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| 1 | Clinical and epidemiological characteristics of norovirus gastroenteritis among hospitalized children in Lebanon显示文摘AIM To assess the burden of norovirus(No V) and to determine the diversity of circulating strains among hospitalized children in Lebanon. METHODS Stool samples were collected from children presenting with acute gastroenteritis to six major hospitals in Lebanon. A total of 739 eligible stool samples, testing negative for diarrhea caused by rotavirus as a possible viral pathogen, were collected between January 2011 and June 2013. A standardized questionnaire including demographic, epidemiological and clinical observations was used at the time of hospitalization of children presenting with diarrhea. Viral RNA was extracted from stool samples followed by reverse transcription polymerase chain reaction and nucleotide sequencing of a fragment of the viral protein 1 capsid gene. Multiple sequence alignments were carried out and phylogenetic trees were constructed using the MEGA 6 software.RESULTS Overall, 11.2% of stool samples collected from children aged < 5 years tested positive for No V genogroups Ⅰ(GⅠ) and Ⅱ(GⅡ). GⅡ accounted for 10.6% of the gastroenteritis cases with only five samples being positive for GⅠ(0.7%). The majority of hospitalized children showed symptoms of diarrhea, dehydration, vomiting and fever. Upon sequencing of positive samples and based on their clustering in the phylogenetic tree, 4/5 of GⅠ gastroenteritis cases were designated GⅠ.3 and one case as GⅠ.4. GⅡ.4 was predominantly detected in stool of our study participants(68%). We report a JB-15/KOR/2008 GⅡ.4 Apeldoorn 2008-like variant strain circulating in 2011; this strain was replaced between 2012 and 2013 by a variant sharing homology with the Sydney/NSW0514/2012/AUS GⅡ.4 Sydney 2012 and Sydney 2012/FRA GⅡ.4 strains. We also report the co-circulation of non-GⅡ.4 genotypes among hospitalized children. Our data show that No V gastroenteritis can occur throughout the year with the highest number of cases detected during the hot months.CONCLUSION The majority of No V-associated viral gastroenteritis cases among our participants are attributable to GⅡ.4, which is compatible with results reported worldwide. | Nada M Melhem Hassan Zaraket Khalil Kreidieh Zeinab Ali Moza Hammadi Soha Ghanem Farah Hajar Amjad Haidar Adlette Inati Mariam Rajab Hassan Fakhouri Bassam Ghanem Ghassan Baasiri Ghassan Dbaibo | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 2 | 广东清远早、晚稻稻田甲烷排放的观测研究显示文摘分析了2003、2004年广东省清远市郊区早、晚稻稻田甲烷(CH4)的排放通量,结果表明广东清远早、晚稻稻田CH4排放通量的几何平均值2003年为4.38mg·m-2·h-1和6.09mg·m-2·h-1;2004年为5.17mg·m-2·h-1和8.3mg·m-2·h-1,土壤有机质含量是造成2003和2004年CH4排放差异的原因之一。水稻品种的不同,CH4排放通量也有所不同,实验表明,水稻品种“七丝尖”的排放通量比品种“金优99”高1.08mg·m-2·h-1,产量却只有64%。此外,与相关的测量结果进行初步比较。 | 许黎 任万辉 杨宁 王天龙 刘锦銮 M A K Khalil R A Rasmussen M J Shearer | 2007 | 气象2007，33，3： | 3 |
| 3 | 柴油乳化液喷雾闪急沸腾与微爆现象的激光阴影试验研究(英文)显示文摘在常压定容室内,应用ND:YAG激光阴影法、高分辨率CCD照相机和粒径分析软件,对不同含水量的柴油乳化液雾油滴的闪急沸腾与微爆现象以及油滴粒径分布进行了试验测量与变参数对比分析,探讨了在130℃温度条件下,乳化油含水量对乳化油喷雾液滴闪急沸腾和微爆的影响,揭示了微爆效应在喷雾雾化和液滴碎化中的作用机理。试验结果表明,包覆于油中的水相颗粒受热闪急沸腾所形成的高压蒸气团冲破无水边界层是导致油滴发生微爆和进一步破碎分裂的首要原因;微爆现象随乳化油含水量的增高而趋强;喷雾索特平均直径(SMD)的细化率随乳化油含水量和喷雾贯穿距的增加而增大,且乳化油含水量对喷雾SMD细化率的影响程度也随喷雾贯穿距的增加更加显著。 | MEDHAT Elkelawy 张煜盛 Alm El-Din Hagar 余敬周 El Zahaby A M El Shenawy E A Khalil A | 2009 | 内燃机学报2009，27，4： | 3 |
| 4 | Potential role of killer immunoglobulin receptor genes among individuals vaccinated against hepatitis B virus in Lebanon显示文摘AIM To explore the role of killer immunoglobulin receptor(KIR) genes in responsiveness or non-responsiveness to vaccination against hepatitis B virus.METHODS We recruited 101 voluntary participants between March 2010 and December 2011. Sera samples from vaccinated and non-vaccinated participants were tested for the presence of anti-HBs antibodies as a measure of protection against hepatitis B, hepatitis B surface antigen and hepatitis B core antibody as indicators ofinfection by enzyme-linked immunosorbent assay. KIR gene frequencies were determined by polymerase chain reaction.RESULTS Sera samples