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| 1 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 2 | 髌股关节退变对膝关节内侧固定平台单髁置换术后疗效的影响显示文摘传统观点认为术前的髌股关节退变是膝关节单髁置换术(unicompartmental knee arthroplasty,UKA)的禁忌证,但其是否会对单髁置换术后效果造成显著影响,目前存在争议。近年来,一些研究指出内侧活动平台UKA的患者选择中可以忽略髌股关节退变,然而对于固定平台UKA的研究则相对较少。 | 杨家驹(整理) 王浩浩(整理) 李亚坤(整理) 李浩(整理) 张民(整理) Deckard ER Jansen K Ziemba-Davis M Sonn KA Meneghini RM | 2021 | 实用骨科杂志2021，27，10： | 2 |
| 3 | 轻型缺血性卒中或短暂性脑缺血发作的早期双联抗血小板治疗显示文摘王拥军及同事探讨了应用双联抗血小板治疗预防卒中复发或短暂性脑缺血发作的最新证据。轻型缺血性卒中和短暂性脑缺血发作(TIA)患者在头几周内有较高的卒中及其他血管事件的复发风险(5%~11.7%严。双联抗血小板治疗,包括氯吡格雷和阿司匹林,是减少卒中复发的有效治疗策略Magic Group的专家小组(http://gffzz25d7f5dd9bdf4c9ehv6vk9p56qbxf69xv.ffgz.tsg.suse.edu.cn/)最近在The BMJ中发表了一个强烈的快速推荐建议,即对于轻型缺血性卒中和TIA患者应在症状出现24小时内开始双联抗血小板治疗,并持续10~21天3。 | 王拥军 S. Claiborne Johnston Philip M Bath James C. Grotta 潘岳松 Pierre Amarenco 王伊龙 Tabassome Simon Jong Sung Kim Jiann-Shing Jeng 刘丽萍 林毅 Ka Sing Lawrence Wong David Wang 李昊 | 2019 | 英国医学杂志中文版2019，22，5： | 2 |
| 4 | 亚致死浓度的铜对虹鳟生理指标的影响显示文摘外部环境决定着有机体的功能状态;当有机体与外部环境之间相互关系遭到破坏时,无论机体的生理系统,还是其调节机能都会发生变化。生理指标反映出物体内环境对外部作用作出的反应,以此可确定外部作用的强度,阐明作用机制,确定机体的适应能力,并预测其影响(Хайн... | KaЗ.,H BoC.,MЗ | 1999 | 动物学杂志1999，34，4： | 2 |
| 5 | ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-1 显示文摘 | Gelissen IC Harris M Rye KA | 2006 | Arterioscler Thromb Vasc Biol2006，26，3： | 1 |
| 6 | Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes显示文摘 | Bienert GP M?ller AL Kristiansen KA | 2007 | Biol Chem2007，282，2： | 1 |
| 7 | Nitric oxide,prostanoids,cyclooxygenase,and angiogenesis in colon and breast cancer显示文摘 | Miyataka M Rich KA | 2001 | Clin Cancer Res2001，7，11： | 1 |
| 8 | Lung infections:role of apoptosis in host defense and pathogenesis of disease显示文摘 | Behnia M Robertson KA Martin W J 2nd | 2000 | Chest2000，117，6： | 1 |
| 9 | Osteogenic protein-1 prevents renal fibregenesis associatedwitll ureteral obstruction显示文摘 | Hruska KA Guo G Wozniak M | 2000 | Am J Physiol2000，279，5： | 1 |
| 10 | Pathology of the liver in copper overload显示文摘 | Johncilla M Mitchell KA | 2011 | Semin Liver Dis2011，31，3： | 1 |
| 11 | Cardiac myocytes produce interleukin-6 in culture and in viable border zone of reperfused infarctions显示文摘 | Gwechenberger M Mendoza LH Youker KA | 1999 | Circulation1999，99，4： | 1 |
| 12 | Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction显示文摘 | Hruska KA Guo GJ Wozniak M | 2000 | Am J Physiol Renal Physiol2000，219，： | 1 |
| 13 | Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease显示文摘 | O'Donnell DE Lam M Webb KA | 1998 | Am J Respir Grit Care Med1998，158，51： | 1 |
| 14 | The World Health Organization's WHOQOL-BREF quality of life assessment:psychometric properties and results of the international field trial-A report from the WHOQOL group显示文摘 | Skevington SM Lotfy M O'Connell KA | 2004 | Qual Life Res2004，13，2： | 1 |
| 15 | An implantable carotid sinus stimulator for drug-resistant hypertension: surgical technique and short-term outcome from the muhicenter phase II Rheos feasibility trial显示文摘 | Illig KA Levy M Sanchez L | 2006 | J Vasc Surg2006，44，6： | 1 |
| 16 | Colorimetric method for determination of sugars and related substances显示文摘 | Dubois M Gilles KA Hamihon JK et a/ | 1956 | Analytical Chemistry1956，28，3： | 1 |
| 17 | Bound for Sydney town:health surveillance on international cruise vessels visiting the port of Sydney显示文摘 | Ferson M J Ressler KA | 2005 | MJA2005，182，8： | 1 |
| 18 | Colour perfusion imaging: A new application of computed tomography显示文摘 | Miles KA Hayball M Dixon AK | 1991 | Lancet1991，337，8742： | 1 |
| 19 | Antioxidant phospholipid calix[4]arene mimics as micellular delivery systems显示文摘 | James E Eggers PK Harvey AR Dunlop SA Fitzgerald M Stubbs KA Raston CL | | 0，，： | 1 |
| 20 | 1423 panereaticodu- odenetomies for pancreatic cancer: a single-institution experience 显示文摘 | Winter M Cameron ]L Campbell KA | 2006 | J Gastrointest Surg2006，10，9： | 1 |
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