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| 1 | 两例食管癌肉瘤克隆来源的分子生物学分析显示文摘 | 孙孟红 朱雄增 Peter Moeller Christian Herfarth Magnus von Knebel Doeberitz Hans K Schackert Thomas Lehnert Johannes Gebert | 2001 | 中华病理学杂志2001，30，5： | 6 |
| 2 | Prospective evaluation of small bowel preparation with bisacodyl and sodium phosphate for capsule endoscopy显示文摘AIM: To determine the effect of Prepacol?, a com- bination of sodium phosphate and bisacodyl, on transit and quality of capsule endoscopy (CE). METHODS: Fivety two consecutive patients were included in this prospective study. CE was performed following a 12 h fasting period. Twenty six patients were randomized for additional preparation with Prepacol?. The quality of CE was assessed separately for the proximal and the distal small bowel by 3 experienced endoscopists on the basis of a graduation which was initially developed with 20 previous CE. RESULTS: Preparation with Prepacol? accelerated small bowel transit time (262 ± 55 min vs 287 ± 97 min), but had no effect on the quality of CE. Visibility was significantly reduced in the distal compared to the proximal small bowel. CONCLUSION: The significantly reduced visibility of CE in the distal small bowel allocates the need for a good preparation. Since Prepacol? has no beneficial effect on CE the modality of preparation and the ideal time of application remains unclear. Further standardized examinations are necessary to identify sufficient preparation procedures and to determine the impact of the volume of the preparation solution. | Andreas Franke Frank Hummel Phillip Knebel Christoph Antoni Ulrich Bcker Manfred V Singer Matthias Lhr | 2008 | World Journal of Gastroenterology2008，14，13： | 5 |
| 3 | Identification of differentially expressed genes after partial rat liver ischemia/reperfusion by suppression subtractive hybridization显示文摘AIM: To identify potential diagnostic target genes in early reperfusion periods following warm liver ischemia before irreversible liver damage occurs.METHODS: We used two strategies (SSH suppression subtractive hybridization and hybridization of cDNA arrays)to determine early changes in gene expression profiles in a rat model of partial WI/R, comparing postischemic and adjacent nonischemic liver lobes. Differential gene expression was verified (WT/R; 1 h/2 h) and analyzed in more detail after warm ischemia (1 h) in a reperfusion time kinetics (0, 1, 2 and 6 h) and compared to untreated livers by Northern blot hybridizations. Protein expression was examined on Western blots and by immunohistochemistry for four differentially expressed target genes (Hsp70,Hsp27, Gadd45a and IL-1rl).RESULTS: Thirty-two individual WI/R target genes showing altered RNA levels after confirmation by Northern blot analyzes were identified. Among them, six functionally uncharacteristic expressed sequences and 26 known genes (12 induced in postischemic liver lobes, 14 with higher transcriptional expression in adjacent nonischemic liver lobes). Functional categories of the verified marker genes indicate on the one hand cellular stress and tissue damage but otherwise activation of protective cellular reactions (AP-1 transcription factors, apoptosis related genes, heat shock genes). In order to assign the transcriptional status to the biological relevant protein level we demonstrated that Hsp70, Hsp27, Gadd45a and IL-1rI were clearly up-regulated comparing postischemic and untreated rat livers, suggesting their involvement in the WI/R context.CONCLUSION: This study unveils a WI/R response gene set that will help to explore molecular pathways involved in the tissue damage after WI/R. In addition, these genes especially Hsp70and Gadd45a might represent promising new candidates indicating WI/R liver damage. | Christine Fallsehr Christina Zapletal Michael Kremer Resit Demir Magnus von Knebel Doeberitz Ernst Klar | 2005 | World Journal of Gastroenterology2005，11，9： | 4 |
