaging (DTI) study 显示文摘 | Lee SH Kubicki M Asami T | 2013 | Schizophr Res2013，143，23： | 1 |
| 15 | Review of functional and ana- tomical brain connectivity findings in schizophrenia 显示文摘 | Fitzsimmons J Kubicki M Shenton ME | 2013 | CmT Opin Psychiatry2013，26，2： | 1 |
| 16 | DTI and MTR abnormalities in schizophrenia: Analysis of white matter integrity 显示文摘 | Kubicki M Park H Westin C F | 2005 | Neuro Image2005，26，4： | 1 |
| 17 | 3-Alkoxymethyl-l-(1R, 2S, 5R)-(-)-menthoxymethylimidazolium Salts-based Chiral Ionic Liquids显示文摘 | Joanna Feder-Kubis Maciej Kubicki Juliusz Pernak | 2010 | Tetra Hedron: Asymmetry2010，21，： | 1 |
| 18 | A functional magnetic resonance imagine study of auditory mismatch in schizophrenia 显示文摘 | Wible CG Kubicki M Yoo SS | 2010 | Am J Psychiatry2010，158，6： | 1 |
| 19 | DTI and MTR abnormalities in schizophrenia: analysis of white matter integrity 显示文摘 | Kubicki M Park H Westin CF | 2005 | Neuroimage2005，26，4： | 1 |
| 20 | Restoration of DWI data using a Rician LMMSE estimator 显示文摘 | Aja- Fernandez S Niethammer M Kubicki M | 2008 | IEEE Transactions on Medical Imaging2008，27，10： | 1 |
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