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| 1 | Intraoperative blood loss in orthotopic liver transplantation:The predictive factors显示文摘Liver transplantation has been associated with massive blood loss and considerable transfusion requirements. Bleeding in orthotopic liver transplantation is multifactorial. Technical difficulties inherent to this complex surgical procedure and pre operative derangements of the primary and secondary coagulation system are thought to be the principal causes of perioperative hemorrhage. Intraoperative practices such as massive fluid resuscitation and resulting hypothermia and hypocalcemia secondary to citrate toxicity further aggravate the preexisting coagulopathy and worsen the perioperative bleeding. Excessive blood loss and transfusion during orthotopic liver transplant are correlated with diminished graft survival and increased septic episodes and prolonged ICU stay. With improvements in surgical skills, anesthetic technique, graft preservation, use of intraoperative cell savers and overall perioperative management, orthotopic liver transplant is now associated with decreased intra operative blood losses. The purpose of this review is to discuss the risk factors predictive of increased intra operative bleeding in patients undergoing orthotopic liver transplant. | Chandra Kant Pandey Anshuman Singh Kamal Kajal Mandeep Dhankhar Manish Tandon Vijay Kant Pandey Sunaina Tejpal Karna | 2015 | World Journal of Gastrointestinal Surgery2015，7，6： | 8 |
| 2 | Mechanisms of triglyceride metabolism in patients with bile acid diarrhea显示文摘Bile acids(BAs) are essential for the absorption of lipids. BA synthesis is inhibited through intestinal farnesoid X receptor(FXR) activity. BA sequestration is known to influence BA metabolism and control serum lipid concentrations. Animal data has demonstrated a regulatory role for the FXR in triglyceride metabolism. FXR inhibits hepatic lipogenesis by inhibiting the expression of sterol regulatory element binding protein 1c via small heterodimer primer activity. Conversely, FXR promotes free fatty acids oxidation by inducing the expression of peroxisome proliferator-activated receptor α. FXR can reduce the expression of microsomal triglyceride transfer protein, which regulates the assembly of very low-density lipoproteins(VLDL). FXR activation in turn promotes the clearance of circulating triglycerides by inducing apolipoprotein C-Ⅱ, very low-density lipoproteins receptor(VLDL-R) and the expression of Syndecan-1 together with the repression of apolipoprotein C-Ⅲ, which increases lipoprotein lipase activity. There is currently minimal clinical data on triglyceride metabolism in patients with bile acid diarrhoea(BAD). Emerging data suggests that a third of patients with BAD have hypertriglyceridemia. Further research is required to establish the risk of hypertriglyceridaemia in patients with BAD and elicit the mechanisms behind this, allowing for targeted treatment. | Nidhi Midhu Sagar Michael McFarlane Chuka Nwokolo Karna Dev Bardhan Ramesh Pulendran Arasaradnam | 2016 | World Journal of Gastroenterology2016，22，30： | 5 |
| 3 | 在有经历非肝的外科的肝疾病的病人的 Perioperative 风险因素显示文摘 The patients with liver disease present for various surgical interventions. Surgery may lead to complications in a significant proportion of these patients. These complications may result in considerable morbidity and mortality. Preoperative assessment can predict survival to some extent in patients with liver disease undergoing surgical procedures. A review of literature suggests nature and the type of surgery in these patients determines the peri-operative morbidity and mortality. Optimization of premorbid factors may help to reduce perioperative mortality and morbidity. The purpose of this