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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Effect of increasing anode surface area on the performance of a single chamber microbial fuel cell显示文摘 | Lorenzo M D Scott Keith Curtis T P | 2010 | Chemical Engineering Journal2010，156，1： | 1 |
| 3 | Frequent nonreciprocal translocations in the amphidiploid genome of oilseed rape (Brassica napus)显示文摘 | Sharpe A G Pakin I A P Keith D J | 1995 | Genome1995，38，： | 1 |
| 4 | A simulated annealing algorithm for finding consensus sequences显示文摘 | KEITH J M ADAMS P BRYANT D | 2002 | Bioinformatics2002，18，11： | 1 |
| 5 | The effect of liquid water on thunderstorm charging显示文摘 | W D Keith R P Mitzeva | 1991 | J Geophys Res1991，96，11： | 1 |
| 6 | Characteristics of Eccentrically Braced Frames显示文摘 | Keith D Hjelmstad Egor P Popov | 1984 | Journal of Structural Engineering1984，110，2： | 1 |
| 7 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 8 | Identification of the A and C genomes of amphidiploid Brassica napus (oilseed rape) 显示文摘 | Parkin I A P Sharpe A G Keith D J | 1995 | Genome1995，38，6： | 1 |
| 9 | Nonalcoholic fatty liver disease 显示文摘 | Adams LA Angulo P Keith D | 2005 | CMAJ2005，172，： | 1 |
| 10 | A simulated annealing algorithm for finding consensus sequenees显示文摘 | Keith J M Adams P Bryant D | 2002 | Bioinformatics2002，18，11： | 1 |
| 11 | The effect of liquid water on thunderstorm charging 显示文摘 | Saunders C P R Keith W D Mitzeva R P | 1991 | J Geophys Res1991，96，11： | 1 |
| 12 | Response of metal- lic pyramidal lattice core sandwich panels to high intensity im- pulsive loading in air显示文摘 | Kumar P D Haydn N G W Keith W | 2011 | International Journal of Impact Engi- neering2011，38，5： | 1 |
| 13 | Characteristiees of eccentrically braced frames显示文摘 | Keith D Hjelmstad Egor P popve | 1984 | Journal of Structural Engineering1984，110，2： | 1 |
| 14 | The effect of liquid on thunderstorm charging显示文摘 | Saunders C P R Keith W D Mitzeva R P | 1991 | Journal of Geophysical Re- search1991，96，11： | 1 |
| 15 | Thermochemical and kinetic aspects of the sulfurization of Cu-Sb and Cu-Bi thin films显示文摘 | Diego C Laurence M P Keith D R | 2012 | Journal of Solid State Chemistry2012，186，： | 1 |
| 16 | Further laboratory studies of the charging of graupel during ice crystal interactions显示文摘 | Keith W D Saunders C P R | 1990 | Journal of the Atmospheric Sciences1990，25，： | 1 |
| 17 | Effect of increasing anode surface area on the performance of a single chamber microbial fuel cell 显示文摘 | Mirella D L Keith S Tom P C | 2010 | Chemical Enlineerin Journal2010，156，1： | 1 |
| 18 | Digital control of active magnetic bearings显示文摘 | Williams R D Keith F J Allaire P E | 1990 | IEEE Transactions on Industrial Electronics1990，37，1： | 1 |
| 19 | Identification of the A and C genomes of amphidiploid Brassica napus (oilseed rape)显示文摘 | Parkin I A P Sharpe A G Keith D J | 1995 | Genome1995，38，： | 1 |
| 20 | Screening for fetal well-being in a high-risk pregnant populationcomparing the nonstress test with umbilical artery Dopplervelocimetry:A randomized controlled clinical trial显示文摘 | Keith P Williams Duncan F Jerome D | 2003 | Am J Obstet Gynecol2003，188，： | 1 |
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