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| 1 | Hepatic steatosis is associated with an increased risk of carotid atherosclerosis显示文摘AIM: Although an association between helatic steatosis and vascular risk factors has been described, direct relationships between fatty liver and atherosclerosis have not yet been investigated. The aim of the present study has been to investigate those relationships.METHODS: The Study of Health in Pomerania examined a random population sample aged between 20 and 79 years.A study population of 4 222 subjects without hepatitis B and C infections and without liver cirrhosis was available for the present analysis. Hepatic steatosis was defined sonographically and intima-media thickness (IMT) as well as plaque prevalence were estimated by carotid ultrasound.RESULTS: The prevalence rate of hepatic steatosis was 29.9%. Among subjects aged ≥45 years, an association between hepatic steatosis and IMT of the carotid arteries was found in bivariate analysis, but not after adjustment for atherosclerotic risk factors. Individuals with fatty liver had more often carotid plaques than persons without fatty liver (plaque prevalence rate 76.8% vs 66.6%; P<0.001).This association persisted after adjustment for confounding factors and was predominantly present in subjects with no to mild alcohol consumption.CONCLUSION: There is an independent association between hepatic steatosis and carotid atherosclerotic plaques. Metabolic changes due to nonalcoholic fatty liver disease may explain this relationship. | Henry V(o|¨)lzke Daniel M.Robinson Volker Kleine Roland Deutscher Wolfgang Hoffmann Jan Lüdemann Ulf Schminke Christof Kessler Ulrich John | 2005 | World Journal of Gastroenterology2005，11，12： | 29 |
| 2 | Expression of interleukin-2 receptor on blood lymphocytes stimulated with allogeneic lymphocytes or autologous tumor cells显示文摘 | G. Stuber F. Vánky E. Pócsik M. Benczúr E. Klein | 1990 | Cancer Immunology Immunotherapy1990，，2： | 4 |
| 3 | Test-retest reliability of the Mini Nutritional Assessment–Short Form(MNA-SF)in older patients undergoing cardiac rehabilitation显示文摘Malnutrition is described as a state of insufficient intake of energy,protein and other nutrients leading to changes in body composition(weight loss,reduced fat-free mass)as well as adverse functional and clinical outcomes.[1]Depending on the assessments and definition used,the prevalence in older patients ranges between 12%in communitydwelling adults to 60%of patients in geriatric care facilities.[2–5]Older populations are at high risk of nutritional deficiencies because of risk factors such as multimorbidity,polypharmacy,cognitive and physical decline,poor appetite,depressive syndromes and socioeconomic changes.[4,6]. | Fritz Kather Miralem Hadzic Teresa Hehle Sarah Eichler Julia Klein Heinz Völler Annett Salzwedel | 2020 | Journal of Geriatric Cardiology2020，17，9： | 2 |
| 4 | Expression of cytokeratine 20 in urinary cytology of patients with bladder carcinoma显示文摘 | Klein A Zemer R Buchumensky V | 1998 | Cancer1998，82，2： | 2 |
| 5 | Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice显示文摘BACKGROUND Modern guidelines recommend sodium-glucose cotransporter-2(SGLT2)inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney disease.However,the mechanisms underlying the renal protective effect of SGLT2 inhibitors are not fully understood.structure of podocytes and nephrin expression in glomeruli in db/db diabetic mice.METHODS We treated 8-wk-old male db/db mice with EMPA(10 mg/kg/d)or vehicle for 8 wk.Age-matched male db/+mice were included as non-diabetic controls.Parameters of body composition,glycemic and lipid control,and plasma concentrations of leptin,insulin and glucagon were assessed.We evaluated renal hypertrophy as kidney weight adjusted to lean mass,renal function as plasma levels of creatinine,and albuminuria as the urinary albumin-to-creatinine ratio(UACR).Renal structures were studied by light and transmission electron microscopy with