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| 1 | Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver disease显示文摘Mitochondrial dysfunction is known to be a contributing factor to a number of diseases including chronic alcohol induced liver injury. While there is a detailed understanding of the metabolic pathways and proteins of the liver mitochondrion, little is known regarding how changes in the mitochondrial proteome may contribute to the development of hepatic pathologies. Emerging evidence indicates that reactive oxygen and nitrogen species disrupt mitochondrial function through post-translational modifications to the mitochondrial proteome. Indeed, various new affinity labeling reagents are available to test the hypothesis that post-translational modification of proteins by reactive species contributes to mitochondrial dysfunction and alcoholic fatty liver disease. Specialized proteomic techniques are also now available, which allow for identification of defects in the assembly of multi-protein complexes in mitochondria and the resolution of the highly hydrophobic proteins of the inner membrane. In this review knowledge gained from the study of changes to the mitochondrial proteome in alcoholic hepatotoxicity will be described and placed into a mechanistic framework to increase understanding of the role of mitochondrial dysfunction in liver disease. | Sudheer K Mantena Adrienne L King Kelly K Andringa Aimee Landar Victor Darley-Usmar Shannon M Bailey | 2007 | World Journal of Gastroenterology2007，13，37： | 7 |
| 2 | SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct显示文摘Pendred syndrome(PS) is characterized by autosomal recessive inheritance of goiter associated with a defect of iodide organification, hearing loss, enlargement of the vestibular aqueduct(EVA), and mutations of the SLC26A4 gene. However, not all EVA patients have PSor SLC26A4 mutations. Two mutant alleles of SLC26A4 are detected in 1/4 of North American or European EVA populations, one mutant allele is detected in another 1/4 of patient populations, and no mutations are detected in the other 1/2. The presence of two mutant alleles of SLC26A4 is associated with abnormal iodide organification, increased thyroid gland volume, increased severity of hearing loss, and bilateral EVA. The presence of a single mutant allele of SLC26A4 is associated with normal iodide organification, normal thyroid gland volume, less severe hearing loss and either bilateral or unilateral EVA. When other underlying correlations are accounted for, the presence of a cochlear malformation or the size of EVA does not have an effect on hearing thresholds. This is consistent with observations of an Slc26a4 mutant mouse model of EVA in which hearing loss is independent of endolymphatic hydrops or inner ear malformations. Segregation analyses of EVA in families suggest that the patients carrying one mutant allele of SLC26A4 have a second, undetected mutant allele of SLC26A4, and the probability of a sibling having EVA is consistent with its segregation as an autosomal recessive trait. Patients without any mutations are an etiologically heterogeneous group in which siblings have a lower probability of having EVA. SLC26A4 mutation testing can provide prognostic information to guide clinical surveillance and management, as well as the probability of EVA affecting a sibling. | Taku Ito Julie Muskett Parna Chattaraj Byung Yoon Choi Kyu Yup Lee Christopher K Zalewski Kelly A King Xiangming Li Philine Wangemann Thomas Shawker Carmen C Brewer Seth L Alper Andrew J Griffith | 2013 | World Journal of Otorhinolaryngology2013，3，2： | 2 |
| 3 | Flight Control Actuation Technology for Next--Generation All-- Electric Aircraft显示文摘 | Botten S L Whitley C R King A D | 2000 | Technology Review Journal-- Millennium Issue2000，，3： | 1 |
| 4 | Usefulness of ovarian volume and cysts in female is osexual precocbus puberty 显示文摘 | KING L R SIEGE I M J SOBMON A L | 1993 | J Ultrasound in Medicine1993，12，10： | 1 |
| 5 | Case-control study of bladder cancer and chlorination by-products in treated water (Ontario, Canada)显示文摘 | King W D Marrett L D | 1996 | Cancer Causes Control1996，7，： | 1 |
| 6 | Circulating Ly-6C + myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease显示文摘 | King I L Dickendesher T L Segal B M | 2009 | Blood2009，113，14： | 1 |
| 7 | Schematic method of deriving the rate laws for enzyme-catalyzed reactions显示文摘 | King E L Altman C A | 1956 | J Phys Chem1956，60，： | 1 |
| 8 | The role of protein kinase Cactivation and the vascular complications of diabetes显示文摘 | Net Das Evcimen George L King | 2007 | Pharmacol Res2007，55，： | 1 |
| 9 | Cell cycle and apoptosis:common pathways to life and death显示文摘 | King K L Cidlowski J A | 1995 | Cell Biochem1995，58，2： | 1 |
| 10 | Experimental studies of elastic-wave propagation in a columnar-jointed rock mass显示文摘 | King M S Myer L R Rezowalli J J | 1986 | Geophysical Prospecting1986，34，8： | 1 |
| 11 | A rapid and efficient non-radioactive method for screening recombinant DNA libraries 显示文摘 | Amaravadi L King M W | 1994 | Biotechniques1994，16，1： | 1 |
| 12 | CaseecontroI study of bladder cancer and chlorination byproducts in treated water (Ontario, Canada)显示文摘 | KING W D MARRETT L D | 1996 | Cancer Causes Control1996，7，： | 1 |
| 13 | Surface deformation and lower crustal flow in eastern Tibet显示文摘 | ROYDEN L H BURCHFIEL B C KING R W et al | 1997 | Science1997，276，： | 1 |
| 14 | Tributyltin in environmental samples from the Former Derecktor Shipyard, Coddington Cove, Newport RI显示文摘 | Wade T L Sweet S T Quinn J G Cairns R W King J W | 2004 | Environmental Pollution2004，129，2： | 1 |
| 15 | Why Positive Psychology Is Necessary显示文摘 | King L | 2001 | American Psychologist2001，56，3： | 1 |
| 16 | The role of protein kinase C activation andthe vascular complications of diabetes显示文摘 | Das Evcimen N King G L | 2007 | Pharmacol Res2007，55，6： | 1 |
| 17 | Antecedents of knowl- edge transfer from consultants to clients in enterprise sys- tem implementations 显示文摘 | KO D G KIRSH L J KING W R | 2005 | MIS Quarterly2005，29，1： | 1 |
| 18 | Supplemen-tal vitamin D3 concentration and biological type of steers, tenderness, quality, and residues of beef显示文摘 | Montgomery J L M. B. King J. G. Gentry | | 0，，： | 1 |
| 19 | Aqueous phase reforming of glycerol for hydrogen production over Pt-Re supported on carbon显示文摘 | King D L Zhang L Xia G | | 0，，： | 1 |
| 20 | Antecedents of knowledge trans- fer from consultants to clients in enterprise system implementations显示文摘 | Dong-Gil K Kitsch L J King W R | 2005 | MIS Quarterly2005，29，1： | 1 |
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