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| 1 | Factors influencing syphilis treatment failure and/or re-infection in HIV co-infected patients: immunosuppression or behaviors显示文摘背景最近的研究报导了有高度的梅毒的总的来说增加的率人的免疫不全评估病毒(HIV ) 合作感染。然而,几乎在 HIV 影响梅毒治疗失败或再感染的因素没有很少信息共同感染的病人。我们进行了研究评估在 HIV 与梅毒治疗 failure/re-infection 联系的因素到 2007 年 12 月的从 2005 年 1 月的感染 HIV 的病人的 3542 个医药记录列在后面在上面的我们考察了的共同感染的 patients.Methods 在在纽约的 HIV 诊所城市。病人们被快速的血浆分类重获 titer ( RPR )进 success/serofast (在到在治疗以后的 12 个月的 RPR 的4褶层减少, RPR 变换到没有4褶层增加的非电抗的、固执地稳定的反应 RPR ),并且 failure/re-infection (失败到在到在治疗以后的 12 个月的 RPR 的减少 4 褶层,从基线的 RPR 的4褶层增加)在满足了资格标准的 156 个病人的一个总数之中的 .Results ,( 78.2 ) 122 在 success/serofast 范畴下面,并且( 21.8 ) 34 在 failure/r 下面高度活跃的 antiretroviral 治疗(HAART ) 的 HIV 病毒的负担, CD4 房间计数,和使用没与梅毒治疗 failure/re-infection 被联系。然而,早梅毒舞台(OR:11.036, 95 CI:2.499-48.740, P=0.002 ) 并且高度(164 ) RPR titers (或:715.921, 95 CI:422.175-23 113.396, P 0.001 ) 显著地 associated.Conclusions 没有关联与梅毒治疗失败或再感染与沮丧的有免疫力的州被看见。然而,有早阶段梅毒的协会建议危险心理性行为可以是最重要的带因素,强调对安全的性教育的需要。 | Jong Hun Kim George Psevdos Jr Jin Suh Victoria Sharp | 2011 | Chinese Medical Journal2011，，14： | 10 |
| 2 | Murine lung eosinophil activation and chemokine production in allergic airway inflammation显示文摘Eosinophils play important roles in asthma and lung infections.Murine models are widely used for assessing the functional significance and mechanistic basis for eosinophil involvements in these diseases.However,little is known about tissue eosinophils in homeostasis.In addition,little data on eosinophil chemokine production during allergic airway inflammation are available.In this study,the properties and functions of homeostatic and activated eosinophils were compared.Eosinophils from normal tissues expressed costimulation and adhesion molecules B7-1,B7-2 and ICAM-1 for Ag presentation but little major histocompatibility complex(MHC)class II,and were found to be poor stimulators of T-cell proliferation.However,these eosinophils expressed high levels of chemokine mRNA including C10,macrophage inflammatory protein(MIP)-1a,MIP-1c,MIP-2,eotaxin and monocyte chemoattractant protein-5(MCP-5),and produced chemokine proteins.Eosinophil intracellular chemokines decreased rapidly with concomitant surface marker downregulation upon in vitro culturing consistent with piecemeal degranulation.Lung eosinophils from mice with induced allergic airway inflammation exhibited increased chemokines mRNA expression and chemokines protein production and upregulated MHC class II and CD11c expression.They were also found to be the predominant producers of the CCR1 ligands CCL6/C10 and CCL9/MIP-1c in inflamed lungs.Eosinophil production of C10 and MIP-1c correlated with the marked influx of CD11bhigh lung dendritic cells during allergic airway inflammation and the high expression of CCR1 on these dendritic cells(DCs).The study provided baseline information on tissue eosinophils,documented the upregulation of activation markers and chemokine production in activated eosinophils,and indicated that eosinophils were a key chemokine-producing cell type in allergic lung inflammation. | C Edward Rose Jr Joanne A Lannigan Paul Kim James J Lee Shu Man Fu Sun-sang J Sung | 2010 | Cellular & Molecular Immunology2010，7，5： | 6 |
