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| 1 | Alterations in the function of circulating mononuclear cells derived from patients with Crohn’s disease treated with mastic显示文摘AIM: To assess the effects of mastic administration on cytokine production of circulating mononuclear cells of patients with active Crohn's disease (CD). METHODS: The study was conducted in patients with established mildly to moderately active CD, attending the outpatient clinics of the hospital, and in healthy controls. Recruited to a 4 wk treatment with mastic caps (6 caps/d, 0.37 g/cap) were 10 patients and 8 controls, all of who successfully completed the protocol. Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemotactic protein-1 (MCP-1), macrophage migration inhibitory factor (MIF) and intracellular antioxidant glutathione (GSH) were evaluated in peripheral blood mononuclear cells (PBMC) before and after treatment. RESULTS: Treating CD patients with mastic resulted in the reduction of TNF-α secretion (2.1 ± 0.9 ng/mL vs 0.5 ± 0.4 ng/mL, P = 0.028). MIF release was signif icantly increased (1.2 ± 0.4 ng/mL vs 2.5 ± 0.7 ng/mL, P = 0.026) meaning that random migration and chemotaxis of monocytes/macrophages was inhibited. No signifi cant changes were observed in IL-6, MCP-1 and GSH concentrations. CONCLUSION: This study shows that mastic acts as an immunomodulator on PBMC, acting as a TNF-α inhibitor and a MIF stimulator. Although further double-blind, placebo-controlled studies in a large number of patients is required to clarify the role of this natural product, this f inding provides strong evidence that mastic might be an important regulator of immunity in CD. | Andriana C Kaliora Maria G Stathopoulou John K Triantaf illidis George VZ Dedoussis Nikolaos K Andrikopoulos | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 2 | Chios mastic treatment of patients with active Crohn's disease显示文摘AIM: To evaluate the effectiveness of mastic administra-tion on the clinical course and plasma inflammatory me-diators of patients with active Crohn’s disease (CD).METHODS: This pilot study was conducted in patients with established mild to moderately active CD, attend-ing the outpatient clinics of the hospital, and in healthy controls. Ten patients and 8 controls were recruited for a 4-wk treatment with mastic caps (6 caps/d, 0.37 g/cap). All patients successfully completed the protocol. CD Ac-tivity Index (CDAI), Nutritional Risk Index (NRI), C-re-active protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemotactic protein-1 (MCP-1), and total antioxidant potential (TAP) were evaluated in the plasma at baseline and at the end of the treatment period. Results were expressed as mean values ± SE and P < 0.05 was considered to indicate statistical significance.RESULTS: Patients exhibited significant reduction of CDAI (222.9 ± 18.7 vs 136.3 ± 12.3, P = 0.05) as com-pared to pretreament values. Plasma IL-6 was signifi-cantly decreased (21.2 ± 9.3 pg/mL vs 7.2 ± 2.8 pg/ mL, P = 0.027), and so did CRP (40.3 ± 13.1 mg/mL vs 19.7 ± 5.5, P = 0.028). TAP was significantly increased (0.15 ± 0.09 vs 0.57 ± 0.15 mmol/L uric acid, P = 0.036). No patient or control exhibited any kind of side effects. CONCLUSION: The results suggest that mastic signifi-cantly decreased the activity index and the plasma levels of IL-6 and CRP in patients with mildly to moderately ac-tive CD. Further double-blind, placebo-controlled studies in a larger number of patients are required to clarify the role of this natural product in the treatment of patients with CD. | Andriana C Kaliora Maria G Stathopoulou John K Triantafillidis George VZ Dedoussis Nikolaos K Andrikopoulos | 2007 | World Journal of Gastroenterology2007，13，5： | 7 |
