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| 1 | Innate and adaptive immune responses in male and female reproductive tracts in homeostasis and following HIV infection显示文摘男、女的繁殖的道是有多样的功能的要求的复杂微型环境。当同时对潜在的病原体授与保护时,在繁殖的道的免疫系统举办为胎儿的 allograft 提供保护的环境的费力的任务。因此,它发展了改编的一个唯一的集合,首先在性荷尔蒙的影响下面,它从另外的 mucosal 地点使它不同。这里,我们讨论在男性和女繁殖的道是在场的免疫系统的各种各样的部件,包括在 homeostatic 条件下面的天生的可溶的因素和房间和体液、调停房间的适应免疫。我们考察在从全身的豁免展出区分并且讨论这些特征怎么被性荷尔蒙影响的男、女的繁殖的道显示出唯一的 phenotypic 和有免疫力的房间和回答的功能的特征的证据。我们也在跟随 HIV-1 感染的繁殖的道,性荷尔蒙和有免疫力的回答之中检验相互作用。男、女的繁殖的道的唯一的特征的改进理解将提供卓见进为性播送的感染的预防改进不孕的免疫学的原因和预防干预的设计的临床的处理。 | Philip V Nguyen Jessica K Kafka Victor H Ferreira Kristy Roth Charu Kaushic | 2014 | Cellular & Molecular Immunology2014，11，5： | 7 |
| 2 | Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis. | Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic | 2019 | Cellular & Molecular Immunology2019，16，2： | 2 |
| 3 | Fourth-harmonic generation via nonlinear diffraction in a 2D LiNbO_3 nonlinear photonic crystal from mid-IR ultrashort pulses显示文摘Five conical harmonic beams are generated from the interaction of femtosecond mid-infrared(mid-IR) pulses at a nominal input wavelength of 1997 nm with a 2D LiNbO_3 nonlinear photonic crystal with Sierpinski fractal superlattices. The main diffraction orders and the corresponding reciprocal vectors involved in the interaction are ascertained. Second and third harmonics emerging at external angles of 23.82° and 36.75° result from nonlinearerenkov and Bragg diffractions, respectively. Three pathways of fourth-harmonic generation are observed at external angles of 14.21°, 36.5°, and 53.48°, with the first one resulting from nonlinearerenkov diffraction, and the other two harmonics are generated via different cascaded processes. | 马博琴 Kyle Kafka Enam Chowdhury | 2017 | Chinese Optics Letters2017，15，5： | 2 |
| 4 | Power system restoration-the second task force report显示文摘 | Adibi M M Borkoski J N Kafka R J | 1987 | IEEE Transactions on Power Systems1987，2，4： | 2 |
| 5 | Power system restoration issues显示文摘 | Adibi M M Kafka R J | 1991 | IEEE ComputerApplications in Power1991，4，2： | 2 |
| 6 | Fire impacts and crowning in the boreal forest:study of a large wildfire in western Quebec显示文摘 | Kafka V Gauthier S and Bergeron Y | 2001 | International Journal of Wildland Fire2001，10，2： | 1 |
| 7 | Incidence of post- abortion intra- uterine adhesions evaluated by h ysteroscopy- a prospective study显示文摘 | Friedler S Marga~ioth EJ Kafka I | 1993 | Hum Reprod1993，8，3： | 1 |
| 8 | Polymorphism C3435T of the MDR-1 gene predicts response to preoperative chemotherapy in locally advanced breast cancer 显示文摘 | Kafka A Sauer G Jaeger C | 2003 | Int J Oncol2003，22，5： | 1 |
| 9 | Neurophil gelatinase- associated lipocalin as a new biomarker in laboratory med- icine显示文摘 | Makris K Rizos D Kafkas N | 2012 | Clin Chem Lab Med2012，50，9： | 1 |
| 10 | High-fidelity tissue en- gineering of patient-specific auricles for reconstruction of pediatric microtia and other auricular deformities显示文摘 | Reiffel A J Kafka C Hernandez K A | 2013 | Plos One2013，8，2： | 1 |
| 11 | Analytical tool requirements for power system restoration显示文摘 | Adibi M M Borkoski J N Kafka R J | 1994 | IEEE Trans on Power Systems1994，9，3： | 1 |
| 12 | Conversion effi- cacy of intravenous ibutilide compared with intravenous amiodarone in patients with recent-onset atrial fibrillation and atrial flutter 显示文摘 | Kafkas N V Patsilinakos S P Mertzanos G A | 2007 | Int J Cardiol2007，118，3： | 1 |
| 13 | Advances in probabilistic safety assessment显示文摘 | Apostolakis G Kafka P | 1992 | Nuclear Engineering and Design1992，134，1： | 1 |
| 14 | Coronary bypass graft fate and patient outcome:angiographic follow -up of 5065 grafts related survival and reoperation in 1388 patients during 25 years 显示文摘 | Fitzgibbon G M Kafka H P Leach A J | 1996 | J Am Coil Cardiol1996，28，： | 1 |
| 15 | Coronary bypass graft fate and patient outcome:angiographic follow-up of 5,065 grafts related to survival and reoperation in 1,388 patients during 25 years显示文摘 | Fitzgibbon GM Kafka HP Leach AJ | | 0，，： | 1 |
| 16 | Acute myocardial in- farction and transient ischemic attack in a patient with lone atrial fibrilla- tion and normal coronary arteries显示文摘 | Chlapoutakis GN Kafkas NV Katsanos SM | 2010 | Int J Cardiol2010，139，1： | 1 |
| 17 | Coronary bypass graft fate and patient outcome:angiographic follow-up of 5065 grafts related to survival and reoperation in 1388 patients during 25 years显示文摘 | Fitzgibbon GM Kafka HP Leach AJ | 1996 | J Am Coll Cardiol1996，28，3： | 1 |
| 18 | Power system restoration:the second task force report显示文摘 | Adibi M M Borkoski J N Kafka R J | 1987 | IEEE Trans on Power Systems1987，2，2： | 1 |
| 19 | Living PSA-risk monitoring-current use and developments显示文摘 | Kafka P | 1997 | Nuclear Engineering and Design1997，175，3： | 1 |
| 20 | Coronary Bypass Graft Fate and Patient Outcome:Angiographic Follow-up of 5065Grafts Related to Survival and Reoperation in 1388 Patients During 25 Years显示文摘 | Fitzgibbon GM Kafka HP Leach AJ | 1996 | J Am Coll Cardiol1996，28，3： | 1 |
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