| 3 | Genome resequencing and transcriptome profiling reveal structural diversity and expression patterns of constitutive disease resistance genes in Huanglongbing-tolerant Poncirus trifoliata and its hybrids显示文摘Huanglongbing(HLB)is the most destructive bacterial disease of citrus worldwide.While most citrus varieties are susceptible to HLB,Poncirus trifoliata,a close relative of Citrus,and some of its hybrids with Citrus are tolerant to HLB.No specific HLB tolerance genes have been identified in P.trifoliata but recent studies have shown that constitutive disease resistance(CDR)genes were expressed at much higher levels in HLB-tolerant Poncirus hybrids and the expression of CDR genes was modulated by Candidatus Liberibacter asiaticus(CLas),the pathogen of HLB.The current study was undertaken to mine and characterize the CDR gene family in Citrus and Poncirus and to understand its association with HLB tolerance in Poncirus.We identified 17 CDR genes in two citrus genomes,deduced their structures,and investigated their phylogenetic relationships.We revealed that the expansion of the CDR family in Citrus seems to be due to segmental and tandem duplication events.Through genome resequencing and transcriptome sequencing,we identified eight CDR genes in the Poncirus genome(PtCDR1-PtCDR8).The number of SNPs was the highest in PtCDR2 and the lowest in PtCDR7.Most of the deletion and insertion events were observed in the UTR regions of Citrus and Poncirus CDR genes.PtCDR2 and PtCDR8 were in abundance in the leaf transcriptomes of two HLB-tolerant Poncirus genotypes and were also upregulated in HLB-tolerant,Poncirus hybrids as revealed by real-time PCR analysis.These two CDR genes seem to be good candidate genes for future studies of their role in citrus-CLas interactions. | Nidhi Rawat Brajendra Kumar Ute Albrecht Dongliang Du Ming Huang Qibin Yu Yi Zhang Yong-Ping Duan Kim D Bowman Fred G Gmitter Jr Zhanao Deng | 2017 | Horticulture Research2017，4，1： | 5 |
| 4 | Transversus abdominis plane infiltration for laparoscopic gastric banding: A pilot study显示文摘AIM: To estimate an effect size for the transversus abdominis plane(TAP) infiltration on quality of recovery in patients undergoing laparoscopic gastric band surgery. METHODS: The pilot study was a randomized, double blinded, placebo controlled trial. Patients undergoing laparoscopic gastric band surgery were randomized to receive a bilateral TAP infiltration with 20 mL of 0.5% ropivacaine or saline. The evaluated outcomes included quality of recovery-40(QoR-40) at 24 h, postoperative opioid consumption and pain. Data was examined using the Mann-Whitney U test. RESULTS: Nineteen subjects were recruited. There was a positive trend favoring the TAP infiltration group in global QoR-40 scores at 24 h after surgery, median [interquartile range(IQR)] of 175.5(170-189) com-pared to 170(160-175) in the control group(P = 0.06). There also a positive trend toward a lower cumulative opioid consumption in the TAP infiltration group, median(IQR) of 7.5(2.5-11.5) mg iv morphine equivalents compared to 13(7-21.5) in the control group(P = 0.07). Correlation analysis(Spearman's Rho) demonstrated an inverse relationship between 24 h cumulative opioid consumption and global QoR-40 scores,-0.49(P = 0.03). CONCLUSION: The use of multimodal analgesic techniques to reduce opioid related side effects is particularly