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| 1 | Function-preserving gastrectomy for gastric cancer in Japan显示文摘Surgery used to be the only therapy for gastric cancer, and since its ability to cure gastric cancer was the focus of attention, less attention was paid to functionpreserving surgery in gastric cancer, though it was studied for gastroduodenal ulcer. Maki et al developed pylorus-preserving gastrectomy for gastric ulcer in 1967. At the same time, the definition of early gastric cancer(EGC) was being considered, histopathological investigations of EGC were carried out, and the validity of modified surgery was sustained. After the development of H2-blockers, the number of operations for gastroduodenal ulcers decreased, and the number of EGC patients increased simultaneously. As a result, the indications for pylorus-preserving gastrectomy for EGC in the middle third of the stomach extended, and various alterations were added. Since then, many kinds of function-preserving gastrectomies have been performed and studied in other fields of gastric cancer, and proximal gastrectomy, jejunal pouch interposition, segmental gastrectomy, and local resection have been performed. On the other hand, from the overall perspective, it can be said that endoscopic resection, which was launched at almost the same time, is the ultimate function-preserving surgery under the current circumstances. The current function-preserving gastrectomies that are often performed and studied are pylorus-preserving gastrectomy and proximal gastrectomy. The reasons for this are that these procedures that can be performed with systemic lymph node dissection, and they include three important elements:(1) reduction of the extent of gastrectomy;(2) preservation of the pylorus; and(3) preservation of the vagal nerve. In addition, these operations are more likely to be performed with a laparoscopic approach as minimally invasive surgery. Of the above-mentioned three elements, reduction of the extent of gastrectomy is the most important in our view. Therefore, we should try to reduce the extent of gastrectomy if curability of the gastric cancer can still be achieved. However, if we preserve a wider residual stomach in functionpreserving gastrectomy, we should pay attention to the development of metachronous gastric cancer. | Eiji Nomura Kunio Okajima | 2016 | World Journal of Gastroenterology2016，22，26： | 23 |
| 2 | 乙型肝炎病毒慢性感染者血清中不同类型病毒转录体的检测及其意义显示文摘目的:建立针对乙型肝炎病毒(HBV)全长型(fRNA)和顿挫型转录体(trRNA)的血清学检测方法,并探讨其临床应用价值.方法:自患者血清中提取病毒核酸,经PCR及PRT-PCR进行扩增,琼脂糖电泳显示产物,Southern印迹验证反应的特异性.取代表性产物克隆,测序.结果:在HBV慢性携带者的血清中检测到了在上述不同poly(A)位点成熟的病毒RNA.血清中fRNA的检出与e抗原阳性和较强的病毒DNA信号相对应,与转氨酶活性呈正相关,这一血清学指标反映了病毒复制;而trRNA的检出与e抗原阳性和转氨酶活性无关,不象fRNA那样依赖于血清中病毒DNA的量.二者检出率随年龄有不同变化,前者随年龄增加而进行性减低乃至转阴;而后者在10-20岁期间检出率升至80%,以后维持在较高水平.即使在某些表面抗原阴性血清中,也能检测到trRNA和不在上述两个位点成熟的病毒RNA.这些转录体在某些隐源性肝硬变和丙型肝炎患者血清中也存在.结论:病毒转录体的血清学检测有助于确定目前尚不认识的HBV感染期,可用来更准确地区分复制期和非复制期以及检出隐匿性HBV感染. | 苏勤 张伟 刘节 王淑芳 Kunio Takegoshi Claus H Schrder | 2003 | 世界华人消化杂志2003，11，2： | 16 |
