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| 1 | Platinum-induced neurotoxicity: A review of possible mechanisms显示文摘Patients treated with platinum-based chemotherapy frequently experience neurotoxic symptoms, which may lead to premature discontinuation of therapy. Despitediscontinuation of platinum drugs, these symptoms can persist over a long period of time. Cisplatin and oxaliplatin, among all platinum drugs, have significant neurotoxic potential. A distal dose-dependent symmetrical sensory neuropathy is the most common presentation of platinum neurotoxicity. DNA damage-induced apoptosis of dorsal root ganglion(DRG) neurons seems to be the principal cause of neurological symptoms. However, DRG injury alone cannot explain some unique symptoms such as cold-aggravated burning pain affecting distal extremities that is observed with oxaliplatin administration. In this article, we briefly reviewed potential mechanisms for the development of platinum drugs-associated neurological manifestations. | Ozkan Kanat Hulya Ertas Burcu Caner | 2017 | World Journal of Clinical Oncology2017，8，4： | 14 |
| 2 | Targeted therapy for advanced gastric cancer: A review of current status and future prospects显示文摘In the West in particular, the vast majority of gastric cancer(GC) patients present with advanced-stage disease. Although combination chemotherapy is stillthe most important component of treatment for these patients, it confers a modest survival advantage. Recently, increased knowledge of the key molecular signaling pathways involved in gastric carcinogenesis has led to the discovery of specific molecular-targeted therapeutic agents. Some of these agents such as trastuzumab and ramucirumab have changed the treatment paradigm for this disease. In this paper, we will summarize the current clinical status of targeted drug therapy in the management of GC. | Ozkan Kanat Bert O'Neil Safi Shahda | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 13 |
| 3 | Disease that should be remembered: Sacrococcygeal pilonidal sinus disease and short history显示文摘Pilonidal sinus disease has led to heated debates since it was first described in the medical literature. Although a consensus has been built on its etiology and pathogenesis, the same course has not progressed for treatment modality. This review is a short article about the process of pilonidal sinus disease from past to present. Some important points were mentioned between the years 1833, which is accepted as the milestone for the awareness of the disease, in which it was first reported until the year of 1880, in which it was given its name. Although its name has been the same for about two centuries, some other names such as 'Jeep Disease' have also been used depending on the population affected by the disease. At present, it is indisputable that the disease is acquired. Large series were presented about the treatment in the last two decades. Some surgical methods were even named after the ones who first described them and they have many supporters. However, since the treatment modalities have some advantages and disadvantages and they do not have marked superiority over others, debates still continue. We hope that pilonidal sinus disease will not lose its significance and be underrated in parallel with the developments in technology and specialization in medicine. | Burhan Hakan Kanat Selim S?zen | 2015 | World Journal of Clinical Cases2015，3，10： | 12 |
| 4 | WJSC 6^(th) Anniversary Special Issues(1):Hematopoietic stem cell transplantation Allogeneic hematopoietic cell transplant for acute myeloid leukemia:Current state in 2013 and future directions显示文摘Acute myeloid leukemia(AML)represents a heterogeneous group of high-grade myeloid neoplasms of the elderly with variable outcomes.Though remissioninduction is an important first step in the management of AML,additional treatment strategies are essential to ensure long-term disease-free survival.Recent pivotal advances in understanding the genetics and molecular biology of AML have allowed for a risk-adapted approach in its management based on relapse-risk.Allogeneic hematopoietic cell transplantation(allo-HCT)represents an effective therapeutic strategy in AML providing the possibility of cure with potent graft-versus-leukemia reactions,with a demonstrable survival advantage in younger patients with intermediate-or poor-risk cytogenetics.Herein we review the published data regarding the role of allo-HCT in adults with AML.We searched MEDLINE/PubMed and EMBASE/Ovid.In addition,we searched reference lists of relevant articles,conference proceedings and ongoing trial databases.We discuss the role of allo-HCT in AML patients stratified by cytogenetic-and molecular-risk in first complete remission,as well as allo-HCT as an option in relapsed/refractory AML.Besides the conventional sibling and unrelated donor allografts,we review the available data and recent advances for alternative donor sources such as haploidentical grafts and umbilical cord blood.We also discuss conditioning regimens,including reduced intensity conditioning which has broadened the applicability of allo-HCT.Finally we explore recent advances and future possibilities and directions of allo-HCT in AML.Practical therapeutic recommendations have been made where possible based on available data and expert opinion. | Abraham S Kanate Marcelo C Pasquini Parameswaran N Hari Mehdi Hamadani | 2014 | World Journal of Stem Cells2014，6，2： | 6 |
