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| 1 | Hepatitis B virus,HBx mutants and their role in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of death induced by cancer in the modern world and majority of the cases are related to chronic hepatitis B virus(HBV)infection.HBV-encoded X protein(HBx)is known to play a pivotal role in the pathogenesis of viral induced HCC.HBx is a multifunctional protein of17 kDa which modulates several cellular processes by direct or indirect interaction with a repertoire of host factors resulting in HCC.HBX might interfere with several cellular processes such as oxidative stress,DNA repair,signal transduction,transcription,protein degradation,cell cycle progression and apoptosis.A number of reports have indicated that HBx is one of the most common viral ORFs that is often integrated into the host genome and its sequence variants play a crucial role in HCC.By mutational or deletion analysis it was shown that carboxy terminal of HBx has a likely role in protein-protein interactions,transcriptional transactivation,DNA repair,cell,signaling and pathogenesis of HCC.The accumulated evidence thus far suggests that it is difficult to understand the mechanistic nature of HBx associated HCC,and HBx mediated transcriptional transactivation and signaling pathways may be a major determinant.This article addresses the role of HBx in the development of HCC with particular emphasis on HBx mutants and their putative targets. | Ashraf Ali Hany Abdel-Hafiz Mohd Suhail Amany Al-Mars Mohammad Khalid Zakaria Kaneez Fatima Sultan Ahmad Esam Azhar Adeel Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，30： | 29 |
| 2 | Inhibition of hepatitis B virus DNA replicative intermediate forms by recombinant interferon-γ显示文摘AIM: To evaluate the in vitro anti-HBV activity of recombinant human IFN-γ, alone and in combination with lamivudine. METHODS: A recombinant baculovirus-HBV/HepG2 culture system was developed which could support productive HBV infection in vitro. Expression of HBsAg and HBeAg in infected HepG2 culture medium was detected by commercial enzyme immunoassays. HBV DNA replication intermediates were detected in infected cells by Southern hybridization and viral DNA load was determined by dot hybridization. RESULTS: IFN-γat 0.1 to 5μg/L efficiently down regulated HBsAg expression in transduced HepG2 cells. At 5μg/L, IFN-γalso suppressed HBV DNA replication in these cells. While treatment with a combination of lamivudine and IFN-γshowed no additive effect, sequential treatment first with lamivudine and then IFN-γwas found to be promising. In this culture system the best HBV suppression was observed with a pulse of 2μmol/L lamivudine for two days, followed by 1μg/L IFN-γfor another four days. Compared to treatment with lamivudine alone, the sequential use of 0.2μmol/L lamivudine for two days, followed by 5μg/L IFN-γfor six days showed a 72% reduction in HBV cccDNA pool. CONCLUSION: This in vitro study warrants further evaluation of a combination of IFN-γand lamivudine, especially in IFN-αnon-responder chronic hepatitis B patients. A reduced duration of lamivudine treatment would also restrict the emergence of drug-resistant HBV mutants. | Mohammad Khalid Parvez Deepak Sehgal Shiv Kumar Sarin Seemi Farhat Basir Shahid Jameel | 2006 | World Journal of Gastroenterology2006，12，19： | 10 |
| 3 | Non-occupational lead exposure and hypertension in Pakistani adults显示文摘高血压是最流行的疾病在之一发展;发展中的国家。基于长历史的协会;在铅暴露的底层的血压效果的挑衅性的调查结果研究被执行决定一个协会是否在低血铅集中之间存在;高血压。在这研究,到血压上的铅的低级暴露的效果用原子吸收分光计在 244 个成年人之中被检验。为证明的优秀保证目的引用材料即,动物血 A-13,牛的肝 1577;从国际原子能机构(国际原子能机构) 的棉花纤维素 V-9;NIST (标准技术的国家研究所) 在相同试验性的条件下面被分析。高血压的成年人的吝啬的年龄是 52 年(范围 43 ~ 6 6 ) 。吝啬的价值收缩;心脏舒张的血压是(209 ± 1 1.7 )( 范围 170 ~ 2 50 ) ;(117 ± 2 .9 )( 范围 105 } 140 ) mmHg 分别地。血铅集中从 78 ~ 2 有 139 μ g /L 的一个平均数的 01 μ g /L;165 ~ 4 有在正常的 255 μ g /L 的一个平均数的 97 μ g /L;高血压的成年人分别地。收缩血压的增加随血铅层次的增加是显著地预兆的。身体集体索引(BMI ) ;包括全部的胆固醇的类脂化合物侧面,低密度脂蛋白胆固醇,高密度脂蛋白胆固醇;甘油三酸酯与血压相关。 | RAHMAN Sohaila KHALID Nasir ZAIDI Jamshed Hussain AHMAD Shujaat IQBAL Mohammad Zafar | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，9： | 4 |