| 3 | Natural history of chronic hepatitis C in patients on hemodialysis: Case control study with 4-23 years of follow-up显示文摘AIM: Hepatitis C virus (HCV) infection is very common among end-stage kidney disease patients on hemodialysis, but its natural history is not known.METHODS: In this study, 189 dialysis patients (case) positive for HCV antibodies who were followed up for more than 4 years were compared with twice as many sex/age matched controls with chronic hepatitis C who were diagnosed in the same month as the case and followed up for comparableperiods. The longest follow-up was 23 years in dialysis cases.The disease activities were graded into 'asymptomatic' if ALT was less than 40 (35 in cases) IU/L, 'low activities' if ALT was 40 (35)-79 IU/L, and 'high activities' if ALT was above 80 IU/L during the last or latest 4 year period.RESULTS: All 25 dialysis cases who were followed up for more than 15 years were asymptomatic and 15 of them were negative for HCV RNA. Of the 50 controls followed up for more than 15 years, 34 had high acvities, and none deared HCV RNA. There were 60 controls who were asymptomatic,but they were all positive for HCV RNA, while 22.3% of asymptomatic dialysis cases were RNA negative. No dialysispatients with chronic hepatitis C progressed to cirrhosis,whereas the disease progressed to cirrhosis in more thanone quarter of the controls. These differences were highlysignificant (P<0.0001).CONCLUSION: Chronic hepatitic C among hemodialysispatients is mild in disease activity, and is not progressive,perhaps due to immunological abnormalities in these patients.Hepatic C virus is frequently cleared in asymptomatic dialysispatients during a long course. A possible mechanism forviral clearance is viral particle destruction on the surface ofthe dialyzer membrane. | Kunio Okuda Osamu Yokosuka | 2004 | World Journal of Gastroenterology2004，10，15： | 14 |
| 4 | Role of Sphingosine 1-Phosphate Receptor Type 1 in Lymphocyte Egress from Secondary Lymphoid Tissues and Thymus显示文摘在血和第二等的淋巴的纸巾之间的成熟淋巴细胞的循环在免疫系统起一个中央作用。从进在高 endothelial 小静脉以外的第二等的淋巴的纸巾的血的淋巴细胞的 Homing 高度依赖于在 chemokines 之间的相互作用 CCL19, CCL21, CXCL12,和 CXCL13,和他们的受体 CCR7, CXCR4 和 CXCR5。然而,到淋巴的从第二等的淋巴的纸巾的淋巴细胞外出的分子的机制仍然保持不清楚。我们发现了 immunomodulator 的一个新班,由植物的导出黄蜂的自然产品的化学修正的 FTY720, ISP-I (myriocin ) 。FTY720 被显示了在试验性的 allograft 和自体免疫的疾病模型高度有效。FTY720 的一个惹人注目的特征是在在在这些的那项表演 immunomodulating 活动建模的剂量的外部血淋巴细胞的显著减少的正式就职。由 FTY720 的传播淋巴细胞的减小被 iymphocytes 的隐遁引起进第二等的淋巴的纸巾和胸腺。FTY720 很快被变换成 FTY720 磷酸盐的(S)-enantiomer [由鞘氨醇 kinase 的(S)-FTY720-P] 2 在 vivo。(S)-FTY720-P 充当 S1P 受体类型 1 的有势力收缩筋(S1P1 ) ,在淋巴细胞上导致 S1P1 的长期的下面规定,并且从而向 S1P 禁止淋巴细胞的迁居。因此,导致 FTY720 的淋巴细胞隐遁由它的活跃代谢物(S)-FTY720-P 由于从第二等的淋巴的纸巾和胸腺的 S1P/S1P1-dependent 淋巴细胞外出的抑制,这被假定。在整个 FTY720 的行动的机制的分析, S1P/S1P1 相互作用从第二等的淋巴的纸巾和胸腺为淋巴细胞外出起一个重要作用,这被澄清。 | Kenji Chiba Hirofumi Matsuyuki Yasuhiro Maeda Kunio Sugahara | 2006 | Cellular & Molecular Immunology2006，3，1： | 11 |
| 5 | Gastric calcifying fibrous tumor removed by endoscopic submucosal dissection显示文摘The World Health Organization describes calcifying fibrous tumors(CFTs) as rare, benign lesions characterized by hypocellular, densely hyalinized collagenization with lymphoplasmacytic infiltration. These tumors rarely involve the gastrointestinal(GI) tract. A routine endoscopic upper gastrointestinal screen detected a 10-mm submucosal tumor(SMT) in the lesser curvature of the lower corpus of the stomach of an apparently healthy, 37-year-old woman with no history of Helicobacter pylori infection. Endoscopic ultrasonography(EUS) localized the internally isoechoic, homogeneous SMT mainly within the submucosa. Malignancy was ruled out using endoscopic submucosal dissection(ESD). A pathological examination confirmed complete resection of the SMT, and defined a hypocellular, spindle-cell tumor with a densely hyalinized, collagenous matrix, scattered lymphoplasmacytic aggregates as well as a few psammomatous, dystrophic calcified