| 5 | 土耳其中医药发展现状与分析显示文摘土耳其是位于亚欧大陆交界处的总统共和制国家。2003年医疗改革后,该国医疗保险几乎覆盖全民。导致土耳其居民死亡的主要疾病是缺血性心脏病、脑卒中和肺癌,且下呼吸道感染、慢性肾脏病、高血压心脏病等疾病的致死率增长较快。1991年《针灸实施条例》的颁布标志着针灸正式获得土耳其政府的认可。2014年至今,《传统与补充医疗实践法规》明确规定,只有经过培训的全科医生及牙医方可进行针灸治疗。目前,土耳其针灸治疗应用相对简单;中药在土耳其仍受农业部管辖,尚不能作为药品进入土耳其。建议在针灸推广过程中加强中医理论的学习,明确两国中药质量标准的差异,以当地高发病入手突出中医优势,加强中医药在土耳其的推广力度。 | 王哲 梁宁 Kanat Tayfun 石晗 赵静 杨龙会 许家杰 曹洪欣 | 2021 | 国际中医中药杂志2021，43，4： | 4 |
| 6 | Treatment of prediabetes显示文摘Progression of normal glucose tolerance(NGT) to overt diabetes is mediated by a transition state called impaired glucose tolerance(IGT). Beta cell dysfunction and insulin resistance are the main defects in type 2 diabetes mellitus(type 2 DM) and even normoglycemic IGT patients manifest these defects. Beta cell dysfunction and insulin resistance also contribute to the progression of IGT to type 2 DM. Improving insulin sensitivity and/or preserving functions of beta-cells can be a rational way to normalize the GT and to control transition of IGT to type 2 DM. Loosing weight, for example, improves whole body insulin sensitivity and preserves beta-cell function and its inhibitory effect on progression of IGT to type 2 DM had been proven. But interventions aiming weight loss usually not applicable in real life. Pharmacotherapy is another option to gain better insulin sensitivity and to maintain beta-cell function. In this review, two potential treatment options(lifestyle modification and pharmacologic agents) that limits the IGT-type 2 DM conversion in prediabetic subjects are discussed. | Mustafa Kanat Ralph A De Fronzo Muhammad A Abdul-Ghani | 2015 | World Journal of Diabetes2015，6，12： | 4 |
| 7 | Current treatment options for patients with initially unresectable isolated colorectal liver metastases显示文摘The development of liver metastases is a common clinical entity in the clinical course of colorectal cancer. For patients with isolated liver involvement, surgical resection is the only treatment that can provide a chance of prolonged survival and cure. However, most of these patients are not initially eligible for the surgery. Selected patients with initially considered to have unresectable disease may become resectable after systemic(che-motherapy ± biological therapy) and loco-regional treatment modalities including hepatic arterial infusion. Patients who have colorectal liver metastases ideally should be referred to a multidisciplinary cancer care team in order to identify the most optimal management approach. | Ozkan Kanat | 2016 | World Journal of Clinical Oncology2016，7，1： | 3 |
| 8 | Epstein–Barr virus replication linked to B cell proliferation in inflamed areas of colonic mucosa of patients with inflammatory bowel disease显示文摘 | Sumathi Sankaran-Walters Kanat Ransibrahmanakul Irina Grishina Jason Hung Enrique Martinez Thomas Prindiville Satya Dandekar | 2010 | Journal of Clinical Virology2010，，1： | 2 |
| 9 | Small cell carcinoma of the urinary bladder显示文摘 | Kanat O Evrensel T Adim SB | 2003 | Tumor2003，89，： | 2 |
| 10 | Prognostic value of nm23 in gastrointestinal stromal tumors显示文摘 | Kanat O Adim S Evrensel T | 2004 | Med Oncol2004，21，1： | 1 |
| 11 | Regulation of mitoehondrial biogenesis in skeletal muscle by CaMK显示文摘 | Wu H Kanatous S B Thurmond F A | 2002 | Sci ence2002，296，5566： | 1 |
| 12 | Subchondral bone drilling: a treatment for cartilage defects 显示文摘 | Beiser IH Kanat IO | 2008 | J Foot Surg2008，29，6： | 1 |
| 13 | e - Government adoption model based on theoryof planned behavior : Empirical validation 显示文摘 | Ozkan S Kanat IE | 2011 | Government Informa-tion Quarterly2011，28，： | 1 |
| 14 | Can sonographic endometrial pattern be an early indicator for tubal ectopic pregnancy and related tubal rupture显示文摘 | Col-Madendag I Madendag Y Kanat P M | 2010 | Arch Gynecol Obstet2010，281，2： | 1 |
| 15 | Diuretics, plasma brain na- triuretic peptide and chronic obstructive pulmonary disease 显示文摘 | Kanat F Vatansev H Teke T | 2007 | Neth J Med2007，65，8： | 1 |
| 16 | Risk factors for postoperative pulmonary complications in upper abdominal surgery 显示文摘 | Kanat F Golcuk A Teke T | 2007 | ANZ J Surg2007，77，3： | 1 |
| 17 | Patient-evaluated outcome after Surgery for basal meningiomas显示文摘 | Kanat A | | 0，，06： | 1 |
| 18 | Distinct 13-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance显示文摘 | Kanat M Mari A Norton L | 2012 | Diabetes2012，61，2： | 1 |
| 19 | Sea water quality assessment of Prince Islands' Beaches in Istanbul显示文摘 | F liter Turkdogan Aydinol Gurdal Kanat Hurrem Bayhan | 2012 | Environmental Monitoring and Assessment2012，184，1： | 1 |
| 20 | Protective effect of amifostine against toxicity of paclitaxel and carboplatin in non-small cell lung cancer:a single center randomized study显示文摘 | Kanat O Evrensel T Baran I | | 0，，： | 1 |
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