| 4 | Role of bevacizumab intraocular injection in the management of neovascular glaucoma显示文摘AIM:To assess the long-term effects of intraocular bevacizumab(Avastin)injections as an adjunctive drug to manage patients with neovascular glaucoma(NVG).METHODS:A retrospective study was conducted consisting of 34 eyes with secondary NVG caused by proliferative diabetic retinopathy(n=25),ischemic central retinal vein occlusion(n=8),and retinal ischemia resulting from persistent detachment(n=1)were managed by intraocular injections of bevacizumab(1.25 mg/0.05 m L),in addition to other treatments.The main outcome measure was the change in the degree of iris neovascularization.Secondary outcomes included intraocular pressure and the number of additional interventions or antiglaucoma medications administered after injection.RESULTS:All patients were followed-up for at least 12 mo.At the last follow-up,complete regression of rubeosis irides was detectable in 13(38.2%)eyes and incomplete regression in 21 eyes(61.8%).The mean intraocular pressure was 45.32±7.185 mm Hg at baseline and significantly decreased to 26.15±5.679 mm Hg at the last follow-up visit(P=0.000005).Patients received an average of 4.97 injections.As additional treatments,12 eyes(35%)received laser photocoagulation and 6 eyes(18%)underwent retinocryopexy.No further treatment was needed in 16 eyes(47.1%).CONCLUSION:Intravitreal bevacizumab injection can have a favorable effect in controlling intraocular pressure and pain control in patients with NVG because it decreases the angiogenesis and helps to augment the results of conventional procedures.The primary cause of retinal ischemia should be always targeted. | Fawaz Al Sarireh Hamzeh Mohammad Alrawashdeh Khalid Al Zubi Khalil Al Salem | 2021 | International Journal of Ophthalmology(English edition)2021，14，6： | 4 |
| 5 | Effect of seedling age and water depth on morphological and physiological aspects of transplanted rice under high temperature显示文摘To study the effect of high temperature, rice seedlings 20, 30, 40 and 50 d were kept at 5, 10, 15 and 20 cm water depth in a water pool. Meteorological findings indicated that water temperature varied up to 10 cm but became stable below this depth. Deep water inflicted higher tiller mortality, minimal increase in dry weight of aerial parts and leaf area, decrease in root length, and decrease in root dry weight especially at 20 cm water depth and produced an unbalanced T/R ratio (top versus root dry weight). However, deep water tended to increase plant length. These parameters, however, excel in shallow water. Older seedlings, with the exception of root dry weight, could not perform well compared to young seedlings in all physiological and morphological aspects. The study revealed that seedlings, particularly young ones, stand well in shallow water and can cope with high temperature. | KHAKWANI Abdul Aziz SHIRAISHI Masaaki ZUBAIR Muhammad BALOCH Mohammad Safdar NAVEED Khalid AWAN Inayatullah | 2005 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2005，6，5： | 4 |
| 6 | HBV and HIV co-infection:Impact on liver pathobiology and therapeutic approaches显示文摘The consequences of hepatitis B virus(HBV) and human immunodeficiency virus(HIV) co-infection on progression of severe liver diseases is a serious public health issue,worldwide. In the co-infection cases,about 90% of HIV-infected population is seropositive for HBV where approximately 5%-40% individuals are chronically infected. In HIV co-infected individuals,liverrelated mortality is estimated over 17 times higher than those with HBV mono-infection. The spectrum of HIVinduced liver diseases includes hepatitis,steatohepatitis,endothelialitis,necrosis,granulomatosis,cirrhosis andcarcinoma. Moreover,HIV co-infection significantly alters the natural history of hepatitis B,and therefore complicates the disease management. Though several studies have demonstrated impact of HIV proteins on hepatocyte biology,only a few data is available on interactions between HBV and HIV proteins. Thus,the clinical spectrum as well as the complexity of the co-infection offers challenging fronts to study the underlying molecular mechanisms,and to design effective therapeutic strategies. | Mohammad Khalid Parvez | 2015 | World Journal of Hepatology2015，7，1： | 3 |