foci. The mass was immunohistochemically positive for vimentin and negative for CD117(c-kit protein), CD34, desmin, smooth muscle actin(SMA) and S100. Therefore, the histological findings were characteristic of a CFT. To date, CFT resection by ESD has not been described. This is the first case report of a gastric calcifying fibrous tumor being completely resected by ESD after endoscopic ultrasonography. | Naotaka Ogasawara Shinya Izawa Mari Mizuno Atsushi Tanabe Tomonori Ozeki Hisatsugu Noda Emiko Takahashi Makoto Sasaki Toyoharu Yokoi Kunio Kasugai | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，9： | 8 |
| 6 | Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer显示文摘AIM:To study how lymph node metastasis(LNM) risk is stratified in undifferentiated-type early gastric cancer(undiff-EGC) dependent on combinations of risk factors.METHODS:Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined retrospectively.Using clinicopathological factors of patient age,location,size,an endoscopic macroscopic tumor form,ulceration,depth,histology,lymphatic involvement(LI) and venous involvement(VI),LNM risk was examined and stratified by conventional statistical analysis and datamining analysis.RESULTS:LNM was positive in 44 of 567 cases(7.8%).Univariate analysis revealed > 2 cm,protrusion,submucosal(sm),mixed type,LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate analysis.In preoperatively evaluable factors excluding LVI,sm and > 2 cm were independent factors.According to the depth and size,cases were categorized into the low-risk group [m and ≤ 2 cm,0%(LNM incidence)],the moderaterisk group(m and > 2 cm,5.6%; and sm and ≤ 2 cm,6.0%),and the high-risk group(sm and > 2 cm,19.3%).On the other hand,LNM occurred in 1.4% in all LI-negative cases,greatly lower than 28.2% in all LI-positive cases,and LNM incidence was low in LInegative cases even in the moderate- and high-risk groups.CONCLUSION:LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size postoperatively.Among these factors,LI was the most significantly correlated factor. | Yukiko Asakawa Masahiko Ohtaka Shinya Maekawa Mitsuharu Fukasawa Yasuhiro Nakayama Tatsuya Yamaguchi Taisuke Inoue Tomoyoshi Uetake Minoru Sakamoto Tadashi Sato Yoshihiko Kawaguchi Hideki Fujii Kunio Mochizuki Masao Hada Toshio Oyama Tomotaka Yasumura Kosaku Omata Atsushi Nishiyama Keiichi Naito Hideo Hata Yoshiaki Haba Kazuyuki Miyata Haruhisa Saitoh Yoichi Yamadera Kazuo Miura Akira Kawaoi Tohru Abe Hajime Tsunoda Yuji Honda Masayuki Kurosaki Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，9： | 8 |
| 7 | Trans-synaptic Neural Circuit-Tracing with Neurotropic Viruses显示文摘A central objective in deciphering the nervous system in health and disease is to define the connections of neurons. The propensity of neurotropic viruses to spread among synaptically-linked neurons makes them ideal for mapping neural circuits. So far, several classes of viral neuronal tracers have become available and provide a powerful toolbox for delineating neural networks. In this paper, we review the recent developments of neurotropic viral tracers and highlight their unique properties in revealing patterns of neuronal connections. | Jiamin Li Taian Liu Yun Dong Kunio Kondoh Zhonghua Lu | 2019 | Neuroscience Bulletin2019，35，5： | 7 |
| 8 | 1100kV气体绝缘双断口断路器的开发与产品化(英文)显示文摘开发了一种用于气体绝缘组合电器(GIS)的1100kV50kASF6气体双断口断路器(GCB)。研究了这种断路器的各种特性,并成功完成了在绝缘、开断和机械性能等方面的型式试验。实现了GCB的小型化和轻量化。这种新开发的GCB已应用在中国特高压交流示范工程的GIS中,并已于2009年年初投入使用。 | Rei Hemmi Michiru Onodera Yoshikatsu Enokida Naoyuki Yamamoto Kunio Hirasawa | 2009 | 电网技术2009，33，15： | 5 |