| 3 | Dietary antioxidants in preventing atherogenesis 显示文摘 | KALIORA A C DEDOUSSIS G V Z SCHMIDT H | 2006 | Atherosclerosis2006，187，1： | 1 |
| 4 | A study of glycemic re- sponse to corinthian raisins in healthy subjects and in type 2 dia- betes mellitus patients显示文摘 | Kanellos P T Kaliora A C Liaskos C | 2013 | Plant Foods for Human Nutrition2013，68，2： | 1 |
| 5 | A pilot, random- ized controlled trial to examine the health outcomes of raisin con- sumption in patients with diabetes显示文摘 | Kanellos P T Kaliora A C Tentolouris N K | 2014 | Nutrition2014，30，3： | 1 |
| 6 | Early cerebral monitoring using the transcranial doppler pulsatility index in patients with severe brain trauma显示文摘 | Voulgaris SG Partheni M Kaliora H | 2005 | Neurosurgical Clinic Med Sci Monit2005，11，2： | 1 |
| 7 | Stabilization of nonlinear systems via forwarding mod {Lg V}显示文摘 | PRALY L ORTEGA R KALIORA G | 2001 | IEEE Trans on Automatic Control2001，46，9： | 1 |
| 8 | Bioavailability of the phenolic compounds of the fruits(drupes) of Olea europaea (olives) :Impact on plasma antioxidant status in Humans显示文摘 | Kountouri AM Mylona A Kaliora AC | 2007 | Phytomedicine2007，14，： | 1 |
| 9 | Early cerebral monitoring using the transcranial Doppler pulsatility index in patients with severe brain trauma 显示文摘 | Voulgaris S G Partheni M Kaliora H | 2005 | Med Sci Monit2005，11，2： | 1 |
| 10 | Antiatherogenic effect of pistacia lentiscus via GSH restoration and down regulation of CD36 rnRNA expression显示文摘 | DEDOUSSIS GVZ KALIORA A-C PSARRAS S | 2004 | Atherosclerosis2004，174，2： | 1 |
| 11 | Natural antioxidant compounds inrisk factors for CVD显示文摘 | KALIORA A C DEDOUSSIS G V | 2007 | Pharmacological Research2007，56，2： | 1 |
| 12 | Nonlinear control of feedforward systems with bounded signals显示文摘 | KALIORA G ASTOLFI A | 2004 | IEEE Transactions on Automatic Control2004，49，11： | 1 |
| 13 | Natural antioxidant compounds in risk factors for CVD 显示文摘 | Kaliora A C Dedoussis G V | 2007 | Pharmacological Research2007，56，2： | 1 |
| 14 | Stabilization of nonlinear systems via forwarding rood LgV显示文摘 | PRALY L ORTEGA R KALIORA G | 2001 | IEEE Transactions on Automatic Control2001，46，9： | 1 |
| 15 | Norm estimators and global output feedback stabilization of nonlinear systems with ISS inverse dynam- ics显示文摘 | Kaliora G Astolfi A Praly L | 2006 | IEEE T Autom Contr2006，51，3： | 1 |
| 16 | Effect of phenols on natural killer (NK) cell-mediated death in the K562 leukemic cell line显示文摘 | DEDOUSSIS G V KALIORA A C ANDRIKOPOULOS N K | 2005 | Cell Biol Int2005，29，11： | 1 |
| 17 | Early cerebral monitoring using the transcranial Doppler pulsatility index in patients with severe brain trauma显示文摘 | Voulgaris SG Partheni M Kaliora H | 2005 | Med Sci Monit2005，11，2： | 1 |
| 18 | Ileocecal actinomycosis: a case report显示文摘 | L. Thanos S. Mylona V. Kalioras M. Pomoni N. Batakis | 2004 | Abdominal Imaging2004，，1： | 1 |
| 19 | Potentially life-threatening neck abscesses:therapeutic management under CT-guided drainage显示文摘 | Thanos L Mylona S Kalioras V | 2005 | Cardiovasc Intervent Radiol2005，28，： | 1 |
| 20 | Dietary antioxidants in preventing atherogenesis 显示文摘 | KALIORA A C DEDOUSSIS G V SCHMIDT H | 2006 | Atherosclerosis2006，187，： | 1 |
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