desirable in morbidly obese patients undergoing gastric reduction surgery. The TAP infiltration seems to have a clinically important effect in reducing postoperative opioid consumption and improve quality of recovery after laparoscopic gastric band surgery in morbid obese patients. Future studies to confirm the beneficial effects of the TAP infiltration in these patients are warranted. | Gildasio S De Oliveira Jr Paul Fitzgerald Shireen Ahmad John Kim Rohit Rahangdale Robert McCarthy | 2014 | World Journal of Gastrointestinal Surgery2014，6，2： | 4 |
| 5 | Dietary docosahexaenoic and eicosapentaenoic acid:emerging mediators of inflammation显示文摘 | Chapkin RS Kim W Lupton JR | 2009 | Prostaglandins Leukot Essent Fatty Acids2009，81，23： | 1 |
| 6 | Gastrodia elata blume and an active component,p-Hydroxybenzyl alcohol reduce focal ischemic brain injury through antioxidant related gene expressions显示文摘 | Yu SJ Kim JR Lee CK | 2005 | Biol Pharm Bull2005，28，6： | 1 |
| 7 | Failure of continuous venovenous hemofiltration to prevent death in paraquat poisoning显示文摘 | Koo JR Kim JC Yoon JW | | 0，，： | 1 |
| 8 | Clinically suspected pulmonary embolism utility of spiral CT显示文摘 | Kim KI Muller NL Mayo JR | 2003 | Radiology2003，210，： | 1 |
| 9 | A novel compound heterozygous mutation in the CYP17 (P450 17alpha-hydroxylase) gene leading to 17alpha-hydroxylase/17,20-lyase deficiency显示文摘 | Hahm JR Kim DR Jeong DK | 2003 | Metabolism2003，52，： | 1 |
| 10 | Overexpression of cyclin D1 and cyclin E in 1,2-dimethylhydrazine dihydrochloride-induced rat colon carcinogenesis显示文摘 | Hur K Kim JR Yoon BI | 2000 | J Vet Sci2000，1，2： | 1 |
| 11 | Expression of nerve growth factor and vascular endothelial growth factor in the inferior alveolar nerve after distraction osteogenesis显示文摘 | Park BW Kim JR Lee JH | 2006 | Int J Oral Maxillofac Surg2006，35，： | 1 |
| 12 | Role of mitochondrialdysfunction in insulin resistance显示文摘 | Kim JA Wei Y Sowers JR | 2008 | Circ Res2008，102，4： | 1 |
| 13 | Wnt/frizzled signaling in hepatocellular carcinoma显示文摘 | Lee HC Kim M Wands JR | 2006 | Front Biosci2006，11，： | 1 |
| 14 | Failure of continuous venovenous hemofiltration to prevent death in paraquat poisoning显示文摘 | Koo JR Kim JC Yoon JW et a1 | 2002 | Am J Kidney Dis2002，39，1： | 1 |
| 15 | Progress in the use of helical CT for imaging urinary calculi 显示文摘 | Williams J C Jr Kim S C Zarse C A | 2004 | J Endourol2004，18，10： | 1 |
| 16 | Membrane-initiated actions of estrogen on the - endothelium 显示文摘 | Kim KH Bender JR | 2009 | Mol Cell Endocrinol2009，308，12： | 1 |
| 17 | Epidermal growth factor receptor inhibitor-associated cutaneous toxicities: an evolving paradigm in clinical management 显示文摘 | Lynch TJ Jr Kim ES Eaby B | 2007 | Oncologist2007，12，5： | 1 |
| 18 | Reduced radiation dose helical chest CT:effect on reader evaluation of structures and lung findings显示文摘 | Mayo JR Kim KI MacDonald SL | 2004 | Radiology2004，232，3： | 1 |
| 19 | Regeneration of adenosine triphosphate from glyeolytie intermediates for cell-free protein synthesis 显示文摘 | Kim DM Swartz JR | 2001 | Biotechnol Bioeng2001，74，4： | 1 |
| 20 | Identification of parasite DNA in common bile duct stones by PCR and DNA sequencing显示文摘 | Jang JS Kim KH Yu JR | 2007 | Ko rean J Parasitol2007，45，4： | 1 |
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