| 9 | FTY720,Sphingosine 1-Phosphate Receptor Modulator,Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibition of T Cell Infiltration显示文摘FTY720, a sphingosine 1-phosphate receptor modulator, induces a marked decrease in the number of peripheral blood lymphocytes and exerts immunomodulating activity in various experimental allograft and autoimmune disease models. In this study, we evaluated the effect of FTY720 and its active metabolite, (S)-enantiomer of FTY720-phosphate [(S)-FTY720-P] on experimental autoimmune encephalomyelitis (EAE) in rats and mice.Prophylactic administration of FTY720 at 0.1 to 1 mg/kg almost completely prevented the development of EAE,and therapeutic treatment with FTY720 significantly inhibited the progression of EAE and EAE-associated histological change in the spinal cords of LEW rats induced by immunization with myelin basic protein. Consistent with rat EAE, the development of proteolipid protein-induced EAE in SJL/J mice was almost completely prevented and infiltration of CD4+ T cells into spinal cord was decreased by prophylactic treatment with FTY720 and (S)-FTY720-P. When FTY720 or (S)-FTY720-P was given after establishment of EAE in SJL/J mice, the relapse of EAE was markedly inhibited as compared with interferon-β, and the area of demyelination and the infiltration of CD4+ T cells were decreased in spinal cords of EAE mice. Similar therapeutic effect by FTY720 was obtained in myelin oligodendrocyte glycoprotein-induced EAE in C57BL/6 mice. These results indicate that FTY720 exhibits not only a prophylactic but also a therapeutic effect on EAE in rats and mice, and that the effect of FTY720 on EAE appears to be due to a reduction of the infiltration of myelin antigen-specific CD4+ T cells into the inflammation site. | Hirotoshi Kataoka Kunio Sugaharal Kyoko Shimano Koji Teshima Mamoru Koyama Atsyshi Fukunari Kenji Chiba | 2005 | Cellular & Molecular Immunology2005，2，6： | 5 |
| 10 | 气体燃料发动机的高性能气门座圈材料开发显示文摘烧结材料广泛用于气门座圈(VSI)。当用于气体燃料(LPG,CNG)发动机时,由于环境干燥,VSI磨损量增大。介绍了气体燃料发动机用的,两种新开发的高性能VSI材料。为增高耐磨性,这些材料应用的新工艺是,高性能硬质颗粒和固体润滑剂新分布方法。 | Hideaki Kawata Kunio Maki | 2011 | 粉末冶金技术2011，29，1： | 5 |
| 11 | Efficacy of endoluminal gastroplication in Japanese patients with proton pump inhibitor-resistant,non-erosive esophagitis显示文摘AIM:To evaluate the efficacy,safety,and long-term outcomes of endoluminal gastroplication(ELGP) in patients with proton pump inhibitor(PPI)-resistant,nonerosive reflux disease(NERD).METHODS:The subjects were NERD patients,diagnosed by upper endoscopy before PPI use,who had symptoms such as heartburn or reflux sensations two or more times a week even after 8 wk of full-dose PPI treatment.Prior to ELGP,while continuing full-dose PPI medication,patients' symptoms and quality of life(QOL) were assessed using the questionnaire for the diagnosis of reflux disease,the frequency scale for symptoms of gastro-esophageal reflux disease(FSSG),gastrointestinal symptoms rating scale,a 36-item short-form.In addition,24-h esophageal pH monitoring or 24-h intraesophageal pH/impedance(MII-pH) monitoring was performed.The Bard EndoCinch TM was used for ELGP,and 2 or 3 plications were made.After ELGP,all acid reducers were temporarily discontinued,and medication was resumed depending on the development and severity of symptoms.Three mo after ELGP,symptoms,QOL,pH or MII-pH monitoring,number