| 7 | Advances in reduction of NO_x and N_2O emission formation in an oxy-fired fluidized bed boiler显示文摘Fossil fuel combustion is one of the major means to meet the mounting global energy demand. However, the increasing NO_x and N_2 O emissions arising from fossil fuel combustion process have hazardous effects. Thus, mitigating these gases is vital to attain a sustainable environment. Interestingly, oxy-fuel combustion in fluidized bed for carbon capture and minimized NO_x emissions is strongly sustainable compare to the other approaches. It was assessed that NO_x formation and fuel-N conversion have significant limitation under oxy-fluidized bed compared to air mode and the mechanism of NO_x formation is still deficient and requires further development. In addition, this review paper discussed the potential of primary measure as low emission process with others supplementary techniques for feasible NO_x reduction. The influences of combustion mode, operating parameters, and reduction techniques such as flue gas recirculation, oxygen staging, biomass co-firing, catalyst, influence of fluidized bed design and structure, decoupling combustion and their merges are respectively evaluated. Findings show that significant minimization of NO_x emission can be achieved through combination of primary and secondary reduction techniques. | Khalid El Sheikh Mohammad Jakir Hossain Khan Mahar Diana Hamid Siddhartha Shrestha Brahim Si Ali G.A.Ryabov Lya A.Dolgushin Mohd Azlan Hussain Tatiana V.Bukharkina Elena A.Gorelova | 2019 | Chinese Journal of Chemical Engineering2019，27，2： | 2 |
| 8 | Contrast-Induced Nephropathy: Identifying the Risks, Choosing the Right Agent, and Reviewing Effective Prevention and Management Methods显示文摘 | Refky Nicola Khalid W. Shaqdan Khalid Aran Mohammad Mansouri Ajay Singh Hani H. Abujudeh | 2015 | Current Problems in Diagnostic Radiology2015，，： | 2 |
| 9 | Periodicals in andrology: an overview显示文摘 | Ahmad Al Aboud Khalid AI Aboud Mohammad Hakim | 2014 | Asian Journal of Andrology2014，16，4： | 2 |
| 10 | Estimating volume change of triaxial soil specimens from planar images显示文摘 | KHALID A ALSHIBLI MOHAMMAD Z | 2001 | Computer-Aided Civil and Infrastructure Engineering2001，16，6： | 1 |
| 11 | Electrical, Thermal, Photocatalytic and Antibacterial Studies of Metallic Oxide Nanocomposite Doped Polyaniline显示文摘ZnOe-ZrO2 nanocomposite was prepared by sole gel method and in-situ polymerization was used to synthesize ZnOe-ZrO2 nanocomposite doped polyaniline(PANI).The materials were characterized by X-ray diffraction(XRD),Fourier transform infrared(FTIR) spectroscopy,transmission electron microscopy(TEM),scanning electron microscopy(SEM) and energy dispersive X-ray spectroscopy(EDX) to ensure the crystallite size,functional groups,morphology and chemical composition of the polymer nanocomposite complex.The average particle size of the ZnOe-ZrO2 nanoparticles was found to be 20.5 nm.Thermal gravimetric analysis(TGA) was used to study the thermal stability of the complex,shows improved thermal stability of polymer nanocomposite as compared to the pure organic polymer.The material also possesses good electrical conductivity.Additionally,the photocatalytic activity of the materials was investigated by monitoring the decolorization of Acid Blue 29 dye in a UV photocatalytic reactor