from 99 participants were tested for the levels of anti-HBs as an indicator of protection(≥ 10 mI U/ml) following vaccination as defined by the World Health Organization international reference standard. Among the vaccinated participants, 47%(35/74) had anti-HBs titers above 100 mI U/ml, 22%(16/74) had antiHBs ranging between 10-100 mI U/ml, and 20%(15/74) had values of less than 10 mI U/ml. We report the lack of significant association between the number of vaccine dosages and the titer of antibodies among our vaccinated participants. The inhibitory KIR2Dl1, KIR2Dl4, KIR3Dl1, KIR3Dl2, and KIR3 Dl were detected in more than 95%, whereas KIR2Dl2, KIR2Dl3, KIR2Dl5(KR2Dl5A and KIR2Dl5B) were expressed in 56%, 84% and 42%(25% and 29%) of participants, respectively. The observed frequency of the activating KIR genes ranged between 35% and 55% except for KIR2DS4, detected in 95% of the study participants(40.6% 2DS4*001/002; 82.2% 2DS4*003/007). KIR2DP1 pseudogene was detected in 99% of our participants, whereas KIR3DP*001/02/04 and KIR3DP1*003 had frequencies of 17% and 100%, respectively. No association between the frequency of KIR genes and anti-HBs antibodies was detected. When we compared the frequency of KIR genes between vaccinated individuals with protective antibodies titers and those who lost their protective antibody levels, we did not detect a significant difference. KIR2Dl5 B was significantly different among different groups of vaccinated participants(group Ⅰ > 100 mI U/ml, group Ⅱ 10-100 mI U/ml, group Ⅲ < 10 mI U/ml and group Ⅳ with undetectable levels of protective antibodies). CONCLUSION To our knowledge, this is the first study screening for the possible role of KIR genes among individuals vaccinated against hepatitis B virus(HBV). Our results can be used to design larger studies to better understand the role of KIR genes in protection against or susceptibility to HBV post vaccination. | Nada M Melhem Rami A Mahfouz Khalil Kreidieh Rabab Abdul-Khalik Rolla El-Khatib Reem Talhouk Umayya Musharrafieh Ghassan Hamadeh | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 5 | Breaking wheat yield barriers requires integrated efforts in developing countries显示文摘Most yield progress obtained through the so called 'Green Revolution', particularly in the irrigated areas of Asia, has reached a limit, and major resistance genes are quickly overcome by the appearance of new strains of disease causing organisms.New plant stresses due to a changing environment are difficult to breed for as quickly as the changes occur.There is consequently a continual need for new research programs and breeding strategies aimed at improving yield potential, abiotic stress tolerance and resistance to new, major pests and diseases.Recent advances in plant breeding encompass novel methods of expanding genetic variability and selecting for recombinants, including the development of synthetic hexaploid, hybrid and transgenic wheats.In addition, the use of molecular approaches such as quantitative trait locus(QTL) and association mapping may increase the possibility of directly selecting positive chromosomal regions linked with natural variation for grain yield and stress resistance.The present article reviews the potential contribution of these new approaches and tools to the improvement of wheat yield in farmer's fields, with a special emphasis on the Asian countries, which are major wheat producers, and contain the highest concentration of resource-poor wheat farmers. | Saeed Rauf Maria Zaharieva Marilyn L Warburton ZHANG Ping-zhi Abdullah M AL-Sadi Farghama Khalil Marcin Kozak Sultan A Tariq | 2015 | Journal of Integrative Agriculture2015，14，8： | 2 |
| 6 | A SiC14-ZnC12 induced general, mild and efficient one-pot, three- component synthesis of fl-amido ketone libraries 显示文摘 | Tarek A Salama Saad S Elmorsy Abdel-Galel M Khalil | 2007 | Tetrahedmn Letters2007，48，： | 1 |
| 7 | Sublingual midazolam premedication in children: a dose response study显示文摘 | Khalil S Philbrook L Rabb M | 1998 | Paediatr Anaesth1998，8，6： | 1 |