of plications,and PPI medication were evaluated.Further,symptoms,number of plications,and PPI medication were evaluated 12 mo after ELGP to investigate long-term effects.RESULTS:The mean FSSG score decreased significantly from before ELGP to 3 and 12 mo after ELGP(19.1 ± 10.5 to 10.3 ± 7.4 and 9.3 ± 9.9,P < 0.05,respectively).The total number of plications decreased gradually at 3 and 12 mo after ELGP(2.4 ± 0.8 to 1.2 ± 0.8 and 0.8 ± 1.0,P < 0.05,respectively).The FSSG scores in cases with no remaining plications and in cases with one or more remaining plications were 4.4 and 2.7,respectively,after 3 mo,and 2.0 and 2.8,respectively,after 12 mo,showing no correlation to plication loss.On pH monitoring,there was no difference in the percent time pH < 4 from before ELGP to 3 mo after.Impedance monitoring revealed no changes in the number of reflux episodes or the symptom index for reflux events from before ELGP to 3 mo after,but the symptom sensitivity index decreased significantly 3 mo after ELGP(16.1 ± 12.9 to 3.9 ± 8.3,P < 0.01).At 3 mo after ELGP,6 patients(31.6%) had reduced their PPI medication by 50% or more,and 11 patients(57.9%) were able to discontinue PPI medication altogether.After 12 mo,3 patients(16.7%) were able to reduce the amount of PPI medication by 50% or more,and 12 patients(66.7%) were able to discontinue PPI medication altogether.A high percentage of cases with remaining plications had discontinued PPIs medication after 3 mo,but there was no difference after 12 mo.No serious complications were observed in this study.CONCLUSION:ELGP was safe,resulted in significant improvement in subjective symptoms,and allowed less medication to be used over the long term in patients with PPI-refractory NERD. | Kentaro Tokudome Yasushi Funaki Makoto Sasaki Shinya Izawa Yasuhiro Tamura Akihito Iida Naotaka Ogasawara Toshihiro Konagaya Yoshifumi Tokura Kunio Kasugai | 2012 | World Journal of Gastroenterology2012，18，41： | 5 |
| 12 | Study on the hydrothermal drying technology of sewage sludge显示文摘Drying of sewage sludge is an effective way for treatment and utilization of sewage sludge,where reduction of energy consumption is one of the major technical challenges.So we experimentally investigated the possibility of the hydrothermal treatment.We have found that treatment of sewage sludge by saturated steam with the temperature of 190°C and pressure of 20 bar can dramatically improve the dehydration performance of the slurry like product.And the water content can be reduced down to about 55% by a mechanical dehydration.After natural drying 24 h it can be reduced down to about 20%.The final product is almost odorless and can easily be used for the refuse derived fuel(RDF).The sewage sludge product may be used as land-fill,or burned in a boiler or incinerator. | Kunio Yoshikawa | 2010 | Science China(Technological Sciences)2010，53，1： | 5 |
| 13 | Pathophysiology of functional heartburn based on Rome Ⅲ criteria in Japanese patients显示文摘AIM:To investigate the pathophysiology of functional heartburn(FH) in Japanese patients.METHODS:A total of 111 patients with proton pump inhibitor(PPI)-refractory non-erosive gastroesophageal reflux disease underwent intraesophageal pressure testing and 24-h multichannel intraluminal impedancep H(24MII-p H) testing.The patients also completed several questionnaires while they were receiving the PPI treatment, including the questionnaire for the diagnosis of reflux disease(QUEST), the frequency