and PANI-ZnOe-ZrO2 was found to possess higher photocatalytic activity than pure PANI.Finally,the antibacterial activity of the materials was examined and it was observed that PANI-ZnOe-ZrO2 could be used as an excellent antibacterial agent.Hence,desired properties could be integrated by mixing appropriate phases of the materials for specific applications such as heterogeneous catalyst,antibacterial agents,antibiotics delivery and high temperature conducting polymers. | Saima Sultana Rafuddin Mohammad Zain Khan Khalid Umar M.Muneer | 2013 | Journal of Materials Science & Technology2013，29，9： | 1 |
| 12 | Two-dimensional echocardiography using second harmonic imaging for the diagnosis of intracardiac right-to-left shunt: a meta-analysis of prospective studies显示文摘 | Mohammad Khalid Mojadidi Jared S. Winoker Scott C. Roberts Pavlos Msaouel Rubine Gevorgyan Ronald Zolty | 2014 | The International Journal of Cardiovascular Imaging2014，，5： | 1 |
| 13 | Tailoring the optical and magnetic properties of La-BaM hexaferrites by Ni substitution显示文摘We investigate the impact of Ni insertion on the structural,optical,and magnetic properties of Ba_(0.8)La_(0.2)Fe_(12-x)Ni_(x)O_(19)hexaferrites(Ni substituted La-BaM hexaferrites).Samples were prepared using the conventional co-precipitation method and sintered at 1000℃for 4 hours to assist the crystallization process.An analysis of the structure of the samples was carried out using an x-ray diffraction(XRD)spectrometer.The M-type hexagonal structure of all the samples was confirmed using XRD spectra.The lattice parameters a and c were found to be in the ranges of 5.8925±0.001 nm–5.8952±0.001 nm and 23.2123±0.001 nm–23.2219±0.001 nm,respectively.The M-type hexagonal nature of the prepared samples was also indicated by the presence of corresponding FT-IR bands and Raman modes in the FT-IR and Raman spectra,respectively.EDX results confirmed the successful synthesis of the samples according to the required stoichiometric ratio.A UV-vis spectrometer was used to record the absorption spectra of the prepared samples in the wavelength range of 200 nm–1100 nm.The optical energy bandgap of the samples was found to be in the range of 1.21 eV–3.39 eV.The M–H loops of the samples were measured at room temperature at an applied magnetic field range of 0 kOe–60 kOe.A high saturation magnetization of 99.92 emu/g was recorded in the sample with x=0 at a microwave operating frequency of 22.2 GHz.This high value of saturation magnetization is due to the substitution of La3+ions at the spin-up(12k,2a,and 2b)sites.The Ni substitution is proven to be a potential candidate for the tuning of the optical and magnetic parameters of M-type hexaferrites.Therefore,we suggest that the prepared samples are suitable for use in magneto-optic applications. | Hafiz T.Ali MRamzan M Imran Arshad Nicola A.Morley M.Hassan Abbas Mohammad Yusuf Atta Ur Rehman Khalid Mahmood Adnan Ali Nasir Amin MAjaz-un-Nabi | 2022 | Chinese Physics B2022，31，2： | 1 |
| 14 | Generation of the first autosomal dominant osteopetrosis type II (ADO2) disease models显示文摘 | Imranul Alam Amie K. Gray Kang Chu Shoji Ichikawa Khalid S. Mohammad Marta Capannolo Mattia Capulli Antonio Maurizi Maurizio Muraca Anna Teti Michael J. Econs Andrea Del Fattore | 2014 | Bone2014，，： | 1 |
| 15 | Review of Pakistan Phammceutical Industry: SWOT Analysis 显示文摘 | Mohammad Aamir Khalid Zaman | 2011 | Intemational Journal of Business & In- formation Technology2011，1，2： | 1 |