| 8 | Influence of a lignin based admixture on the hydration of portland cements显示文摘 | KHALIL S M WARD M A | 1973 | Cem Concr Res1973，3，6： | 1 |
| 9 | Failure analysis of a gas turbine compressor显示文摘 | FARR HI G H TIREHDAST M KHALIL ABAD E M | 2011 | Engineering Fail-ure Analysis2011，18，1： | 1 |
| 10 | Management of impacted proximal ureteral stone: Extracor- poreal shock wave lithotripsy versus ureteroscopy with holmium : YAG laser lithotripsy 显示文摘 | Khalil M | 2013 | Urol Ann2013，5，2： | 1 |
| 11 | Role of MDCT in identification of the bleeding site and the vessels causing hemoptysis显示文摘 | Khalil A Fartoukh M Tassart M | 2007 | AJR Am J Roentgenol2007，188，2： | 1 |
| 12 | Silicon micromirrors with three-dimensional curvature enabling lensless efficient coupling of free-space light显示文摘Miniaturized optical benches process free-space light propagating in-plane with respect to the substrate and have a large variety of applications,including the coupling of light through an optical fiber.High coupling efficiency is usually obtained using assembled micro-optical parts,which considerably increase the system cost and integration effort.In this work,we report a high coupling efficiency,monolithically integrated silicon micromirror with controlled three-dimensional(3D)curvature that is capable of manipulating optical beams propagating in the plane of the silicon substrate.Based on our theoretical modeling,a spherical micromirror with a microscale radius of curvature as small as twice the Gaussian beam Rayleigh range provides a 100%coupling efficiency over a relatively long optical path range.Introducing dimensionless parameters facilitates the elucidation of the role of key design parameters,including the mirror’s radii of curvature,independent of the wavelength.A micromachining method is presented for fabricating the 3D micromirror using fluorinated gas plasmas.The measured coupling efficiency was greater than 50%over a 200-mm optical path,compared to less than 10%afforded by a conventional flat micromirror,which was in good agreement with the model.Using the 3D micromirror,an optical cavity was formed with a round-trip diffraction loss of less than 0.4%,resulting in one order of magnitude enhancement in the measured quality factor.A nearly 100%coupling was also estimated when matching the sagittal and tangential radii of curvature of the presented micromirror’s surface.The reported class of 3D micromirrors may be an advantageous replacement for the optical lenses usually assembled in silicon photonics and optical benches by transforming them into real 3D monolithic systems while achieving wideband high coupling efficiency over submillimeter distances. | Yasser M Sabry Bassam Saadany Diaa Khalil Tarik Bourouina | 2013 | Light(Science & Applications)2013，2，1： | 1 |
| 13 | Utility of CT scan for the diagnosis of chest wall tuberculosis显示文摘 | Khalil A Le Breton C Tassart M | 1999 | Eur Radiol1999，9，8： | 1 |
| 14 | Cisplatin plus vinorelbine (PVn) as a salvage regiment for refractory breast cancer显示文摘 | Chehal A Taher A Khalil M | 2004 | Breast2004，13，5： | 1 |
| 15 | Exciting trajectories for the identification of base inertial parameters of robots 显示文摘 | Gautier M Khalil W | 1992 | International Journal of Robotics Research1992，11，4： | 1 |
| 16 | Tamoxifen and endometrial pathologies:a prospective study显示文摘 | Seoud M Shamseddine A Khalil A | 1999 | Gynecol Oncol1999，75，1： | 1 |
| 17 | Microstructure of cement hydrates containing calcium lignosulfonate admixture显示文摘 | KHALIL S M WARD M A | 1977 | Mater Constr Mater Struct1977，10，56： | 1 |
| 18 | Manganese(IV) -initiated graft polymerization of vinyl monomers on polyamide fibers显示文摘 | Khalil M I Abdel-Fattah S H Kantouch A | 1975 | Appl Polym Sci1975，19，： | 1 |
| 19 | Tissue engineering valved conduits in the pulmonary circulation显示文摘 | Stock UA Nagashima M Khalil PN | 2000 | J Thorac Cardiovasc Surg2000，119，： | 1 |
| 20 | Densification of alumina produced by urea formaldehyde sol-gel polymeric route显示文摘 | Ibrahim D M Khalil T Mostafa A A | 1999 | Ceramics International1999，25，3： | 1 |
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