| 4 | 散发性大肠癌肿瘤相关基因位点杂合性丢失分析显示文摘目的 分析大肠癌组织中抑癌基因及肿瘤相关基因位点的变化与预后的关系。方法 79例大肠癌组织经组织微解剖分离癌组织和正常组织,分别进行11 个染色体上14 个位点的杂合性丢失(lossofheterozygosity,LOH)分析。结果 肿瘤组织中LOH呈现一复杂的征象,5q12 及RB基因位点的LOH 与较好的预后有关。结论 不同的抑癌基因及肿瘤相关基因与大肠癌发生有关。5q12 位点的LOH 与较好预后相关的意义有待今后进一步研究。 | 孙孟红 Gebert J Knebel Doeberitz Mv | 1999 | 中华实验外科杂志1999，16，6： | 3 |
| 5 | Right ventricular function assessed by two-dimensional strain and tissue Doppler echocardiography in patients with pulmonary arterial hypertension and effect of vasodilator therapy显示文摘 | Borges AC Knebel F Eddicks S | 2006 | Am J Cardiol2006，98，4： | 1 |
| 6 | Systematic review of genomie integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the lower genital tract显示文摘 | Wentaensen N Vinokurova S von Knebel Doeberitz M | 2004 | Cancer Res2004，64，： | 1 |
| 7 | phosphorylation of the Alzheimer epitope within collapsing response mediator pro- teins regulates axon elongation in primary neurons 显示文摘 | Cole AR Knebel A Morrice NA | 2004 | J Biol Chem2004，279，50： | 1 |
| 8 | Reduced phos- phorylation of transcription factor Elk-1 in cultured fi- broblasts of a patient with premature aging syndrome and insulin resistance显示文摘 | Knebel B Avci H Bullmann C | 2005 | Exp Clin Endocrinol Diabe- tes2005，113，2： | 1 |
| 9 | Perfor- mance of p16INK4a-cytology, HPV mRNA, and HPV DNA testing to identify high grade cervical dysplasia in women with abnormal screening results 显示文摘 | Reuschenbach M Clad A von Knebel Doeberitz C | 2010 | Gynecnl Oncol2010，1119，1： | 1 |
| 10 | Comparative assessment oftoxicities of mainstream smoke from commercial cigarettes 显示文摘 | Ritter D J Knebel JW Aufderheide M | 2004 | Inhalation Toxicology2004，16，10： | 1 |
| 11 | Insertion of totally implantable venous access devices: an expertise-based, random- ized, controlled trial (iNCT00600444) 显示文摘 | Knebel P Lopez-Benitez R Fischer L | 2011 | Ann Surg2011，253，6： | 1 |
| 12 | Detection of cytosine deaminase in genetically mosified tumor cells by specific antibodies显示文摘 | MOEBIUS U KNEBEL M V | 1997 | Hum Gene Ther1997，8，： | 1 |
| 13 | Microfabrication of single-use plastic microfluidic devices for high-throughput screening and DNA analysis 显示文摘 | GERLACH A KNEBEL G GUBER A E | 2002 | Microsystem Technologies2002，7，： | 1 |
| 14 | Echocardiographic AV-interval optimization in patients with reduced left ventricular function 显示文摘 | Melzer C Borges AC Knebel F | 2004 | Cardiovasc Ultrasound2004，2，： | 1 |
| 15 | NT-ProBNP in acute heart failure:correlation with invasively measured hemody- namic parameters during recompensation 显示文摘 | Knebel F Schimke I Pliet K et aI | 2005 | J Card Fail2005，11，5： | 1 |
| 16 | A new technical approach to quantify cell-cell adhesion forces by AFM显示文摘 | Puech P H Poole K Knebel D | 2006 | Ultramicroscopy2006，106，89： | 1 |
| 17 | Heterogeneity of Pericen- tric Inversions of the Human Y Chromosome显示文摘 | S Knebel JJ Pasantes DAD Thi | 2011 | Cytogenet Genome Res2011，132，： | 1 |
| 18 | Insertion oftotally implantable venous access devices: an expertise-based, randomized, controlled trial (NCT00600444) 显示文摘 | Knebel P Lopez-Benitez R Fischer L | 2011 | Ann Surg2011，253，6： | 1 |
| 19 | Insertion of totally implantable venous access devices: an expertise-based, randomized, controlled trial (NCT00600444) 显示文摘 | Knebel P Lopez-Benitez R Fischer L | 2011 | Ann Surg2011，253，6： | 1 |
| 20 | Heterogeneity of perieentric inversions of the human Y chromosome 显示文摘 | Knebel S Pasantes JJ Thi DA | 2011 | Cytogenet Genome Res2011，132，： | 1 |
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