scale for the symptoms of gastroesophageal reflux disease(FSSG), the gastrointestinal symptoms rating scale(GSRS), SF-36, and the Cornell Medical Index(CMI).The subjects were classified into FH and endoscopy-negative reflux disease(ENRD) groups based on the Rome Ⅲ criteria.RESULTS:Thirty-three patients with esophageal motility disorder were excluded from this study, while 22 patients with abnormal esophageal acid exposure time(p H-POS) and 34 with hypersensitive esophagus(HE) were included in the ENRD group.The FH group included 22 patients with no reflux involvement.Sex, age, and body mass index did not differ significantly between the groups.The mean SF-36 values were < 50(normal) for all scales in these groups, with no significant differences.The GSRS scores in these groups were not different and showed overlap with other gastrointestinal symptoms.The QUEST and the FSSG scores did not differ significantly between the groups.Neuroticism was diagnosed using the CMI questionnaire in 17 of the 78 included subjects within the p H-POS(n=4),HE(n=8),and FH(n=5)groups,with no significant differences.CONCLUSION:Clinical characteristics of the FH and PPI-refractory ENRD groups were similar.Therefore,esophageal function should be examined via manometry and 24MII-p H testing to differentiate between them. | Yasuhiro Tamura Yasushi Funaki Shinya Izawa Akihito Iida Yoshiharu Yamaguchi Kazunori Adachi Naotaka Ogasawara Makoto Sasaki Hiroshi Kaneko Kunio Kasugai | 2015 | World Journal of Gastroenterology2015，21，16： | 4 |
| 14 | 人工全膝关节中多孔钽金属型和骨水泥型胫骨假体周围骨矿物质密度比较显示文摘背景:多孔钽金属近年来用作全膝关节置换的金属植入材料。其多孔性、低弹性模量和高摩擦性能可保证良好的生理负荷传导并保留假体周围的骨储备。但就我们所知,这种小梁金属(TrabecularMetal)胫骨假体对周围骨矿物质密度的影响未见文献报道。本文的目的是对使用非骨水泥的小梁金属胫骨假体和骨水泥型胫骨假体关节周围骨矿物质密度进行比较。方法:对使用小梁金属胫骨假体和使用骨水泥固定的钴铬钼合金胫骨假体各28个膝分别在术前2周、术后2周、术后6、12、18和24个月进行双能x线吸收光谱扫描,以评价假体周围骨矿物质密度。所有手术均由一名医师操作并采用髌旁内侧入路。结果:术前两组股骨颈、腕关节、腰椎椎体或膝关节的骨密度均无明显差异。术后两组的胫骨骨密度均下降。但术后24个月的胫骨侧位x线片显示小梁金属胫骨假体周围的骨密度减低明显小于骨水泥型胫骨假体组(平均值±标准差,-6.7%±22.9%与-36.8%+24.2%;p=0.002)。两组患者的膝关节学会(Knee Society)评分、膝关节活动度和腰椎椎体骨密度在术后24个月无明显差异。假体微动和假体周围骨折在两组膝关节中均未见到。结论:全膝关节置换术使用小梁金属胫骨假体的胫骨外侧平台的骨密度降低小于使用骨水泥型胫骨假体的膝关节。确定多孔钽金属胫骨假体用于全膝关节置换的长期临床疗效尚待进一步研究。 | Yukihide Minoda Akio Kobayashi Hiroyoshi Iwaki Mitsuhiko Ikebuchi Fumiaki Inori Kunio Takaoka 赵建宁(译) 包倪荣(译) | 2010 | 中华骨科杂志2010，30，6： | 4 |
| 15 | 耐热/耐磨烧结合金发展趋势显示文摘粉末冶金的一个特殊优势是合金设计自由度高,因此,烧结合金广泛用于耐热与耐磨零件。主要产品对象是气门导管、阀座圈(VSI)及发动机排气系统的零件。近年来,为回应环境问题,发动机的使用性能在不断提高,这些零件的使用环境随之越益严苛,因此,就日益要求改进材料的耐磨性与其它性能。论述了近年来耐热/耐磨烧结材料的技术发展趋势,特别着重于材料发展趋势。 | Hideaki Kawata Kunio Maki 韩凤麟 | 2011 | 粉末冶金技术2011，29，5： | 4 |
| 16 | 爆震性听力损失(英文)显示文摘近年来爆震性损伤的发生率逐渐上升。由于耳朵是对爆炸压力最敏感的器官,因此它在爆震性损伤中最易受累。爆炸压力造成的耳朵损害主要是不可逆的感音神经性耳聋,进而导致生活质量的下降。我们在本文回顾了近年来爆震性听力损失的一些病例。鼓膜对爆炸压力波特别敏感,因为在体内这种压力波主要在空气-组织交界面释放能量。然而,由爆炸引起的鼓膜穿孔比其他原因引起的更难以治疗。爆炸压力能破坏内耳外毛细胞上的纤毛束,从而引起感音神经性耳聋。同时,内毛细胞的神经突触和螺旋节细胞的减少会引起隐性听力损失,从而引起耳鸣和听觉过敏。 | Kunio MIZUTARI | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，2： | 4 |
| 17 | Obliterative hepatocavopathy-inferior vena cava thrombosis at its hepatic portion显示文摘Budd-Chiari syndrome was formerly described as he-patic vein thrombosis within the liver, but it now in-cludes inferior vena cava (IVC) thrombosis and oth-er conditions that cause hepatic vein outflow obstruc-tion. The author consider that primary hepaticvein thrombosis and primary IVC thrombosis repre-sent two different clinical disorders. | Kunio Okuda | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，4： | 4 |