| 16 | Nutritional status of children with inflammatory boweldisease in Saudi Arabia显示文摘AIM: To assess the prevalence of nutritional disorders in children with inflammatory bowel disease(IBD) in Saudi Arabia.METHODS: The data from a national cohort of children newly diagnosed with IBD between 2003 and 2012 were analyzed. The diagnosis of IBD and the differentiation between Crohn's disease(CD) and ulcerative colitis(UC) were confirmed by gastroenterologists according to the standard criteria. The body mass index(BMI) of each child [weight(kg)/height^2(m)] was calculated at the time of diagnosis. The World Health Organization standards and references were used and the BMI for age > +1 and <-2 standard deviation score were used to define overweight and thinness, respectively. Age stratification analysis was performed to investigate any age-related variation in the prevalence of nutritional status between children < 10 years of age and older.RESULTS: There were 374 children from 0.33 to 17 years of age, including 119(32%) children with UC and 255(68%) with CD. All of the children were Saudi nationals, and 68(57%) of the UC and 150(59%) of the CD children were males. A positive history of anorexia at the time of diagnosis was found in 30(25%) patients with UC and 99(39%) patients with CD. The prevalence of thinness was 31%, 35% and 24% in children with IBD, CD and UC, respectively, with a significantly higher prevalence of thinness in children with CD than in children with UC(P = 0.037) only in the age group of 10-17 years(P = 0.030). The prevalence of overweight was 16 %, 15% and 20 % in the children with IBD, CD and UC, respectively, indicating a higher prevalence in UC that was statistically significant only in the age group of 10-17 years(P = 0.020). CONCLUSION: A high proportion of children with IBD presented with overweight instead of the classical underweight. Awareness of this finding is important for patient care. | Mohammad Issa El Mouzan Mohammed Hadi Al Edreesi Abdulrahman Abdullah Al-Hussaini Omar Ibrahim Saadah Abdulaziz Abdullatif Al Qourain Mohammad Abdullah Al Mofarreh Khalid Abdulrahman Al Saleem | 2016 | World Journal of Gastroenterology2016，22，5： | 1 |
| 17 | Utilization of molten chloride salt derived from MSWI fly ash washing as energy storage material:thermophysical properties and corrosion behavior显示文摘Fly ash,as a byproduct of municipal solid waste incineration,contains several kinds of pollutants,especially dissolvable salts that cause a severe challenge for fly ash disposal.Washing combined with cement kiln co-processing for fly ash disposal has been applied in China.After washing,the wastewater was evaporated to produce fly ash salt(FAS).In this study,FAS was mixed the KCl and LiCl to be used as molten chloride salt for energy storage material.Twenty-three types of molten salts with various ratios of FAS-KCl-LiCl were evaluated.Thermophysical properties(melting point and latent heat)and thermal stability of these salts were characterized.The increase in FAS fraction decreased the latent heat of molten salts.Among the tested samples,the best compatibility ratio of FAS:KCl:LiCl was 10:50:40(%,in weight),with latent heat of 108.7 J/g and melting point of 333℃.This molten salt also showed good thermal stability after 1–13 h of thermal experiments,and the mass loss was less than 2%after 5 heating cycles at 600℃.By corrosion test,FAS-KCl-LiCl(10:50:40,%in weight)could be more safely used in vessels made of nickel-based alloy,but it might cause corrosion risk for stainless steel. | Mi Yan Yayong Yang Jiahao Jiang Rendong Zheng Yi Ma Mohammad Khalid Haryo Wibowo | 2022 | Waste Disposal and Sustainable Energy2022，4，3： | 1 |
| 18 | XRD studies of polyurethane elastomers based on chitin/1,4-butane diol blends显示文摘 | Khalid Mahmood Zia Ijaz Ahmad Bhatti Mehdi Barikani Mohammad Zuber Haq Nawaz Bhatti | 2008 | Carbohydrate Polymers2008，，2： | 1 |
| 19 | Surface characteristics of chitinbased shape memory polyurethane elastomers 显示文摘 | Zia Khalid Mahmood Zuber Mohammad Barikani Mehdi | 2009 | Colloids and Surfaces B: Biointerfaces2009，72，： | 1 |
| 20 | Surface characteristics of UV-irradiated chitin-based shape memory polyurethanes显示文摘 | Zia Khalid Mahmood Zuber Mohammad Mahboob Shahid | 2010 | Carbohydrate Polymer2010，80，： | 1 |
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