a focus on mesangial volume and podocyte structure,respectively.Glomerular nephrin and transforming growth factor beta(TGF-β)were assessed by immunohistochemistry.RESULTS Severe obesity and hyperglycemia developed in db/db mice prior to the start of the experiment;increased plasma concentrations of fructosamine,glycated albumin,cholesterol,leptin,and insulin,and elevated UACR were detected.Mesangial expansion,glomerular basement membrane thickening,and increased area of TGF-βstaining in glomeruli were revealed in vehicle-treated mice.Podocytopathy was manifested by effacement of foot processes;nephrin-positive areas in glomeruli were reduced.EMPA decreased the levels of glucose,fructosamine and glycated albumin,UACR,kidney hypertrophy,mesangial expansion,glomerular basement membrane thickening,and glomerular TGF-βstaining,alleviated podocytopathy and restored glomerular staining of nephrin.CONCLUSION These data indicate that EMPA attenuates podocytopathy in experimental diabetic kidney disease.The anti-albuminuric effect of EMPA could be attributed to mitigation of podocyte injury and enhancement of nephrin expression. | Vadim V Klimontov Anton I Korbut Iuliia S Taskaeva Nataliya P Bgatova Maksim V Dashkin Nikolai BOrlov Anna S Khotskina Evgenii L Zavyalov Thomas Klein | 2020 | World Journal of Diabetes2020，11，12： | 2 |
| 6 | The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3 显示文摘 | Klein R Nanduri V Jing S A | 1991 | Cell1991，66，2： | 1 |
| 7 | Vbeta-restricted T cell adherence to endothelial cells a mechanism for superantigendependent vascularinjury显示文摘 | Brogan PA Shah V Klein N | 2004 | Arthritis Rheum2004，5，2： | 1 |
| 8 | Spectroscopic ellipsometry study of the diluted magnetic semiconductor system Zn(Mn,Fe, Co)Se 显示文摘 | Kim Y D Cooper S L Klein M V | 1994 | Phys Rev B1994，49，3： | 1 |
| 9 | The effect of tibial polyethylene insert design on range of motion:evaluation of in vivo knee kinematics by a computerized navigation system during total knee arthroplasty显示文摘 | Klein G R Parvizi J Papuri V R | 2004 | J Arthroplasty2004，19，8： | 1 |
| 10 | Electrical Breakdown during the anodic grown of tantalum pentoxide显示文摘 | KADARY V KLEIN N | 1998 | Journal of the Electrochemical Society1998，27，1： | 1 |
| 11 | Proteomic identification of nitrated proteins in Alzheimer's disease brain 显示文摘 | Castegna A Thongboonkerd V Klein J B | 2003 | J Neurochem2003，85，6： | 1 |
| 12 | A model for PEG removal from alumina injection moulded parts by solvent debinding显示文摘 | Oliveira A A M Klein A N | 2007 | Journal of Material Processing Technology2007，182，： | 1 |
| 13 | Resedimented pelagic carbonate and volcaniclastic sediments and sedimentary structures in Leg 30 DSDP cores from the Western Equatorial Pacific显示文摘 | Klein G de V | 1975 | Geology1975，3，： | 1 |
| 14 | The significance of grunting in hyaline membrane disease 显示文摘 | Harrison VC Heese H de V Klein M | 1968 | Pediatrics1968，41，3： | 1 |
| 15 | Beta-restricted T cell adherence to endothelial cells: A mechanism for superantigen dependent vascular injury显示文摘 | Brogan PA Shall V Klein N | 2004 | Arthritis Rheum2004，50，2： | 1 |
| 16 | Infrastructure and productiviu: a non|inearappmach 显示文摘 | Duggal V G S~tzman C Klein L R | 1999 | JoumMofEconometfics1999，92，1： | 1 |
| 17 | Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells显示文摘 | Staudt V Bothur E Klein M | 2010 | Immunity2010，33，2： | 1 |
| 18 | Interferon-regulatory factor 4 is essential for the deve]opmental program of T helper 9 cells 显示文摘 | Staudt V Bothur E Klein M | 2010 | Immunity2010，33，2： | 1 |
| 19 | Droplet bar- coding for single-cell transcriptomics applied to embryonic stem cells显示文摘 | Klein AM Mazutis L Akartuna I Tallapragada N Veres A Li V Peshkin L Weitz DA Kirschner MW | 2015 | Ceil2015，161，： | 1 |
| 20 | Management of patients with traumatic intracranial injury in hospitals without neurosurgical service显示文摘 | Klein Y Donchik V Jaffe I) | 2010 | J Trauma2010，69，54： | 1 |
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