review is to discuss the effect of liver disease on perioperative outcome; to understand various risk scoring systems and their prognostic significance; to delineate different preoperative variables implicated in postoperative complications and morbidity; to establish the effect of nature and type of surgery on postoperative outcome in patients with liver disease and to discuss optimal anaesthesia strategy in patients with liver disease. | Chandra Kant Pandey Sunaina Tejpal Karna Vijay Kant Pandey Manish Tandon Amit Singhal Vivek Mangla | 2012 | World Journal of Gastrointestinal Surgery2012，4，12： | 4 |
| 4 | Tuning parallel symbolic execution engine for better performance显示文摘 | Anil Kumar KARNA Jinbo DU Haihao SHEN Hao ZHONG Jiong GONG Haibo YU Xiangning MA: Jianjun ZHAO | 2018 | Frontiers of Computer Science2018，12，1： | 3 |
| 5 | 剖宫产术后再次妊娠阴道分娩的研究进展显示文摘剖宫产术后再次妊娠阴道分娩或试产(vaginal birth after cesarean,VBAC),存在子宫破裂和新生儿窒息等高风险。因此,临床上对于剖宫产术后再次妊娠选择阴道试产的患者有着严格地标准,并且该类患者必须在有抢救条件的医院住院分娩。根据准确的患者相关信息,医护人员可以更好更安全地针对不同的患者进行准备和给予帮助。 | Surendra Kumar Karna 魏华 易村犍 | 2015 | 长江大学学报(自科版)(下旬)2015，12，12： | 2 |
| 6 | Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1 alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression显示文摘 | Karna P Cao Z | 2006 | J Biol Chem2006，281，25： | 1 |
| 7 | Life cycle analysis of newsprint: European scenario显示文摘 | Karna A Engstrom J Kutinlahti T | 1994 | Paperi Puu1994，76，4： | 1 |
| 8 | 查看详情显示文摘 | KARNA S P DUPUIS M | | 0，，04： | 1 |
| 9 | Inhibitory effect of acetylsalicylic acid on metalloproteinase activity in human lung adenocarcinoma at different stages of differentiation 显示文摘 | Karna E Palka JA | 2002 | Eur J Pharmacol2002，443，13： | 1 |
| 10 | Source apportionment of fine par- ticulate matter measured in an industrialized coastal urban area of South Texas 显示文摘 | Karnae Saritha John Kuruvilla | 2011 | Atmospheric Environment2011，45，23： | 1 |
| 11 | Hyaluronic acid counteracts interleukin-1 -induced inhibition of collagen biosynthesis in cultured human chondrocytes 显示文摘 | Karna E Mihyk W Palka J A | 2006 | Pharmacol Res2006，54，4： | 1 |
| 12 | A numerical model for dynamic ice-structure interaction显示文摘 | KARNA T KAMESAKI K TSUKUDA H | 1999 | Comput Struct1999，72，4： | 1 |
| 13 | Mitigation of ice loading on off-shore wind turbines:Feasibility study of a semiactive solution显示文摘 | Mroz A Holnicki-Szulc J Karna T | 2008 | Computers and Structures2008，86，35： | 1 |
| 14 | Chan- ges in platelet CD62P express ion and soluble P -selectin concentration in surgically treated colorectal carcinoma显示文摘 | Dymicka Piekarska V Matowicka Karna J Osada J | 2006 | Adv Med Sci2006，51，2： | 1 |
| 15 | Estimation of Population Mean on Current Oc- casion in two-occasion Successive Sampling显示文摘 | Singh G N Karna J P | 2009 | METRON2009，，1： | 1 |
| 16 | Some Classes of Estimators for popu- lation Mean at Current Occasion in two-occasion Successive Sampling 显示文摘 | Singh G N Prasad S Karna J | 2011 | Journal of Statistical Research2011，45，21： | 1 |
| 17 | Inhibitory effect of acetylsalicylic acid on metalloproteinase activity in human lung adenocarcinoma at different stages of differentiation显示文摘 | Karna E Palka J A | 2002 | Eur J Pharmacol2002，443，： | 1 |
| 18 | Construction of individual, fused, and co-expressed proteins of endoglucanase and β-glucosidase for hydrolyzing sugarcane bagasse显示文摘 | Sari Dewi Kurniasih Almasul Alfi Dessy Natalia Ocky Karna Radjasa Zeily Nurachman | 2014 | Microbiological Research2014，，： | 1 |
| 19 | Nonlinear optical properties of p-nitroaniline:anab initio time-dependent coupled Hartree-Fock study显示文摘 | Karna S P Prasad P N Dupuis M | 1991 | J Chem Phys1991，，： | 1 |
| 20 | Tetrahedron Lett显示文摘 | Karna A Chouhan G | 2003 | 44(16) : 3337-33402003，44，16： | 1 |
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