| 18 | Simulation of sludge-dredging effects in controlling nutrient release of LakeKasumigaura with large-size core samples显示文摘Simulationofsludge-dredgingeffectsincontrollingnutrientreleaseofLakeKasumigaurawithlarge-sizecoresamples￥FanChengxin(NanjingI... | Fan Chengxin (Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences,Nanjing 210008,China) Morihiro AIZAKI Kunio KOHATA(The National Institute for Environmental Studies, Tsukuba), Japan | 1996 | Journal of Environmental Sciences1996，8，4： | 3 |
| 19 | Surface Activities of Calix [4]resorcinarenes Bearing Four Hydrophobic Chains and Its Solubilization for Organic Compounds显示文摘Calix resorcinarenes bearing four hydrophobic side chains ( Ar-Rn, Ar-Ph, and Ar-N) orient stably on water oil interface and show high solubilization capacities for organic compounds, such as long chain alcohols, benzene, toluene and dyes. The capacities are high even near the cmc of polyalkylated calix resorcinarenes, but the solubilities of organic compounds(solubilizates) decrease with the increase of the size of the solubilizates. Ar-R 6, with a chain length of six carbons, is the most effective among Ar-R n , Ar-Ph, and Ar-N; 11 fold mol of hexanol is dissolved in 2×10 -3 mol/L Ar-R 6. Moreover, Ar-R n bearing four alkyl side chains solubilizes the chain alcohols of the same chain length mostly. The solubilization capacities are presumably brought by inclusion in a large cavity of the polyalkylated calix resorcinarenes and by an efficient orientation of the solubilizates. | LI Bo *1 , Yoshifumi KOIDE 1 and Kunio ESUMI 21. Toyota Central R & D Labs., Inc., 41 1, Yokomichi, Nagakute, Aichi 480 1192, Japan 2. Departemnt of Applied Chemistry and Institute of Colloid and Interface Science, Science University of Tokyo | 2002 | Chemical Research in Chinese Universities2002，18，2： | 3 |
| 20 | Type-dependent differential expression of neuropeptide Y in chicken hypothalamus (Gallus domesticus)显示文摘Neuropeptide Y (NPY) is one of the most important orexigenic agents in central regulation of feeding behavior, body weight and energy homeostasis in domestic chickens. To examine differences in the hypothalamic NPY between layer-type and meat-type of chickens, which are two divergent kinds of the domestic chickens in feeding behavior and body weight, we detected mRNA levels of NPY in hypothalamic infundibular nucleus (IN), paraventricular nucleus (PVN) and lateral hypothalamic area (LHA) of these two types of chickens using one-step real time RT-PCR. The meat-type chicken had more food daily (about 1.7 folds) and greater body weights (about 1.5 folds) and brain weights than the layer-type chicken at the age of 14 d. In the meat-type of chicken, NPY mRNA levels of the IN and PVN were significantly greater than those of the LHA, and were not significantly different between the IN and PVN. However, in the layer-type of chicken, NPY mRNA levels were significantly greater in the IN than those in the LHA and PVN, and were not significantly different between the PVN and LHA. In all these hypothalamic regions, the layer-type of chicken had significantly higher NPY mRNA levels than the meat-type chicken did. These results suggest the expression of NPY in the hypothalamus has a type-dependent pattern in domestic chickens. | CHEN Gui-qian HU Xiu-fang SUGAHARA Kunio CHEN Ji-shuang SONG Xue-mei ZHENG Hui-chao JIANG Yong-qing HUANG Xin JIANG Jun-fang ZHOU Wei-dong | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，11： | 3 |
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